LOCUS       NM_020768              13488 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens potassium channel tetramerization domain containing 16
            (KCTD16), mRNA.
ACCESSION   NM_020768 XM_098368
VERSION     NM_020768.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13488)
  AUTHORS   Zuo,H., Glaaser,I., Zhao,Y., Kurinov,I., Mosyak,L., Wang,H.,
            Liu,J., Park,J., Frangaj,A., Sturchler,E., Zhou,M., McDonald,P.,
            Geng,Y., Slesinger,P.A. and Fan,Q.R.
  TITLE     Structural basis for auxiliary subunit KCTD16 regulation of the
            GABAB receptor
  JOURNAL   Proc Natl Acad Sci U S A 116 (17), 8370-8379 (2019)
   PUBMED   30971491
  REMARK    GeneRIF: Investigated structure/interaction of GABAB receptors and
            potassium channel tetramerization domain containing 16 (KCTD16).
            Found that mutating certain conserved KCTD16 interfacial residues
            disrupted modulation of GABAB receptors, suggesting a common mode
            of KCTD interaction with GABAB receptors.
REFERENCE   2  (bases 1 to 13488)
  AUTHORS   Yu,Y., Li,Y. and Zhang,Y.
  TITLE     Yeast Two-Hybrid Screening for Proteins that Interact with the
            Extracellular Domain of Amyloid Precursor Protein
  JOURNAL   Neurosci Bull 32 (2), 171-176 (2016)
   PUBMED   26960425
REFERENCE   3  (bases 1 to 13488)
  AUTHORS   Xie,T., Deng,L., Mei,P., Zhou,Y., Wang,B., Zhang,J., Lin,J.,
            Wei,Y., Zhang,X. and Xu,R.
  TITLE     Genome-wide association study combining pathway analysis for
            typical sporadic amyotrophic lateral sclerosis in Chinese Han
            populations
  JOURNAL   Neurobiol Aging 35 (7), 1778 (2014)
   PUBMED   24529757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK292477.1 and AC008716.7.
            
            On Nov 23, 2018 this sequence version replaced NM_020768.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749266.1, AK292477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000512467.6/ ENSP00000424151.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1631              AK292477.1         42-1672
            1632-5183           AC008716.7         175389-178940       c
            5184-13488          AC008716.7         167084-175388       c
FEATURES             Location/Qualifiers
     source          1..13488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..13488
                     /gene="KCTD16"
                     /note="potassium channel tetramerization domain containing
                     16"
                     /db_xref="GeneID:57528"
                     /db_xref="HGNC:HGNC:29244"
                     /db_xref="MIM:613423"
     exon            1..137
                     /gene="KCTD16"
                     /inference="alignment:Splign:2.1.0"
     exon            138..303
                     /gene="KCTD16"
                     /inference="alignment:Splign:2.1.0"
     exon            304..1461
                     /gene="KCTD16"
                     /inference="alignment:Splign:2.1.0"
     CDS             630..1916
                     /gene="KCTD16"
