LOCUS       NM_020822               7123 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens potassium sodium-activated channel subfamily T member
            1 (KCNT1), transcript variant 1, mRNA.
ACCESSION   NM_020822 XM_029962
VERSION     NM_020822.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7123)
  AUTHORS   Cole,B.A., Kalli,A.C., Pilati,N., Muench,S.P. and Lippiat,J.D.
  TITLE     A molecular switch in RCK2 triggers sodium-dependent activation of
            KNa1.1 (KCNT1) potassium channels
  JOURNAL   Biophys J 123 (14), 2145-2153 (2024)
   PUBMED   38605520
  REMARK    GeneRIF: A molecular switch in RCK2 triggers sodium-dependent
            activation of KNa1.1 (KCNT1) potassium channels.
REFERENCE   2  (bases 1 to 7123)
  AUTHORS   Yuan,T., Wang,Y., Jin,Y., Yang,H., Xu,S., Zhang,H., Chen,Q., Li,N.,
            Ma,X., Song,H., Peng,C., Geng,Z., Dong,J., Duan,G., Sun,Q.,
            Yang,Y., Yang,F. and Huang,Z.
  TITLE     Coupling of Slack and NaV1.6 sensitizes Slack to quinidine blockade
            and guides anti-seizure strategy development
  JOURNAL   Elife 12, 87559 (2024)
   PUBMED   38289338
  REMARK    GeneRIF: Coupling of Slack and NaV1.6 sensitizes Slack to quinidine
            blockade and guides anti-seizure strategy development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7123)
  AUTHORS   Zhang,J., Liu,S., Fan,J., Yan,R., Huang,B., Zhou,F., Yuan,T.,
            Gong,J., Huang,Z. and Jiang,D.
  TITLE     Structural basis of human Slo2.2 channel gating and modulation
  JOURNAL   Cell Rep 42 (8), 112858 (2023)
   PUBMED   37494189
REFERENCE   4  (bases 1 to 7123)
  AUTHORS   Hinckley,C.A., Zhu,Z., Chu,J.H., Gubbels,C., Danker,T.,
            Cherry,J.J., Whelan,C.D., Engle,S.J. and Nguyen,V.
  TITLE     Functional evaluation of epilepsy-associated KCNT1 variants in
            multiple cellular systems reveals a predominant gain of function
            impact on channel properties
  JOURNAL   Epilepsia 64 (8), 2126-2136 (2023)
   PUBMED   37177976
  REMARK    GeneRIF: Functional evaluation of epilepsy-associated KCNT1
            variants in multiple cellular systems reveals a predominant gain of
            function impact on channel properties.
REFERENCE   5  (bases 1 to 7123)
  AUTHORS   Barcia,G., Fleming,M.R., Deligniere,A., Gazula,V.R., Brown,M.R.,
            Langouet,M., Chen,H., Kronengold,J., Abhyankar,A., Cilio,R.,
            Nitschke,P., Kaminska,A., Boddaert,N., Casanova,J.L., Desguerre,I.,
            Munnich,A., Dulac,O., Kaczmarek,L.K., Colleaux,L. and Nabbout,R.
  TITLE     De novo gain-of-function KCNT1 channel mutations cause malignant
            migrating partial seizures of infancy
  JOURNAL   Nat Genet 44 (11), 1255-1259 (2012)
   PUBMED   23086397
  REMARK    GeneRIF: Our data identify KCNT1 as a major disease-associated gene
            in Malignant migrating partial seizures of infancy .
REFERENCE   6  (bases 1 to 7123)
  AUTHORS   Heron,S.E., Smith,K.R., Bahlo,M., Nobili,L., Kahana,E.,
            Licchetta,L., Oliver,K.L., Mazarib,A., Afawi,Z., Korczyn,A.,
            Plazzi,G., Petrou,S., Berkovic,S.F., Scheffer,I.E. and Dibbens,L.M.
