LOCUS       NM_173562               5384 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens potassium channel tetramerization domain containing 20
            (KCTD20), transcript variant 1, mRNA.
ACCESSION   NM_173562
VERSION     NM_173562.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5384)
  AUTHORS   Zhang,J., Li,Y., Liu,Y., Xu,G., Hei,Y., Lu,X. and Liu,W.
  TITLE     Long non-coding RNA NEAT1 regulates glioma cell proliferation and
            apoptosis by competitively binding to microRNA-324-5p and
            upregulating KCTD20 expression
  JOURNAL   Oncol Rep 46 (1) (2021)
   PUBMED   33982764
  REMARK    GeneRIF: Long noncoding RNA NEAT1 regulates glioma cell
            proliferation and apoptosis by competitively binding to
            microRNA3245p and upregulating KCTD20 expression.
REFERENCE   2  (bases 1 to 5384)
  AUTHORS   Huggett,S.B. and Stallings,M.C.
  TITLE     Cocaine'omics: Genome-wide and transcriptome-wide analyses provide
            biological insight into cocaine use and dependence
  JOURNAL   Addict Biol 25 (2), e12719 (2020)
   PUBMED   30734435
  REMARK    GeneRIF: Cocaine'omics: Genome-wide and transcriptome-wide analyses
            provide biological insight into cocaine use and dependence.
REFERENCE   3  (bases 1 to 5384)
  AUTHORS   Zhang,X., Zhou,H., Cai,L., Fan,C., Liu,Y., Wang,L., Li,Q. and
            Miao,Y.
  TITLE     Kctd20 promotes the development of non-small cell lung cancer
            through activating Fak/AKT pathway and predicts poor overall
            survival of patients
  JOURNAL   Mol Carcinog 56 (9), 2058-2065 (2017)
   PUBMED   28398603
  REMARK    GeneRIF: results suggest that Kctd20 impacts proliferation and
            invasion of non-small cell lung cancer through enhancing Fak and
            Akt phosphorylation
REFERENCE   4  (bases 1 to 5384)
  AUTHORS   Nawa,M. and Matsuoka,M.
  TITLE     KCTD20, a relative of BTBD10, is a positive regulator of Akt
  JOURNAL   BMC Biochem 14, 27 (2013)
   PUBMED   24156551
  REMARK    GeneRIF: KCTD20 is a positive regulator of Akt and may play an
            important role in regulating the death and growth of some
            non-nervous and nervous cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5384)
  AUTHORS   Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J Biol Chem 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   6  (bases 1 to 5384)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY305862.1, BC023525.2, CX872315.1 and BI493539.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173562.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.284837.1,
                                           SRR1803614.55229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373731.7/ ENSP00000362836.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2746              AY305862.1         234-2979
            2747-4620           BC023525.2         2220-4093
            4621-4922           CX872315.1         494-795
            4923-5384           BI493539.1         60-521
FEATURES             Location/Qualifiers
     source          1..5384
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..5384
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /note="potassium channel tetramerization domain containing
                     20"
                     /db_xref="GeneID:222658"
                     /db_xref="HGNC:HGNC:21052"
                     /db_xref="MIM:615932"
     exon            1..112
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            113..318
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1418
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /note="isoform a is encoded by transcript variant 1;
                     BTB/POZ domain-containing protein KCTD20; potassium
                     channel tetramerisation domain containing 20"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD20 isoform
                     a"
                     /protein_id="NP_775833.2"
                     /db_xref="CCDS:CCDS4821.1"
