LOCUS       NM_031954               3920 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens potassium channel tetramerization domain containing 10
            (KCTD10), transcript variant 2, mRNA.
ACCESSION   NM_031954
VERSION     NM_031954.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3920)
  AUTHORS   Zhou,Q., Yu,H., Chen,Y., Ren,J., Lu,Y. and Sun,Y.
  TITLE     The CRL3KCTD10 ubiquitin ligase-USP18 axis coordinately regulates
            cystine uptake and ferroptosis by modulating SLC7A11
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2320655121 (2024)
   PUBMED   38959043
  REMARK    GeneRIF: The CRL3[KCTD10] ubiquitin ligase-USP18 axis coordinately
            regulates cystine uptake and ferroptosis by modulating SLC7A11.
REFERENCE   2  (bases 1 to 3920)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   3  (bases 1 to 3920)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3920)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3920)
  AUTHORS   Liutkeviciene,R., Vilkeviciute,A., Gedvilaite,G., Kaikaryte,K. and
            Kriauciuniene,L.
  TITLE     Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI
            rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene
            Polymorphisms in Age-Related Macular Degeneration
  JOURNAL   Dis Markers 2019, 9602949 (2019)
   PUBMED   31583032
  REMARK    GeneRIF: The study showed that ERCC6 and HTRA1single nucleotide
            polymorphisms rs3793784 and rs11200638 were associated with
            increased odds of early and exudative age-related macular
            degeneration, while the variant in KCTD10 (rs56209061) was found to
            be protective.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3920)
  AUTHORS   Wang,Y., Zheng,Y., Luo,F., Fan,X., Chen,J., Zhang,C. and Hui,R.
  TITLE     KCTD10 interacts with proliferating cell nuclear antigen and its
            down-regulation could inhibit cell proliferation
  JOURNAL   J Cell Biochem 106 (3), 409-413 (2009)
   PUBMED   19125419
  REMARK    GeneRIF: KCTD10 may be associated with DNA synthesis and cell
            proliferation
REFERENCE   7  (bases 1 to 3920)
  AUTHORS   Liu,R., Zhou,A., Ren,D., He,A., Hu,X., Zhang,W., Yang,L., Liu,M.,
            Li,H., Zhou,J., Xiang,S. and Zhang,J.
  TITLE     Transcription factor specificity protein 1 (SP1) and activating
            protein 2alpha (AP-2alpha) regulate expression of human KCTD10 gene
            by binding to proximal region of promoter
  JOURNAL   FEBS J 276 (4), 1114-1124 (2009)
   PUBMED   19154347
  REMARK    GeneRIF: binding of SP1 to the proximal promoter region stimulated
            the promoter activity and endogenous KCTD10 expression, whereas
            binding of AP-2alpha to this region showed opposite effects.
REFERENCE   8  (bases 1 to 3920)
  AUTHORS   Kathiresan,S., Willer,C.J., Peloso,G.M., Demissie,S., Musunuru,K.,
            Schadt,E.E., Kaplan,L., Bennett,D., Li,Y., Tanaka,T., Voight,B.F.,
            Bonnycastle,L.L., Jackson,A.U., Crawford,G., Surti,A., Guiducci,C.,
            Burtt,N.P., Parish,S., Clarke,R., Zelenika,D., Kubalanza,K.A.,
            Morken,M.A., Scott,L.J., Stringham,H.M., Galan,P., Swift,A.J.,
            Kuusisto,J., Bergman,R.N., Sundvall,J., Laakso,M., Ferrucci,L.,
            Scheet,P., Sanna,S., Uda,M., Yang,Q., Lunetta,K.L., Dupuis,J., de
            Bakker,P.I., O'Donnell,C.J., Chambers,J.C., Kooner,J.S.,
            Hercberg,S., Meneton,P., Lakatta,E.G., Scuteri,A., Schlessinger,D.,
            Tuomilehto,J., Collins,F.S., Groop,L., Altshuler,D., Collins,R.,
            Lathrop,G.M., Melander,O., Salomaa,V., Peltonen,L.,
            Orho-Melander,M., Ordovas,J.M., Boehnke,M., Abecasis,G.R.,
            Mohlke,K.L. and Cupples,L.A.
