LOCUS       NM_001363642            2783 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens potassium channel tetramerization domain containing 11
            (KCTD11), transcript variant 1b, mRNA.
ACCESSION   NM_001363642
VERSION     NM_001363642.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2783)
  AUTHORS   Lospinoso Severini,L., Loricchio,E., Navacci,S., Basili,I.,
            Alfonsi,R., Bernardi,F., Moretti,M., Conenna,M., Cucinotta,A.,
            Coni,S., Petroni,M., De Smaele,E., Giannini,G., Maroder,M.,
            Canettieri,G., Mastronuzzi,A., Guardavaccaro,D., Ayrault,O.,
            Infante,P., Bufalieri,F. and Di Marcotullio,L.
  TITLE     SALL4 is a CRL3REN/KCTD11 substrate that drives Sonic
            Hedgehog-dependent medulloblastoma
  JOURNAL   Cell Death Differ 31 (2), 170-187 (2024)
   PUBMED   38062245
  REMARK    GeneRIF: SALL4 is a CRL3[REN/KCTD11] substrate that drives Sonic
            Hedgehog-dependent medulloblastoma.
REFERENCE   2  (bases 1 to 2783)
  AUTHORS   Yang,M., Han,Y.M., Han,Q., Rong,X.Z., Liu,X.F. and Ln,X.Y.
  TITLE     KCTD11 inhibits progression of lung cancer by binding to
            beta-catenin to regulate the activity of the Wnt and Hippo pathways
  JOURNAL   J Cell Mol Med 25 (19), 9411-9426 (2021)
   PUBMED   34453479
  REMARK    GeneRIF: KCTD11 inhibits progression of lung cancer by binding to
            beta-catenin to regulate the activity of the Wnt and Hippo
            pathways.
REFERENCE   3  (bases 1 to 2783)
  AUTHORS   Smaldone,G., Pirone,L., Pedone,E., Marlovits,T., Vitagliano,L. and
            Ciccarelli,L.
  TITLE     The BTB domains of the potassium channel tetramerization domain
            proteins prevalently assume pentameric states
  JOURNAL   FEBS Lett 590 (11), 1663-1671 (2016)
   PUBMED   27152988
REFERENCE   4  (bases 1 to 2783)
  AUTHORS   Zazzeroni,F., Nicosia,D., Tessitore,A., Gallo,R., Verzella,D.,
            Fischietti,M., Vecchiotti,D., Ventura,L., Capece,D., Gulino,A. and
            Alesse,E.
  TITLE     KCTD11 tumor suppressor gene expression is reduced in prostate
            adenocarcinoma
  JOURNAL   Biomed Res Int 2014, 380398 (2014)
   PUBMED   25045667
  REMARK    GeneRIF: Our study demonstrates and supports that KCTD11, as well
            as negatively regulated downstream effectors belonging to Hh
            signaling, plays a role in prostate cancer pathogenesis.
REFERENCE   5  (bases 1 to 2783)
  AUTHORS   De Smaele,E., Di Marcotullio,L., Moretti,M., Pelloni,M.,
            Occhione,M.A., Infante,P., Cucchi,D., Greco,A., Pietrosanti,L.,
            Todorovic,J., Coni,S., Canettieri,G., Ferretti,E., Bei,R.,
            Maroder,M., Screpanti,I. and Gulino,A.
  TITLE     Identification and characterization of KCASH2 and KCASH3, 2 novel
            Cullin3 adaptors suppressing histone deacetylase and Hedgehog
            activity in medulloblastoma
  JOURNAL   Neoplasia 13 (4), 374-385 (2011)
   PUBMED   21472142
REFERENCE   6  (bases 1 to 2783)
  AUTHORS   Correale,S., Pirone,L., Di Marcotullio,L., De Smaele,E., Greco,A.,
            Mazza,D., Moretti,M., Alterio,V., Vitagliano,L., Di Gaetano,S.,
            Gulino,A. and Pedone,E.M.
  TITLE     Molecular organization of the cullin E3 ligase adaptor KCTD11
  JOURNAL   Biochimie 93 (4), 715-724 (2011)
   PUBMED   21237243
  REMARK    GeneRIF: the protein is expressed in two alternative variants: a
            short previously characterized form (sKCTD11) composed by 232 amino
            acids and a longer variant (lKCTD11) which contains an N-terminal
            extension of 39 residues.
REFERENCE   7  (bases 1 to 2783)
  AUTHORS   Mancarelli,M.M., Zazzeroni,F., Ciccocioppo,L., Capece,D., Po,A.,
            Murgo,S., Di Camillo,R., Rinaldi,C., Ferretti,E., Gulino,A. and
            Alesse,E.
