LOCUS       NM_014379               6912 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens potassium voltage-gated channel modifier subfamily V
            member 1 (KCNV1), mRNA.
ACCESSION   NM_014379 XM_005250866
VERSION     NM_014379.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6912)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   2  (bases 1 to 6912)
  AUTHORS   Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D.,
            Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W.
            and Wang,X.
  TITLE     International Union of Pharmacology. LIII. Nomenclature and
            molecular relationships of voltage-gated potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 473-508 (2005)
   PUBMED   16382104
  REMARK    Review article
REFERENCE   3  (bases 1 to 6912)
  AUTHORS   Ebihara,M., Ohba,H., Kikuchi,M. and Yoshikawa,T.
  TITLE     Structural characterization and promoter analysis of human
            potassium channel Kv8.1 (KCNV1) gene
  JOURNAL   Gene 325, 89-96 (2004)
   PUBMED   14697513
REFERENCE   4  (bases 1 to 6912)
  AUTHORS   Sano,A., Mikami,M., Nakamura,M., Ueno,S., Tanabe,H. and Kaneko,S.
  TITLE     Positional candidate approach for the gene responsible for benign
            adult familial myoclonic epilepsy
  JOURNAL   Epilepsia 43 Suppl 9, 26-31 (2002)
   PUBMED   12383276
REFERENCE   5  (bases 1 to 6912)
  AUTHORS   Salinas,M., de Weille,J., Guillemare,E., Lazdunski,M. and
            Hugnot,J.P.
  TITLE     Modes of regulation of shab K+ channel activity by the Kv8.1
            subunit
  JOURNAL   J Biol Chem 272 (13), 8774-8780 (1997)
   PUBMED   9079713
REFERENCE   6  (bases 1 to 6912)
  AUTHORS   Hugnot,J.P., Salinas,M., Lesage,F., Guillemare,E., de Weille,J.,
            Heurteaux,C., Mattei,M.G. and Lazdunski,M.
  TITLE     Kv8.1, a new neuronal potassium channel subunit with specific
            inhibitory properties towards Shab and Shaw channels
  JOURNAL   EMBO J 15 (13), 3322-3331 (1996)
   PUBMED   8670833
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK308123.1, DC321870.1,
            AF167082.2, AC027451.11 and AF035317.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014379.3.
            
            Summary: Voltage-gated potassium (Kv) channels represent the most
            complex class of voltage-gated ion channels from both functional
            and structural standpoints. Their diverse functions include
            regulating neurotransmitter release, heart rate, insulin secretion,
            neuronal excitability, epithelial electrolyte transport, smooth
            muscle contraction, and cell volume. This gene encodes a member of
            the potassium voltage-gated channel subfamily V. This protein is
            essentially present in the brain, and its role might be to inhibit
            the function of a particular class of outward rectifier potassium
            channel types. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.151515.1,
                                           SRR1803611.82049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2152798
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524391.6/ ENSP00000435954.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AK308123.1         77-318
