LOCUS       NP_065748                477 aa            linear   PRI 27-APR-2025
DEFINITION  delayed-rectifier potassium channel regulatory subunit KCNS2 [Homo
            sapiens].
ACCESSION   NP_065748 XP_043106
VERSION     NP_065748.1
DBSOURCE    REFSEQ: accession NM_020697.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 477)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 477)
  AUTHORS   Smith,P., Arias,R., Sonti,S., Odgerel,Z., Santa-Maria,I.,
            McCabe,B.D., Tsaneva-Atanasova,K., Louis,E.D., Hodge,J.J.L. and
            Clark,L.N.
  TITLE     A Drosophila Model of Essential Tremor
  JOURNAL   Sci Rep 8 (1), 7664 (2018)
   PUBMED   29769701
  REMARK    GeneRIF: KCNS2 mutation is associated with Essential Tremor.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 477)
  AUTHORS   Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D.,
            Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W.
            and Wang,X.
  TITLE     International Union of Pharmacology. LIII. Nomenclature and
            molecular relationships of voltage-gated potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 473-508 (2005)
   PUBMED   16382104
  REMARK    Review article
REFERENCE   4  (residues 1 to 477)
  AUTHORS   Salinas,M., Duprat,F., Heurteaux,C., Hugnot,J.P. and Lazdunski,M.
  TITLE     New modulatory alpha subunits for mammalian Shab K+ channels
  JOURNAL   J Biol Chem 272 (39), 24371-24379 (1997)
   PUBMED   9305895
REFERENCE   5  (residues 1 to 477)
  AUTHORS   Banfi,S., Borsani,G., Rossi,E., Bernard,L., Guffanti,A.,
            Rubboli,F., Marchitiello,A., Giglio,S., Coluccia,E., Zollo,M.,
            Zuffardi,O. and Ballabio,A.
  TITLE     Identification and mapping of human cDNAs homologous to Drosophila
            mutant genes through EST database searching
  JOURNAL   Nat Genet 13 (2), 167-174 (1996)
   PUBMED   8640222
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003355.2, BC034778.1, BI819243.1 and AB032970.1.
            
            On Mar 22, 2004 this sequence version replaced XP_043106.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032970.1, SRR1660805.179991.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2153980
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287042.5/ ENSP00000287042.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..477
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.2"
     Protein         1..477
                     /product="delayed-rectifier potassium channel regulatory
                     subunit KCNS2"
                     /note="potassium voltage-gated channel subfamily S member
                     2; voltage-gated potassium channel subunit Kv9.2;
                     delayed-rectifier K(+) channel alpha subunit 2; potassium
                     voltage-gated channel, delayed-rectifier, subfamily S,
                     member 2; delayed-rectifier potassium channel subunit
                     Kv9.2"
                     /calculated_mol_wt=54106
     Region          18..124
                     /region_name="BTB_POZ_KCNS2"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in potassium
                     voltage-gated channel subfamily S member 2 (KCNS2);
                     cd18427"
                     /db_xref="CDD:349734"
     Site            order(22,24..31,34,70,72..73,76,79,83,86,89,91,99..100,
                     103)
                     /site_type="other"
                     /note="putative tetramer interface [polypeptide binding]"
                     /db_xref="CDD:349734"
     Site            185..206
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ULS6.2)"
     Region          186..421
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Site            226..248
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ULS6.2)"
     Site            260..280
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ULS6.2)"
     Site            291..311
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ULS6.2)"
     Site            327..348
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ULS6.2)"
     Region          374..379
                     /region_name="Selectivity filter.
                     /evidence=ECO:0000250|UniProtKB:P63142"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ULS6.2)"
     Site            389..417
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ULS6.2)"
     CDS             1..477
                     /gene="KCNS2"
                     /gene_synonym="KV9.2"
                     /coded_by="NM_020697.4:415..1848"
                     /db_xref="CCDS:CCDS6279.1"
                     /db_xref="GeneID:3788"
                     /db_xref="HGNC:HGNC:6301"
                     /db_xref="MIM:602906"
ORIGIN      
        1 mtgqslwdvs eanvedgeir invggfkrrl rshtllrfpe trlgrlllch sreailelcd
       61 dyddvqrefy fdrnpelfpy vlhfyhtgkl hvmaelcvfs fsqeieywgi neffidsccs
      121 ysyhgrkvep eqekwdeqsd qesttssfde ilafyndask fdgqplgnfr rqlwlaldnp
      181 gysvlsrvfs ilsilvvmgs iitmclnslp dfqipdsqgn pgedprfeiv ehfgiawftf
      241 elvarfavap dflkffknal nlidlmsivp fyitlvvnlv vestptlanl grvaqvlrlm
      301 rifrilklar hstglrslga tlkysykevg llllylsvgi sifsvvayti ekeeneglat
      361 ipacwwwatv smttvgygdv vpgttagklt asacilagil vvvlpitlif nkfshfyrrq
      421 kqlesamrsc dfgdgmkevp svnlrdyyah kvkslmaslt nmsrsspsel slndslr
//