  TITLE     Missense mutations in the sodium-gated potassium channel gene KCNT1
            cause severe autosomal dominant nocturnal frontal lobe epilepsy
  JOURNAL   Nat Genet 44 (11), 1188-1190 (2012)
   PUBMED   23086396
  REMARK    GeneRIF: Mutations in KCNT1 cause a severe form of ADNFLE and
            sporadic NFLE.
REFERENCE   7  (bases 1 to 7123)
  AUTHORS   Wei,A.D., Gutman,G.A., Aldrich,R., Chandy,K.G., Grissmer,S. and
            Wulff,H.
  TITLE     International Union of Pharmacology. LII. Nomenclature and
            molecular relationships of calcium-activated potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 463-472 (2005)
   PUBMED   16382103
  REMARK    Review article
REFERENCE   8  (bases 1 to 7123)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   9  (bases 1 to 7123)
  AUTHORS   Gertler,T., Bearden,D., Bhattacharjee,A. and Carvill,G.
  TITLE     KCNT1-Related Epilepsy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   30234941
REFERENCE   10 (bases 1 to 7123)
  AUTHORS   Kurahashi,H. and Hirose,S.
  TITLE     Autosomal Dominant Sleep-Related Hypermotor (Hyperkinetic) Epilepsy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301348
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK127272.1, BC171770.1,
            DA095802.1, BX110871.1 and AL158822.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020822.2.
            
            Summary: Potassium channels represent the most complex class of
            voltage-gated ion channels from both functional and structural
            standpoints. Their diverse functions include regulating
            neurotransmitter release, heart rate, insulin secretion, neuronal
            excitability, epithelial electrolyte transport, smooth muscle
            contraction, and cell volume. This gene encodes a sodium-activated
            potassium channel subunit which is thought to function in ion
            conductance and developmental signaling pathways. Mutations in this
            gene cause the early-onset epileptic disorders, malignant migrating
            partial seizures of infancy and autosomal dominant nocturnal
            frontal lobe epilepsy. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC136618.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371757.7/ ENSP00000360822.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AK127272.1         1-28
            29-1817             BC171770.1         1-1789
            1818-1979           DA095802.1         256-417
            1980-2496           BC171770.1         1952-2468
            2497-2506           AK127272.1         2362-2371
            2507-4724           BC171770.1         2479-4696
            4725-4768           BX110871.1         299-342
            4769-7123           AL158822.19        40137-42491         c
FEATURES             Location/Qualifiers
     source          1..7123
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..7123
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /note="potassium sodium-activated channel subfamily T
                     member 1"
                     /db_xref="GeneID:57582"
                     /db_xref="HGNC:HGNC:18865"
                     /db_xref="MIM:608167"
     exon            1..184
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..3782
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potassium channel, subfamily T, member 1; Sequence like a