                     /note="potassium channel tetramerisation domain containing
                     16; potassium channel tetramerization domain-containing
                     protein 16"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD16"
                     /protein_id="NP_065819.1"
                     /db_xref="CCDS:CCDS34260.1"
                     /db_xref="GeneID:57528"
                     /db_xref="HGNC:HGNC:29244"
                     /db_xref="MIM:613423"
                     /translation="MALSGNCSRYYPREQGSAVPNSFPEVVELNVGGQVYFTRHSTLI
                     SIPHSLLWKMFSPKRDTANDLAKDSKGRFFIDRDGFLFRYILDYLRDRQVVLPDHFPE
                     KGRLKREAEYFQLPDLVKLLTPDEIKQSPDEFCHSDFEDASQGSDTRICPPSSLLPAD
                     RKWGFITVGYRGSCTLGREGQADAKFRRVPRILVCGRISLAKEVFGETLNESRDPDRA
                     PERYTSRFYLKFKHLERAFDMLSECGFHMVACNSSVTASFINQYTDDKIWSSYTEYVF
                     YREPSRWSPSHCDCCCKNGKGDKEGESGTSCNDLSTSSCDSQSEASSPQETVICGPVT
                     RQTNIQTLDRPIKKGPVQLIQQSEMRRKSDLLRTLTSGSRESNMSSKKKAVKEKLSIE
                     EELEKCIQDFLKIKIPDRFPERKHPWQSELLRKYHL"
     exon            1462..13488
                     /gene="KCTD16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5158..5163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCTD16"
                     /note="hexamer: AATAAA"
     polyA_site      5185
                     /gene="KCTD16"
     regulatory      13470..13475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCTD16"
                     /note="hexamer: AATAAA"
     polyA_site      13488
                     /gene="KCTD16"
                     /note="major polyA site"
ORIGIN      
        1 agacctaggt gatggaggaa gactgggagg cgctaaaatg agacagacgg agtcccctct
       61 cctgtccaca aactacaatg cctacaatgc ctcggtgtca gcatttactg tgattcaagc
      121 actgtgctaa agtgtttttc atatgtcatg aaaagttgtg ccagaaaatt atggtttgaa
      181 catgggcagt tttctcctac cgtcagctat atccacaagc atcacatgaa gtggagatct
      241 ggcagctctg tgtatttcag tcaagttcca caatgaaacc tgacaataat ggtaaaaacc
      301 aatacggaca tctgagtaac tggggaattg gcctgccttg catgtgagct tgatggaaga
      361 ttggatatag acgagttgat tatattttat gaagtagcag ctcactacca tccaccatcc
      421 agggtttaaa ctactttttc agcatcactt cacctgtgga ctcttataca ttttgatttc
      481 ttgggggaaa aatactggga taagaggagg tcatttttta ataagttagc atccttttcc
      541 ctttcttaca agttgatcca aaggataagg ctgtgactcc attggattgc acctttaaat
      601 caaaatagca gcagcagaag aaagggacaa tggctctgag tggaaactgt agtcgttatt
      661 atcctcgaga acaagggtcc gcagttccca actccttccc tgaggtggta gagctgaatg
      721 tcgggggtca agtttatttt actcgccatt ccacattgat aagcatccct cattccctcc
      781 tgtggaaaat gttttcccca aagagagaca cggctaatga tctagccaag gactccaagg
      841 gaaggttttt cattgacaga gatggattct tgttccgtta tattctggac tatctcaggg
      901 acaggcaggt ggtcctgcct gatcactttc cagaaaaagg aagactgaaa agggaagctg
      961 aatacttcca gctcccagac ttggtcaaac tcctgacccc cgatgaaatc aagcaaagcc
     1021 cagatgaatt ctgccacagt gactttgaag atgcctccca aggaagcgac acaagaatct
     1081 gccccccttc ctccctgctc cctgccgacc gcaagtgggg tttcattact gtgggttaca