                     /db_xref="GeneID:222658"
                     /db_xref="HGNC:HGNC:21052"
                     /db_xref="MIM:615932"
                     /translation="MNVHRGSDSDRLLRQEASCLVDDTLAVAQEKEANSLASSGPHNL
                     TYPLGPRNEDLSLDYASQPANLQFPHIMPLAEDIKGSCFQSGNKRNHEPFIAPERFGN
                     SSVGFGSNSHSQAPEKVTLLVDGTRFVVNPQIFTAHPDTMLGRMFGPGREYNFTRPNE
                     KGEYEIAEGISATVFRTVLDYYKTGIINCPDGISIPDLRDTCDYLCINFDFNTIRCQD
                     LSALLHELSNDGAHKQFDHYLEELILPIMVGCAKKGERECHIVVLTDEDSVDWDEDHP
                     PPMGEEYSQILYSSKLYRFFKYIENRDVAKTVLKERGLKNIRIGIEGYPTCKEKIKRR
                     PGGRSEVIYNYVQRPFIQMSWEKEEGKSRHVDFQCVRSKSLTNLVAAGDDVLEDQEIL
                     MHHPPQVDELDRLNAPLSQMASNDFQD"
     exon            319..592
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..695
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            696..816
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1014
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1125
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..5384
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5366..5371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /note="hexamer: AATAAA"
     polyA_site      5384
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgccgct gcggcacagc cggtcccggc tgcggcttct ggctgcgcgg cctgcgcgcg
       61 cctcccgggc ggattccagc cccgagcggg acagcgcggc ggggagcgac gagatttctc
      121 tctgatcaaa cggacagttc aggactcaga atctaaggat gaatgttcac cgtggcagtg
      181 acagtgacag gttattgcgg caggaggcca gctgcttagt ggatgatact ttagctgtag
      241 cccaagaaaa agaagcaaac agcctggctt catctggtcc tcataatctt acttatcctc
      301 taggtcccag gaatgaagac ctctcacttg actatgcctc tcagccagca aatcttcagt
      361 tccctcacat aatgcccctt gctgaagaca tcaaaggttc ttgcttccaa agtgggaata
      421 aacggaacca tgaacctttt attgctccag aaagatttgg aaacagtagt gtgggctttg
      481 gcagtaattc ccattcccaa gcaccagaga aagtgacgct tcttgtagat ggcacacgtt
      541 ttgttgtgaa tccacagatt ttcactgctc atccggatac catgctggga aggatgtttg
      601 gaccaggaag agagtacaac ttcactcggc ccaatgagaa gggagagtat gagattgctg
      661 aaggcatcag tgcaactgta tttcgcacag tgctggatta ttacaaaacc ggtatcatca
      721 attgtcctga tggcatctct atcccagatc ttagagatac ttgtgattat ctctgcatta
      781 attttgactt caacactatc cgatgtcaag atctgagtgc tttactccat gaactgtcta
      841 atgacggtgc tcataagcag tttgatcact acctcgaaga gctcatcttg cccatcatgg
      901 tgggctgtgc caagaaagga gaacgagagt gccacattgt tgtgctgacg gatgaggatt
      961 ctgtggactg ggatgaagac caccctccac caatggggga ggaatattcc caaattcttt
     1021 atagctccaa gctctacaga ttcttcaaat atattgagaa tagggatgtt gcaaaaacag
     1081 tgttaaagga acggggccta aaaaacattc gcattggaat tgaaggttac cctacctgta
     1141 aagaaaaaat taagagaagg cctggcggcc ggtctgaagt catctataat tatgtacaac
     1201 gccccttcat ccagatgtca tgggaaaagg aagaagggaa gagtcgccat gtggatttcc
     1261 agtgtgttcg aagcaaatcc ctcacgaatc tggtagctgc tggagatgat gtcttggagg
     1321 accaggagat attaatgcat cacccacccc aagtggatga acttgaccgg ctaaatgccc
     1381 cactttctca gatggcttct aacgactttc aggattaggg ccagctgtgg gtctactcct
     1441 tgttggagcc catctcacct gggatgcctg cagccagccc tccctcgtga tttgtctcac
     1501 cttgagtagg agacatgctt ctcccctaac cttttccttt ctgccataat taacatatgt
     1561 ccttttcagt aagtccatgc ctctggcagg ggatgaagaa gtactcactg gtaattagct
     1621 accatctttg cagcagccct ggtaacttga aaaatttggg tctggtgctg ttcattgagt
     1681 ctttgtgtaa ctgcaaaagc aggaaaggaa gtcaagactc ctgttgcctc gtgcttagca
     1741 aagcagtcct tatcctttat actctgttct tgggttttgt ttttgtcttg ttttatacca
     1801 ggcaaattgc ttagtagcaa agggaccaaa ctgaaaaggt gacaatctct aacttctaaa
     1861 agcagacacc aatcggatgc tcattagagg ttaatgaaga tgccattctt ggtggcctct
     1921 gcacccaaat tgcatctgga aagaactagg gtctcattca gaatgtccaa aaggaaattc
     1981 ttaagagctt aaattcagat ttgtgtctca ttaatgcagt gaacaattca aaaccacaca
     2041 gattccttgg caggaaggat aatggaataa cagtgttgat gagacctttt tagcttcaag
     2101 gtttcggagt ctaaacaaat ggatgattca tttggaatga aactcacaat gcaagtagaa
