LOCUS       NM_172107               9247 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily Q member 2
            (KCNQ2), transcript variant 1, mRNA.
ACCESSION   NM_172107
VERSION     NM_172107.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9247)
  AUTHORS   Wong,S.H., Liou,Y.M., Yang,J.J. and Lee,I.C.
  TITLE     KCNQ2 mutations cause unique neonatal behavior arrests without
            motor seizures: Functional characterization
  JOURNAL   Epilepsy Behav 156, 109798 (2024)
   PUBMED   38788659
  REMARK    GeneRIF: KCNQ2 mutations cause unique neonatal behavior arrests
            without motor seizures: Functional characterization.
REFERENCE   2  (bases 1 to 9247)
  AUTHORS   Cao,B., Peng,B., Tian,Y., Wang,X., Li,X., Zhu,H., Shen,H. and
            Chen,W.
  TITLE     Clinical and genetic analysis of 18 patients with KCNQ2 mutations
            from South China
  JOURNAL   Turk J Pediatr 66 (2), 191-204 (2024)
   PUBMED   38814296
  REMARK    GeneRIF: Clinical and genetic analysis of 18 patients with KCNQ2
            mutations from South China.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9247)
  AUTHORS   Mehrdel,B. and Villalba-Galea,C.A.
  TITLE     Effect of a sensing charge mutation on the deactivation of KV7.2
            channels
  JOURNAL   J Gen Physiol 156 (3) (2024)
   PUBMED   38236165
  REMARK    GeneRIF: Effect of a sensing charge mutation on the deactivation of
            KV7.2 channels.
REFERENCE   4  (bases 1 to 9247)
  AUTHORS   Zhang,Y., Xue,Y., Ma,Y., Du,X., Lu,B., Wang,Y. and Yan,Z.
  TITLE     Improved classification and pathogenicity assessment by
            comprehensive functional studies in a large data set of KCNQ2
            variants
  JOURNAL   Life Sci 339, 122378 (2024)
   PUBMED   38142737
  REMARK    GeneRIF: Improved classification and pathogenicity assessment by
            comprehensive functional studies in a large data set of KCNQ2
            variants.
REFERENCE   5  (bases 1 to 9247)
  AUTHORS   Iftimovici,A., Charmet,A., Desnous,B., Ory,A., Delorme,R.,
            Coutton,C., Devillard,F., Milh,M. and Maruani,A.
  TITLE     Familial KCNQ2 mutation: a psychiatric perspective
  JOURNAL   Psychiatr Genet 34 (1), 24-27 (2024)
   PUBMED   38108335
  REMARK    GeneRIF: Familial KCNQ2 mutation: a psychiatric perspective.
REFERENCE   6  (bases 1 to 9247)
  AUTHORS   Yang,W.P., Levesque,P.C., Little,W.A., Conder,M.L.,
            Ramakrishnan,P., Neubauer,M.G. and Blanar,M.A.
  TITLE     Functional expression of two KvLQT1-related potassium channels
            responsible for an inherited idiopathic epilepsy
  JOURNAL   J Biol Chem 273 (31), 19419-19423 (1998)
   PUBMED   9677360
REFERENCE   7  (bases 1 to 9247)
  AUTHORS   Biervert,C., Schroeder,B.C., Kubisch,C., Berkovic,S.F.,
            Propping,P., Jentsch,T.J. and Steinlein,O.K.
  TITLE     A potassium channel mutation in neonatal human epilepsy
  JOURNAL   Science 279 (5349), 403-406 (1998)
   PUBMED   9430594
REFERENCE   8  (bases 1 to 9247)
  AUTHORS   Singh,N.A., Charlier,C., Stauffer,D., DuPont,B.R., Leach,R.J.,
            Melis,R., Ronen,G.M., Bjerre,I., Quattlebaum,T., Murphy,J.V.,
            McHarg,M.L., Gagnon,D., Rosales,T.O., Peiffer,A., Anderson,V.E. and
            Leppert,M.
  TITLE     A novel potassium channel gene, KCNQ2, is mutated in an inherited
            epilepsy of newborns
  JOURNAL   Nat Genet 18 (1), 25-29 (1998)
   PUBMED   9425895
REFERENCE   9  (bases 1 to 9247)
  AUTHORS   Yokoyama,M., Nishi,Y., Yoshii,J., Okubo,K. and Matsubara,K.