     1141 gaggatcctg caccttgggc agagagggac aggcagatgc caagtttcgg agagttcccc
     1201 ggattttggt ttgtggaagg atttccttgg caaaagaagt ctttggagaa actttgaatg
     1261 aaagcagaga ccctgatcga gccccagaaa gatacacctc cagattttat ctcaaattca
     1321 agcacctgga aagggctttt gatatgttgt cagagtgtgg attccacatg gtggcctgta
     1381 actcatcggt gacagcatct ttcatcaacc aatatacaga tgacaagatc tggtcaagct
     1441 acactgaata tgtcttctac cgtgagcctt ccagatggtc accctcacac tgcgattgct
     1501 gctgcaagaa tggcaaaggt gacaaagaag gggagagcgg cacgtcttgc aatgacctct
     1561 ccacatctag ctgcgacagc cagtctgagg ccagctctcc ccaggagacg gtcatctgtg
     1621 gtcccgtgac acgccagacc aacatccaga ctctggaccg tcccatcaag aagggccctg
     1681 tccagctgat ccaacagtca gagatgcggc ggaaaagcga cttactccgg actctgactt
     1741 caggctccag ggaatcgaac atgagcagca aaaaaaaagc tgttaaagaa aagctctcaa
     1801 ttgaggagga gctggagaaa tgtatccagg atttcctaaa aatcaaaatt ccagatcggt
     1861 ttcctgagag aaaacatcct tggcaatctg aacttttaag gaagtatcat ctataaggga
     1921 gggctggggg cgggaaaaga aaaaaaaaag tcattttgaa attaacctcc taaaaggaat
     1981 tcatatttta aaggaaaaaa atacaactaa tgatgcacat ttcttagaac acaatagtcc
     2041 attgatatac tactgcctac tttacctagt tcaccttaac atgtaaatcc acagggtaga
     2101 tttctttcta gatgtggaag tacaagaaaa tcttttttag ttatttgttt gtttacttcg
     2161 tcccatgtgc taactatctt atatataatg agagccagct acgtaaaagt agctgagagg
     2221 ccttgggagt catttatccc aaactgggtt ttttctctca tccttctacc tccctccttt
     2281 gaatgagggt atggtagaaa aagatctggc ccaatggcat aagtttggaa tttttaattt
     2341 tggtttttcc ttttgtttat ggggttgggg ggaatggcag atttatatga cttttcactc
     2401 aaatctatat gtgccagttt atattgactc cgtatgcatg agtatttgtg caacacaagc
     2461 acaactaagt atgtatatac acatgacgca cacgatgcca gggcctagac ctcccaaggg
     2521 ctgtgctcct gctcccagca gccctctctt agaatatttc agatggatga gcttctgact
     2581 ctttcttaaa attcttttgg gaagatttcc cagcctttct tcacaacact ttctaacatc
     2641 aaatgactct catcatcaac aaattgtatt ccttattgtg aaattaatac cctcaggctc
     2701 cattttactg ctttgctctt tgtctgcatt aagagaggat gaggagagct ggtcaaacat
     2761 tccttgtgtt aaaaaaatca aacattcata tccacaaaat tttctgctaa atgactccac
     2821 actcagcctt ctctaccctg aactgaatta tcaccctttt ctccatgttt tcagagttct
     2881 tactgcccac agtttaatgg tgtggccttt ccacataatc cacattaagt tctgtgttcc
     2941 tgtgttgttg tggaactaag gacaacacac agtacttgaa taagggtccg gccttttgtt
     3001 tgttttagag aaagttgtat tccacacaca acctaataat ttcttataaa aattttaaac
     3061 tacaaagcta catttttact tgcttgtagc cgtttttgtt tgcctttggg attcgggctt
     3121 tggctgtgcc catgctagga tttagctgtg tcatttttat gatgtctgta acaacccaac
     3181 aaggtaactg aagctccaga gttaaggttt cagatttcta aatgaaacta tctttttcaa
     3241 ttacatcctg acttgtatag acacagccaa aaagaaactg ttaatagcca tccgtccatg
     3301 taactctgta ttttactaag gtaccaatag ctctttcata gacttgtgct acaagaaggt
     3361 taaaagacca gttttatttt cagcattcct catgcatttc agtggtaacc aaaaaataat
     3421 ttgtcaatta atagttgtgt gccaagcact cctaatttgt tttattgcgt gtgtgtgcat
     3481 gtgtgtatgt gtatcacagg taataaaggc aattggatga tatctgtagg aggaaaacaa
     3541 tgactaattt cttccttttg aaatctttca ttgatgcaca tttattatgt aagatgttct
     3601 gtcttgattt ctgttcttag tgatgattag tatatgaata tctttctgaa tttttgtaat