  TITLE     Common variants at 30 loci contribute to polygenic dyslipidemia
  JOURNAL   Nat Genet 41 (1), 56-65 (2009)
   PUBMED   19060906
REFERENCE   9  (bases 1 to 3920)
  AUTHORS   Willer,C.J., Sanna,S., Jackson,A.U., Scuteri,A., Bonnycastle,L.L.,
            Clarke,R., Heath,S.C., Timpson,N.J., Najjar,S.S., Stringham,H.M.,
            Strait,J., Duren,W.L., Maschio,A., Busonero,F., Mulas,A., Albai,G.,
            Swift,A.J., Morken,M.A., Narisu,N., Bennett,D., Parish,S., Shen,H.,
            Galan,P., Meneton,P., Hercberg,S., Zelenika,D., Chen,W.M., Li,Y.,
            Scott,L.J., Scheet,P.A., Sundvall,J., Watanabe,R.M., Nagaraja,R.,
            Ebrahim,S., Lawlor,D.A., Ben-Shlomo,Y., Davey-Smith,G.,
            Shuldiner,A.R., Collins,R., Bergman,R.N., Uda,M., Tuomilehto,J.,
            Cao,A., Collins,F.S., Lakatta,E., Lathrop,G.M., Boehnke,M.,
            Schlessinger,D., Mohlke,K.L. and Abecasis,G.R.
  TITLE     Newly identified loci that influence lipid concentrations and risk
            of coronary artery disease
  JOURNAL   Nat Genet 40 (2), 161-169 (2008)
   PUBMED   18193043
REFERENCE   10 (bases 1 to 3920)
  AUTHORS   Zhou,J., Ren,K., Liu,X., Xiong,X., Hu,X. and Zhang,J.
  TITLE     A novel PDIP1-related protein, KCTD10, that interacts with
            proliferating cell nuclear antigen and DNA polymerase delta
  JOURNAL   Biochim Biophys Acta 1729 (3), 200-203 (2005)
   PUBMED   15982757
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY205299.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031954.4.
            
            Summary: The protein encoded by this gene binds proliferating cell
            nuclear antigen (PCNA) and may be involved in DNA synthesis and
            cell proliferation. In addition, the encoded protein may be a tumor
            suppressor. Several protein-coding and non-protein coding
            transcript variants have been found for this gene. [provided by
            RefSeq, Dec 2015].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (2)
            has the same N- and C-termini but is 1 aa shorter compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY205299.1, SRR1803612.254298.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228495.11/ ENSP00000228495.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3920              AY205299.1         51-3970
FEATURES             Location/Qualifiers
     source          1..3920
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..3920
                     /gene="KCTD10"
                     /gene_synonym="BTBD28; hBACURD3; MSTP028; ULRO61"
                     /note="potassium channel tetramerization domain containing
                     10"
                     /db_xref="GeneID:83892"
                     /db_xref="HGNC:HGNC:23236"
                     /db_xref="MIM:613421"
     exon            1..41
                     /gene="KCTD10"
                     /gene_synonym="BTBD28; hBACURD3; MSTP028; ULRO61"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..980
                     /gene="KCTD10"
                     /gene_synonym="BTBD28; hBACURD3; MSTP028; ULRO61"
                     /note="isoform 2 is encoded by transcript variant 2;
                     BTB/POZ domain-containing protein KCTD10; BTB/POZ
                     domain-containing adapter for CUL3-mediated RhoA
                     degradation protein 3; potassium channel tetramerization
                     domain-containing protein 10; potassium channel
                     tetramerisation domain containing 10"
                     /codon_start=1
                     /product="BTB/POZ domain-containing adapter for
                     CUL3-mediated RhoA degradation protein 3 isoform 2"
                     /protein_id="NP_114160.1"