  TITLE     Identification and cloning of neuroblastoma-specific and nerve
            tissue-specific genes through compiled expression profiles
  JOURNAL   DNA Res 3 (5), 311-320 (1996)
   PUBMED   9039501
REFERENCE   10 (bases 1 to 9247)
  AUTHORS   Miceli,F., Soldovieri,M.V., Weckhuysen,S., Cooper,E. and
            Taglialatela,M.
  TITLE     KCNQ2-Related Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20437616
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB636326.1, AL121829.30,
            D82346.1, AF033348.1, AF074247.1, AL121827.34, KF456987.1 and
            Y15065.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_172107.3.
            
            Summary: The M channel is a slowly activating and deactivating
            potassium channel that plays a critical role in the regulation of
            neuronal excitability.  The M channel is formed by the association
            of the protein encoded by this gene and a related protein encoded
            by the KCNQ3 gene, both integral membrane proteins. M channel
            currents are inhibited by M1 muscarinic acetylcholine receptors and
            activated by retigabine, a novel anti-convulsant drug. Defects in
            this gene are a cause of benign familial neonatal convulsions type
            1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At
            least five transcript variants encoding five different isoforms
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF033348.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359125.7/ ENSP00000352035.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DB636326.1         23-23
            2-15                AL121829.30        1646-1659           c
            16-1310             D82346.1           1-1295
            1311-3030           AF033348.1         1246-2965
            3031-3266           AF074247.1         2960-3195
            3267-5440           AL121827.34        173518-175691       c
            5441-5824           KF456987.1         1-384
            5825-8773           AL121827.34        170185-173133       c
            8774-9241           Y15065.1           6942-7409
            9242-9247           AL121827.34        169711-169716       c
FEATURES             Location/Qualifiers
     source          1..9247
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..9247
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /note="potassium voltage-gated channel subfamily Q member
                     2"
                     /db_xref="GeneID:3785"
                     /db_xref="HGNC:HGNC:6296"
                     /db_xref="MIM:602235"
     exon            1..488
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..2811
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /note="isoform a is encoded by transcript variant 1;
                     potassium voltage-gated channel subfamily KQT member 2;
                     voltage-gated potassium channel subunit Kv7.2;
                     neuroblastoma-specific potassium channel subunit alpha
                     KvLQT2; potassium channel, voltage gated KQT-like
                     subfamily Q, member 2"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily KQT
                     member 2 isoform a"
                     /protein_id="NP_742105.1"
                     /db_xref="CCDS:CCDS13520.1"
                     /db_xref="GeneID:3785"
                     /db_xref="HGNC:HGNC:6296"
                     /db_xref="MIM:602235"
                     /translation="MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAG
