LOCUS       NM_018992               2434 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens potassium channel tetramerization domain containing 5
            (KCTD5), mRNA.
ACCESSION   NM_018992
VERSION     NM_018992.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2434)
  AUTHORS   Rizk,R., Devost,D., Petrin,D. and Hebert,T.E.
  TITLE     KCTD Proteins Have Redundant Functions in Controlling Cellular
            Growth
  JOURNAL   Int J Mol Sci 25 (9), 4993 (2024)
   PUBMED   38732215
  REMARK    GeneRIF: KCTD Proteins Have Redundant Functions in Controlling
            Cellular Growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2434)
  AUTHORS   Muntean,B.S., Marwari,S., Li,X., Sloan,D.C., Young,B.D.,
            Wohlschlegel,J.A. and Martemyanov,K.A.
  TITLE     Members of the KCTD family are major regulators of cAMP signaling
  JOURNAL   Proc Natl Acad Sci U S A 119 (1) (2022)
   PUBMED   34934014
  REMARK    GeneRIF: Members of the KCTD family are major regulators of cAMP
            signaling.
REFERENCE   3  (bases 1 to 2434)
  AUTHORS   Canales,J., Cruz,P., Diaz,N., Riquelme,D., Leiva-Salcedo,E. and
            Cerda,O.
  TITLE     K+ Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell
            Migration, Focal Adhesion Dynamics and Spreading through Modulation
            of Ca2+ Signaling and Rac1 Activity
  JOURNAL   Cells 9 (10), 2273 (2020)
   PUBMED   33053687
  REMARK    GeneRIF: K(+) Channel Tetramerization Domain 5 (KCTD5) Protein
            Regulates Cell Migration, Focal Adhesion Dynamics and Spreading
            through Modulation of Ca(2+) Signaling and Rac1 Activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2434)
  AUTHORS   Rivas,J., Diaz,N., Silva,I., Morales,D., Lavanderos,B., Alvarez,A.,
            Saldias,M.P., Pulgar,E., Cruz,P., Maureira,D., Flores,G.,
            Colombo,A., Blanco,C., Contreras,H.R., Jana,F., Gallegos,I.,
            Concha,M.L., Vergara-Jaque,A., Poblete,H., Gonzalez,W., Varela,D.,
            Trimmer,J.S., Caceres,M. and Cerda,O.
  TITLE     KCTD5, a novel TRPM4-regulatory protein required for cell migration
            as a new predictor for breast cancer prognosis
  JOURNAL   FASEB J 34 (6), 7847-7865 (2020)
   PUBMED   32301552
  REMARK    GeneRIF: KCTD5, a novel TRPM4-regulatory protein required for cell
            migration as a new predictor for breast cancer prognosis.
REFERENCE   5  (bases 1 to 2434)
  AUTHORS   He,H., Peng,Y., Fan,S., Chen,Y., Zheng,X. and Li,C.
  TITLE     Cullin3/KCTD5 induces monoubiquitination of DeltaNp63alpha and
            impairs its activity
  JOURNAL   FEBS Lett 592 (13), 2334-2340 (2018)
   PUBMED   29782646
  REMARK    GeneRIF: Cullin3/KCTD5 downregulates the DNA-binding affinity of
            DeltaNp63alpha, impairing either its transactivity or its
            transinhibitory activity. Functionally, Cullin3/KCTD5 abates the
            proproliferation activity of DeltaNp63alpha. These findings suggest
            that KCTD5-based CRL3 may mediate monoubiquitination and is a novel
            regulator of DeltaNp63alpha.
REFERENCE   6  (bases 1 to 2434)
  AUTHORS   Ahmed,S.M., Theriault,B.L., Uppalapati,M., Chiu,C.W., Gallie,B.L.,
            Sidhu,S.S. and Angers,S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
REFERENCE   7  (bases 1 to 2434)
  AUTHORS   Dementieva,I.S., Tereshko,V., McCrossan,Z.A., Solomaha,E.,
            Araki,D., Xu,C., Grigorieff,N. and Goldstein,S.A.