     3661 tctcgccttc acactaggat gacagactca gctaatgttt ccttgtcctg aaggtttgaa
     3721 tggagttgaa agttttacat aagtgaaaaa gaaagtttat cttgggagtt gagttgtcaa
     3781 gagaattata atttatgaat ttaagtggta ttcttttctg tattaatata ttagcagata
     3841 tttggtctta actacaacat agctttgttt gtaaacttac cagtatgtct tgattctttt
     3901 caatgtttct tgatagcaca tggcaatacc atcatcctaa taacagaaga tcttgcaaag
     3961 aatcacagag cttaatgggt caagaagttg aatttgggga aaatatcctg aaactcactt
     4021 tggtcaaatg attattgtgt tgtcactgga agtactgtca aagactttgg gggtctaact
     4081 aaaatggcca aagttccaac ttccttaaat ttcagacctg actgtaatgg cctcaagata
     4141 gagagatacc cttataagag taaagaatta agatgatagt caacccaata tttctactac
     4201 attctttaaa caggaaatta aacactgcaa aaggagtgtt cgtggcagtg ttcctctgac
     4261 ccctgacctg tcatgagttt tctctgctct gacattcctt atacatccag tgaacaaagc
     4321 tggaatagaa aacctgttta aaaccatcac aacagcaata tttttattct gggccacctc
     4381 tcgactggca ctcatcccat ggtaaaatat tcaagtaact aagacaacag catggcattt
     4441 atttgtgtga gtgtttatat agaaatgaac atagacctgg ccagtaaaag gctctgagga
     4501 ggcttaaagt acctagtttg agtggagtta tcaagtgagg tccaggtagc ctgcaacact
     4561 ggaaatgagt tctgggtaag tgagttataa gagtacatgc tctagtaact ctggtagtca
     4621 ctgtgactcg ggcatgtttc cctgaagtta aaatagtttt tagaactttt tgtttaattc
     4681 tgaagaaaac aatatatatg gtttacttct cgaacattgg ttatgacaag ggccataaat
     4741 tgctaatata aagaagttag tagtattgag tggatacaat gaatggggaa tcacatgtgt
     4801 agagccccaa cttagattgc cttctgggaa atcccgcgat actaaaatcc agtgagcttt
     4861 gggagatcat tccctaaagg tatgtgggtt gtctgaagtc agaaacatat ttacaaagtc
     4921 cttctaccca ctatcaaaaa tgaactgatc tgcattcagc aggaaaaggg gaagacagga
     4981 atgtaaaact actagatcat atggtattgt gattttcttt cccctgctag gaaaaaattg
     5041 cactgaaatg ctgacaaaaa ataatgaaat gaagtggctt ccaaaatatg cactgatgtt
     5101 atcctttgta tttataggca cagttatctt actgaaaatg catgcatggt gaattaaaat
     5161 aaaaggggga acaatgcaca aataataagc gttccctttg ctctttattc ctttatagtt
     5221 gtatctattc caaccaattc attttggggg aacacattta ttaagggatg ttgacatgga
     5281 atttttctct tttcaattag ccttgttaga ttcagaggaa tctttatcca taggcacagg
     5341 tgtgttgctt gttctgggcc ccattactgc ctgcgcttct ggattacttt tgctttcctg
     5401 ggctttagat tcttctctga ggatcctttg ttggtgtcag acaaaacatg ttacaatgag
     5461 acaaaaggaa ggcatgtatg gtgttttgta aaattacttg acaccagctc ccacaatggg
     5521 aaccaaattt tgattcttat acattttcct ttgctacaat tccaaccttc aactttgtat
     5581 ctactatagt gtagatctgt gaatttgagt gctggtattt tctgccacta tataccatgc
     5641 catggaattt gactagcctt ggtcttctag atgatcttta ctagaattaa taatactctt
     5701 tctgtgaact tttaggaaga attctttgtc acctccacct gacataccaa ttttcaaaag
     5761 aaaaacgaag ggagtttatt tttccttatg gtgactctgt ggcagataaa tgtttttgcc
     5821 aatttgcatg ctggtttata ggtttagcat gggccatttc tctctttaat gtcttggtat
     5881 tgttggtgtc ttgcaatctt gatgccccac agtttcaatt tatttatttt cttttatatt
     5941 gtcaaaatag cacactagag aaagaaccag agtgaacatt ctgtatcctg agttacaatg
     6001 gagttacatg tcatttgtat agaactgtat aatgattaat atctgcagag aaattagacc
     6061 aaatgaaacc tgctggaata ggtttgattt atattgcctt catcattctg gtttcagacg
