LOCUS       NM_173605               1337 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens potassium channel regulator (KCNRG), transcript
            variant 1, mRNA.
ACCESSION   NM_173605
VERSION     NM_173605.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1337)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1337)
  AUTHORS   Usman,H. and Mathew,M.K.
  TITLE     Potassium channel regulator KCNRG regulates surface expression of
            Shaker-type potassium channels
  JOURNAL   Biochem Biophys Res Commun 391 (3), 1301-1305 (2010)
   PUBMED   19968958
  REMARK    GeneRIF: KCNRG is an ER-associated protein, which is proposed to
            regulate Kv1 family channel proteins by retaining a fraction of
            channels in endomembranes.
REFERENCE   3  (bases 1 to 1337)
  AUTHORS   Birerdinc,A., Nohelty,E., Marakhonov,A., Manyam,G., Panov,I.,
            Coon,S., Nikitin,E., Skoblov,M., Chandhoke,V. and Baranova,A.
  TITLE     Pro-apoptotic and antiproliferative activity of human KCNRG, a
            putative tumor suppressor in 13q14 region
  JOURNAL   Tumour Biol 31 (1), 33-45 (2010)
   PUBMED   20237900
  REMARK    GeneRIF: The haploinsufficiency of KCNRG might be relevant to the
            progression of chronic lymphocytic leukemia (CLL)and multiple
            myeloma(MM) at least in a subset of patients.
REFERENCE   4  (bases 1 to 1337)
  AUTHORS   Xin,X., Rual,J.F., Hirozane-Kishikawa,T., Hill,D.E., Vidal,M.,
            Boone,C. and Thierry-Mieg,N.
  TITLE     Shifted Transversal Design smart-pooling for high coverage
            interactome mapping
  JOURNAL   Genome Res 19 (7), 1262-1269 (2009)
   PUBMED   19447967
REFERENCE   5  (bases 1 to 1337)
  AUTHORS   Alimohammadi,M., Dubois,N., Skoldberg,F., Hallgren,A., Tardivel,I.,
            Hedstrand,H., Haavik,J., Husebye,E.S., Gustafsson,J., Rorsman,F.,
            Meloni,A., Janson,C., Vialettes,B., Kajosaari,M., Egner,W.,
            Sargur,R., Ponten,F., Amoura,Z., Grimfeld,A., De Luca,F.,
            Betterle,C., Perheentupa,J., Kampe,O. and Carel,J.C.
  TITLE     Pulmonary autoimmunity as a feature of autoimmune polyendocrine
            syndrome type 1 and identification of KCNRG as a bronchial
            autoantigen
  JOURNAL   Proc Natl Acad Sci U S A 106 (11), 4396-4401 (2009)
   PUBMED   19251657
  REMARK    GeneRIF: Autoantibodies to KCNRG were present in 7 of the 8
            patients with respiratory symptoms in autoimmune polyendocrine
            syndrome type 1
REFERENCE   6  (bases 1 to 1337)
  AUTHORS   Cho,Y.G., Kim,C.J., Song,J.H., Rhie,D.J., Park,Y.K., Kim,S.Y.,
            Nam,S.W., Yoo,N.J., Lee,J.Y. and Park,W.S.
  TITLE     Genetic and expression analysis of the KCNRG gene in hepatocellular
            carcinomas
  JOURNAL   Exp Mol Med 38 (3), 247-255 (2006)
   PUBMED   16819283
  REMARK    GeneRIF: Results suggest that genetic alterations and the
            expression of KCNRG might play an important role in the development
            and/or progression of a subset of hepatocellular carcinoma.
REFERENCE   7  (bases 1 to 1337)
  AUTHORS   Skoblov,M., Shakhbazov,K., Oshchepkov,D., Ivanov,D., Guskova,A.,
            Ivanov,D., Rubtsov,P., Prasolov,V., Yankovsky,N. and Baranova,A.
  TITLE     Human RFP2 gene promoter: unique structure and unusual strength
  JOURNAL   Biochem Biophys Res Commun 342 (3), 859-866 (2006)
   PUBMED   16499869
REFERENCE   8  (bases 1 to 1337)
  AUTHORS   Corcoran,M.M., Hammarsund,M., Zhu,C., Lerner,M., Kapanadze,B.,
            Wilson,B., Larsson,C., Forsberg,L., Ibbotson,R.E., Einhorn,S.,
            Oscier,D.G., Grander,D. and Sangfelt,O.
  TITLE     DLEU2 encodes an antisense RNA for the putative bicistronic
            RFP2/LEU5 gene in humans and mouse
  JOURNAL   Genes Chromosomes Cancer 40 (4), 285-297 (2004)
   PUBMED   15188451
REFERENCE   9  (bases 1 to 1337)
  AUTHORS   Ivanov,D.V., Tyazhelova,T.V., Lemonnier,L., Kononenko,N.,
            Pestova,A.A., Nikitin,E.A., Prevarskaya,N., Skryma,R.,
            Panchin,Y.V., Yankovsky,N.K. and Baranova,A.V.
  TITLE     A new human gene KCNRG encoding potassium channel regulating
            protein is a cancer suppressor gene candidate located in 13q14.3
  JOURNAL   FEBS Lett 539 (1-3), 156-160 (2003)
   PUBMED   12650944
  REMARK    GeneRIF: the primary characterization of a new gene KCNRG mapped at
            chromosome band 13q14.3; is a candidate for a B-cell chronic
            lymphocytic leukemia and prostate cancer tumor suppressor gene
            GeneRIF: KCNRG suppresses K+ channel activity in human prostate
            cell line LNCaP.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY169388.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173605.1.
