LOCUS       NM_001366122            5098 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens kielin cysteine rich BMP regulator (KCP), transcript
            variant 3, mRNA.
ACCESSION   NM_001366122 XM_017012185
VERSION     NM_001366122.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5098)
  AUTHORS   Nagasaki,K., Yamada,A., Sasa,K. and Kamijo,R.
  TITLE     Kielin/chordin-like protein enhances induction of osteoblast
            differentiation by Bone Morphogenetic Protein-2
  JOURNAL   FEBS Open Bio 13 (7), 1357-1364 (2023)
   PUBMED   37226930
  REMARK    GeneRIF: Kielin/chordin-like protein enhances induction of
            osteoblast differentiation by Bone Morphogenetic Protein-2.
REFERENCE   2  (bases 1 to 5098)
  AUTHORS   Ye,J., Wang,Z., Wang,M., Xu,Y., Zeng,T., Ye,D., Liu,J., Jiang,H.,
            Lin,Y. and Wan,J.
  TITLE     Increased kielin/chordin-like protein levels are associated with
            the severity of heart failure
  JOURNAL   Clin Chim Acta 486, 381-386 (2018)
   PUBMED   30144436
  REMARK    GeneRIF: The KCP was closely associated with heart failure. The
            regulation of BMP2/7 and TGF-beta1 expression may be the possible
            mechanisms.
REFERENCE   3  (bases 1 to 5098)
  AUTHORS   Lin,J., Patel,S.R., Cheng,X., Cho,E.A., Levitan,I., Ullenbruch,M.,
            Phan,S.H., Park,J.M. and Dressler,G.R.
  TITLE     Kielin/chordin-like protein, a novel enhancer of BMP signaling,
            attenuates renal fibrotic disease
  JOURNAL   Nat Med 11 (4), 387-393 (2005)
   PUBMED   15793581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            KF495713.1, AC025594.5 and KF510975.1.
            
            On Sep 22, 2018 this sequence version replaced XM_017012185.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000610776.5/ ENSP00000479679.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               KF495713.1         138-246             c
            110-252             AC025594.5         97576-97718         c
            253-442             AC025594.5         96414-96603         c
            443-519             AC025594.5         96251-96327         c
            520-604             AC025594.5         95429-95513         c
            605-687             AC025594.5         93206-93288         c
            688-781             AC025594.5         92877-92970         c
            782-864             AC025594.5         91927-92009         c
            865-958             AC025594.5         83350-83443         c
            959-1038            AC025594.5         83126-83205         c
            1039-1132           AC025594.5         82956-83049         c
            1133-1218           KF510975.1         173-258
            1219-1266           KF510975.1         330-377
            1267-1300           AC025594.5         82389-82422         c
            1301-1453           AC025594.5         82020-82172         c
            1454-1560           AC025594.5         81839-81945         c
            1561-1654           AC025594.5         81665-81758         c
            1655-1828           AC025594.5         80797-80970         c
            1829-1911           AC025594.5         80602-80684         c
            1912-2005           AC025594.5         80336-80429         c
            2006-2197           AC025594.5         80056-80247         c
            2198-2368           AC025594.5         79494-79664         c
            2369-2545           AC025594.5         78014-78190         c