            243-244             DC321870.1         242-243
            245-631             AK308123.1         319-705
            632-3114            AF167082.2         16-2498
            3115-6210           AC027451.11        40225-43320
            6211-6903           AF035317.1         1039-1731
            6904-6912           AC027451.11        44014-44022
FEATURES             Location/Qualifiers
     source          1..6912
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.2"
     gene            1..6912
                     /gene="KCNV1"
                     /gene_synonym="HNKA; KCNB3; KV2.3; KV8.1"
                     /note="potassium voltage-gated channel modifier subfamily
                     V member 1"
                     /db_xref="GeneID:27012"
                     /db_xref="HGNC:HGNC:18861"
                     /db_xref="MIM:608164"
     exon            1..153
                     /gene="KCNV1"
                     /gene_synonym="HNKA; KCNB3; KV2.3; KV8.1"
                     /inference="alignment:Splign:2.1.0"
     exon            154..1418
                     /gene="KCNV1"
                     /gene_synonym="HNKA; KCNB3; KV2.3; KV8.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             958..2460
                     /gene="KCNV1"
                     /gene_synonym="HNKA; KCNB3; KV2.3; KV8.1"
                     /note="potassium channel Kv8.1; potassium channel,
                     subfamily V, member 1; neuronal potassium channel alpha
                     subunit HNKA; voltage-gated potassium channel subunit
                     Kv8.1; potassium channel, voltage gated modifier subfamily
                     V, member 1"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily V
                     member 1"
                     /protein_id="NP_055194.1"
                     /db_xref="CCDS:CCDS6314.1"
                     /db_xref="GeneID:27012"
                     /db_xref="HGNC:HGNC:18861"
                     /db_xref="MIM:608164"
                     /translation="MPSSGRALLDSPLDSGSLTSLDSSVFCSEGEGEPLALGDCFTVN
                     VGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYF
                     FDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKE
                     LSETLDFKKDTEDQESQHESEQDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISII
                     FVVVSIINMALMSAELSWLDLQLLEILEYVCISWFTGEFVLRFLCVRDRCRFLRKVPN
                     IIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGRHSTGLRS
                     LGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFTSVPCAWWWATTSMTT
                     VGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQREA
                     LKKLTKNIATDSYISVNLRDVYARSIMEMLRLKGRERASTRSSGGDDFWF"
     exon            1419..1948
                     /gene="KCNV1"
                     /gene_synonym="HNKA; KCNB3; KV2.3; KV8.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..6912
                     /gene="KCNV1"
                     /gene_synonym="HNKA; KCNB3; KV2.3; KV8.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3519..3524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNV1"