            
            Summary: This gene encodes a protein which regulates the activity
            of voltage-gated potassium channels. This gene is on chromosome 13
            and overlaps the gene for tripartite motif containing 13 on the
            same strand. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Feb
            2012].
            
            Transcript Variant: This variant (1) is the shorter transcript and
            encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY129654.1, AY169388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312942.2/ ENSP00000324191.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1337              AY169388.1         191-1527
FEATURES             Location/Qualifiers
     source          1..1337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..1337
                     /gene="KCNRG"
                     /gene_synonym="DLTET"
                     /note="potassium channel regulator"
                     /db_xref="GeneID:283518"
                     /db_xref="HGNC:HGNC:18893"
                     /db_xref="MIM:607947"
     exon            1..628
                     /gene="KCNRG"
                     /gene_synonym="DLTET"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..869
                     /gene="KCNRG"
                     /gene_synonym="DLTET"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative potassium channel regulatory protein"
                     /codon_start=1
                     /product="potassium channel regulatory protein isoform 1"
                     /protein_id="NP_775876.1"
                     /db_xref="CCDS:CCDS9424.1"
                     /db_xref="GeneID:283518"
                     /db_xref="HGNC:HGNC:18893"
                     /db_xref="MIM:607947"
                     /translation="MSSQELVTLNVGGKIFTTRFSTIKQFPASRLARMLDGRDQEFKM
                     VGGQIFVDRDGDLFSFILDFLRTHQLLLPTEFSDYLRLQREALFYELRSLVDLLNPYL
                     LQPRPALVEVHFLSRNTQAFFRVFGSCSKTIEMLTGRITVFTEQPSAPTWNGNFFPPQ
                     MTLLPLPPQRPSYHDLVFQCGSDSTTDNQTGVRYVSIKPDNRKLANGTNVLGLLIDTL
                     LKEGFHLVSTRTVSSEDKTECYSFERIKSPEVLITNETPKPETIIIPEQSQIKK"
     exon            629..1337
                     /gene="KCNRG"
                     /gene_synonym="DLTET"
                     /inference="alignment:Splign:2.1.0"
     regulatory      865..870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNRG"
                     /gene_synonym="DLTET"
                     /note="hexamer: AATGAA"
     polyA_site      890
                     /gene="KCNRG"
                     /gene_synonym="DLTET"
     regulatory      1303..1308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNRG"
                     /gene_synonym="DLTET"
                     /note="hexamer: AATAAA"
     polyA_site      1337
                     /gene="KCNRG"
                     /gene_synonym="DLTET"
                     /note="major polyA site"
ORIGIN      
        1 gatttcctaa gtgtggctga tggtagcctc tagtttgaag tgagggaaga atgagtagtc
       61 aggaactggt cactttgaat gtgggaggga agatattcac gacaaggttt tctacgataa
      121 agcagtttcc tgcttctcgt ttggcacgca tgttagatgg cagagaccaa gaattcaaga
      181 tggttggtgg ccagattttt gtagacagag atggtgattt gtttagtttc atcttagatt
      241 ttttgagaac tcaccagctt ttattaccca ctgaattttc agactatctt aggcttcaga
      301 gagaggctct tttctatgaa cttcgttctc tagttgatct cttaaaccca tacctgctac
      361 agccaagacc tgctcttgtg gaggtacatt tcctaagccg gaacactcaa gcttttttca
      421 gggtgtttgg ctcttgcagc aaaacaattg agatgctaac agggaggatt acagtgttta
      481 cagaacaacc ttcagcgccg acctggaatg gtaacttttt ccctcctcag atgaccttac
      541 ttccactgcc tccacaaaga ccttcttacc atgacctggt tttccagtgt ggttctgaca
      601 gcactactga taaccaaact ggagtcaggt atgtttctat aaaacctgat aaccgaaaat
      661 tggccaacgg aacaaatgtc ctcggcttac tgattgacac tttattaaag gaaggctttc
      721 atttggtcag cactagaaca gtatcttctg aagacaaaac tgaatgctat agctttgaaa
      781 ggataaaaag ccctgaagtg ctcatcacga atgaaacacc aaaaccagag actatcatca
      841 taccagagca atctcagata aagaaatgaa gttgtctatc ctcttttaaa gagaaattgc
      901 catttttctt gtttcattac gtatttaggg catacatgtt agccaaatct acactcagcc
      961 taactcttgg cttcatctgc tgccatgccg tctctgggca accaggcccc aactgtgctt
     1021 aagccataat gcctgctgct ctctagacaa ctccatgtac ttggtgcttt ggtatatgtt
     1081 ctaccttcaa tacatctttc cctttctctt cttcatgaat gcttatgagc cgagattgcg
     1141 ccactgcaca ctagcttggg tgacagagga agactgtctc aaaaaaaaaa aaattgatca
     1201 aactgatgga taccctaagt accctgactt gatcattaca ccttctatgc atgcaacaaa
     1261 atgccacgtg taccccataa atatgtagaa atattatatg taaataaata gttgggcctt
     1321 ccgtattttc ccactta
//