            2546-2631           AC025594.5         76366-76451         c
            2632-2722           AC025594.5         76027-76117         c
            2723-2805           AC025594.5         75806-75888         c
            2806-2899           AC025594.5         75615-75708         c
            2900-3073           AC025594.5         74248-74421         c
            3074-3156           AC025594.5         73932-74014         c
            3157-3277           AC025594.5         73153-73273         c
            3278-3357           AC025594.5         71088-71167         c
            3358-3457           AC025594.5         70777-70876         c
            3458-3546           AC025594.5         70148-70236         c
            3547-3649           AC025594.5         69770-69872         c
            3650-3792           AC025594.5         69537-69679         c
            3793-3965           AC025594.5         69064-69236         c
            3966-4077           AC025594.5         68869-68980         c
            4078-4179           AC025594.5         68673-68774         c
            4180-4344           AC025594.5         67709-67873         c
            4345-4651           AC025594.5         66635-66941         c
            4652-5098           AC025594.5         66016-66462         c
FEATURES             Location/Qualifiers
     source          1..5098
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..5098
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /note="kielin cysteine rich BMP regulator"
                     /db_xref="GeneID:375616"
                     /db_xref="HGNC:HGNC:17585"
                     /db_xref="MIM:609344"
     exon            1..109
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..4920
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; kielin/chordin-like protein 1; cysteine rich
                     BMP regulator 2 (chordin-like); cysteine-rich motor neuron
                     2 protein"
                     /codon_start=1
                     /product="kielin/chordin-like protein isoform 3 precursor"
                     /protein_id="NP_001353051.1"
                     /db_xref="CCDS:CCDS94194.1"
                     /db_xref="GeneID:375616"
                     /db_xref="HGNC:HGNC:17585"
                     /db_xref="MIM:609344"
                     /translation="MAGVGAAALSLLLHLGALALAAGAEGGAVPREPPGQQTTAHSSV
                     LAGNSQEQWHPLREWLGRLEAAVMELREQNKDLQTRVRQLESCECHPASPQCWGLGRA
                     WPEGARWEPDACTACVCQDGAAHCGPQAHLPHCRGCSQNGQTYGNGETFSPDACTTCR
                     CLEGTITCNQKPCPRGPCPEPGACCPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCL
                     RSRVRCMALKCPPSPCPEPVLRPGHCCPTCQGCTEGGSHWEHGQEWTTPGDPCRICRC
                     LEGHIQCRQRECASLCPYPARPLPGTCCPVCDGCFLNGREHRSGEPVGSGDPCSHCRC
                     ANGSVQCEPLPCPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRC
                     SCQAGEVSCEEQECPVTPCALPASGRQLCPACELDGEEFAEGVQWEPDGRPCTACVCQ
                     DGVPKCGAVLCPPAPCQHPTQPPGACCPSCDSCTYHSQVYANGQNFTDADSPCHACHC
                     QDGTVTCSLVDCPPTTCARPQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECR
                     CQEGHAHCQPRPCPRAPCAHPLPGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCR
                     CLSGNVQCLARRCVPLPCPEPVLLPGECCPQCPAAPAPAGCPRPGAAHARHQEYFSPP
                     GDPCRRCLCLDGSVSCQRLPCPPAPCAHPRQGPCCPSCDGCLYQGKEFASGERFPSPT
                     AACHLCLCWEGSVSCEPKACAPALCPFPARGDCCPDCDGCEYLGESYLSNQEFPDPRE