                     /gene_synonym="HNKA; KCNB3; KV2.3; KV8.1"
                     /note="hexamer: ATTAAA"
     polyA_site      3544
                     /gene="KCNV1"
                     /gene_synonym="HNKA; KCNB3; KV2.3; KV8.1"
                     /note="major polyA site"
     regulatory      6022..6027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNV1"
                     /gene_synonym="HNKA; KCNB3; KV2.3; KV8.1"
                     /note="hexamer: AATAAA"
     polyA_site      6065
                     /gene="KCNV1"
                     /gene_synonym="HNKA; KCNB3; KV2.3; KV8.1"
                     /note="major polyA site"
     regulatory      6877..6882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNV1"
                     /gene_synonym="HNKA; KCNB3; KV2.3; KV8.1"
                     /note="hexamer: ATTAAA"
     polyA_site      6912
                     /gene="KCNV1"
                     /gene_synonym="HNKA; KCNB3; KV2.3; KV8.1"
ORIGIN      
        1 aaggcagcag gcgctgggta gagctcagct ggaacacagt ttccctcctg gaccggtcga
       61 gtcagacctc acgtgtagac taagaggatc aaaagaagag tacgttacct gcggcgccgg
      121 ttgtgcgcag accagatgtg ccgggagctg caggaggtca gaacctaagg gagacggcgg
      181 aagaaaatgg agcgtcagtg atcatcagac tagaatgaga gtgaattggg agaaaatggt
      241 gcggccccct cacccagaga accctccccc acctgctcac acccccagcg aacaccccgg
      301 gggaggccta tgaagcagca gtaaaagaaa agggaggaat ataaattctc aagttggaag
      361 ggacccggtt accacttcct ttgctttctg aactttttgt tttggtctcc tgcgggcagg
      421 agtgagtctc gccatccccc ttgcttgctt gcttgcttgc gttcagctaa gagtcatctt
      481 ctctcctctt cctcctcctc cgccccacat ctccctcctt cctcccttcc ccaacccctc
      541 cacccaccaa gtagcgagtc attcaatctg tacacctcct gggctgggaa tcgcaattgc
      601 gaagttggga ggcggggtga caacgtttgg gaagggccag ggcgaccggc agtgtgcaca
      661 gggactgtgt cgggcttgga cctcacctga tcctctctct tagcgcgacc cttcctctgc
      721 tccctgtctc ctctttctgc cacttgtgcg ctgcttccgc gcactcccgg ctccctagcg
      781 gcaggaggag gaaggcgcac agcgggtgga gagggtgcgc caaggagagg taaccccttc
      841 gggagcccgg ggaatcccgg ccgccaccag gggccgtgcc accgccctcg cgggaccaaa
      901 gcttccggcg tgtccccaac tttgtggcgc cctcaggccg cggcgactgg gttagagatg
      961 ccttccagcg gcagagcgct gctggactcg ccgctggaca gcggctccct gacctccctg
     1021 gactctagtg tcttctgcag cgagggtgaa ggggagccct tggcgctcgg ggactgcttc
     1081 acggtcaacg tgggcggcag ccgcttcgtg ctctcgcagc aggcgctgtc ctgcttcccg
     1141 cacacgcgcc ttggcaagct ggccgtggtg gtggcttcct accgccgccc cggggccctg
     1201 gccgccgtgc ccagccctct ggagctttgc gacgatgcca accccgtgga caacgagtac
     1261 ttcttcgacc gcagctcgca ggcgttccga tatgtcctgc actactaccg caccggccgc
     1321 ctgcatgtca tggagcagct gtgcgcgctc tccttcctgc aggagatcca gtactggggc
     1381 atcgatgagc tcagcatcga ttcctgctgc agggacagat acttcagaag gaaagagctg
     1441 agtgaaactt tagacttcaa gaaggacaca gaagaccagg aaagtcaaca tgagagtgaa
     1501 caggacttct cccaaggacc ttgtcccact gttcgccaga agctctggaa tatcctggag
     1561 aaacctggat cttccacagc tgcccgtatc tttggcgtca tctccattat cttcgtggtg
     1621 gtgtccatca ttaacatggc cctgatgtca gctgagttaa gctggctgga cctgcagctg
     1681 ctggaaatcc tggagtatgt gtgcattagc tggttcaccg gggagtttgt cctccgcttc
     1741 ctgtgtgtgc gggacaggtg tcgcttccta agaaaggtgc caaacatcat agacctcctt