  TITLE     Pentameric assembly of potassium channel tetramerization
            domain-containing protein 5
  JOURNAL   J Mol Biol 387 (1), 175-191 (2009)
   PUBMED   19361449
  REMARK    GeneRIF: structure reveals assemblies of five subunits while
            tetramers were anticipated; pentameric stoichiometry is observed
            also in solution by scanning transmission electron microscopy mass
            analysis and analytical ultracentrifugation
REFERENCE   8  (bases 1 to 2434)
  AUTHORS   Bayon,Y., Trinidad,A.G., de la Puerta,M.L., Del Carmen
            Rodriguez,M., Bogetz,J., Rojas,A., De Pereda,J.M., Rahmouni,S.,
            Williams,S., Matsuzawa,S., Reed,J.C., Crespo,M.S., Mustelin,T. and
            Alonso,A.
  TITLE     KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases
  JOURNAL   FEBS J 275 (15), 3900-3910 (2008)
   PUBMED   18573101
  REMARK    GeneRIF: Analysis of the interaction with cullin3 showed that, in
            addition to the BTB domain, some amino acids in the N-terminus of
            KCTD5 are required for binding to cullin3. Findings suggest that
            KCTD5 is a substrate-specific adaptor for cullin3-based E3 ligases
REFERENCE   9  (bases 1 to 2434)
  AUTHORS   Weger,S., Hammer,E., Gotz,A. and Heilbronn,R.
  TITLE     Identification of a cytoplasmic interaction partner of the large
            regulatory proteins Rep78/Rep68 of adeno-associated virus type 2
            (AAV-2)
  JOURNAL   Virology 362 (1), 192-206 (2007)
   PUBMED   17239418
  REMARK    GeneRIF: we have identified a novel cellular AAV-2 Rep78/Rep68
            interaction partner, KCTD5, located predominantly in the cytoplasm.
REFERENCE   10 (bases 1 to 2434)
  AUTHORS   Gandhi,T.K., Zhong,J., Mathivanan,S., Karthick,L., Chandrika,K.N.,
            Mohan,S.S., Sharma,S., Pinkert,S., Nagaraju,S., Periaswamy,B.,
            Mishra,G., Nandakumar,K., Shen,B., Deshpande,N., Nayak,R.,
            Sarker,M., Boeke,J.D., Parmigiani,G., Schultz,J., Bader,J.S. and
            Pandey,A.
  TITLE     Analysis of the human protein interactome and comparison with
            yeast, worm and fly interaction datasets
  JOURNAL   Nat Genet 38 (3), 285-293 (2006)
   PUBMED   16501559
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA134449.1 and BC007314.2.
            
            On Nov 23, 2018 this sequence version replaced NM_018992.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000047.1, SRR1660805.185512.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301738.9/ ENSP00000301738.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DA134449.1         30-47
            19-2434             BC007314.2         1-2416
FEATURES             Location/Qualifiers
     source          1..2434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2434
                     /gene="KCTD5"
                     /note="potassium channel tetramerization domain containing
                     5"
                     /db_xref="GeneID:54442"
                     /db_xref="HGNC:HGNC:21423"
                     /db_xref="MIM:611285"
     exon            1..278
                     /gene="KCTD5"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..731
                     /gene="KCTD5"
                     /note="potassium channel tetramerisation domain containing
                     5"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD5"
                     /protein_id="NP_061865.1"
                     /db_xref="CCDS:CCDS10475.1"
                     /db_xref="GeneID:54442"
                     /db_xref="HGNC:HGNC:21423"
                     /db_xref="MIM:611285"
                     /translation="MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSK
                     WVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPV
                     LNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQVPVKHVYRV
                     LQCQEEELTQMVSTMSDGWKFEQLVSIGSSYNYGNEDQAEFLCVVSKELHNTPYGTAS