                     SEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLL
                     VFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGR
                     LKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTW
                     KLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLT
                     TIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRN
                     PAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGASRLIPPLNQLE
                     LLRNLKSKSGLAFRKDPPPEPSPSKGSPCRGPLCGCCPGRSSQKVSLKDRVFSSPRGV
                     AAKGKGSPQAQTVRRSPSADQSLEDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSE
                     EASLPGEDIVDDKSCPCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMD
                     VIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAITDKDRTKGPAEAELPEDPSMMGRLG
                     KVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFGAKEPEPAPPYHSPEDSREHVDR
                     HGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQPQSHPRQGHGTSPVGDHGSLV
                     RIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGNLRDSDTSISIPSVDHEEL
                     ERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSA
                     TGEGPFGDVGWAGPRK"
     exon            489..579
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            580..706
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..882
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1008
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1119
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1215
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1310
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1340
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1409
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1439
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1493
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1717
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1823
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1955
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..2079
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..9247
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9222..9227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /note="hexamer: AGTAAA"
     polyA_site      9247
                     /gene="KCNQ2"
                     /gene_synonym="BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11;
                     KV7.2"
                     /note="major polyA site"
ORIGIN      
        1 aggcgccgag gtgcgcgcgg agcgaggtgg ccgcagcgtc tccgcgcgcg gcccaagccc
       61 ggcaggagtg cggaaccgcc gcctcggcca tgcggctccc ggccgggggg cctgggctgg
      121 ggcccgcgcc gccccccgcg ctccgccccc gctgagcctg agcccgaccc ggggcgcctc
      181 ccgccaggca ccatggtgca gaagtcgcgc aacggcggcg tataccccgg cccgagcggg
      241 gagaagaagc tgaaggtggg cttcgtgggg ctggaccccg gcgcgcccga ctccacccgg
      301 gacggggcgc tgctgatcgc cggctccgag gcccccaagc gcggcagcat cctcagcaaa
      361 cctcgcgcgg gcggcgcggg cgccgggaag ccccccaagc gcaacgcctt ctaccgcaag
      421 ctgcagaatt tcctctacaa cgtgctggag cggccgcgcg gctgggcgtt catctaccac
      481 gcctacgtgt tcctcctggt tttctcctgc ctcgtgctgt ctgtgttttc caccatcaag
      541 gagtatgaga agagctcgga gggggccctc tacatcctgg aaatcgtgac tatcgtggtg
      601 tttggcgtgg agtacttcgt gcggatctgg gccgcaggct gctgctgccg gtaccgtggc
      661 tggagggggc ggctcaagtt tgcccggaaa ccgttctgtg tgattgacat catggtgctc
      721 atcgcctcca ttgcggtgct ggccgccggc tcccagggca acgtctttgc cacatctgcg