                     /db_xref="CCDS:CCDS9128.1"
                     /db_xref="GeneID:83892"
                     /db_xref="HGNC:HGNC:23236"
                     /db_xref="MIM:613421"
                     /translation="MEEMSGESVVSSAVPAAATRTTSFKGTSPSSKYVKLNVGGALYY
                     TTMQTLTKQDTMLKAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGAVPLPESR
                     REIEELLAEAKYYLVQGLVEECQAALQNKDTYEPFCKVPVITSSKEEQKLIATSNKPA
                     VKLLYNRSNNKYSYTSNSDDNMLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYG
                     QGRKIAEVCCTSIVYATEKKQTKVEFPEARIYEETLNILLYEAQDGRGPDNALLEATG
                     GAAGRSHHLDEDEERERIERVRRIHIKRPDDRAHLHQ"
     exon            42..255
                     /gene="KCTD10"
                     /gene_synonym="BTBD28; hBACURD3; MSTP028; ULRO61"
                     /inference="alignment:Splign:2.1.0"
     exon            256..425
                     /gene="KCTD10"
                     /gene_synonym="BTBD28; hBACURD3; MSTP028; ULRO61"
                     /inference="alignment:Splign:2.1.0"
     exon            426..512
                     /gene="KCTD10"
                     /gene_synonym="BTBD28; hBACURD3; MSTP028; ULRO61"
                     /inference="alignment:Splign:2.1.0"
     exon            513..565
                     /gene="KCTD10"
                     /gene_synonym="BTBD28; hBACURD3; MSTP028; ULRO61"
                     /inference="alignment:Splign:2.1.0"
     exon            566..761
                     /gene="KCTD10"
                     /gene_synonym="BTBD28; hBACURD3; MSTP028; ULRO61"
                     /inference="alignment:Splign:2.1.0"
     exon            762..3920
                     /gene="KCTD10"
                     /gene_synonym="BTBD28; hBACURD3; MSTP028; ULRO61"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2582..2587
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCTD10"
                     /gene_synonym="BTBD28; hBACURD3; MSTP028; ULRO61"
                     /note="hexamer: AATAAA"
     polyA_site      2599
                     /gene="KCTD10"
                     /gene_synonym="BTBD28; hBACURD3; MSTP028; ULRO61"
                     /note="major polyA site"
     regulatory      3901..3906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCTD10"
                     /gene_synonym="BTBD28; hBACURD3; MSTP028; ULRO61"
                     /note="hexamer: AATAAA"
     polyA_site      3920
                     /gene="KCTD10"
                     /gene_synonym="BTBD28; hBACURD3; MSTP028; ULRO61"
ORIGIN      
        1 agtccgggtt tggagactcc tgcgtcctcc gacttttcat ggaagagatg tcaggagaaa
       61 gtgtggtgag ctcagcggtg ccagcggctg ctacccgcac cacttccttc aagggcacga
      121 gccccagctc caaatacgtg aagctgaatg tgggtggagc cctctactat accaccatgc
      181 agacgctgac caagcaggac accatgctga aggccatgtt cagcgggcgc atggaagtgc
      241 tcaccgacag tgaaggctgg atcctcattg accgctgtgg gaagcacttt ggtacgatac
      301 tcaactacct tcgagacggg gcggtgcctt tacccgagag ccgccgggag atcgaggagc
      361 tgctagcaga agccaagtac tacctagtcc aaggcctggt ggaagagtgc caggcggccc
      421 tacaaaacaa agatacttat gagcctttct gcaaggtccc tgtgatcacc tcatccaagg
      481 aagaacaaaa acttatagcg acttcaaata agccagccgt gaagttgctc tacaacagaa
      541 gtaacaacaa atactcatat accagcaatt ctgacgacaa tatgttgaaa aacattgaac
      601 tgtttgataa gctgtctctg cgctttaacg gaagggtcct gttcataaag gatgttattg
      661 gggatgaaat ctgctgctgg tccttttatg gtcagggccg gaagattgct gaagtctgtt
      721 gtacctccat cgtctatgcc actgagaaga aacagaccaa ggtggagttt cccgaagccc
      781 ggatttatga ggagaccctg aacattttgc tgtatgaggc ccaggatggc cggggacctg
      841 acaatgcgct cctggaggcc acaggcgggg cggcggggcg ctcccaccac ctggacgagg
      901 acgaggagcg ggagcggatc gagcgcgtgc ggaggatcca catcaagcgc cctgatgacc