                     PCNLCTCLGGFVTCGRRPCEPPGCSHPLIPSGHCCPTCQGCRYHGVTTASGETLPDPL
                     DPTCSLCTCQEGSMRCQKKPCPPALCPHPSPGPCFCPVCHSCLSQGREHQDGEEFEGP
                     AGSCEWCRCQAGQVSCVRLQCPPLPCKLQVTERGSCCPRCRGCLAHGEEHPEGSRWVP
                     PDSACSSCVCHEGVVTCARIQCISSCAQPRQGPHDCCPQCSDCEHEGRKYEPGESFQP
                     GADPCEVCICEPQPEGPPSLRCHRRQCPSLVGCPPSQLLPPGPQHCCPTCAEALSNCS
                     EGLLGSELAPPDPCYTCQCQDLTWLCIHQACPELSCPLSERHTPPGSCCPVCRECVVE
                     AEGRRVADGESWRDPSNACIACTCHRGHVECHLEECQALSCPHGWAKVPQADSCCERC
                     QAPTQSCVHQGREVASGERWTVDTCTSCSCMAGTVRCQSQRCSPLSCGPDKAPALSPG
                     SCCPRCLPRPASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHSGDFSVHVTNDDRG
                     RSGVAWTQEVAVLLGDMAVRLLQDGAVTVDGHPVALPFLQEPLLYVELRGHTVILHAQ
                     PGLQVLWDGQSQVEVSVPGSYQGRTCGLCGNFNGFAQDDLQGPEGLLLPSEAAFGNSW
                     QVSEGLWPGRPCSAGREVDPCRAAGYRARREANARCGVLKSSPFSRCHAVVPPEPFFA
                     ACVYDLCACGPGSSADACLCDALEAYASHCRQAGVTPTWRGPTLCVVGCPLERGFVFD
                     ECGPPCPRTCFNQHIPLGELAAHCVRPCVPGCQCPAGLVEHEAHCIPPEACPQVLLTG
                     DQPLGARPSPSREPQETP"
     exon            110..252
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            253..442
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            443..519
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            520..604
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            605..687
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            688..781
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            782..864
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            865..958
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1038
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1132
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1218
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1300
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1453
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1560
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1654
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1828
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1911
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2005
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2197
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2368
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2545
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2631
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2722
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2805
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2899
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..3073
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            3074..3156
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3277
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            3278..3357
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3457
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            3458..3546
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3649
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            3650..3792
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3965
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            3966..4077
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            4078..4179