     1801 gccatcttgc ccttctacat cactcttctg gtagagagcc taagtgggag ccagaccacg
     1861 caggagctgg agaacgtggg gcgcattgtc caggtgttga ggctgctcag ggctctgcgc
     1921 atgctaaagc tgggcagaca ttccacagga ttacgctccc ttgggatgac aatcacccag
     1981 tgttacgaag aagtcggcct actgctccta tttctatccg tgggaatctc tatattttca
     2041 actgtagaat actttgctga gcaaagcatt cctgacacaa ccttcacaag tgtcccttgt
     2101 gcatggtggt gggccaccac ctctatgact actgtgggat atggggacat tagaccagac
     2161 accaccacag gcaaaatcgt ggccttcatg tgtatattat cgggaattct tgtcttggcc
     2221 ttgcctattg ctattattaa cgatcgcttc tctgcttgct acttcacctt gaaactcaag
     2281 gaagcagctg ttagacagcg tgaagcccta aagaagctta ccaagaatat agccactgac
     2341 tcatatatca gtgttaactt gagagatgtc tatgcccgga gtatcatgga gatgctgcga
     2401 ctgaaaggca gagaaagagc aagtactagg agcagcgggg gagatgattt ctggttttga
     2461 attaattttc aatttattta caaaagctat gtacaattaa ctaaaatgat aaagcagtga
     2521 tgtggatttc tgtattctga tgatgagtct cttcagagta ctgctcatct taattaattt
     2581 ttgctgatat attgcttcat ctactagaat atttcacatc acctataaca actgcacagt
     2641 gttctgacac atttgagtgt ccaaaatagc caattaacac aaccaaatac aactgggcca
     2701 atataaacat gtttgaattg tcaaatataa aataatgtta ttgcaataca tacaaaaaag
     2761 ttaaagattt tatgtatcac taacattaga agttttttgc accactaatt ttttaaaaat
     2821 ggaaggtaaa ctgcatagcc cagagaaaga taagtaaata tttaagaaca tattgaacaa
     2881 ctttgctatt taaagatatt atccaagtac ataaattact ccgttctcta tcagttaaag
     2941 ctattgaata taatacttag ctttacaaga gaaaacccat atttgatggg cagagattat
     3001 atccctatct tctttttcat gtaaaccact ggtcacaaat gaactgatct ctgtatccca
     3061 ttattactat aagaggtggg aatcccaaaa ctgcttagat tgcagtacat gagtctacac
     3121 aaagacttca acaattgcac atcttcattc tcccaactga gtgtagtatg tggagcataa
     3181 aacagcatat ttcttagtat ttcatgaata tcagatggtc tttaaatgtc tctttatgga
     3241 tgtattgttc acattatggc tttaaaataa tgaatatgta aaagtgaggt agtgaacatc
     3301 ctaaatttct acactggaat tactaaataa tcttatttca taaaatggga aatatatgtt
     3361 aaatgacatc actggatgaa cttgaagatc ttttacttgt taacaaaaaa atactatgga
     3421 cagctttctg attgttgggg taaatagcaa atgttcaaac tttgcaggca ttttgacatt
     3481 catcataaca acacaattcc tagacattgt attatataat taaagccaaa acctctaaag
     3541 ctaagaacta gctcatgatt cccattattt tagtaaatga gattctacaa cctaagaata
     3601 acaaggaatg catcacttta atacctacat ttccaatata atagagcccc caaggggaag
     3661 aaaattggtt cttgaggaaa aaaaaatctt atcacttcat ttacaaaaca cagataagca
     3721 tattgagtat atctgtggta ttaacatttc atgggggtga gatgttaggg aaaaaagcct
     3781 agaaggctct ttgccagggg tgaatggtga taagaaataa acattgagga ctgctttaat
     3841 atatagctat aaggtatttc ataaactcta tttaagacat catattatgc tatgcactac
     3901 caagaaagaa agatgccagt caattgtaag atgccattaa ctgtaaaatg catccggatt
     3961 tcagatatgt aaaaatttaa aataagcacc ttaaaatcaa tgaaatatcg catgtactac
     4021 ctcctgtttt ctggtatgca tggttaagct ctgaaaacat tttcactgat ggcatgagtt
     4081 ttagattgtg tgctaaagta ctttaattca tttaacttgt ttccacttct cctaaatatt
     4141 ataaaaggtt caggagatat gaatattagt aagataaata ttttacttct tacacacata
     4201 catgggtgct agattgtggc acagggccac tagtcatagt ataaatccct tccacaatct
     4261 gaagggaaag tagaagttag acacagaagg taaacttact ccagcttttc tagaactttc
     4321 cctaataaga atagttactc tgatccagga ctatgctctg tattcatcat gtattatgcc
