LOCUS       NM_178863               1716 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens potassium channel tetramerization domain containing 13
            (KCTD13), transcript variant 1, mRNA.
ACCESSION   NM_178863
VERSION     NM_178863.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1716)
  AUTHORS   Seth,A., Rivera,A., Chahdi,A., Choi,I.S., Medina-Martinez,O.,
            Lewis,S., O'Neill,M., Ridgeway,A., Moore,J., Jorgez,C. and
            Lamb,D.J.
  TITLE     Gene dosage changes in KCTD13 result in penile and testicular
            anomalies via diminished androgen receptor function
  JOURNAL   FASEB J 36 (11), e22567 (2022)
   PUBMED   36196997
  REMARK    GeneRIF: Gene dosage changes in KCTD13 result in penile and
            testicular anomalies via diminished androgen receptor function.
REFERENCE   2  (bases 1 to 1716)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   3  (bases 1 to 1716)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1716)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1716)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1716)
  AUTHORS   Tomaru,T., Satoh,T., Yoshino,S., Ishizuka,T., Hashimoto,K.,
            Monden,T., Yamada,M. and Mori,M.
  TITLE     Isolation and characterization of a transcriptional cofactor and
            its novel isoform that bind the deoxyribonucleic acid-binding
            domain of peroxisome proliferator-activated receptor-gamma
  JOURNAL   Endocrinology 147 (1), 377-388 (2006)
   PUBMED   16239304
  REMARK    GeneRIF: PDIP1 mRNA was expressed in 3T3-L1 adipocytes and THP-1
            macrophages
REFERENCE   7  (bases 1 to 1716)
  AUTHORS   Zhou,J., Hu,X., Xiong,X., Liu,X., Liu,Y., Ren,K., Jiang,T., Hu,X.
            and Zhang,J.
  TITLE     Cloning of two rat PDIP1 related genes and their interactions with
            proliferating cell nuclear antigen
  JOURNAL   J Exp Zool A Comp Exp Biol 303 (3), 227-240 (2005)
   PUBMED   15726626
REFERENCE   8  (bases 1 to 1716)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   9  (bases 1 to 1716)
  AUTHORS   Kutsenko,A.S., Gizatullin,R.Z., Al-Amin,A.N., Wang,F., Kvasha,S.M.,
            Podowski,R.M., Matushkin,Y.G., Gyanchandani,A., Muravenko,O.V.,
            Levitsky,V.G., Kolchanov,N.A., Protopopov,A.I., Kashuba,V.I.,
            Kisselev,L.L., Wasserman,W., Wahlestedt,C. and Zabarovsky,E.R.
  TITLE     NotI flanking sequences: a tool for gene discovery and verification
            of the human genome
  JOURNAL   Nucleic Acids Res 30 (14), 3163-3170 (2002)
   PUBMED   12136098
REFERENCE   10 (bases 1 to 1716)
  AUTHORS   He,H., Tan,C.K., Downey,K.M. and So,A.G.
  TITLE     A tumor necrosis factor alpha- and interleukin 6-inducible protein
            that interacts with the small subunit of DNA polymerase delta and
            proliferating cell nuclear antigen
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 11979-11984 (2001)
   PUBMED   11593007
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI553707.1, BC036228.1 and AF289573.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178863.4.
            
            Transcript Variant: This variant (1) encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036228.1, SRR3476690.960557.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000568000.6/ ENSP00000455785.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BI553707.1         16-17
            3-858               BC036228.1         1-856
            859-1716            AF289573.1         812-1669
FEATURES             Location/Qualifiers
     source          1..1716
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1716
                     /gene="KCTD13"
                     /gene_synonym="BACURD1; FKSG86; hBACURD1; PDIP1; POLDIP1"
                     /note="potassium channel tetramerization domain containing
                     13"
                     /db_xref="GeneID:253980"
                     /db_xref="HGNC:HGNC:22234"
                     /db_xref="MIM:608947"
     exon            1..437
                     /gene="KCTD13"
                     /gene_synonym="BACURD1; FKSG86; hBACURD1; PDIP1; POLDIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..1183
                     /gene="KCTD13"
                     /gene_synonym="BACURD1; FKSG86; hBACURD1; PDIP1; POLDIP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BTB/POZ domain-containing protein KCTD13; polymerase
                     delta-interacting protein 1; BTB/POZ domain-containing
                     adapter for CUL3-mediated RhoA degradation protein 1;
                     TNFAIP1-like protein; potassium channel tetramerisation
                     domain containing 13; CTD-2574D22.4"
