LOCUS       NM_001286579            4886 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens potassium channel tetramerization domain containing 20
            (KCTD20), transcript variant 2, mRNA.
ACCESSION   NM_001286579 XM_005248942
VERSION     NM_001286579.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4886)
  AUTHORS   Zhang,J., Li,Y., Liu,Y., Xu,G., Hei,Y., Lu,X. and Liu,W.
  TITLE     Long non-coding RNA NEAT1 regulates glioma cell proliferation and
            apoptosis by competitively binding to microRNA-324-5p and
            upregulating KCTD20 expression
  JOURNAL   Oncol Rep 46 (1) (2021)
   PUBMED   33982764
  REMARK    GeneRIF: Long noncoding RNA NEAT1 regulates glioma cell
            proliferation and apoptosis by competitively binding to
            microRNA3245p and upregulating KCTD20 expression.
REFERENCE   2  (bases 1 to 4886)
  AUTHORS   Huggett,S.B. and Stallings,M.C.
  TITLE     Cocaine'omics: Genome-wide and transcriptome-wide analyses provide
            biological insight into cocaine use and dependence
  JOURNAL   Addict Biol 25 (2), e12719 (2020)
   PUBMED   30734435
  REMARK    GeneRIF: Cocaine'omics: Genome-wide and transcriptome-wide analyses
            provide biological insight into cocaine use and dependence.
REFERENCE   3  (bases 1 to 4886)
  AUTHORS   Zhang,X., Zhou,H., Cai,L., Fan,C., Liu,Y., Wang,L., Li,Q. and
            Miao,Y.
  TITLE     Kctd20 promotes the development of non-small cell lung cancer
            through activating Fak/AKT pathway and predicts poor overall
            survival of patients
  JOURNAL   Mol Carcinog 56 (9), 2058-2065 (2017)
   PUBMED   28398603
  REMARK    GeneRIF: results suggest that Kctd20 impacts proliferation and
            invasion of non-small cell lung cancer through enhancing Fak and
            Akt phosphorylation
REFERENCE   4  (bases 1 to 4886)
  AUTHORS   Nawa,M. and Matsuoka,M.
  TITLE     KCTD20, a relative of BTBD10, is a positive regulator of Akt
  JOURNAL   BMC Biochem 14, 27 (2013)
   PUBMED   24156551
  REMARK    GeneRIF: KCTD20 is a positive regulator of Akt and may play an
            important role in regulating the death and growth of some
            non-nervous and nervous cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4886)
  AUTHORS   Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J Biol Chem 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   6  (bases 1 to 4886)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY305862.1, BC023525.2, CX872315.1 and BI493539.1.
            
            On Jun 1, 2019 this sequence version replaced NM_001286579.1.
            
            Transcript Variant: This variant (2) lacks three alternate exons,
            resulting in the loss of an in-frame segment in the 5' coding
            region, compared to variant 1. The encoded isoform (b) is shorter
            than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.29785.1, BC023525.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AY305862.1         234-262
            30-4122             BC023525.2         1-4093
            4123-4424           CX872315.1         494-795
            4425-4886           BI493539.1         60-521
FEATURES             Location/Qualifiers
     source          1..4886
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..4886
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /note="potassium channel tetramerization domain containing
                     20"
                     /db_xref="GeneID:222658"
                     /db_xref="HGNC:HGNC:21052"
                     /db_xref="MIM:615932"
     exon            1..112
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            113..318
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..920
