LOCUS       NM_001029859            3389 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens potassium channel tetramerization domain containing 21
            (KCTD21), mRNA.
ACCESSION   NM_001029859 XM_374915
VERSION     NM_001029859.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Spiombi,E., Angrisani,A., Fonte,S., De Feudis,G., Fabretti,F.,
            Cucchi,D., Izzo,M., Infante,P., Miele,E., Po,A., Di Magno,L.,
            Magliozzi,R., Guardavaccaro,D., Maroder,M., Canettieri,G.,
            Giannini,G., Ferretti,E., Gulino,A., Di Marcotullio,L., Moretti,M.
            and De Smaele,E.
  TITLE     KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by
            increasing protein levels of the oncosuppressor KCASH2
  JOURNAL   Oncogenesis 8 (11), 64 (2019)
   PUBMED   31685809
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3389)
  AUTHORS   De Smaele,E., Di Marcotullio,L., Moretti,M., Pelloni,M.,
            Occhione,M.A., Infante,P., Cucchi,D., Greco,A., Pietrosanti,L.,
            Todorovic,J., Coni,S., Canettieri,G., Ferretti,E., Bei,R.,
            Maroder,M., Screpanti,I. and Gulino,A.
  TITLE     Identification and characterization of KCASH2 and KCASH3, 2 novel
            Cullin3 adaptors suppressing histone deacetylase and Hedgehog
            activity in medulloblastoma
  JOURNAL   Neoplasia 13 (4), 374-385 (2011)
   PUBMED   21472142
  REMARK    GeneRIF: Rescuing KCASHs expression reduces the Hedgehog-dependent
            medulloblastoma growth, suggesting that loss of members of this
            novel family of native HDAC inhibitors is crucial in sustaining Hh
            pathway-mediated tumorigenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC342183.1 and AK095233.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001029859.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DC325444.1, BC036058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340067.4/ ENSP00000339340.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-572               DC342183.1         4-575
            573-3389            AK095233.1         325-3141
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..3389
                     /gene="KCTD21"
                     /gene_synonym="KCASH2"
                     /note="potassium channel tetramerization domain containing
                     21"
                     /db_xref="GeneID:283219"
                     /db_xref="HGNC:HGNC:27452"
                     /db_xref="MIM:618790"
     exon            1..54
                     /gene="KCTD21"
                     /gene_synonym="KCASH2"
                     /inference="alignment:Splign:2.1.0"
     exon            55..3389
                     /gene="KCTD21"
                     /gene_synonym="KCASH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..866
                     /gene="KCTD21"
                     /gene_synonym="KCASH2"
                     /note="potassium channel tetramerisation domain containing
                     21; potassium channel tetramerization domain-containing
                     protein 21"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD21"
                     /protein_id="NP_001025030.1"
                     /db_xref="CCDS:CCDS31645.1"
                     /db_xref="GeneID:283219"
                     /db_xref="HGNC:HGNC:27452"
                     /db_xref="MIM:618790"
                     /translation="MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQ
                     GNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEALQEKEVE
                     LSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLG
                     SKLFYCSNGNLSSITSHLQDPNHLTLDWVANVEGLPEEEYTKQNLKRLWVVPANKQIN
                     SFQVFVEEVLKIALSDGFCIDSSHPHALDFMNNKIIRLIRYR"
     regulatory      1594..1599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCTD21"
                     /gene_synonym="KCASH2"
                     /note="hexamer: AATGAA"
     polyA_site      1615
                     /gene="KCTD21"
                     /gene_synonym="KCASH2"
     regulatory      3374..3379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCTD21"
                     /gene_synonym="KCASH2"
                     /note="hexamer: TATAAA"
     polyA_site      3389
                     /gene="KCTD21"
                     /gene_synonym="KCASH2"