     6121 aaatggttat tgctctctac ccctgctgaa agaatagagt cttaaacttt aataatcaca
     6181 gccttgtgat gcaaacacag agcttatttg tttgaaatgc ctattattct catcttgctg
     6241 tatacgttgg aatggagatt ctttttccag tgatctccat tgcaaacttt ttaatagtgt
     6301 tttttaatac tcagtatgca caaaaatcat gtgtagcact tgtaaaaatg cagattcctt
     6361 caacctaact tcaaagagtc tgattcagaa acttgaagca gggcaaagaa atttgtattt
     6421 tgagctagtc tccttaataa ttttgatgag gattgtctat agaccttact ttgaaaaatt
     6481 ctgctgttta gggaatatgc agaggccaag agttccttta ctccttagaa gcacttcctc
     6541 attttctctt actttcttcc cactacaaat aagtcaaagc atgcattatt cattatctta
     6601 agagaaaaca cccaaagaaa aatatcctaa gactagggca gaatagattt tcatgaattc
     6661 tttgccattt catctgctgt ctgtcaacca taaccctttc tccatattgt gtgtgtatgt
     6721 gtatgtgtat gtgtatgggt tttttcccaa aataaaagcc tgcattatta tagtcttagc
     6781 tctgggtaga tgggagcata tctctgagtg agatgtattc taatgatacc caacaagaaa
     6841 taaaaataat gatctttccc aaggagagtt gtttatttct aggcccttac ttagtatgag
     6901 tgggaggaaa ttgaaagtga tccataattt aatggtgtat atggccccaa aggtgattcc
     6961 attaactgca cataaaatat aaccaaaatg aatatggaat gattagtgaa ttcagctata
     7021 tttaaccaat caaatcctgc gccattgaac tgctaaattt gtccaatttg actcaatcag
     7081 gactatgaag ctctcagata attgaagatc ctgaaccctg acattaacta aaaacttgaa
     7141 gccaaactga tgtgtaagaa taaatgcaaa aaaaaaaaaa aaagaaaaag aaaaagaaag
     7201 caagaaagag tgaattcaaa agggtttcaa tgatccaatt gaccctattc atttaacaga
     7261 gtaactggat acataccaaa ttcccacgtt ataagaaaga tgaaaataga gatcatgctt
     7321 gtcatgatca tgagtgaata tttgagtaaa tattgccaaa ggaaagtgaa ggatgtttaa
     7381 tgaaactgat gaacatgagc aactaattat gttaaattgg ccaagattaa aacaaaaatg
     7441 gttaaatttg attcagtttg ttgccctctc tcctctactt cctaagtggg atcccttttc
     7501 tgtcccggct tcctaatgtt caaaaaatgt ttctcttgct tgtgaacaaa ttttgttgcc
     7561 aattaggtaa aaaatgttaa gttcccagac tgtcatcctt gcattattta ggaaatttac
     7621 ttttaaaagg ataaagaaaa atgtgcctgg cctagcaact atcaagggct tgtcctggag
     7681 gagggtgggg gtaatcttcc tgttaatcag ctttgtaaaa cacttatatg ccaaccagag
     7741 ggtttattaa gtctcttgtc tccagcaacc tcctccatct tatcagttta tttttagaat
     7801 tgacctttag ataatttacc tgcatttgca cagtgaaaaa tcaacataac tttatattct
     7861 cttcctgctg atgtggtctc catccatcac aaatggaagc agaactgatg cttagtaaag
     7921 taatgagagt tgctttcaaa ttacattagt gtgcatgtgt gtgtgtgcac atggccatgt
     7981 gcaattttta ggtttatgtc agctcagtgg ataatgtgcg tgggagtgct atccgagtgc
     8041 atggaaaaag cctttggtta catagtttaa cagcttttta gttcagcaca atagtttgtc
     8101 tctactgtgg atgtcagtcc ttgagaatgt taagtaaagc ttgagcttgt ctcctcatgt
     8161 gaaattcaaa caatactaat ttctggggaa aaatcaaact catatccatg tatatagtga
     8221 agagtagcat cttattcaaa aaaagaatgt atttttgaaa gctaagatag acatagaata
     8281 catattaatc atcagtagtc ttttttaatt gcagccagtg atcagtggtt tatctatacc
     8341 ctttaggtga gagacagaga gaaacaattt caggaaactc tccttgattc atgtgggtta
     8401 tgtgcattta aggccgtggc tctcaaccag gagtggtttt gcataccaga gatcttttgg
     8461 caatgcctgg agatattttt tgtttcatga tttgaggggt gctactgaca attaatgggt
     8521 ataggccaga gatgctgcta aagatcctac agtgtactgg aaagccctcc ataacaaaaa
