LOCUS       NM_020697               5288 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens potassium voltage-gated channel modifier subfamily S
            member 2 (KCNS2), mRNA.
ACCESSION   NM_020697 XM_043106
VERSION     NM_020697.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5288)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5288)
  AUTHORS   Smith,P., Arias,R., Sonti,S., Odgerel,Z., Santa-Maria,I.,
            McCabe,B.D., Tsaneva-Atanasova,K., Louis,E.D., Hodge,J.J.L. and
            Clark,L.N.
  TITLE     A Drosophila Model of Essential Tremor
  JOURNAL   Sci Rep 8 (1), 7664 (2018)
   PUBMED   29769701
  REMARK    GeneRIF: KCNS2 mutation is associated with Essential Tremor.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5288)
  AUTHORS   Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D.,
            Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W.
            and Wang,X.
  TITLE     International Union of Pharmacology. LIII. Nomenclature and
            molecular relationships of voltage-gated potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 473-508 (2005)
   PUBMED   16382104
  REMARK    Review article
REFERENCE   4  (bases 1 to 5288)
  AUTHORS   Salinas,M., Duprat,F., Heurteaux,C., Hugnot,J.P. and Lazdunski,M.
  TITLE     New modulatory alpha subunits for mammalian Shab K+ channels
  JOURNAL   J Biol Chem 272 (39), 24371-24379 (1997)
   PUBMED   9305895
REFERENCE   5  (bases 1 to 5288)
  AUTHORS   Banfi,S., Borsani,G., Rossi,E., Bernard,L., Guffanti,A.,
            Rubboli,F., Marchitiello,A., Giglio,S., Coluccia,E., Zollo,M.,
            Zuffardi,O. and Ballabio,A.
  TITLE     Identification and mapping of human cDNAs homologous to Drosophila
            mutant genes through EST database searching
  JOURNAL   Nat Genet 13 (2), 167-174 (1996)
   PUBMED   8640222
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003355.2, BC034778.1, BI819243.1 and AB032970.1.
            
            On May 17, 2019 this sequence version replaced NM_020697.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032970.1, SRR1660805.179991.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2153980
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287042.5/ ENSP00000287042.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AP003355.2         56213-56276
            65-86               BC034778.1         1-22
            87-87               BI819243.1         23-23
            88-2110             BC034778.1         24-2046
            2111-2111           AB032970.1         1852-1852
            2112-3136           BC034778.1         2048-3072
            3137-3137           AB032970.1         2878-2878
            3138-3232           BC034778.1         3074-3168
            3233-5288           AP003355.2         60053-62108
FEATURES             Location/Qualifiers
     source          1..5288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.2"
     gene            1..5288
                     /gene="KCNS2"
                     /gene_synonym="KV9.2"
                     /note="potassium voltage-gated channel modifier subfamily
                     S member 2"
                     /db_xref="GeneID:3788"
                     /db_xref="HGNC:HGNC:6301"
                     /db_xref="MIM:602906"
     exon            1..372
                     /gene="KCNS2"
                     /gene_synonym="KV9.2"
                     /inference="alignment:Splign:2.1.0"
     exon            373..5288
                     /gene="KCNS2"
                     /gene_synonym="KV9.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..1848
                     /gene="KCNS2"
                     /gene_synonym="KV9.2"
                     /note="potassium voltage-gated channel subfamily S member
                     2; voltage-gated potassium channel subunit Kv9.2;
                     delayed-rectifier K(+) channel alpha subunit 2; potassium
                     voltage-gated channel, delayed-rectifier, subfamily S,
                     member 2; delayed-rectifier potassium channel subunit
                     Kv9.2"
                     /codon_start=1
                     /product="delayed-rectifier potassium channel regulatory
                     subunit KCNS2"