     4381 attttatcct caaaatatcc ctattatata attactattc ttatactctt caaaatacat
     4441 attttatata tttattaact caacaaatat ttattaagga tctttggtgt tctggggact
     4501 agggagtctt tcttaaacaa gactaggtcc tgttttcttg tagttaatat tctgttcaaa
     4561 ggtgtgtgag gaaaagacag cgaaactgaa acattaaaag gtataaactt gcctaaattc
     4621 acacaggcta tagatggcag agccagcgct gaataccaat ctgcctgacc cggaaaacga
     4681 cactcctaaa agtcaaattg cagatttcat tcttcctaca caagctctgc atagaaattt
     4741 attttttagg caggcaagcc aacttcttgt gcatggagaa gttcaatatg ccttaagtaa
     4801 aatatcagct tattctcaga ggtggaatgg tgcttttaag aaaaggctgt ggtgacacct
     4861 tatagtcatt attagattaa aaatatatta tctttagagt aaatagtagt tggaaataaa
     4921 aaaaattaaa aactatgtgt atacatatgt atatatgttt ttatcatgga ggatcctaaa
     4981 catcttctct acaaatgtgc tgttagctat ataaatgttg tcaagatgta ggtcttcaga
     5041 aagaagtttt aaaatatcat tgcttactca attttgctgt taaataaaat atcattttat
     5101 ttattcaatg aatgtatata taagcaaacc aaatttcatt taggtaaaaa aatcaaggca
     5161 ggaactctgc caattttata acccattatt ttaaaacagt aaacactttt taaacatcta
     5221 agaattattg ttataaaaca atatttaatt ttttaaaata taaaataatt gaattattgt
     5281 ctttctctaa gctatttaga gaacactact ttctttgttt tgttttggtt tggttttttg
     5341 agacggagtg tccgtctgtc gcccaggctg gagtgccagt ggcgcgatct cggctcactg
     5401 caagctccac ctcttgggtt cacaccattc tcctgcgtca acctcgcgag tagctgggac
     5461 tagaggcgcc cgccaccacg cctggctaat tttttgtatt tttagcagag acggggtttc
     5521 accgtgttag ccactttctt tgttaattta actgttattt taagttcagg gatacatgtg
     5581 cgggtttgtt atacaggtaa tcttgtgtca tgagagtttt tttgcacgga ttatttcatc
     5641 acccaggtat taaacctagc accagttatt tttcctgatt ctctccctcc tcctacccag
     5701 caccctctga taggccccaa tgtgtgttgt ttccctctat gtgttcatgt gctctcatca
     5761 tttagctccc acttataagt gagaacatgt ggtatttggt tttctcttcc tgcattagtt
     5821 tgctaaggat aatagcctcc agctccatcc atgtccctgc aaatgacatg atctcattct
     5881 ttcatatggc tggatagtac ttcatggtgt atacatacat tttctttatc cagtctacag
     5941 ttgatgggca tttaggttta ttccatgtct ttgctactgt gaataatgct gcattgaaca
     6001 tacgtgtgca tgtatcttta taataaaaca atttatattt cttgggtata tacccattaa
     6061 tgggattgct ggatccagtg gtatttctgt ttttaggtct ttgaggaatt gccacactct
     6121 cacatggctg aactaattta cactcccagt atcagtgtat atgcgttcca attgctccat
     6181 aacttcgcca gcatctgctt tttttttttt gctttttaat aatagccatt ctgactagtg
     6241 tgagatggta tctcattatg gttttgattt gcgtttctct aatgatcagt gatattgagg
     6301 ctttttttca tatcattgtt ggctgcatgt atgttttctt ttgaaaagtg tctgttcata
     6361 tcctttgccc actttttaat gggatttttt tttcttgtaa atttgtttaa gtttcttata
     6421 gatgctggaa tattagactt ttgtagatgt atagtttgca aatattttcc cccaatctgt
     6481 aggttgtctg ttcactctgt tgataggttc ctttgctctg acaaagctct agagtttaat
     6541 tagatcccat ttgccaattt ttgctttcgt tgcaaccacc ttttgtgtct tcatcatgaa
     6601 atctttgcct gttagaaaac actactttca gacatttaaa tgcatatagg caatgcttaa
     6661 gtacctaaaa aagcaatttt aagaaattac tgaggtatct ctattaagag tgacatattc
     6721 atattttatt ttatgtatat attatttcta taacatacaa gaaattgttg catttatcat
     6781 tttaatgcaa agtagtatca agtataatgg attagatgca aaaataactg aggtaggaat
     6841 ctcagttctg tgttttaatg tggaattctt atgcttatta aaatattttg attagctgtt
     6901 gcagaaaata ta
//