      961 gggcccacct ccaccagtga gcaggcaaga gaccgagccg ccctcctctc accgccccca
     1021 ctccctgccg tgctacaccc agatcctgtg caggctgccg ggccccttct gcttcccttg
     1081 gagcctggag atacttttgt aacaagccag atgattattt tggtattgct tgacaaggca
     1141 aattgattgt cttgacccag gcgtatgacc cctgtcgttg aacaagctgt gtctaagatc
     1201 tctacttttc atgagaatct gagactcttt ggagccaggc tttctcggtt ctcagaggaa
     1261 aagtatgaat gagtgtgaag tgtatgtgag aacttttgtt tgcaatattt atttttgtgg
     1321 gtgtcgactt cctatgtggg ctttttgggt gacactccct taagggttca gtttgacaat
     1381 tctgagagtt gtcctgcagt tggaggccac cagaggtatc tgagctccct gcttcctatt
     1441 tcataatcct ccagccccag caggtccact cctggttcct gtgtgtttgg cccgggcaca
     1501 atccccactg ctttgctaga cgtgctttct gccatgtggc tttgggccta gagcttgttg
     1561 ataattgcag cttgtggcag tggaaatatg gctgaatgag cgtctaaatc gttgagacca
     1621 gtgcaacttt gggtgcaagg ctttgtttag ggatcaagcc ttttgccacc ttgggctggt
     1681 ctttggcctg gtgctcactg ggaccccata tgtctgcgta ggagcagaac tttccatggc
     1741 agtaagtgtc cagctctgtt tctggttctt tccccaactc cagccccgtc cagttgttct
     1801 cctgattgac ccgactccac tccaggaagg ccatctgacc ctgtgacagg catagctcat
     1861 aaactacccc tccctgggat cccgctcctc ttcagcctcc ttccccatga agctgggcta
     1921 actttctaag tcattttgct tagaaattca gtgtggccca taccctttgt cctcccagcc
     1981 tggcatccag gcagggacac cctcacacca ccagccccag ggagcttccc tgctataaac
     2041 acagaccccc ttgtctttgc ctctgatttt tacacagtgt agagtggcca gcagtgaaca
     2101 ggttgaggat gtgcgggtag atagataact ttgggtctgg tttgtgtctg tgttcatgtt
     2161 tgtttaaggg atatgtgtga ctgtgggtgg ggacgtgtgc ttgtggggca caggtggcgg
     2221 cccctgctgg agcccggctg ggcgcagcgc ctatgtagga cgggtgttct cagtgaccta
     2281 cctcccaggc tcctctgcac ctgcaaagga acaggagtga gtcgtgactg acaggggtgg
     2341 ttgagactag actaggtaga gtagttacca ggagatgtga atgtgcgtca ggtgatggat
     2401 gggtttgtca agggaatcgt taccgtttta taccaaaggt attaacatgg gcagcctttg
     2461 acacatgtat tccaaaaacg agtttatatt ttcaaacggt ttttacagct tagactttgt
     2521 acttactgcc ctgcctgtga cagttgtatg ccttcatttt gtatccaaca gcaaagtcta
     2581 caataaaact ttaaaacaat catgactgaa tgtcaaaatc gtgtattggg cagatgcttt
     2641 ttaaactgtc gtgtgagaaa cttttatatt aggccatttg gattttatta agtgctaagg
     2701 aaagagggct tacaaaatgt ttcgtaaata ttttatactg tttaagtgtt aaacaccaac
     2761 cctgtctttc ttttgggttg agctttttta gaaagtcgaa gtgaatgttg gccaggaaaa
     2821 tggaaaagcc attgtataaa tttttttttg aggcggagtc ttgctctatt ggccaggctg
     2881 gagtgtagtg gcaccatctc cacttaccac aacttgtgcc tcctgggttc aagcgattct
     2941 gctgcctcag cctcccgagt agctgggatt gcaggtaccc atcagcccat gcccagctaa
     3001 ttttgtattt ttagtagaga tggggtttca ccatgttggc caggctggtc ttgaactcct
     3061 gaccctgtga tccgaccacc ttggcctccc aaagtgctgg gattacaggt gtgagtcacc
     3121 acacctggct gcatagtgtt ttaaatgttt gtgtgaagaa tgagtttgtg gaacaatttg
     3181 atttgctgtg gcctctatgc ctaatgagct agtgtttctg gcagctctct ctacccaact
     3241 ttgcacttgt agttttgagt ctttgtctct ctggaatatg aacaggttta taaaacattc
     3301 catggtgaac aattctgtcg gctgcattat agccatgagt gaatagacag cattggctgg
     3361 tccaagctct gttattgagt atacaaggaa ctgatttttc ttatgttagc actaagggca
     3421 aaaaccaata tttataatgt aagcactatc caggtaaaac actggcccaa gatttggtaa
     3481 agagatttca ttgcaatgta ataactacag ttttttacaa attggaacag ctttggtgtg
     3541 tcgtaatcaa gggttttttt tgtttgtttg tttcaaataa gccatctgat tgtggtgact
     3601 ggggcccatg tccaagacaa ttcctggcat attctgtcac cctcccgtgg ggcgatcact
     3661 gtgtggggac cccattcccc agttaaagtg tgtctctgta ccttacaaca gcgattcagg
     3721 acccaagtgt gaacaacact cagcccgccc tctggagcgt gtgctgtctt tagggcccta
     3781 cccaaagtca ctgtaacagt taagtgtgtc attaaccttt ctgtctcttt gcgccataaa
     3841 aaaatgctca aagttttaga tgtagccact gtatgttgta caaacgttgg cgacatgtaa
     3901 aataaaagtc ataaaatgct
//