                     calcium-activated K+ channel; potassium channel, sodium
                     activated subfamily T, member 1; sodium and
                     chloride-activated ATP-sensitive potassium channel Slo2.2"
                     /codon_start=1
                     /product="potassium channel subfamily T member 1 isoform
                     1"
                     /protein_id="NP_065873.2"
                     /db_xref="CCDS:CCDS35175.2"
                     /db_xref="GeneID:57582"
                     /db_xref="HGNC:HGNC:18865"
                     /db_xref="MIM:608167"
                     /translation="MPLPDGARTPGGVCREARGGGYTNRTFEFDDGQCAPRRPCAGDG
                     ALLDTAGFKMSDLDSEVLPLPPRYRFRDLLLGDPSFQNDDRVQVEFYVNENTFKERLK
                     LFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDPALGIGCWGCPKQNYSFNDSSS
                     EINWAPILWVERKMTLWAIQVIVAIISFLETMLLIYLSYKGNIWEQIFRVSFVLEMIN
                     TLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFC
                     TLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGDVTPKIWPSQLLVVIM
                     ICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNE
                     FYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNG
                     EACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVC
                     EEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRM
                     GDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAASDTCFY
                     INITKEENSAFIFKQEEKRKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGTEHR
                     PTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQSEDEVTPSD
                     DEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGF
                     KNKLIIVSAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMV
                     YYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPS
                     LSITTELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSI
                     SMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKITEGDLWIRTYGRLFQKLC
                     SSSAEIPIGIYRTESHVFSTSEPHDLRAQSQISVNVEDCEDTREVKGPWGSRAGTGGS
                     SQGRHTGGGDPAEHPLLRRKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSER
                     QELSELVKNRMKHLGLPTTGYDEMNDHQNTLSYVLINPPPDTRLEPSDIVYLIRSDPL
                     AHVASSSQSRKSSCSHKLSSCNPETRDETQL"
     exon            185..328
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            329..408
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            409..508
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            509..565
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            566..614
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..674
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            675..749
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            750..833
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            834..928
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1109
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1274
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1411
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1475
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1584
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1693
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1843
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2082
