LOCUS       NM_015353               3657 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens potassium channel tetramerization domain containing 2
            (KCTD2), transcript variant 1, mRNA.
ACCESSION   NM_015353 XM_496244
VERSION     NM_015353.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3657)
  AUTHORS   Rizk,R., Devost,D., Petrin,D. and Hebert,T.E.
  TITLE     KCTD Proteins Have Redundant Functions in Controlling Cellular
            Growth
  JOURNAL   Int J Mol Sci 25 (9), 4993 (2024)
   PUBMED   38732215
  REMARK    GeneRIF: KCTD Proteins Have Redundant Functions in Controlling
            Cellular Growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3657)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3657)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 3657)
  AUTHORS   Boada,M., Antunez,C., Ramirez-Lorca,R., DeStefano,A.L.,
            Gonzalez-Perez,A., Gayan,J., Lopez-Arrieta,J., Ikram,M.A.,
            Hernandez,I., Marin,J., Galan,J.J., Bis,J.C., Mauleon,A.,
            Rosende-Roca,M., Moreno-Rey,C., Gudnasson,V., Moron,F.J.,
            Velasco,J., Carrasco,J.M., Alegret,M., Espinosa,A., Vinyes,G.,
            Lafuente,A., Vargas,L., Fitzpatrick,A.L., Launer,L.J., Saez,M.E.,
            Vazquez,E., Becker,J.T., Lopez,O.L., Serrano-Rios,M., Tarraga,L.,
            van Duijn,C.M., Real,L.M., Seshadri,S. and Ruiz,A.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     ATP5H/KCTD2 locus is associated with Alzheimer's disease risk
  JOURNAL   Mol Psychiatry 19 (6), 682-687 (2014)
   PUBMED   23857120
  REMARK    GeneRIF: By merging results of a meta-GWAS, results in the CHARGE
            consortium data sets and an in vivo genotyping comprising 4501
            individuals, detected a novel locus ATP5H/KCTD2 associated with
            Alzheimer's disease risk
REFERENCE   5  (bases 1 to 3657)
  AUTHORS   Ahmed,S.M., Theriault,B.L., Uppalapati,M., Chiu,C.W., Gallie,B.L.,
            Sidhu,S.S. and Angers,S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
REFERENCE   6  (bases 1 to 3657)
  AUTHORS   Sidjanin,D.J., Miller,B., Kijas,J., McElwee,J., Pillardy,J.,
            Malek,J., Pai,G., Feldblyum,T., Fraser,C., Acland,G. and Aguirre,G.
  TITLE     Radiation hybrid map, physical map, and low-pass genomic sequence
            of the canine prcd region on CFA9 and comparative mapping with the
            syntenic region on human chromosome 17
  JOURNAL   Genomics 81 (2), 138-148 (2003)
   PUBMED   12620391
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB460074.1, D79998.1, BC033329.1 and CD742648.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015353.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D79998.1, SRR3476690.830899.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322444.7/ ENSP00000312814.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               DB460074.1         69-257
            190-886             D79998.1           170-866
            887-3064            BC033329.1         809-2986
            3065-3657           CD742648.1         17-609              c
FEATURES             Location/Qualifiers
     source          1..3657
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..3657
                     /gene="KCTD2"
                     /note="potassium channel tetramerization domain containing