     2161 ggacctctcc aaatcaggcc agttgggtta tcctggcttg gaatctggtg tgaaaccata
     2221 ggtcttaaca ctctggagca gcacattgct gtggatatgt ccaggagacc ttagatatgg
     2281 cttaaaggct ttcaagatga ggacagaaat tgcttacaat tgctcagttt ctcaacagaa
     2341 agactcataa gagtgccagc atggggtaca tggagtgaag ctgggtggga agcatcatct
     2401 gcacagtccc tgtcctagtg caggactttt ctctgtatgt tttcatacca tgggattttt
     2461 ggatatcagt gtattttggt tcttgaaata gcctaatagc tgctcacaca ttgggtagga
     2521 atattatacc aatgtcatcc ccaaaggaag ggtgagctga atggaaatta agcccagtca
     2581 ttttatttga tctattagct ctgttatcag tgcatgatca cccagatcac cctcctcagc
     2641 ccacacagtg ctgaaccatc ttccctcctg ttctccatgg ctattaatag tatagctaaa
     2701 tttagagtgc agagccagat ataagtattt tggaattatc tcccagtttg tggtagaagc
     2761 tgactggaat acaggttgag tatctcttat ccaaaatgct agggaccaga aaggtttcag
     2821 attttttcag attttggaat acttaacagt tgagcacccc aaatctgaaa ggcttctgaa
     2881 cgtcatgtca gcactcaaaa aagtggattt tggagcactt caaatttcgg atttttggat
     2941 ttgggatgct catcctgtgt aggagaggct actcgattcc atttaatgac tgtcctagtc
     3001 ataatcatcc aaagataaaa gccaggtaga tgttgaaagc tctttccagg gctgaaaaag
     3061 tgttcttacg ttctctgcat gtgactagca tcactgtgga aattaatgct ctgttcttca
     3121 ctagaatgta gtaagtggtt aaactgagct atcccccacc tgatgactat tggcatccat
     3181 ttgcaaggcc aatggcctgg attaagggtt aggattattt gtagctagaa ggtaatttta
     3241 tttctgtgaa actaattggc tcatatttga ggttaggtgt ggccttgacc ttaccagtac
     3301 atttataccc actaccagtt gactagccca gataattgtt aaatggtgct tcttttctgc
     3361 ttctcagtag acttccatgc cattacaaag gaaatttgaa ttacctagtg tttgtatatt
     3421 ccatgataac tatgtataac ttctgttaca cagcttatgt attgttaaca tttaagtgta
     3481 aaccatgcca cagctaacac ttaaaaatga aaactaatta gttcttgctt agggaaaatg
     3541 ccaggtatga agtatggcat atacttgaca ctgtcctgtg taacccttta ctttgctcag
     3601 gctttcaaga ttgagtcttt tttcccccaa attaggttaa catgcatttg accccaacct
     3661 gtggggtttg agtaagctgg aaatctgtga cggtaggctt tctagtgtca cgaggtggtg
     3721 gtgactgaag gaaaagctgg gatcacaggt tccttctgat ggagaggaag gtttatttct
     3781 atgcccctcc caccaccctc cacctagagc tcacccaagc ctgctccagt cccaggggca
     3841 ggccattctg caaaagcagg acctcacaga aacaagggct gggttgaggt cacccccttc
     3901 agagttggtt cctggccaga tgggtaagag gcatttgtaa ttttaaaaat gtgaaacttg
     3961 ggtttggtgt tttcttctaa gtgcctaaat aagcaagcca ggctgttgat attttagcca
     4021 gagaaatcgg caagccaaga ttaacccgaa tctgaagttt agaatcttga gtttgcatct
     4081 gcatcatatc atgctgtttt gatgaggaaa catttgccac tgaggagttg gagggagggc
     4141 aagacgacag tgttaagtca gatcatttaa tggtttcccc taagccctgg aaaaatattt
     4201 gaaagaatgg cagcaaaaag gttaagaaag caagccagat ttactgcaca atatgcagta
     4261 cccagtacta ctttaaatcc caagagaaca gtgtgatgtc taatatatac aggtctatga
     4321 aaatactgtg gaataagccc aggaaggtta gatgtgtttg caaataagtt gcccaaaggg
     4381 tccccctcta agtaaaacaa atattcagac cacaggcttt aatgtaaact gtcaaaaagt
     4441 gggatgtgga ggatttttgt taagtgtcaa tcgaagttaa aaagcaaggg tttttggcca
     4501 ggcgtggtgg ctcacgcctg taatcccagc actttgggag gccgaggccg gcaaatcacc
     4561 taaggtcagg agttcgagac cagcctggcc aacatggtga aaccccgtct ctactaaaaa
     4621 tacaaaaaaa ttagcccggt gtggtggcaa gtgcctgtag tcccagctac ttgggaggct
     4681 gaggcaggag aactgcttga acccgggagg tagaggttgc agtgagccac gatcatgcca
     4741 ctgcactcca gcctgggcaa cagagcaaga ctccatctca aaaaagaaaa aaaaaaatta
     4801 aaggttttgg ctgggtgcag tggctcatgc cggtaatccc agcactttgg gaggccaagg
     4861 tgggaggatc acttgaggtc aggagtttca gactggcctg ggcaacgtaa aaaattaaaa
     4921 aaatagccag gcatggacat ggtagtgcat acctgtggtc ccagccactc aagaggctga
     4981 gacaggatga ttgcttgagc ccaggaggat gaggctgcag tgagccatga tgacgctact
     5041 gcactccagc ctggatgaca gggcaagacc ctgtctcaat attttaagtc aagggtttgt
     5101 agtaatgtat tcagtgccac ttcttgccat cactttgcaa ttattgaaat gggaatactg
     5161 agctcagaaa gcaaatatga tgctttcatg ggagatggag ccacatttgt gttctgggtg
     5221 ggatcactag tgcaggagaa cattacattt tcttctgaag gcaaaatgct tgtaggtttt
     5281 gcctctactt tgtatttact tttaaaattg cacttgttca cctaccagtg tttacgaaat
     5341 cctgtatttg ggatgctttt tctataataa aatattataa tttg
//