                     EPSEKAKILQERGSRM"
     exon            279..387
                     /gene="KCTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            388..479
                     /gene="KCTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            480..575
                     /gene="KCTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            576..701
                     /gene="KCTD5"
                     /inference="alignment:Splign:2.1.0"
     exon            702..2434
                     /gene="KCTD5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2413..2418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCTD5"
                     /note="hexamer: AATAAA"
     polyA_site      2434
                     /gene="KCTD5"
                     /note="major polyA site"
ORIGIN      
        1 gagctgttgc ggggcttgct gggatcatgg cggagaatca ctgcgagctc ctgtcgccgg
       61 cccggggcgg catcggggcg gggctggggg gcggcctgtg ccgccgctgc agcgctgggc
      121 tcggcgccct ggcccagcgc cctggcagcg tgtccaagtg ggtccgactc aacgtcggcg
      181 gcacctactt cctcaccact cggcagaccc tgtgccggga cccgaaatcc ttcctgtacc
      241 gcttatgcca ggccgatccc gacctggact cagacaagga tgaaacaggc gcctatttaa
      301 tcgacagaga ccccacctac tttgggcctg tgctgaacta cctgagacac ggcaagctgg
      361 tgattaacaa agacctcgcg gaggaaggag tgttggagga agcagaattt tacaatatca
      421 cctcattaat aaaacttgta aaggacaaaa ttagagaacg agacagcaaa acatcgcagg
      481 tgcctgtgaa gcatgtgtac cgtgtgctgc agtgccagga ggaggagctc acgcagatgg
      541 tgtccaccat gtccgacggc tggaagttcg agcagttggt cagcatcggc tcctcttaca
      601 actatgggaa cgaagaccaa gccgagttcc tctgtgtggt gtccaaggag ctgcacaaca
      661 ccccgtacgg tacggccagc gagcccagcg agaaggccaa gattttgcaa gaacgaggct
      721 caaggatgtg agggacacag tattgacagc tgaagaaatg atttacgttt tcccgagatg
      781 taatgaactg ccatgtccag gaagcttggc tgtgagaaga aacctgcttt tgatcatttt
      841 tctagagatc tgggtgtgaa tccttttttg cctctgaggt gggtggtgag agacgggccc
      901 agctgtccaa ggccagacgt ccccaagttg ggggagcacg gcggccgggt gggcgctgcc
      961 tcttgggggg gcctcgctct gttttttcca agtgccacgt gggactgagg cagacactcc
     1021 cagtcagccc gctcgatcct gaagatcgtg tgaaggaagc gttcttggtg ctacacacag
     1081 tctggaaaag cagcctgggc ttcactggca ggaagcggcc gcagccgcgt cagtgtccag
     1141 cacgtcgtgg cctctggtcc gaccaccagg ccctagtctc ggtcagggag tctgctctgc
     1201 ctcccaggcg ggatcgctgg tttctctcga cctcgcagag ctcctgacaa aggcggcttc
     1261 tgcgtcgtca ctgcttcccg gcgccattcc gaggccgggc cttcttctga cacgggctcc
     1321 aaccccacct gaccaagccc gggacagtca aggcttctca atttgtattt tccaggcaag
     1381 agaactttgt accccttctc tgtgtggata gactccccag cgtttttcct ctggaaatgc
     1441 ccacagggct tgccgcgtgg agactgatct gttccatccg ttagcgcgag gtagcagtgt
     1501 cgcctcgccc ctcccactgc gggctcacgg ggagctggcg tctgtcagtg ccttgtcacg
     1561 cctggcatag aggttgggct ggaggcctgt ccactggctt ctggagctga aggtctgcgt
     1621 cacggtgaaa attcgggatg tttacagagc atcacaaatg cctctctctc gccgctctct
     1681 cattttcttt gtataactat gcagccttcc ctctctttct gggatgtttg ggacttcact
     1741 cgacctgcac gggctctgcc cgacatgccg tgggagctgc tgggattcct ttagaaaccg
     1801 ctgcccgcat gctttgaaaa cagacctttc tcagctggct gtggggacct gtcagagtct
     1861 ggggactcgg cgtgcagggc gggctccaag cgctttgctt ccggaactcc ggcttcccaa
     1921 ggggtactgt gcagactgac caccggcctc ccgcctgcag gtcagaggct ctgacactgt
     1981 ctggtttcca atgcttctgg agacttcctg cctaggcctc atcctcctct ttgccagtca
     2041 cctgattaac caattctcca gcattaggac ttacctcctt ctttttgtaa ggtctcttgt
     2101 atgttgttaa atgtttggct taaacaattt ataaaagcct ttctagaagg cagacttagc
     2161 cccagcagag cctgggagga aggcggccgc tggggctcct gggcatcctc tctggggagc
     2221 tgctggccgc ttagcgttgt ttgatttttg accttgacat agtagatagg cttgtggttt
     2281 ttttaattta aagatattaa gacttaattc actaaaattt attctaaggg gatatttata
     2341 cttttatact tttttaggta tcgtatttta tcagcttaca gtttaatgcc taagtttccc
     2401 ctggaaatag caaataaaat tgtgtattta tgaa
//