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /note="isoform b is encoded by transcript variant 2;
                     BTB/POZ domain-containing protein KCTD20; potassium
                     channel tetramerisation domain containing 20"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD20 isoform
                     b"
                     /protein_id="NP_001273508.1"
                     /db_xref="CCDS:CCDS69096.1"
                     /db_xref="GeneID:222658"
                     /db_xref="HGNC:HGNC:21052"
                     /db_xref="MIM:615932"
                     /translation="MNVHRGSDSDRLLRQEASCLVDDTLAVAQEKEANSLASSGPHNL
                     TYPLGPRNEGALLHELSNDGAHKQFDHYLEELILPIMVGCAKKGERECHIVVLTDEDS
                     VDWDEDHPPPMGEEYSQILYSSKLYRFFKYIENRDVAKTVLKERGLKNIRIGIEGYPT
                     CKEKIKRRPGGRSEVIYNYVQRPFIQMSWEKEEGKSRHVDFQCVRSKSLTNLVAAGDD
                     VLEDQEILMHHPPQVDELDRLNAPLSQMASNDFQD"
     exon            319..516
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            517..627
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            628..4886
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4868..4873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /note="hexamer: AATAAA"
     polyA_site      4886
                     /gene="KCTD20"
                     /gene_synonym="C6orf69; dJ108K11.3"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgccgct gcggcacagc cggtcccggc tgcggcttct ggctgcgcgg cctgcgcgcg
       61 cctcccgggc ggattccagc cccgagcggg acagcgcggc ggggagcgac gagatttctc
      121 tctgatcaaa cggacagttc aggactcaga atctaaggat gaatgttcac cgtggcagtg
      181 acagtgacag gttattgcgg caggaggcca gctgcttagt ggatgatact ttagctgtag
      241 cccaagaaaa agaagcaaac agcctggctt catctggtcc tcataatctt acttatcctc
      301 taggtcccag gaatgaaggt gctttactcc atgaactgtc taatgacggt gctcataagc
      361 agtttgatca ctacctcgaa gagctcatct tgcccatcat ggtgggctgt gccaagaaag
      421 gagaacgaga gtgccacatt gttgtgctga cggatgagga ttctgtggac tgggatgaag
      481 accaccctcc accaatgggg gaggaatatt cccaaattct ttatagctcc aagctctaca
      541 gattcttcaa atatattgag aatagggatg ttgcaaaaac agtgttaaag gaacggggcc
      601 taaaaaacat tcgcattgga attgaaggtt accctacctg taaagaaaaa attaagagaa
      661 ggcctggcgg ccggtctgaa gtcatctata attatgtaca acgccccttc atccagatgt
      721 catgggaaaa ggaagaaggg aagagtcgcc atgtggattt ccagtgtgtt cgaagcaaat
      781 ccctcacgaa tctggtagct gctggagatg atgtcttgga ggaccaggag atattaatgc
      841 atcacccacc ccaagtggat gaacttgacc ggctaaatgc cccactttct cagatggctt
      901 ctaacgactt tcaggattag ggccagctgt gggtctactc cttgttggag cccatctcac
      961 ctgggatgcc tgcagccagc cctccctcgt gatttgtctc accttgagta ggagacatgc
     1021 ttctccccta accttttcct ttctgccata attaacatat gtccttttca gtaagtccat
     1081 gcctctggca ggggatgaag aagtactcac tggtaattag ctaccatctt tgcagcagcc
     1141 ctggtaactt gaaaaatttg ggtctggtgc tgttcattga gtctttgtgt aactgcaaaa
     1201 gcaggaaagg aagtcaagac tcctgttgcc tcgtgcttag caaagcagtc cttatccttt
     1261 atactctgtt cttgggtttt gtttttgtct tgttttatac caggcaaatt gcttagtagc
     1321 aaagggacca aactgaaaag gtgacaatct ctaacttcta aaagcagaca ccaatcggat
     1381 gctcattaga ggttaatgaa gatgccattc ttggtggcct ctgcacccaa attgcatctg
     1441 gaaagaacta gggtctcatt cagaatgtcc aaaaggaaat tcttaagagc ttaaattcag
     1501 atttgtgtct cattaatgca gtgaacaatt caaaaccaca cagattcctt ggcaggaagg
     1561 ataatggaat aacagtgttg atgagacctt tttagcttca aggtttcgga gtctaaacaa
     1621 atggatgatt catttggaat gaaactcaca atgcaagtag aaggacctct ccaaatcagg
     1681 ccagttgggt tatcctggct tggaatctgg tgtgaaacca taggtcttaa cactctggag
     1741 cagcacattg ctgtggatat gtccaggaga ccttagatat ggcttaaagg ctttcaagat
     1801 gaggacagaa attgcttaca attgctcagt ttctcaacag aaagactcat aagagtgcca
     1861 gcatggggta catggagtga agctgggtgg gaagcatcat ctgcacagtc cctgtcctag