     8581 gttatccagc ccacaatgtc aatagtgctt agcttgagaa actctaaatt aagcatgagt
     8641 ttaaatttgt caaggcattt ttttttctgt accatatacg ggaagtcttc caggtcaata
     8701 aataggataa aatagaaaaa taaaaatcgg aaccagttta aatgtgtata gaaattatat
     8761 gtatggaaat tatttgaagt tagacataat tatctcttta tgcagatgtg aaagctgaga
     8821 tttacagaaa taggaaactt tttccaggga tctggtagtg atgaggaagg cctgtagttt
     8881 aggtgtcttg tgttcttcta cttcagtctt tctgcctcag aaaaattata cttcagtgat
     8941 gttgtcaatc tttcaacagc taaatgtgtt tgttgtgaag cactctggga tccttttcag
     9001 tttacatgat cctgttaaag atgtttccca agctgatcaa cagtagacca caaagtgctc
     9061 tcagaaatga aactagtaag ggggagaaag tgttttgagc aggccaatga tttcattgtc
     9121 tgtaactgct tatcataccc tttgttactt tgagttgaat attccctctc tgaggatggt
     9181 aaaatcttat tggaaaatat gtttcctaga ctcacccagg ggtggctccc aagtccttgt
     9241 ttccaaacat gtgacaagtc taagcacaag tccttgctac tgagtcttat tgtttagttt
     9301 atatacactg actttattag aacacaattt gtgtctgaaa tgatttgaca tttttctttt
     9361 aatgtatcat accaatatcc cagggatgga attatggtag ggtcattcta attccatttt
     9421 atacaaggga aactaaggac ccagaaagtt taaatcggtc atttatttgt ttgtttatgc
     9481 atatatccag caaatatttg ttgggtacat actatatata ggtcactgtc gtgagcatta
     9541 taatgtctaa gcaatcaaat ttggagtaaa gaacttgaat taagttcatt caattcctag
     9601 actaacatta tttctatatg tagttctgat cagtattcta gaattatggt ttaaatatcc
     9661 agttataaat aatatatatt acagatttat tattatgtac ctgaaactct actgagtact
     9721 tttcatgcct tatctcattt aatcctatca taatccaatg aagtaagccc taccactatc
     9781 ctctctttac agatgaggtc agtgaggctc agaaagataa agtagcacat aaaggctcat
     9841 agctaaaaag tggcagagcc agattttcct ctgagtttat tagactctaa aggctgctgg
     9901 cttaaccatc tctttgtaca atctgttctc tctgttctct gaactttgcc tgtttctcct
     9961 ctctcctatg ctaaacaagg tgagatccca gcctgacatc cttcctaaaa gtcatcagtt
    10021 ttttttgttt gtttgtgact tgtatctgcc taggaggtaa agaaagggca gatttgctac
    10081 agcttgtact ttatgccaca aaaattttca agggggcaat aatgttgtag aacaagtatc
    10141 tggtgagtac tgatacccta agaaactcac cgtgataagc tagcttccac gtctggagaa
    10201 aatgacacct gcaattgctt gctgtgctgc acacaggtca ctagggcaag cttcaggaga
    10261 agtaaaatag gtgtatgagc gtgtttatat gtgtttatgc atgagtgtat ctaggtatct
    10321 gctattttca tcttttggct tgttaaacag tctcaggttt ttattcaaga caggtcaaaa
    10381 gcccaaatgt gattaactgc cctcagcatc tcattgttac tgttataagt tgggaaaaag
    10441 agaggcagct ttagaaaaga aacttcaccg aaatacgtgc atgcatgtgt gagtgtgtgt
    10501 gtgtgaggag tgtgtgtatt tatgtgtgtt ttgtgtttat gtataaaatt atgtatatat
    10561 atgtacatat gtgtgtacat ctatcttaat gtgtatatat aaatatatat ctatagctgt
    10621 acatatgtat acacccataa acaaagctca tagtttaaaa ctttggaatt ttcagtttgg
    10681 agaacttatt attattacaa tttatatttg gtttcctaga cggtctaata tagttctaat
    10741 ttccaaaatt ctcttccact aaaagtggat atatttattt atggtgccga gaacattaac
    10801 aaaatattta gatttaatat ctatgaataa taaaccaaaa aaagtgcatt taaggaaaca
    10861 ccaaacttgt aaaaactggc tctcttatcc aaaccatttg ttggaatttc aaactacatg
    10921 ttttcacact tcttcattcc aaaaaaaaaa aaaaaaccaa accagaaaaa acccaaaaca
    10981 ctaccaaatg aacagtgata atgtttaaga agaaaaagaa aaatgtaggt gtatgatagc