                     /protein_id="NP_065748.1"
                     /db_xref="CCDS:CCDS6279.1"
                     /db_xref="GeneID:3788"
                     /db_xref="HGNC:HGNC:6301"
                     /db_xref="MIM:602906"
                     /translation="MTGQSLWDVSEANVEDGEIRINVGGFKRRLRSHTLLRFPETRLG
                     RLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFS
                     QEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAFYNDASK
                     FDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQ
                     GNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLV
                     VNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLL
                     YLSVGISIFSVVAYTIEKEENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTAS
                     ACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMKEVPSVNLRDYYAH
                     KVKSLMASLTNMSRSSPSELSLNDSLR"
     regulatory      2091..2096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNS2"
                     /gene_synonym="KV9.2"
                     /note="hexamer: CATAAA"
     polyA_site      2110
                     /gene="KCNS2"
                     /gene_synonym="KV9.2"
                     /note="major polyA site"
     regulatory      4299..4304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNS2"
                     /gene_synonym="KV9.2"
                     /note="hexamer: TATAAA"
     polyA_site      4320
                     /gene="KCNS2"
                     /gene_synonym="KV9.2"
                     /note="major polyA site"
     polyA_site      5288
                     /gene="KCNS2"
                     /gene_synonym="KV9.2"
                     /note="major polyA site"
ORIGIN      
        1 ccaccgcgcc gcgccccgcg cagggcgggc gccccgtcac acccgctctg ctcccgcccc
       61 ggctcacggg gcgaatgcgg cgcgggttcc tgcctctctg ggtgggtgag gggcgcgcgg
      121 atccggagag ggggctccgg gagcggcggg accacgcagc cacctgtgag ccttcggcag
      181 ctgcgggcgg cggcggcgta cccggcccga gacgggagga gacgctcggc ggcccccgcc
      241 cgccggcccg ccgggcgcac acactcgcac ccgcgcacgc accgccagca ggcagcggcc
      301 accgccgcga tgctcgcccg cgggttgggg aagtttcccg ccggcctcgg ccgcgggcac
      361 ccgtgctccc aggtgtagcg cccccgcgcg gcgcgggcgg ccggcgcctc cagcatgacc
      421 ggccagagcc tgtgggacgt gtcggaggct aacgtcgagg acggggagat ccgcatcaat
      481 gtgggcggct tcaagaggag gctgcgctcg cacacgctgc tgcgcttccc cgagacgcgc
      541 ctgggccgct tgctgctctg ccactcgcgc gaggccattc tggagctctg cgatgactac
      601 gacgacgtcc agcgggagtt ctacttcgac cgcaaccctg agctcttccc ctacgtgctg
      661 catttctatc acaccggcaa gcttcacgtc atggctgagc tatgtgtctt ctccttcagc
      721 caggagatcg agtactgggg catcaacgag ttcttcattg actcctgctg cagctacagc
      781 taccatggcc gcaaagtaga gcccgagcag gagaagtggg acgagcagag tgaccaggag
      841 agcaccacgt cttccttcga tgagatcctt gccttctaca acgacgcctc caagttcgat
      901 gggcagcccc tcggcaactt ccgcaggcag ctgtggctgg cgctggacaa ccccggctac
      961 tcagtgctga gcagggtctt cagcatcctg tccatcctgg tggtgatggg gtccatcatc
     1021 accatgtgcc tcaatagcct gcccgatttc caaatccctg acagccaggg caaccctggc
     1081 gaggacccta ggttcgaaat cgtggagcac tttggcattg cctggttcac atttgagctg
     1141 gtggccaggt ttgctgtggc ccctgacttc ctcaagttct tcaagaatgc cctaaacctt
     1201 attgacctca tgtccatcgt ccccttttac atcactctgg tggtgaacct ggtggtggag
     1261 agcacaccta ctttagccaa cttgggcagg gtggcccagg tcctgaggct gatgcggatc
     1321 ttccgcatct taaagctggc caggcactcc actggcctcc gctccctggg ggccactttg
     1381 aaatacagct acaaagaagt agggctgctc ttgctctacc tctccgtggg gatttccatc
     1441 ttctccgtgg tggcctacac cattgaaaag gaggagaacg agggcctggc caccatccct
     1501 gcctgctggt ggtgggctac cgtcagtatg accacagtgg ggtacgggga tgtggtccca
     1561 gggaccacgg caggaaagct gactgcctct gcctgcatct tggcaggcat cctcgtggtg
     1621 gtcctgccca tcaccttgat cttcaataag ttctcccact tttaccggcg ccaaaagcaa
     1681 cttgagagtg ccatgcgcag ctgtgacttt ggagatggaa tgaaggaggt cccttcggtc
     1741 aatttaaggg actattatgc ccataaagtt aaatccctta tggcaagcct gacgaacatg
     1801 agcaggagct caccaagtga actcagttta aatgattccc tacgttagcc gggaggactt
     1861 gtcaccctcc accccacatt gctgagctgc ctcttgtgcc tctggcacag cccaggcacc