                     /codon_start=1
                     /product="BTB/POZ domain-containing adapter for
                     CUL3-mediated RhoA degradation protein 1 isoform 1"
                     /protein_id="NP_849194.1"
                     /db_xref="CCDS:CCDS10661.1"
                     /db_xref="GeneID:253980"
                     /db_xref="HGNC:HGNC:22234"
                     /db_xref="MIM:608947"
                     /translation="MSAEASGPAAAAAPSLEAPKPSGLEPGPAAYGLKPLTPNSKYVK
                     LNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLIDRSGRHFGTILNYLRD
                     GSVPLPESTRELGELLGEARYYLVQGLIEDCQLALQQKRETLSPLCLIPMVTSPREEQ
                     QLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLG
                     DEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYETPRGPD
                     PALLEATGGAAGAGGAGRGEDEENREHRVRRIHVRRHITHDERPHGQQIVFKD"
     exon            438..607
                     /gene="KCTD13"
                     /gene_synonym="BACURD1; FKSG86; hBACURD1; PDIP1; POLDIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..697
                     /gene="KCTD13"
                     /gene_synonym="BACURD1; FKSG86; hBACURD1; PDIP1; POLDIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..750
                     /gene="KCTD13"
                     /gene_synonym="BACURD1; FKSG86; hBACURD1; PDIP1; POLDIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..946
                     /gene="KCTD13"
                     /gene_synonym="BACURD1; FKSG86; hBACURD1; PDIP1; POLDIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1716
                     /gene="KCTD13"
                     /gene_synonym="BACURD1; FKSG86; hBACURD1; PDIP1; POLDIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1684..1689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCTD13"
                     /gene_synonym="BACURD1; FKSG86; hBACURD1; PDIP1; POLDIP1"
                     /note="hexamer: ATTAAA"
     regulatory      1697..1702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCTD13"
                     /gene_synonym="BACURD1; FKSG86; hBACURD1; PDIP1; POLDIP1"
                     /note="hexamer: AATAAA"
     polyA_site      1702
                     /gene="KCTD13"
                     /gene_synonym="BACURD1; FKSG86; hBACURD1; PDIP1; POLDIP1"
     polyA_site      1716
                     /gene="KCTD13"
                     /gene_synonym="BACURD1; FKSG86; hBACURD1; PDIP1; POLDIP1"
                     /note="major polyA site"
ORIGIN      
        1 agctgcccgg cgccggcttc cgggtggtgc gagcgagatg gggcggaggg ccggtcttgc
       61 agagtagctg cggtgagtgg gcgtgtgcgc cgagcggtct ggcccaaggg ctgggggccg
      121 gccgagggtc ttcgggagca ggccgcaggg cgcggagaga tcctgggatc gccgtccgcc
      181 gctgctaccc ggcatgtcgg cggaggcctc gggcccggct gccgccgcgg ccccgtccct
      241 ggaagccccc aagccctcgg gtctcgagcc tggccccgcc gcctacggtc tcaagccgct
      301 gaccccgaac agcaaatacg tgaagctgaa cgtgggcggc tcgttgcact acaccacgct
      361 gcgcaccctc acgggacagg acaccatgct caaagccatg ttcagcggcc gcgtggaggt
      421 gctgaccgat gccggaggtt gggtgctgat tgaccggagc ggccgtcact ttggtacaat
      481 cctcaattac ctgcgggatg ggtctgtgcc actgccggag agtacgagag aactggggga
      541 gctgctgggc gaagcacgct actacctggt gcagggcctg attgaggact gccagctggc
      601 gctgcagcaa aaaagggaga cgctgtcccc gctgtgcctc atccccatgg tgacatctcc
      661 ccgggaggag cagcagctcc tggccagcac ctccaagccc gtggtgaagc tcctgcacaa
      721 ccgcagtaac aacaagtact cctacaccag cacttcagat gacaacctac ttaagaacat
      781 cgagctgttc gacaagctgg ccctgcgctt ccacgggcgg ctactcttcc tcaaggatgt
      841 cctgggggac gagatctgct gctggtcttt ctacgggcag ggccgcaaaa tcgccgaggt
      901 gtgctgcacc tccattgtct atgctacgga gaagaagcag accaaggtgg aatttccaga
      961 ggcccggatc ttcgaggaga ccctgaacat cctcatctac gagactcccc ggggcccaga
     1021 cccagccctc ctggaggcca cagggggagc agctggagct ggtggggctg gccgcgggga
     1081 ggatgaagag aaccgagagc accgtgtccg caggatccat gtccggcgcc atatcaccca
     1141 cgacgagcgt cctcatggcc aacaaattgt cttcaaggac tgacctctga ccctccccct
     1201 gccttcctct tgccttggga cccagtccct ctctctttcc ctccccttcc cagacttttg
     1261 ccccggctct gctggccaag tcgtgggtcc tcctctgtcc cttcattgca tggcacagct
     1321 cactttggcc cttctccacc catcccaacc ccattgctaa caacatggta cattccggcc
     1381 ccaccactca gagccttccg aagccaacac ttgtccccac cctggccctg cgtccttccc
     1441 tctccagctg gttaagaggg atttagaatt ccctttctct ttttttagtg catcgtccat
     1501 gccaaagtgt gcggcccttc ctgacatcac cacagtctga gcagcctccc gcgtcctgca
     1561 gggtagtccg ccccctcctc cccaccatcc tccctacctc cttaactttg tactagactg
     1621 gcctgggcct gcccagctca gcgttatcag tctgtttcat attatttatt attttaattt
     1681 tctattaaat tattgaaata aagttaagtt gagaaa
//