      781 ctccggagcc tgcgcttcct gcagattctg cggatgatcc gcatggaccg gcggggaggc
      841 acctggaagc tgctgggctc tgtggtctat gcccacagca aggagctggt cactgcctgg
      901 tacatcggct tcctttgtct catcctggcc tcgttcctgg tgtacttggc agagaagggg
      961 gagaacgacc actttgacac ctacgcggat gcactctggt ggggcctgat cacgctgacc
     1021 accattggct acggggacaa gtacccccag acctggaacg gcaggctcct tgcggcaacc
     1081 ttcaccctca tcggtgtctc cttcttcgcg ctgcctgcag gcatcttggg gtctgggttt
     1141 gccctgaagg ttcaggagca gcacaggcag aagcactttg agaagaggcg gaacccggca
     1201 gcaggcctga tccagtcggc ctggagattc tacgccacca acctctcgcg cacagacctg
     1261 cactccacgt ggcagtacta cgagcgaacg gtcaccgtgc ccatgtacag ttcgcaaact
     1321 caaacctacg gggcctccag acttatcccc ccgctgaacc agctggagct gctgaggaac
     1381 ctcaagagta aatctggact cgctttcagg aaggaccccc cgccggagcc gtctccaagt
     1441 aaaggcagcc cgtgcagagg gcccctgtgt ggatgctgcc ccggacgctc tagccagaag
     1501 gtcagtttga aagatcgtgt cttctccagc ccccgaggcg tggctgccaa ggggaagggg
     1561 tccccgcagg cccagactgt gaggcggtca cccagcgccg accagagcct cgaggacagc
     1621 cccagcaagg tgcccaagag ctggagcttc ggggaccgca gccgggcacg ccaggctttc
     1681 cgcatcaagg gtgccgcgtc acggcagaac tcagaagaag caagcctccc cggagaggac
     1741 attgtggatg acaagagctg cccctgcgag tttgtgaccg aggacctgac cccgggcctc
     1801 aaagtcagca tcagagccgt gtgtgtcatg cggttcctgg tgtccaagcg gaagttcaag
     1861 gagagcctgc ggccctacga cgtgatggac gtcatcgagc agtactcagc cggccacctg
     1921 gacatgctgt cccgaattaa gagcctgcag tccagagtgg accagatcgt ggggcggggc
     1981 ccagcgatca cggacaagga ccgcaccaag ggcccggccg aggcggagct gcccgaggac
     2041 cccagcatga tgggacggct cgggaaggtg gagaagcagg tcttgtccat ggagaagaag
     2101 ctggacttcc tggtgaatat ctacatgcag cggatgggca tccccccgac agagaccgag
     2161 gcctactttg gggccaaaga gccggagccg gcgccgccgt accacagccc ggaagacagc
     2221 cgggagcatg tcgacaggca cggctgcatt gtcaagatcg tgcgctccag cagctccacg
     2281 ggccagaaga acttctcggc gcccccggcc gcgccccctg tccagtgtcc gccctccacc
     2341 tcctggcagc cacagagcca cccgcgccag ggccacggca cctcccccgt gggggaccac
     2401 ggctccctgg tgcgcatccc gccgccgcct gcccacgagc ggtcgctgtc cgcctacggc
     2461 gggggcaacc gcgccagcat ggagttcctg cggcaggagg acaccccggg ctgcaggccc
     2521 cccgagggga acctgcggga cagcgacacg tccatctcca tcccgtccgt ggaccacgag
     2581 gagctggagc gttccttcag cggcttcagc atctcccagt ccaaggagaa cctggatgct
     2641 ctcaacagct gctacgcggc cgtggcgcct tgtgccaaag tcaggcccta cattgcggag
     2701 ggagagtcag acaccgactc cgacctctgt accccgtgcg ggcccccgcc acgctcggcc
     2761 accggcgagg gtccctttgg tgacgtgggc tgggccgggc ccaggaagtg aggcggcgct
     2821 gggccagtgg acccgcccgc ggccctcctc agcacggtgc ctccgaggtt ttgaggcggg
     2881 aaccctctgg ggcccttttc ttacagtaac tgagtgtggc gggaagggtg ggccctggag
     2941 gggcccatgt gggctgaagg atgggggctc ctggcagtga ccttttacaa aagttatttt
     3001 ccaacagggg ctggagggct gggcagggcc ctgtggctcc aggagcagcg tgcaggagca
     3061 aggctgccct gtccactctg ctcagggccg cggccgacat cagcccggtg tgaggagggg
     3121 cgggagtgat gacggggtgt tgccagcgtg gcaacaggcg gggggttgtc tcagccgagc
     3181 ccaggggagg cacaaagggc aggcctgttc cctgaggacc tgcgcaaagg gcgggcctgt
     3241 ttggtgagga cctgcggcct tgggtcccgg tggggtttcc gggcagctac aggcgggtgt
     3301 ggccggccgc tgtgcgtggc ctctgccttc acacctgacc tgcccggcgg gctttcctgt
     3361 tccccacctc aggggcgccc aaatacagag ctattggttg gcgtcttctc cctgtacctt
     3421 ctgggatctg agggctcttt ccatggaagc cagccccgag gtggagacct tcgcctgcag
     3481 ccgaggagcg ggtggggcct gggaaccaaa ctggagccag agtggacgtc cagccctctg
     3541 gtcttggcct ccagagggag ggcctggctc acggtggggc cagggagccg gctccaaagg