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            4180..4344
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            4345..4651
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     exon            4652..5098
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5076..5081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /note="hexamer: AGTAAA"
     polyA_site      5098
                     /gene="KCP"
                     /gene_synonym="CRIM2; KCP1; NET67"
                     /note="major polyA site"
ORIGIN      
        1 gacagacggc gagccgagcg aggcggagct agcatggccg gggtcggggc cgctgcgctg
       61 tcccttctcc tgcacctcgg ggccctggcg ctggccgcgg gcgcggaagg tggggctgtc
      121 cccagggagc cccctgggca gcagacaact gcccattcct cagtccttgc tgggaactcc
      181 caggagcagt ggcaccccct gcgagagtgg ctggggcgac tggaggctgc agtgatggag
      241 ctcagagaac agaataagga cctgcagacg agggtgaggc agctggagtc ctgtgagtgc
      301 caccctgcat ctccccagtg ctgggggctg gggcgtgcct ggcccgaggg ggcacgctgg
      361 gagcctgacg cctgcacagc ctgcgtctgc caggatgggg ccgctcactg tggcccccaa
      421 gcacacctgc cccattgcag gggctgcagc caaaatggcc agacctacgg caacggggag
      481 accttctccc cagatgcctg caccacctgc cgctgtctgg aaggtaccat cacttgcaac
      541 cagaagccat gcccaagagg accctgccct gagccaggag catgctgccc gcactgtaag
      601 ccaggctgtg attatgaggg gcagctttat gaggaggggg tcaccttcct gtccagctcc
      661 aacccttgtc tacagtgcac ctgcctgagg agccgagttc gctgcatggc cctgaagtgc
      721 ccgcctagcc cctgcccaga gccagtgctg aggcctgggc actgctgccc aacctgccaa
      781 ggctgcacag aaggtggctc tcactgggaa catggccaag agtggacaac acctggggac
      841 ccctgccgaa tctgccggtg cctggagggt cacatccagt gccgccagcg agaatgtgcc
      901 agcctgtgtc catacccagc ccggcccctc ccaggcacct gctgccctgt gtgtgatggc
      961 tgtttcctaa acgggcggga gcaccgcagc ggggagcctg tgggctcagg ggacccctgc
     1021 tcgcactgcc gctgtgctaa tgggagtgtc cagtgtgagc ctctgccctg cccgccagtg
     1081 ccctgcagac acccaggcaa gatccctggg cagtgctgcc ctgtctgcga tggctgtgag
     1141 taccagggac accagtatca gagccaggag accttcagac tccaagagcg gggcctctgt
     1201 gtccgctgct cctgccaggc tggcgaggtc tcctgtgagg agcaggagtg cccagtcacc
     1261 ccctgtgccc tgcctgcctc tggccgccag ctctgcccag cctgtgagct ggatggagag
     1321 gagtttgctg agggagtcca gtgggagcct gatggtcggc cctgcaccgc ctgcgtctgt
     1381 caagatgggg tacccaagtg cggggctgtg ctctgccccc cagccccctg ccagcacccc
     1441 acccagcccc ctggtgcctg ctgccccagc tgtgacagct gcacctacca cagccaagtg
     1501 tatgccaatg ggcagaactt cacggatgca gacagccctt gccatgcctg ccactgtcag
     1561 gatggaactg tgacatgctc cttggttgac tgccctccca cgacctgtgc caggccccag
     1621 agtggaccag gccagtgttg ccccaggtgc ccagactgca tcctggagga agaggtgttt
     1681 gtggacggcg agagcttctc ccacccccga gacccctgcc aggagtgccg atgccaggaa
     1741 ggccatgccc actgccagcc tcgcccctgc cccagggccc cctgtgccca cccgctgcct
     1801 gggacctgct gcccgaacga ctgcagcggc tgtgcctttg gcgggaaaga gtaccccagc
     1861 ggagcggact tcccccaccc ctctgacccc tgccgtctgt gtcgctgtct gagcggcaac
     1921 gtgcagtgcc tggcccgccg ctgcgtgccg ctgccctgtc cagagcctgt cctgctgccg
     1981 ggagagtgct gcccgcagtg cccagccgcc ccagcccccg ccggctgccc acggcccggc
     2041 gcggcccacg cccgccacca ggagtacttc tccccgcccg gcgatccctg ccgccgctgc
     2101 ctctgcctcg acggctccgt gtcctgccag cggctgccct gcccgcccgc gccctgcgcg
     2161 cacccgcgcc aggggccttg ctgcccctcc tgcgacggct gcctgtacca ggggaaggag
     2221 tttgccagcg gggagcgctt cccatcgccc actgctgcct gccacctctg cctttgctgg
     2281 gagggcagcg tgagctgcga gcccaaggca tgtgcccctg cactgtgccc cttccctgcc