     1921 ttatggttat ggtgtaagga gtatgcccag cccctgaggg gagagatgca tgggatatgc
     1981 acccaggttt cttttacagt ttttagaatc gtttttagag ggtggtgtgt ctgacaccat
     2041 gcctttgcac ctttccatga aatgacactc actggtcttt gcatcgtggg cataaaatgt
     2101 tcaccttttt gccagatgag tacacccaga atgctaattt ttctgtccat cgtgtacgct
     2161 attctagtgc ttgtggccca gtactgtcta tgagttgtcg tgctcctgtt tctgaggttg
     2221 tcgtgtgagt tctgtacaaa aagcccccac aagtcgtcca gtagaaatgc atctatgagg
     2281 tcagcaagga tatgatgaga ttttgctcac agtcatgtga aaacaaaatc tcagctcttt
     2341 atccattgct ttcacttagt tttagtacca aaacaaagag aatgcaaagt taagcagact
     2401 tgaccaatgc aagtctctaa gttgttttta taaatgatct gtagttccgt ggcttgcatg
     2461 ggtgcaccaa tcatctttag aacgatgtac actgatgttc atctcataaa tgtcactctt
     2521 tagagaatgt tacttagtta aacatgcagt gaagatcgaa tttttttccc aagaacagat
     2581 gtgttaggga gaggggcttc agctaaatag tccaaaccct agggtgctta aagccaagtt
     2641 agtgcaggct gagccccttg gttcacagtc aagcctcctt gtttcctagg gtgactgtag
     2701 agaaatgtat ttccggatga ggtttctgat ctaggccatt tgaccaaact ttgctgtgtc
     2761 taagatatta gcatgttttt gaaatattta ttttttaaga tgtttaggag taaggtcgtg
     2821 ttgtcttcct caactaaaaa gaagtttact gttgtatcgt ctccctgagg tgaacgttgt
     2881 tgggttgcta gcaagggcag tagcttaaat acttttgttg cctactctga aagctcatca
     2941 aatgagagcc cttttatttc caagcagaat ttagtcagat aattttgctt ctaggatata
     3001 gtatgttgta tatgatgctg tgattgccct ggagttcctg ccatgacatg gaaacctggt
     3061 ggtatggaag catgtactca aaatatagac gtgcacgatg gtggtgtggc ttacccagga
     3121 tggaaacact gcagttctta cttgcattcc cactgccttt catggggggt gactgggtag
     3181 aggccaggag aaaggaaaga gttgtaaaat aaaaaactgc tagttcataa aatgtcataa
     3241 aaaattgtaa acttgaaaag cttaatgcta ttcaaaagac cttcaagctt ccaaacttgt
     3301 attgaaggga gacgactgtt tcctcctcca aaatgctcct gctcctcttg ttcggttaac
     3361 cagcacataa cattgtgatg gggaacctgg gttcctctat aagataattc ttctccatca
     3421 tctttaaggt aatctgatgg ttttccaggt ggctttcatt attgttccat ctttgaaaag
     3481 gcaatagaac ccaggggtct gagcatggag ctatccaggg ttttcatcca aaggttgggc
     3541 ctcttcttaa gaggtccttt tgtgtttcag ttgattgaag atgatactta cctcattgga
     3601 ggtgtggcaa ggatcttatc agaaggcttt gtgttcttgt agttgtcatg gctactacag
     3661 tgtgggtgat ttattgaatg aattcactag ccacttgtgt cctggagccc ccagttcaaa
     3721 tctttccatt ggactggagg cttgtgggag gctgggaggt ggctgtctcc tagtgtctac
     3781 atccgtgtct ctgaagcatc aggaaaagtg agatgactta gaggcaactg ggcactgaat
     3841 cagaggagca gagttatttt tcagaatttg cacatggaac acttagattt ggctggtgct
     3901 tccagccctg gaaggcataa catttacgga ctcatcccca gctgcactga aggcaggtgg
     3961 tggtacagac ttatgaggac ggatcagttt gccaaggctg atggtattgg gtcactgagc
     4021 ctggtatcca tggccgctga ccaggaagct tatgcaaagt ggaagcaagg aacaaggcag
     4081 aataactcag tcactttcat gaagattttt ctaaacaaga aggcttacca ccaaaaaaga
     4141 ggtaccctag tggttaccct ttgcagatgt gaaagctgga aaacttgact tttctttttg
     4201 gtaatgactt gcatttatct ggtgcctttc gttggaggaa tcccaacgtg ctttagagac
     4261 tatcttttta acatctcttg tacatacata tatacttata taaaatatta tcttgcccaa
     4321 ctggaccttt actcacttct gagcatgaga atgtcccaat agcattgagt ttttcaagtg
     4381 gtggtttcag ataagtggga gaaagaacaa cccggctggc ttaaaccctg gagctaattc
     4441 ccacaaggaa tgtagactga atggtgaccc agggagaaat aatcttcctc tcccctaaag
     4501 tctcactaag gtttgaagtt tacaggtgct ctccactggg tctttgatcg accttgctag
     4561 ataacatcta accagcagtt tcttttagtc cctgaagcta accagggaga gtcaggttaa
     4621 ttttctgtaa aaatatgagg tgacatcttt ggcaaccagg ctgtcagact gacctgtaaa
     4681 cctcctttag ggggacagag tagaaactgg agatgacttg tttccagctg tgagcttgag
     4741 agaagtgtca ctcccagcat ttgaaggtta ttgttttcaa tgccagtggg ccaaatatat
     4801 gggccaggct ttgatatctg tgatgtgcat tttggaagtg ctgggttggg aagtgacacg
     4861 tctgttgcac aaatgcatat tggttatagg tttgtgtttt ctgccaaacc cccacatttc
     4921 tcgggtttgt gagtgaggaa gggcatgttg taatgccaag ctgatttgta gctcgtaagg
     4981 tagtaattgg tatttaacat ttgcatttgt tatttctact tatcttagca ctcaaataat
     5041 tgaactacct gctaattctt gccgcatttc aaagaaaata agttgttatg cactttggga
     5101 tagtggtgat ctgtacaggc tgtgtgttag ctacttgaag gcgtaactgg tatttcttgt
     5161 gtgttttaac agcatgactt cttacagagc tgtaattttt aaaattgagg atgccatatt
     5221 tgagatgtca gttttaacac tcattaacac actactgtgc aagcattgac acaggctgca
     5281 ctgaacca
//