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2317
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2423
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2596
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2668
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2803
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2915
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3017
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3101
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3230
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3251
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            3252..3576
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..3661
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     exon            3662..7123
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4736..4741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /note="hexamer: ATTAAA"
     polyA_site      4771
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /note="major polyA site"
     regulatory      7097..7102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /note="hexamer: AATAAA"
     polyA_site      7123
                     /gene="KCNT1"
                     /gene_synonym="bA100C15.2; DEE14; EIEE14; ENFL5; KCa4.1;
                     KNa1.1; SLACK; Slo2.2"
                     /note="major polyA site"
ORIGIN      
        1 agggcaacgc gagggaagaa ggtggcggct cccactcgct tctccctcgg gtcgggtccg
       61 agctgccagg ccgcatgcca ctccctgacg gggcgcggac cccggggggc gtctgccggg
      121 aggcgcgcgg cgggggctac accaaccgga ccttcgagtt tgacgacggc caatgcgccc
      181 ccaggcggcc ctgcgcgggg gacggcgcgc tcctggacac cgccggcttc aagatgagcg
      241 acctggactc cgaggtgctg cccttgccgc cgcgctaccg cttccgggac ctgctgctgg
      301 gcgacccgtc cttccagaac gacgacaggg tccaggtgga gttctacgtc aacgagaaca
      361 ccttcaagga gcggctcaag ctgttcttca tcaaaaacca aagatcgagc ctgaggatcc
      421 ggctgttcaa cttctccctg aagctgctca cctgcctgct ctacattgtg cgcgtcctgc
      481 tcgatgaccc ggccctgggc atcggatgct ggggctgccc aaagcagaac tactccttca
      541 atgactcgtc ctccgagatc aactgggctc ctattctgtg ggtggagaga aagatgacac
      601 tgtgggcgat ccaggtcatc gtggccataa taagcttcct ggagacgatg cttctcatct
      661 acctcagcta caaaggcaac atctgggagc agatcttccg cgtgtccttc gtcctggaga
      721 tgatcaacac tctgcccttc atcatcacga tcttctggcc gccgctgcgg aacctgttca
      781 tccccgtctt tctgaactgc tggctggcca agcacgcgct ggaaaacatg attaatgact
      841 tccaccgtgc catcctgcgg acacagtcag ccatgttcaa ccaggtcctc atcctcttct
      901 gcaccctgct gtgcctcgtt ttcacgggga cctgcggcat ccagcacctg gagcgggcgg
      961 gcgagaacct gtccctcctg acctccttct acttctgcat cgtcaccttc tccaccgtgg
     1021 gctacggtga cgtcacgccc aagatctggc catcgcagct gctggtggtc atcatgatct
     1081 gcgtggccct cgtggtgctc ccactgcagt tcgaggagct cgtctacctc tggatggagc
     1141 ggcagaagtc agggggcaac tacagccgcc accgtgcgca gacggagaag cacgtggtcc
     1201 tgtgtgtcag ctccctcaag atcgaccttc tcatggactt cctgaacgag ttctacgccc
     1261 acccccggct ccaggactat tacgtggtca tcctgtgccc cacggagatg gatgtccagg
     1321 tgcgcagagt cctgcagatc cctctgtggt cccagcgggt catctacctc cagggctctg
     1381 cactcaaaga ccaggacctc atgcgagcca agatggacaa tggggaggcc tgcttcatcc
     1441 tcagcagcag gaacgaggtg gaccgcacgg ctgcagacca ccagaccatc ctgcgcgcct
     1501 gggccgtgaa ggacttcgcc cccaactgcc ccctctacgt ccagatcctc aaacctgaaa
     1561 acaagtttca cgtcaagttt gctgaccacg tggtgtgtga ggaggagtgc aagtacgcca