                     2"
                     /db_xref="GeneID:23510"
                     /db_xref="HGNC:HGNC:21294"
                     /db_xref="MIM:613422"
     exon            1..365
                     /gene="KCTD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..818
                     /gene="KCTD2"
                     /note="potassium channel tetramerization domain-containing
                     protein 2; potassium channel tetramerisation domain
                     containing 2"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD2"
                     /protein_id="NP_056168.1"
                     /db_xref="CCDS:CCDS32728.1"
                     /db_xref="GeneID:23510"
                     /db_xref="HGNC:HGNC:21294"
                     /db_xref="MIM:613422"
                     /translation="MAELQLDPAMAGLGGGGGSGVGDGGGPVRGPPSPRPAGPTPRGH
                     GRPAAAVAQPLEPGPGPPERAGGGGAARWVRLNVGGTYFVTTRQTLGREPKSFLCRLC
                     CQEDPELDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGVLEEAEFYNI
                     ASLVRLVKERIRDNENRTSQGPVKHVYRVLQCQEEELTQMVSTMSDGWKFEQLISIGS
                     SYNYGNEDQAEFLCVVSRELNNSTNGIVIEPSEKAKILQERGSRM"
     exon            366..474
                     /gene="KCTD2"
                     /inference="alignment:Splign:2.1.0"
     exon            475..566
                     /gene="KCTD2"
                     /inference="alignment:Splign:2.1.0"
     exon            567..662
                     /gene="KCTD2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..788
                     /gene="KCTD2"
                     /inference="alignment:Splign:2.1.0"
     exon            789..3657
                     /gene="KCTD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3629..3634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCTD2"
                     /note="hexamer: AATAAA"
     polyA_site      3657
                     /gene="KCTD2"
                     /note="major polyA site"
ORIGIN      
        1 agcagcggtg gcggcggcgg tccaagatgg cggaactgca gctggacccg gcgatggcgg
       61 ggctgggagg gggcggcggg agtggggtgg gcgacggggg tggcccagtc cgcgggcccc
      121 ccagcccacg cccggctggc cccacgcccc gcgggcacgg ccgcccggct gccgccgtcg
      181 cgcagccgct ggagccgggt cccggaccac ccgagcgggc agggggcggc ggcgcggccc
      241 gctgggtcag gctgaacgtg ggaggcacct acttcgtgac caccagacag accttaggcc
      301 gggagcccaa gtcatttctc tgccgcctct gctgccagga ggacccggag ctggactcag
      361 acaaggatga gacaggagcc tatctgattg acagggaccc cacctacttt ggtcctatcc
      421 tcaactacct ccgccacggg aaactcatca tcactaagga gttggcagaa gaaggtgtgc
      481 tggaggaagc ggagttttac aacatcgcgt cccttgtgcg gctggttaag gaaaggatac
      541 gggacaatga gaacagaact tcacaaggcc ccgtgaagca cgtgtacaga gtcctgcagt
      601 gtcaggaaga agagctcacg cagatggtgt ccacgatgtc cgacggctgg aaattcgaac
      661 agctcatcag catcggatct tcctataact acggcaatga ggatcaggca gaattcctct
      721 gtgttgtctc cagagaacta aataattcta ccaatggcat cgtcatagag ccgagcgaaa
      781 aggcgaagat tcttcaggag agaggatcgc ggatgtaaac taagaccccg aaaactccag
      841 accttcagga gagcagtcag cagagcccct ctgtgaagtg aaacctcact cctgtccagt
      901 gaccgagcca ctgcaaagca cagctgatcc tggccccctg tgaagaagtg ttctggtcaa
      961 aactaaagga actccctccc cacctgcagg actccgaaga cagtgcgact tctggctgca