    11041 acaaattcaa tggttattgc cctagtggtg cttcacttac ctattggtta atttattata
    11101 tcctggttaa tttcacttta tcactgatga gggttcctgt gtccctacat gatttatcgg
    11161 tggagctaat tatctattta tttaaagcta tagtaaataa tttataatat gcatattgta
    11221 aatagatact aaaagtcatg ggcacattgt aataatcaca aagttttagt ctcctgcaaa
    11281 taacacttga agtctgttta tacaataccc aaatagttgc tcaaagaaag aacaatgtaa
    11341 gtcaaataca agaaaacctt acttacctat tttggcattt tacagacata acaaccaaat
    11401 taacgaattt tggccatctt aagaatacag taagttgtgt actcattcat agccacatgc
    11461 tttgcatatt actggggaat gtgaaaaata tttaaagtca acctatgcaa acagagattc
    11521 cctgctgctc cttgggatca gtttgtatgc acacaagccc atgccttcaa ctgatagtcc
    11581 tagcacagat ccctcctccc agagatctgt caggtgtgcc cacacaacag aagcacttgt
    11641 aaactaatta agcacggtca ctgaatcctt ttttcaccag ccttctaaag atgttgtctt
    11701 aaaaacataa gaaagaaaat ccattttttt aaagcaatga aatgttctaa ttaggtttga
    11761 ggacatttga aggagcgatt gttttttccc caaaattttg gagcagaggg gacgttttac
    11821 atcatcctaa cttcatgttc ctctgtcatt ttattttatt tatttatttt taattccaaa
    11881 ggagaaagtt gaatcaggaa aatttgtctt aaaatatact gcttagttta gagacggaca
    11941 aactaatgta tttttgtaaa tcatgggtgg cggatgtcaa aatctctcat taattaccct
    12001 gtttttttct ttaaggaaat tgattcatga ataattggaa aggtattcta gttaagacac
    12061 acagaaacac aaacttagcg gagctgcact tcagagagtc ccactgtaat ctgttaatag
    12121 aatctgcttt aaatgagtca ctccttagac tggcaatgac acccagctta gtctgtaaaa
    12181 tcaggaatct ttgtgttggc tgaaggaact tagtaatctt agttgaattc ctcttcccca
    12241 tgtctttcaa aaccagagca ctgggtcgaa cctaacccac aaaataattc gtccaaatta
    12301 aattgacttt tttacataac atcagcacca ccccttacac ttttaaagtt aaagaccctg
    12361 ttgatcaggt tacctggaaa tttcaagtgc atctgaccag ggattatcaa gctccttgtg
    12421 acatctgttt ctgatgctgt gaatgtgatg tcaccacaaa tagaggattc tgaattttgc
    12481 tggtactaat gctgagtggt gacttattgg ggccttgctc atgttacttt ttcctgacgt
    12541 cattcaagca cttgatgact tgggtcagtt tgttgcacat tgatgaataa caagtgacac
    12601 ccaatgaaat tacctcttct cctttccaat gcagttcgct tgtacataaa tgtaacgtca
    12661 tattgtttac aggttatttt tgtgcgtaat tgtgatagca gatttagctc aaactttaaa
    12721 ggaatttgtt tactgactgg tgttaaaatg aatgtgctta ttacagtata aacatcatta
    12781 attatggact cacatgaatg catgtctaca tgtcgtcagt tctcagcagc tcagttattc
    12841 agcaaaaagt ctgcagtctg tgaatagcaa atatacataa actactgtga ctctaataac
    12901 tctaactgtt tttaccttgg gatgtaacac tgtagatctt cgcctgctgt atttctttct
    12961 tacctatttg tttttgcgag aaaaacatga tagaaaatgc tactactaat tgtcccaatg
    13021 gaattgcaca tcattttggc aatcattggt tcactcagaa ggcaaccgcc tatagatgga
    13081 acagccctga gcaacatata aatatataca tacatatcta tgtatgcaat atctacactg
    13141 cgaattacta ccatctattc tcactgccaa tggaaacaaa ctactctttt ctttggattc
    13201 attgatggat ataaaaaatt aatttgctat taactgcttt catattctgt ttagttctta
    13261 tagtatggta aatgatacag gtgcagtatc agtattgtaa aattgtatgg tgaaaactac
    13321 aaaagtcatt ctgtggatat attttaaaag gaagaacaga aactatattt cagattcttg
    13381 tgtgaatata attacagaat aggtaactat ttttatgtgt ttccataaat gactccattt
    13441 catatgcatt gtaatttagc acaaatcata ataaatcatt tggtaaca
//