                     /note="major polyA site"
ORIGIN      
        1 gcaaagctgc gctggccgct cgcggaggga gaggctgcag agcgagggca ggaggactac
       61 ttccagcaac ccagtctcct gccatgtccg accccatcac gctgaacgtc ggggggaagc
      121 tctatacaac ctcactggcg accctgacca gcttccctga ctccatgcta ggcgccatgt
      181 tcagcgggaa gatgcccacc aagagggaca gccagggcaa ctgcttcatt gaccgtgacg
      241 gcaaagtgtt ccgctatatc ctcaacttcc tgcggacctc ccaccttgac ctgcctgagg
      301 acttccagga gatggggctg ctccgcaggg aggccgactt ctaccaggtg cagcccctga
      361 ttgaggccct gcaggagaag gaagtggagc tctccaaggc cgagaagaat gccatgctca
      421 acatcacact gaaccagcgt gtgcagacgg tccacttcac tgtgcgcgag gcaccccaga
      481 tctacagcct ctcctcttcc agcatggagg tcttcaacgc caacatcttc agcacctcct
      541 gcctcttcct caagctcctt ggctctaagc tcttctactg ctccaatggc aatctctcct
      601 ccatcaccag ccacttgcag gaccccaacc acctgactct ggactgggtg gccaatgtgg
      661 agggcctgcc agaggaggag tacaccaagc agaacctcaa gaggctctgg gtggtgcccg
      721 ccaacaagca gatcaacagc ttccaggtct tcgtggaaga ggtactgaaa atcgctctga
      781 gcgatggctt ctgcatcgat tcttctcacc cacatgctct ggattttatg aacaataaga
      841 ttattcgatt aatacggtac aggtaaaagg accccaacaa cactggagat ggggagtccc
      901 aggaagctca tgtcagccag gtcttggagg gcatctcgcc agtggtgcga ggcaggggac
      961 tatactaatc tgtattaatt gtgtagcagg acttgattcc ccccatgatg aagtccacct
     1021 tttggaatcc agtgtcctct gaacagaacc accttttttc ttgccatttt gagctgcaga
     1081 caggcggttt attatgacaa gtgaagagtc agctgatgtg tactaaagga ggccatagga
     1141 ggattttcca gccaggacaa aagagcagca gttttctcct gggctccatc tctctgtacc
     1201 gctagccagt gccgcattta tccatctgta agaaggccct ggtggagagg atgggatgag
     1261 aacaagaggc tacctccagt taaccaggac ataaagtccc cagcggttcc tgtcacacct
     1321 gctcctccct ccccagggtg catccatgat cgtggatgtt tgcccagggg tgaccatgtt
     1381 tggctggctt ggaatgctgt gcattctcag agctctgtta gtgtcccctc ttgggggtca
     1441 gagatgaggt gtggcagggt ctagaggaat gagtgtccag gcagagttca gaaggtagga
     1501 atgtccctct tgatagggct gaatcaaggg attcctggct ttagaaaggg tctgctatct
     1561 ttgcaaaaat gtgcaagtat ctgtagccag tgtaatgaaa tcacttccaa atccagcctg
     1621 ttacctgact tttgtcattg ttttcccaaa aatttgaggt atcattgaaa caggtcattt
     1681 taaacaaatc tattacggat tctcagggtt ggaaataatt cgatgattgc ttagtcctcc
     1741 cccaccccta gaacacccca gcacatctga agatgagcgc ctctccctgg gtacctgcaa
     1801 gtgatcacct tggcctgctt gcataccttg gctgatagga agcgcgccat ccccaaggca
     1861 gctcctgctg tggttggaca gtgctgactg ttagacagtt cttccctata ttgagccaaa
     1921 atctgtcctg ccacttgctg gatcttggtt gcagaccttc ccattcaccc agttatatat
     1981 ctttgctttc aaaatagtca ccttgagaga ccagacattt ttctgaaaac atcattactc
     2041 agaattcaga ttcccctctg ggatctgtct tcagaatcaa agttagctct tttctatccc
     2101 ctgtaagtca gtcccctttt gttgtagctt cacctcgttt gtgaccccca cttcacccac
     2161 cttccccacc atctgtggct ccatatacct ttcgaccatt ttctgctgga agaggaagat
     2221 tcacggcccc tgaggagatc cagaggaaag agacggtctc caagggtgct gtgcagcaag
     2281 gagcccagga gtggtatgaa ccgtaacagt gcccttagag taaatgtgcg gcccctaaga
     2341 ccctgccctc aggaaggcgg ccttcccctg cagtcctgtg tcccacccct gggtctctgt
     2401 agggtgccat ccagggcaag caacccaagc actgcttccc accgggtgat gagccatgca
     2461 ggcctccaaa ctgcacgtca tgattcatcc ctaaagtgag tttggccttg agagtcccca
     2521 gggtcctccc ccactgggca ggggtcctca aagccaagga agcctggtga cacaggcacc
     2581 catgggaggt gggcccagaa aggggcttcc catagatagg ccctgtgagt agggagcttg
     2641 tacactgggc catgggcagc gccagttccc ttgagcagta aaggcccttt tccccctacg
     2701 gtgggaccca ggagtctctc tgacagcttt tctgccaggc acagtggctc atgcctgtaa
     2761 tcccaacact ctgggaggcc gaggcgggaa gatcacttga ggtcaggagt tcaagaccag
     2821 cctggccaac atggtgaaac gtcgtctctg ctaaaaatac aaaaattagc tgggtgtggt
     2881 gacaggcgcc tataacccca gctatttggg aggctgaggc agtagaatcg cttgaaccca
     2941 gatagcagag gttgcagtga gctgagagtg tgccattgca gagagactcc atcccaaaaa
     3001 aagacagctg tcccaggcca agggtacttg ggagagcccc tcatggagaa cctagtttag
     3061 accaagtagc agaagctgtg gtcataacaa aacaatttga ggaagaaatc ttacaaatca
     3121 ccactgccct ttctcctttt ccataaaact gtccatcttt tcggtgctcc ctaatccaag
     3181 cagcttgact ttagagaagt tgcagaagca gtgaagccac taacatgctg tgtgacttta
     3241 tgcaagtcac tcacctcact gagccacctc catttcttca tctgtgaaat aggcataaca
     3301 gtaatacata accctaccta cctcacaggg ctgttgtgag gatcaaatga aataatgtaa
     3361 cgtgagaata cagtataaat gataaagga
//