     1021 gaataccttt tcagaaacct gctttcattt gcttagccag tattagaaca gatctttaca
     1081 acagcagctg ggctgggttc ccagtcggag cctttcgggg atctggggga tgagggcgga
     1141 aggcctagct ccttggaaat ggcctgtact ttaaggacgc tggagccaag aggattgttc
     1201 ccgtgccgtg ccatggtttc accctatgtg tgccacaatg gacgttagca gctgcttcgg
     1261 aacaccgtcc ctcctatgca ccctccaaga cgtgcagcag atgcaaaggg ttctagctgc
     1321 agtttgtcga attgaggttt taggtaaagc atagagttgc cagagtaccc cgcattccca
     1381 tgaatagagc ctccaaggaa agggaggatg gggtgtcctt tgttgtggtt ggaggttggt
     1441 gatcattgct ctggatttgg ggctcccggc tgccaccaca tgcagctttg cctcaccttt
     1501 ctccagcagc cgggaccctc tggagagctt gttttccctc caagaagagg tttgagacag
     1561 gcggcatcct gcactgagtc agacaagtgg gagctgtagg aactgcacct gcagcctctt
     1621 cttactcccc attgaccctg tcttccttcc ctggcttttt caactggacc aaagatgaag
     1681 gcacttatgg accctttgat ggcttggagt ggggaaggct gtttctttga aagttgccaa
     1741 atgtgttatg ttgtgtctca gagagagtta tttctgtgac tctcttggaa atgccttgac
     1801 tgaatgtgca atatttgtgt ctcttggttt ctaaccttgg cggacctgct cccctctgta
     1861 ctgtccccag tggtatgtat gtatgtgcta ggcagtctgg ggaccccctg tgtctctgac
     1921 cacccccctg acccccgcca ttactttctt ttctggagtg ccatgctggc gaggatccgg
     1981 atgcggcagc accctctttc gggctgcatc cacagagttt gtgtccacac tttctctccg
     2041 agcatgtggg tctcgctgag cagtcatgga atgcggtaga gccaggggac cctgtctgcc
     2101 ccgaataact ttcagtagta tggcagatgg cacagagaaa gggaaggggc tctggggact
     2161 tctccttcta tgaaagcctc ctcgagccag gtgctcctgg gcaccttcag aagtgatgtc
     2221 ctgtgtgctc cacagctcac ctgcttgcca aggtacgtct gggtagtagt ttctggaaat
     2281 gactgcagac tgtgccaaat gtcttttgag cttctgacct gaccatgccc agatggcata
     2341 acttttccct aggaccctca gtctccttgt ttctctgtat ctgtagcata gcatagaacc
     2401 cggtatacag gggtttctgc tgacacatca acgtctacac acctatgcgc cacattttac
     2461 agctgtaaag tgttagatga actgccgtcc tcagtaaaag cagccacccc ttcaagagtc
     2521 acaggcatcc atccagtcgt atctttcaga gaaaaaaaaa gttagatgta gccaaggaaa
     2581 gtagtgatca cgggaaggac tgctctgagc cgggtaggat ggaggacttt ggaagaggcg
     2641 ctccttggcc aggtccaatg agtaacatca gactgacaga ggaaaagcag cttggtttgc
     2701 ggccttgtgc ccagtctcgt tgaggcgctt gtccctgtct gctttcctgg ggcatgcctg
     2761 atcagcgtgg gctggagctc ctagaccaac cccagctttc tcaccaggtt cagcaaggag
     2821 gcctgggggt cagacaccaa tgttgagcac ctcctgaggg cgccgtttcc ttcattcctc
     2881 ttagattcca tagttgccgc catgaaaaga ctgctcttga gccccaaggc acaggcacgt
     2941 gctctgggaa atagacagga gtggtatttc cgccctctcg gagggctggt gttcaccaag
     3001 tttccctcct cgctgcaacc caatgacacc tgtattgttc cagcgctcca ggactctggg
     3061 ttcttaagat ttctgggagc gttgttcacc cacccccttt aggaaccagg ctggtgttct
     3121 tgcttgaaag cgttgtgccc tctgagtgtc tggctgatca catcagagag gtctgcgtgg
     3181 cagtttgggg ctgtcacgtg accagtgacc cacactctct gctgcccagt actgccaagt
     3241 ggggagggtc ctgccttttt ctctgcccca ggtctgggac gcaggtgatg ccagccaggc
     3301 ccaggagtgc ccagcatccc ccaactgatg acacagtagc actgattctg tcttttcctc
     3361 agaatctggc ctttttccat ggcaatgagg tggggcccag cctcctctaa agtgactttg
     3421 tttctgcaca gttgtaactg ctcttgggga tgtcagtgag gctgggagca gggagccacg
     3481 ggatgctgag agaggaggcc cgagaggaca ccccaccctc cagcgtggcc tttgatccag
     3541 acttagggac gaggctgtca ctggtgggca ccctctgttc ctgtttgtgt gtttgaatag
     3601 tctgaaatgc tgtgactttt tttgtgtgaa taaagatatg aaacttctga atctcaa
//