     1621 tgctggcgct gaactgcatc tgcccggcga cctccaccct catcaccctg ctggtgcaca
     1681 cgtcccgcgg ccaggaggga caggagtctc cggagcagtg gcagcgcatg tatgggcgct
     1741 gctccggcaa cgaggtgtac cacatccgca tgggtgacag caagttcttc cgcgagtacg
     1801 agggcaagag cttcacctac gcggccttcc acgcccacaa gaagtatggc gtgtgcctca
     1861 tcgggctgaa gcgggaggac aacaagagca tcctgctgaa cccggggccc cggcacatcc
     1921 tggccgcctc tgacacctgc ttctacatca acatcaccaa ggaggagaac tcggccttca
     1981 tcttcaagca ggaggagaag cggaagaaga gggccttctc ggggcagggg ctgcacgagg
     2041 gtccggcccg cctgcccgtg cacagcatca tcgcctccat ggggacagtg gccatggacc
     2101 tgcagggcac agagcaccgg cctacgcaga gcggcggtgg gggcgggggc agcaagctgg
     2161 cactgcccac ggagaacggc tcgggcagcc ggcggcccag catcgcgccc gtcctggaac
     2221 tggccgacag ctcagccctg ctgccctgcg acctgctgag cgaccagtcg gaggatgagg
     2281 tgacgccgtc ggacgacgag gggctctccg tggtagagta tgtgaagggc taccctccca
     2341 actcgcccta catcggcagc tccccaaccc tgtgccacct cctgcctgtg aaagccccct
     2401 tctgctgcct gcggctggac aagggctgca agcacaacag ctatgaagac gccaaggcct
     2461 acgggttcaa gaacaagctg atcatcgtct cggcagagac ggccggcaat gggctgtaca
     2521 acttcatcgt gccactgcgg gcctactaca gatcccgcaa ggagctgaac cccatcgtgc
     2581 tgctgctgga caacaagccc gaccaccact tcctggaagc catctgctgc ttccccatgg
     2641 tctactacat ggagggctct gtggacaacc tggacagcct gctgcagtgt ggcatcatct
     2701 atgcggacaa cctggtggtg gtggacaagg agagcaccat gagcgccgag gaggactaca
     2761 tggcggacgc caagaccatc gtcaacgtgc agaccatgtt ccggctcttc cccagcctca
     2821 gcatcaccac ggagctcacc cacccttcca acatgcgctt catgcagttc cgcgccaagg
     2881 acagctactc tctggctctt tccaaactag aaaagaggga gcgagagaat ggctccaacc
     2941 tggccttcat gttccgcctg ccgttcgccg ccggccgcgt cttcagcatc agcatgttgg
     3001 acacactgct ctaccagtcc ttcgtgaagg actacatgat caccatcacc cggctgctgc
     3061 tgggcctgga caccacgccg ggctcggggt acctctgtgc catgaaaatc accgagggcg
     3121 acctgtggat ccgcacgtac ggccgcctct tccagaagct ctgctcctcc agcgccgaga
     3181 tccccattgg catctaccgg acagagagcc acgtcttctc cacctcggag ccccacgacc
     3241 tcagagccca gtcccagatc tcggtgaacg tggaggactg tgaggacaca cgggaagtga
     3301 aggggccctg gggctcccgc gctggcaccg gaggcagctc ccagggccgc cacacgggcg
     3361 gcggtgaccc cgcagagcac ccactgctac ggcgcaagag cctgcagtgg gcccggaggc
     3421 tgagccgcaa ggcgcccaag caggcaggcc gggcggcggc cgcggagtgg atcagccagc
     3481 agcgcctcag cctgtaccgg cgctctgagc gccaggagct ctccgagctg gtgaagaacc
     3541 gcatgaagca cctggggctg cccaccaccg gctacgacga gatgaacgac caccagaaca
     3601 ccctctccta cgtcctcatc aaccctccgc ccgacacgag gctggagccc agtgacattg
     3661 tctatctcat ccgctccgac cccctggctc acgtggccag cagctcccag agccggaaga
     3721 gcagctgcag ccacaagctg tcgtcctgca accccgagac tcgcgacgag acacagctct
     3781 gagccagccc tgcacggagc tcaggccacc aagcccgggg tcctcaggaa ggacgtggag
     3841 gagcgtgtga ggacacggtg gcactagcgt gaccctgggg atggcacact ctactcacca
     3901 tggctcctgg gactccaccc tggaaaggag cccctcatgc ggggggaggg ccagctcacc
     3961 cctgggcacc tgcaggctag tgaggagagt tttttaacct atttttacac gtcgatgcag
     4021 tccacttctc tttacacaga tgtaccgcaa ctcgtgacca gggctggctg ggagggcaac
     4081 gcagggactg gacgccctac agggccgagc ccaggctgtg ctggagggtg gggctggggt
     4141 gcatggggag gggagcagaa cccagaaccc aggagccccg cgtgggccac acccaactca
     4201 gagccggcct gagcgttcac ggccaggcag cctcgcttcc ttgcagccaa gggctggggg
     4261 ccagggctgc tgttctgcac tctggggtgg gtgaggggga ccctgggctg tttgctgtcc
     4321 caagcccctt ctggaagtta gaagcagcaa agggcccggg gaagccgggc atgtgagagg