  TITLE     The tumor suppressor gene KCTD11REN is regulated by Sp1 and
            methylation and its expression is reduced in tumors
  JOURNAL   Mol Cancer 9, 172 (2010)
   PUBMED   20591193
  REMARK    GeneRIF: findings identify KCTD11 as a widely down-regulated gene
            in human cancers, and provide a basis to understand how its
            expression might be deregulated in tumor cells
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2783)
  AUTHORS   Di Marcotullio,L., Ferretti,E., De Smaele,E., Argenti,B.,
            Mincione,C., Zazzeroni,F., Gallo,R., Masuelli,L., Napolitano,M.,
            Maroder,M., Modesti,A., Giangaspero,F., Screpanti,I., Alesse,E. and
            Gulino,A.
  TITLE     REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in
            human medulloblastoma
  JOURNAL   Proc Natl Acad Sci U S A 101 (29), 10833-10838 (2004)
   PUBMED   15249678
  REMARK    GeneRIF: Results identify REN(KCTD11) as a suppressor of Hedgehog
            signaling and suggest that its inactivation might lead to a
            deregulation of the tumor-promoting Hedgehog pathway in
            medulloblastoma.
REFERENCE   9  (bases 1 to 2783)
  AUTHORS   Gallo,R., Zazzeroni,F., Alesse,E., Mincione,C., Borello,U.,
            Buanne,P., D'Eugenio,R., Mackay,A.R., Argenti,B., Gradini,R.,
            Russo,M.A., Maroder,M., Cossu,G., Frati,L., Screpanti,I. and
            Gulino,A.
  TITLE     REN: a novel, developmentally regulated gene that promotes neural
            cell differentiation
  JOURNAL   J Cell Biol 158 (4), 731-740 (2002)
   PUBMED   12186855
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026954.14.
            
            Transcript Variant: This variant (1b) initiates translation at an
            upstream AUU alternate start codon and encodes an isoform (l) with
            a longer N-terminus compared to isoform s. This isoform is
            suggested by experimental data in PMID:21237243.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000333751.8/ ENSP00000328352.5
            non-AUG initiation codon :: PMID: 21237243
            RefSeq Select criteria   :: based on manual assertion,
                                        conservation, expression, longest
                                        protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2783              AC026954.14        73648-76430
FEATURES             Location/Qualifiers
     source          1..2783
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2783
                     /gene="KCTD11"
                     /gene_synonym="C17orf36; KCASH1; REN; REN/KCTD11"
                     /note="potassium channel tetramerization domain containing
                     11"
                     /db_xref="GeneID:147040"
                     /db_xref="HGNC:HGNC:21302"
                     /db_xref="MIM:609848"
     exon            1..2783
                     /gene="KCTD11"
                     /gene_synonym="C17orf36; KCASH1; REN; REN/KCTD11"
                     /inference="alignment:Splign:2.1.0"
     CDS             665..1480
                     /gene="KCTD11"
                     /gene_synonym="C17orf36; KCASH1; REN; REN/KCTD11"
                     /EC_number="2.3.2.27"
                     /exception="alternative start codon"
                     /note="isoform l is encoded by transcript variant 1b;
                     non-AUG (AUU) translation initiation codon; BTB/POZ
                     domain-containing protein KCTD11; retinoic acid, EGF, NGF
                     induced gene protein; RING-type E3 ubiquitin transferase
                     subunit KCTD11; potassium channel tetramerization
                     domain-containing protein 11"
                     /codon_start=1
                     /transl_except=(pos:665..667,aa:Met)
                     /product="BTB/POZ domain-containing protein KCTD11 isoform
                     l"
                     /protein_id="NP_001350571.1"
                     /db_xref="CCDS:CCDS92247.1"
                     /db_xref="GeneID:147040"
                     /db_xref="HGNC:HGNC:21302"
                     /db_xref="MIM:609848"
                     /translation="MSPPPVPSSPPSFGGPVTLNVGGTLYSTTLETLTRFPDSMLGAM
                     FRAGTPMPPNLNSQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALLRAEADF
                     YQIRPLLDALRELEASQGTPAPTAALLHADVDVSPRLVHFSARRGPHHYELSSVQVDT
                     FRANLFCTDSECLGALRARFGVASGDRAEGSPHFHLEWAPRPVELPEVEYGRLGLQPL
                     WTGGPGERREVVGTPSFLEEVLRVALEHGFRLDSVFPDPEDLLNSRSLRFVRH"
     regulatory      2758..2763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCTD11"
                     /gene_synonym="C17orf36; KCASH1; REN; REN/KCTD11"
                     /note="hexamer: AATAAA"
     polyA_site      2783
                     /gene="KCTD11"
                     /gene_synonym="C17orf36; KCASH1; REN; REN/KCTD11"
                     /note="major polyA site"
ORIGIN      
        1 acttcctggg ggcggagagg acctcagcgg ctgcggcgac acccagggaa ggcggcgcgg
       61 ccgggtcccg aaactcctgg ctgtttccat cagagccctc ggacactccc agcccgggct
      121 gagcacgcat cgtcgctccc cggcggatac aagggggctc cgccatccgc tcccgtcagt
      181 tcggcctcca tctcctggga cccgcgccgg cagccaggcc aggcctctga gtggccccag
      241 agccctggct ggactcgtcc acggcggcag cgatctgccc ggggtctcgg aggccatccc
      301 ttcagagtcg gccctgtgct cgccaccgtc acctgctggt tggattccgg aaacccactg
      361 tctgaagacc acagaggggt gtcgctgacc accccaaatc ggatacgtcc agacctcaag
      421 ctcccttccc ctctctggct gccctctgct cttttcatct cttctctcaa ccttttgggg
      481 atttctgtgt cctgacacca cctccccatc caccaccaaa gtagccgggg tgagccccaa
      541 accttactgg gtgtgctcca cctgtgcctc caacccagcg aatctgacag cttcgaccca
      601 attctgcaca cacccaggaa gttctgcctt ttcttttctt tcggtgtctc ctgtacttcc
      661 caaaatttct cctcctcctg tgccctcttc gcccccctcc tttgggggcc ccgtgaccct
      721 gaatgtgggg ggcacactat attccaccac tttggagacc ctgacccgct tcccagactc
      781 tatgctgggg gccatgttta gggccggcac ccccatgccc cccaacctca attcccaagg
      841 aggcggccac tacttcatcg accgggatgg caaggccttc cggcacatcc tcaatttcct
      901 gaggctgggc cgcctggacc tgccccgtgg gtacggagag acagcgctgc tcagggcaga
      961 ggctgacttc taccagatcc ggcccctcct ggacgcgctg cgggaactgg aggcctctca
     1021 ggggacccct gcacccacag ctgccctgct ccacgcagat gtagatgtca gcccccgcct
     1081 ggtgcacttc tctgctcgcc ggggacccca tcactatgag ctgagctccg tccaggtgga
     1141 caccttccga gccaaccttt tctgcaccga ctctgagtgt ctaggtgctt tgcgggcccg
     1201 atttggtgtg gccagtgggg atagggcaga ggggagccca cattttcatc tggagtgggc
     1261 cccccgcccc gtggaactcc ccgaggtgga gtatgggaga ctggggctgc agccgctgtg
     1321 gactgggggg ccaggagagc ggcgggaggt ggtgggcacc ccaagcttcc tggaggaggt
     1381 gctgcgggtg gctctcgagc acggcttccg actagactct gtcttccccg accccgaaga
     1441 cctgctcaac tccaggtctc tgcgctttgt ccggcactga ggatgctgtt ctcagtttga
     1501 ctgtggggag gagagagaat ggggtactag cacccctgaa gcctctttcc agctctgctt
     1561 caggagctat gagagtcggg actctcctgc acctgactgg agctcagatg tgggcaggaa
     1621 ttcccaaacc tgagcccacc aaggactcac aagtggtcca gaaggtctca acctgtgctg
     1681 accctgggag gggtagggaa ggttctctca gcttgttctt gcctaaggct gagcacctcc
     1741 agtctctcct tgatttggag ctcagtgttt aagggcttgg aaaagggggg aacatctctt
     1801 tacccagact agacctagca aaaccctgga aggatattga ggtctgggga aaagggagga
     1861 ctttgcattt tcccaatgcg gtctcttgga ccatggcttc tactcctgaa gctgggtggc
     1921 ctggcctggc ctgaccaatg agaggccaga acactctgga acatcggaag aggagttctt
     1981 tgctatgttc caagccatct actgagggag gcagaaaggc cacaacccac cctaggttga
     2041 tgtatgggag ctaggacagt ccccatggca atggggctgg agcatccctc atctggaaga
     2101 atcccatact gatggcaggg ctggccaggg ggaagagggt agtatctgtg ggtcctggcc
     2161 tttcttcatg tgtgcgtgca tatcagcccg tgtggctgac tgatgtatag gtccctggca
     2221 tcctggttca tatctgtgtt gctgactaca gtgtctgtga tgtccgcatg tccaggcctg
     2281 tttggggttg cctagcgact cttctggcac agggtgtgtc tgtggtatac ctgtgaggtg
     2341 gttgacaatt agtagtttaa tcacagggtg tgtgtgtgtg tgtgtgtgtg tgtgtttatg
     2401 tgcacgcatg tatatgcatc accacgtagc caggaggggc ctgttggggt ttgagtcact
     2461 gggatcttcc tggtgagagg taagagaagt cactgggctt agctgggcct ctgaggcctg
     2521 tatggaactc ttggttgctg aggcaaccat ggacctgttg ctaggagata gctggggaag
     2581 gcccaaggcc gcccagggca gagagaggag acgaagagtt tgggacagtg ggggaggaga
     2641 tgggaaggga tgggatttct gggtcccaga gcgggtggga tactcacgca cagcttcttc
     2701 actggtgggg ggtggggcac acattatttc tcactggtca tgatttacaa gaagaaaaat
     2761 aaaactgctt ttggaaccac aaa
//