     2341 aggggcgact gctgccctga ctgtgatggc tgtgagtacc tgggggagtc ctacctgagt
     2401 aaccaggagt tcccagaccc ccgagaaccc tgcaacctgt gtacctgtct tggaggcttc
     2461 gtgacctgcg gccgccggcc ctgtgagcct ccgggctgca gccacccact catcccctct
     2521 gggcactgct gcccgacctg ccagggatgc cgctaccatg gcgtcactac tgcctccgga
     2581 gagacccttc ctgacccact tgaccctacc tgctccctct gcacctgcca ggaaggttcc
     2641 atgcgctgcc agaagaagcc atgtccccca gctctctgcc cccacccctc tccaggcccc
     2701 tgcttctgcc ctgtttgcca cagctgtctc tctcagggcc gggagcacca ggatggggag
     2761 gagtttgagg gaccagcagg cagctgtgag tggtgtcgct gtcaggctgg ccaggtcagc
     2821 tgtgtgcggc tgcagtgccc accccttccc tgcaagctcc aggtcaccga gcgggggagc
     2881 tgctgccctc gctgcagagg ctgcctggct catggggaag agcaccccga aggcagtaga
     2941 tgggtgcccc ccgacagtgc ctgctcctcc tgtgtgtgtc acgagggcgt cgtcacctgt
     3001 gcacgcatcc agtgcatcag ctcttgcgcc cagccccgcc aagggcccca tgactgctgt
     3061 cctcaatgct ctgactgtga gcatgagggc cggaagtacg agcctgggga gagcttccag
     3121 cctggggcag acccctgtga agtgtgcatc tgcgagccac agcctgaggg gcctcccagc
     3181 cttcgctgtc accggcggca gtgtcccagc ctggtgggct gcccccccag ccagctcctg
     3241 ccccctgggc cccagcactg ctgtcccacc tgtgccgagg ccttgagtaa ctgttcagag
     3301 ggcctgctgg gatctgagct agccccacca gacccctgct acacgtgcca gtgccaggac
     3361 ctgacatggc tctgcatcca ccaggcttgt cctgagctca gctgtcccct ctcagagcgc
     3421 cacactcccc ctgggagctg ctgccccgta tgccgggaat gtgtggtgga ggccgagggc
     3481 cggagagtgg cagatggaga gagctggcgg gaccccagca atgcgtgcat cgcctgcacc
     3541 tgccatcggg gccatgtgga gtgccacctc gaggagtgcc aggccctctc ctgcccccat
     3601 ggctgggcga aggtgcccca ggctgacagc tgctgtgagc gatgccaagc tcccacccag
     3661 tcctgcgtgc accagggccg tgaggtggcc tctggagagc gctggactgt ggacacctgc
     3721 accagctgct cctgcatggc gggcaccgtg cgttgccaga gccagcgctg ctcaccgctc
     3781 tcgtgtggcc ccgacaaggc ccctgccctg agtcctggca gctgctgccc ccgctgcctg
     3841 cctcggcccg cttcctgcat ggccttcgga gacccccatt accgcacctt cgacggccgc
     3901 ctgctgcact tccagggcag ttgcagctat gtgctggcca aggactgcca cagcggggac
     3961 ttcagtgtgc acgtgaccaa tgatgaccgg ggccggagcg gtgtggcctg gacccaggag
     4021 gtggcggtgc tgctgggaga catggccgtg cggctgctgc aggacggggc agtcacggtg
     4081 gatgggcacc cggtggcctt gcccttcctg caggagccgc tgctgtatgt ggagctgcga
     4141 ggacacactg tgatcctgca cgcccagccc gggctccagg tgctgtggga tgggcagtcc
     4201 caggtggagg tgagcgtacc tggctcctac cagggccgga cttgtgggct ctgtgggaac
     4261 ttcaatggct ttgcccagga cgatctgcag ggccctgagg ggctgctcct gccctcggag
     4321 gctgcgtttg ggaatagctg gcaggtctca gaggggctgt ggcctggccg gccctgttct
     4381 gcaggccgag aggtggatcc gtgccgggca gcaggttacc gtgccaggcg tgaggccaat
     4441 gcccggtgtg gggtgctgaa gtcctcccca ttcagtcgct gccatgctgt ggtgccaccg
     4501 gagcccttct ttgccgcctg tgtgtatgac ctgtgtgcct gtggccctgg ctcctccgct
     4561 gatgcctgcc tctgtgatgc cctggaagcc tacgccagtc actgtcgcca ggcaggagtg
     4621 acacctacct ggcgaggccc cacgctgtgt gtggtaggct gccccctgga gcgtggcttc
     4681 gtgtttgatg agtgcggccc accctgtccc cgcacctgct tcaatcagca tatccccctg
     4741 ggggagctgg cagcccactg cgtgaggccc tgcgtgcccg gctgccagtg ccctgcaggc
     4801 ctggtggagc atgaggccca ctgcatccca cccgaggcct gcccccaagt cctgctcact
     4861 ggagaccagc cacttggtgc tcggcccagc cccagccggg agccccagga gacaccctga
     4921 gccaggacag tgcctgataa gggttcatca ggccaggagt ctccccttgg cgagcagttc
     4981 ccaccctggt tagggctatg gagagaatgc cctgcctgga cactggagcc tgggcccctg
     5041 ccctgcaaag acccccgcca tgttgagtca ccagcagtaa actctaggcc tgcccgaa
//