     4381 ggtgcgtccc caggtccccc agagggccct gtcgccgagg acctttctga aggaagcaga
     4441 agacgccatt tcctctactt cacactgaac tgtcccagcc actgcatcta gggggcattg
     4501 ggcggaagat ggtgcatttc catggaccat tttacactta ccttttaaag caaagcctca
     4561 ttttctaaac ccctgacttg tgaagcacaa ttcagcctcc gggctgggcc acgtggagag
     4621 agaggatctt ctcagcaagg cgagatcccg ggcggcggct gacatcagga gcgccaccct
     4681 gcgtcctttg ctgctggttc cttactggtt tgtacggtca gcgctggaaa cttctattaa
     4741 atggatgcat tctggaggca tgaagttaca agtcaagtcg ccctgctcgt gtttccaagg
     4801 ctctcacccc tcccagccac cccactttaa gggttacaaa cacctgctgg ggtccccacc
     4861 ccaaccccat aggcaagccc ccattcccca gccaggccag gacagtcctt ccaaaactcg
     4921 ggaaccaaat tgtatttggc tactggtgac tggatcctgg tagccaggaa acctgcctgg
     4981 tggtgggggt cccagagtcc aggagggctg tctggtgagc tgcccatcag cctcacccct
     5041 gcagccaggc atgtccctgg ggtgggcaca gagaccccag gctctgcccg cagtggcaca
     5101 gaactcatct gaggccagtg gctgctgggg atcccctaca ctgggggtca gggctgcccc
     5161 aggtggggat gtgtgtgcac ctcaccacgt tcacttcagg gtaccccaag aggctgaagg
     5221 ggaaggacca aaaggccgag gtgcagcccc tccccggtgt cagggcagac aacacagcag
     5281 ctgctggagg ggccggccct ggccacacag actagctagt cccttactcc cggcctgtct
     5341 ggaaccctcc tgctcagaag gtgcccacta gccctctgtg ggggacagag ccagacatgg
     5401 gtggtcaggg agaggctgtg tggattcagg ggaccagaaa gtaagtccca ggaccttgat
     5461 ggagcggcag ggattgatgt tgggctaggg tggccagagc ctgtcccagc agggctgggg
     5521 tctatcacgt tcctgggatc caagcagcga gcacgccctg ccccgcagtc accccgcccc
     5581 gcagtcgccc tgcagctgga aggcccaagt ctgcctcacc tgggtggcct ctcatgtccc
     5641 ccacaccctg gcccccaggc gaggggggct gcacagcacc tgcagggagg agaagggaga
     5701 gaaaagccgg tctggctgct gggatgggag ggccacagtt ccagcagtgg caggggaagc
     5761 tgtagcccct ggagccccac actggaagag ctggcctgca ggaggcacca tgggggagtc
     5821 gcatgactta ttcgggattg acttgcgatg tggatggtgt tcccggagtc ccctgtggcc
     5881 actccaccac catgaggccg ggaggcatct tagcctttga gcctctctcc aggggtgagc
     5941 ggagcccccc aaagagggct gaaggcttgc tgcccaagag gggctgggtg agcacttggg
     6001 gcctctgaga acatcagtgg tccgttccct cctgcacact ggtggcaagt ggcagcattt
     6061 tttcataatc tccagtaatg aggccacttc gggtccagcc ctggacatcc gaggaggagg
     6121 cgggcagtcc ctgccccttc actaaccgca gaggatgcca gctctaggcc ccctgctccg
     6181 cctggagctc atgcgggcag ccgtggacac aggtggcacc cagcgcccag cggcctgtga
     6241 atcctcccgt gggcaaagct gggagccagg ggctggaacc aggcaggtca gtgactgtga
     6301 gatgccagct gccagcccaa gaaaagctgc ctgcagcatc tggaaacttc tgtgctctcc
     6361 ttggcctctg tgttcttcat ctccaggttt agggagcacc cgggtgcctc tctgcttgtc
     6421 ccgagcccac tcaccaacag ccccagcttg cacagtcatg acatcaggaa ggtgggtccc
     6481 tgctcccagc cgtcctcgtc caccatcact tctcccagcc tcgtgtcctg ctgacccata
     6541 aaaggtcccc ctgcaaagta caccaagtga agtaggatct gagcaaaggt tgagggactg
     6601 aattccctaa gaagtcatca ctgcctagaa taagcgaaaa gaattttttt taatgtttta
     6661 cggtagaatt atttgaaaca tacaaaatga gtgagacacc tgctattttc cttattcctg
     6721 ttttttgttt gtttttattt tccttatacc taattcatct aacagaaaac tgggcagggc
     6781 gcagtgtctc acacctgtaa tcccagcact ttgggaggcc aaggcaggtg gactgcttga
     6841 gcccaggagt tgagtttaag atcagcgtgg gcaacatgat gaaccctgac tgtatcaaaa
     6901 agtacaaaaa aaaaaatagc tagacgtggt ggcatgtgca tacagtccca ggtacccaag
     6961 aggctgagga aggaggatca cctgagctgg ggaggttgag gctgccgtga gctgagatgg
     7021 caccactgca ctccagcctg ggtggcagag agagaccctg tctcaaacaa aacaaacaaa
     7081 caaaaaagaa aaagaaaata aaactgtttg ctcaaaatca gaa
//