     3601 gtcttcaaaa agggggtcct tgggggctcc agctgcctcg ccctggcctt tctgtgggtg
     3661 cgtgagagcc agcagcaccc cagccttgga gaccgggggg gcaggacccc aagtcctccc
     3721 ctctctcctg actgccctgg ccgggtgccg gcactgcgag acccacctgg tgagcaggcc
     3781 tcacagttct tagccagggc cccacctcgc ctgtgtccca ccagtgcccc gacagacctg
     3841 gggcagggct gggccatgat gcagcgggcc aggatagcct ccaccgtcag cacagggccg
     3901 ccctccccgc ctttccggag gaaaccactc ccacctcagc ccagctgtgc gccctcccta
     3961 gctctcctgc cccctggagc tgatggcccc ttctccactg accgattcct tagcggggcc
     4021 tcttggggtc tcgggcctcg ggtgcaccgt cccatgcccg tcctgttgtg ggcaccgtgg
     4081 cccttggggc aggcggctct aatgcgggag cgagtcccta gctccagact taagaaccag
     4141 accccgggag catctggcat ttggcgtgac ggcgtcgcag gcgggcctgg gctccctgga
     4201 gagtggcctc cctgggagtg agcagggctg gggtcgtggg cgcaaatact cctgcagagc
     4261 aagtgcaggg gagtcctggg cccgtttctc ctccacctgc gttttcagtg cacttggctt
     4321 ggctgggagg tcctgaggcc ctgaggccag caggggaacc agtcctgagg gagaggactt
     4381 tgaaagcagc atttgagggt cgtacgcccc tggctggtgg gggtcctggc gctcagggtg
     4441 ttcggggagc catgtctggc gtccattgtg gggagctgct gccctggcct ctctgcctac
     4501 ccccagcccg gccagggcac tcccaggccc tgtcgccatt gaggtgcctc cgctgggctg
     4561 tctcctcacc cctccctgtg ctggagcctg tcccaaaaag gtgccaactg ggaggcctcg
     4621 gaagccactg tccaggctcc cactgcctgt ctgctctgtt cccaaaggca gcgtgtgtgg
     4681 cctcgggccc tgcggtggca tgaagcatcc cttctggtgt gggcatcgct acgtgttttg
     4741 ggggcagcgt ttcacggcgg tgcccttgct gtctcccttg ggctggctcg agcctggggt
     4801 ccatgtccct ttgccgtccc gtcatggggc agggaatcca tagcggggcc cacaggcagg
     4861 ggtatgagtg cgtcccaccc aacgcagcac cagccccggc caccgctccc cgtgtcccca
     4921 gttccgtctc agctacctgg actccaggac cctggagaag ggagacctgg cagtggaggg
     4981 aggctgtgct gtgtgtcccc ctgcaggtgt gaccccgcct gctctttcct cccccgccag
     5041 gtgtggcccc gcctgctctt tcctccccca ccagtatggc cccacctgct ctttcctccc
     5101 cccccaaggt gtggccccac ctgttctttc ctcccctgcc gaggtgtgac cccacctgct
     5161 ctttcctccc tcccagtatg gccccacctg ctctttcctc ccccgaggtg aggccccgcc
     5221 tgctctttcc tcccatgggg ccgctgaggc atgagcacct gggcacaggt tggggctctg
     5281 caggatgagg aagacaggcc aatcccttcc ctcccagaag ctggccgccc agcaggaggg
     5341 actgaggcca gactcatgtc cagcaaggaa cgtgtggtgt gtcccctggg aagtctctgg
     5401 gccctgggaa gagggaaggt gcacgtcctg ggatggttgc ggggccctgt tttgggagac
     5461 aaaggggtag agggtctgtc ttgggccccc ccagactcta gcctgagcag tgcagccacc
     5521 tactgcccca cctcagagaa gtgcagcggg aaggaggctg gaggtggtgc ggcgctgcct
     5581 cgggtgtctg cgtgaatgag cgtggccaag gaccagtgcc acctcatggc aaagagctcc
     5641 cgcagtgttt gttagagtgc acatccctac gtgcccactg gcacacacac gtgctcacat
     5701 acatgtccgc atacaggcgt acacatgcac gcttgcacac atgcacacag accacatagc
     5761 acacatgtgc actgaccaca cctgtataga ccatgcacag tacacatacg tgcatacaca
     5821 tgcctgcata caggcataca catgcacgct tacatgtaca cgtgcacaga tcacacacat
     5881 gcacacacgt gtagctcaca cacagtatac acatacacaa gtgcacagac cacacacagc
     5941 actaacacat gcacacacaa agtgcatagg ccacacagca catgcacaca ggtgcacaga
     6001 ccacacagca cacacaagtg cacagagcac actgcacaca tgcacacaca cacgcgtgca
     6061 tgcacactcc tcgcacttcc agccttggag cccttctgtc tctggtcttt ctctttgacc
     6121 ctgctgagtg taagctgcct ggggaggggc tacaaggagt aattgtggct ttaggggtcg
     6181 tggtgatgct ggaatgtcaa gcgccgtcgt ggggtatccg actgtccggg ctcctggtcc
     6241 gcagtggcag agcgccaggc agagcccaat cagggtctcg tgctgccctt ccctcccaca
     6301 gcctggcagc catccagagg aggggctcta ccagatgcca aggtgccccg gtgtctgtat
     6361 gggtgtccgg ttgggtcctg tgtttggtct gccctggagg tgctgggccc tcctgggatg