     1921 tgcaggactt ttctctgtat gttttcatac catgggattt ttggatatca gtgtattttg
     1981 gttcttgaaa tagcctaata gctgctcaca cattgggtag gaatattata ccaatgtcat
     2041 ccccaaagga agggtgagct gaatggaaat taagcccagt cattttattt gatctattag
     2101 ctctgttatc agtgcatgat cacccagatc accctcctca gcccacacag tgctgaacca
     2161 tcttccctcc tgttctccat ggctattaat agtatagcta aatttagagt gcagagccag
     2221 atataagtat tttggaatta tctcccagtt tgtggtagaa gctgactgga atacaggttg
     2281 agtatctctt atccaaaatg ctagggacca gaaaggtttc agattttttc agattttgga
     2341 atacttaaca gttgagcacc ccaaatctga aaggcttctg aacgtcatgt cagcactcaa
     2401 aaaagtggat tttggagcac ttcaaatttc ggatttttgg atttgggatg ctcatcctgt
     2461 gtaggagagg ctactcgatt ccatttaatg actgtcctag tcataatcat ccaaagataa
     2521 aagccaggta gatgttgaaa gctctttcca gggctgaaaa agtgttctta cgttctctgc
     2581 atgtgactag catcactgtg gaaattaatg ctctgttctt cactagaatg tagtaagtgg
     2641 ttaaactgag ctatccccca cctgatgact attggcatcc atttgcaagg ccaatggcct
     2701 ggattaaggg ttaggattat ttgtagctag aaggtaattt tatttctgtg aaactaattg
     2761 gctcatattt gaggttaggt gtggccttga ccttaccagt acatttatac ccactaccag
     2821 ttgactagcc cagataattg ttaaatggtg cttcttttct gcttctcagt agacttccat
     2881 gccattacaa aggaaatttg aattacctag tgtttgtata ttccatgata actatgtata
     2941 acttctgtta cacagcttat gtattgttaa catttaagtg taaaccatgc cacagctaac
     3001 acttaaaaat gaaaactaat tagttcttgc ttagggaaaa tgccaggtat gaagtatggc
     3061 atatacttga cactgtcctg tgtaaccctt tactttgctc aggctttcaa gattgagtct
     3121 tttttccccc aaattaggtt aacatgcatt tgaccccaac ctgtggggtt tgagtaagct
     3181 ggaaatctgt gacggtaggc tttctagtgt cacgaggtgg tggtgactga aggaaaagct
     3241 gggatcacag gttccttctg atggagagga aggtttattt ctatgcccct cccaccaccc
     3301 tccacctaga gctcacccaa gcctgctcca gtcccagggg caggccattc tgcaaaagca
     3361 ggacctcaca gaaacaaggg ctgggttgag gtcaccccct tcagagttgg ttcctggcca
     3421 gatgggtaag aggcatttgt aattttaaaa atgtgaaact tgggtttggt gttttcttct
     3481 aagtgcctaa ataagcaagc caggctgttg atattttagc cagagaaatc ggcaagccaa
     3541 gattaacccg aatctgaagt ttagaatctt gagtttgcat ctgcatcata tcatgctgtt
     3601 ttgatgagga aacatttgcc actgaggagt tggagggagg gcaagacgac agtgttaagt
     3661 cagatcattt aatggtttcc cctaagccct ggaaaaatat ttgaaagaat ggcagcaaaa
     3721 aggttaagaa agcaagccag atttactgca caatatgcag tacccagtac tactttaaat
     3781 cccaagagaa cagtgtgatg tctaatatat acaggtctat gaaaatactg tggaataagc
     3841 ccaggaaggt tagatgtgtt tgcaaataag ttgcccaaag ggtccccctc taagtaaaac
     3901 aaatattcag accacaggct ttaatgtaaa ctgtcaaaaa gtgggatgtg gaggattttt
     3961 gttaagtgtc aatcgaagtt aaaaagcaag ggtttttggc caggcgtggt ggctcacgcc
     4021 tgtaatccca gcactttggg aggccgaggc cggcaaatca cctaaggtca ggagttcgag
     4081 accagcctgg ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa aattagcccg
     4141 gtgtggtggc aagtgcctgt agtcccagct acttgggagg ctgaggcagg agaactgctt
     4201 gaacccggga ggtagaggtt gcagtgagcc acgatcatgc cactgcactc cagcctgggc
     4261 aacagagcaa gactccatct caaaaaagaa aaaaaaaaat taaaggtttt ggctgggtgc
     4321 agtggctcat gccggtaatc ccagcacttt gggaggccaa ggtgggagga tcacttgagg
     4381 tcaggagttt cagactggcc tgggcaacgt aaaaaattaa aaaaatagcc aggcatggac
     4441 atggtagtgc atacctgtgg tcccagccac tcaagaggct gagacaggat gattgcttga
     4501 gcccaggagg atgaggctgc agtgagccat gatgacgcta ctgcactcca gcctggatga
     4561 cagggcaaga ccctgtctca atattttaag tcaagggttt gtagtaatgt attcagtgcc
     4621 acttcttgcc atcactttgc aattattgaa atgggaatac tgagctcaga aagcaaatat
     4681 gatgctttca tgggagatgg agccacattt gtgttctggg tgggatcact agtgcaggag
     4741 aacattacat tttcttctga aggcaaaatg cttgtaggtt ttgcctctac tttgtattta
     4801 cttttaaaat tgcacttgtt cacctaccag tgtttacgaa atcctgtatt tgggatgctt
     4861 tttctataat aaaatattat aatttg
//