     6421 ggtggctcag cctcgaatcc caggccccag cccaggcagg tgctgctgcc tgttgtggtt
     6481 tcctggccca gcttctcctt ctccctctgc ataaaatcac agtccgtgag tcttccagct
     6541 gccaccacgg ctgggacacg ctgggggagg gctcctccca tgcctcctgc acacagccgt
     6601 ctgagcaggg caggtgccca acacccccca ccggaggaca cgctgcccct cagcgatgcc
     6661 cctacctttt ggggggcctc gtctcaagcc cccccttgga ggctgaaatc accccaggca
     6721 ctgtgagggc ttctccaggg ggcacccttt gagctgtggg tctgatcacc ccaagtcccg
     6781 cccggaggag aggcacagcc agggcgtgtg gtttaatgtt tgcccccttc ggggctggag
     6841 gtctcagtgt ttctagattc cagaccctgc tgccagagag acctgctgcc ggagagaagg
     6901 ggaggaggac tccagctggg ctcggtcccc cacagtcagg gacccccata aaggacaccc
     6961 ccttctctct agaaagagct gggctctcag ctatttctag ttgcttccca gaagccgagg
     7021 agcagaagga gctgtgagag ctttgcagaa acgcccttgt ccccgccctc ctgagctatg
     7081 aatgccgtac agagcagagg ctggggcatt ggcaagatca caggttgatg ctgcacagcc
     7141 ccattgacac aaaccctcaa agcagacgtg agagggacgg ttcacaaagc tcggacctgc
     7201 cgtggagggt gcccggcaga cgtggcgtga gagggacggc tcacgaggct tggacctgct
     7261 gtggagggtg cccagcagac gtggtgtgag aggaacggct cacgagactt ggacctggtg
     7321 gagggtgccc agcagacgtg gtgtgagagg gacggctcac agggcttgga cctgccatgg
     7381 agggtgcccg gcagacgtgg tgtgagaggg atggttcaca gggcttggac ctgccatgga
     7441 gggtgcccgg cagatgtggt gggagagaga tggctcatga ggcttggacc tgccgtggag
     7501 ggtgcccagc agacgtggta tgagagggat ggctcacgag gcttggacct ggtggagggt
     7561 gcccggcaga cgtgtgagag ggacggttca caaggcttgg acctgccatg gagggtgccc
     7621 agcagacgtg gtgtgagagg gacagctcac gaggcttgga cctgctgtgg agggtgccca
     7681 gcagggggct gagctctgag gggtgggtgc tcagtgcacg ggtgccccca gtgtcctctg
     7741 atcctgtccg gtgcctcccc caacccccac acccatgcag aactcccagg tcacatgcac
     7801 gtatgtccag ggcatggggg tggcgtgaag aggcctggtc agggccttta ggggctgcag
     7861 gacggaatgg ccgcctgggg agcctgtgtg gctgtgccgg gcagccatcc tgcattccca
     7921 cccagcgcgc agtctccacc tcggccccag caaagcgcta agcagccgga gagacagcca
     7981 gggcggcttc ctgaaggatg tgggatggtg gactccgggg tcgagggaat acgcaggttc
     8041 ctgtccctcc gggagaccta gagaagctgc acacccagga gctttccatg acccgggagc
     8101 atgagtgaat gggggttcca gtttgctgaa ctttgccgtc ttgtaagggt gggggctgac
     8161 ggccgaccct gggaggaggt gacatcgccg ggggaggttg tgggcaacgg tggaggagga
     8221 gagacgggag gggaccattt gggatggagg ggcctcttca gagttttaaa aggcgtttgt
     8281 ggggtggagt tgagtgtgct ctgggcttgg acacttgccg tggtgcccct ggctggccga
     8341 ggagactggc tctggccagg ggccccgtcc tgagaggtcc tcagcgtctg actctcggcc
     8401 aggcgccagc aaggaggggc cggtccccgg ggctaccagg caggcacgtg cacatcgcca
     8461 tcgccacacg ccaactccgc ctgggtttta caaagtcgtt gccttaatgc atgtggacag
     8521 gaactccctg aggtcgcccc atgccccctg gctgtgccag gtacggacgc cctggaccct
     8581 gcgaacaggt ggggcgggcg aggggcccaa gggacgggct ccagagacac gcgcagggca
     8641 ggaggggtct cacggagggg tctcgcactg aggcgcccag agctggtggt cccgctggac
     8701 gccatccctc tgcccgggat ccacacggcc cacgtgtgcc cgccatgccc gcgccccacg
     8761 ccattgcagt ctgccatcct ctggccgtga cggtggctgc agcttcccca tttgcgccgt
     8821 tgcctctggc tgtctgcact tttgttcatg ctccaaagaa catttcataa tgccttcagt
     8881 accgacgtac acttctgacc attttgtatg tgtccttgtg ccgtagtgac caggcctttt
     8941 tttggtggat gtgttacccc gcacacttca atctcaactt tgtgcaccgt ccattttcta
     9001 gggatagacg cccagggaat gaactctagt tttctaacag attagctgag atattaactt
     9061 actcacacgg acaggttgat gccagagccg taagaatgcg ccagtgcggg tttgcggggg
     9121 acttcgggtg tggggtcctg cggccgcgat ggccgtggaa ggttctgggg atccctgctg
     9181 ccacggggac gagttcggac gccaggtgga cctgtgcact cagtaaaacg cagtgattca
     9241 acctgga
//
