LOCUS       NM_002250               1956 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens potassium calcium-activated channel subfamily N member
            4 (KCNN4), mRNA.
ACCESSION   NM_002250
VERSION     NM_002250.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1956)
  AUTHORS   Segura,E., Zhao,J., Broszczak,M., Audet,F., Sauve,R. and Parent,L.
  TITLE     Investigating the Impact of Electrostatic Interactions on
            Calmodulin Binding and Ca2+-Dependent Activation of the
            Calcium-Gated Potassium SK4 Channel
  JOURNAL   Int J Mol Sci 25 (8), 4255 (2024)
   PUBMED   38673845
  REMARK    GeneRIF: Investigating the Impact of Electrostatic Interactions on
            Calmodulin Binding and Ca[2+]-Dependent Activation of the
            Calcium-Gated Potassium SK4 Channel.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1956)
  AUTHORS   Nikitin,E.S., Postnikova,T.Y., Proskurina,E.Y., Borodinova,A.A.,
            Ivanova,V., Roshchin,M.V., Smirnova,M.P., Kelmanson,I.,
            Belousov,V.V., Balaban,P.M. and Zaitsev,A.V.
  TITLE     Overexpression of KCNN4 channels in principal neurons produces an
            anti-seizure effect without reducing their coding ability
  JOURNAL   Gene Ther 31 (3-4), 144-153 (2024)
   PUBMED   37968509
  REMARK    GeneRIF: Overexpression of KCNN4 channels in principal neurons
            produces an anti-seizure effect without reducing their coding
            ability.
REFERENCE   3  (bases 1 to 1956)
  AUTHORS   Petkova-Kirova,P., Murciano,N., Iacono,G., Jansen,J., Simionato,G.,
            Qiao,M., Van der Zwaan,C., Rotordam,M.G., John,T., Hertz,L.,
            Hoogendijk,A.J., Becker,N., Wagner,C., Von Lindern,M., Egee,S., Van
            den Akker,E. and Kaestner,L.
  TITLE     The Gardos Channel and Piezo1 Revisited: Comparison between
            Reticulocytes and Mature Red Blood Cells
  JOURNAL   Int J Mol Sci 25 (3), 1416 (2024)
   PUBMED   38338693
  REMARK    GeneRIF: The Gardos Channel and Piezo1 Revisited: Comparison
            between Reticulocytes and Mature Red Blood Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1956)
  AUTHORS   Charlick,J.N., Bozadzhieva,D., Butler,A.S., Wilkinson,K.A. and
            Marrion,N.V.
  TITLE     A single coiled-coil domain mutation in hIKCa channel subunits
            disrupts preferential formation of heteromeric hSK1:hIKCa channels
  JOURNAL   Eur J Neurosci 59 (1), 3-16 (2024)
   PUBMED   38018635
  REMARK    GeneRIF: A single coiled-coil domain mutation in hIKCa channel
            subunits disrupts preferential formation of heteromeric hSK1:hIKCa
            channels.
REFERENCE   5  (bases 1 to 1956)
  AUTHORS   Ran,L., Ye,T., Erbs,E., Ehl,S., Spassky,N., Sumara,I., Zhang,Z. and
            Ricci,R.
  TITLE     KCNN4 links PIEZO-dependent mechanotransduction to NLRP3
            inflammasome activation
  JOURNAL   Sci Immunol 8 (90), eadf4699 (2023)
   PUBMED   38134241
  REMARK    GeneRIF: KCNN4 links PIEZO-dependent mechanotransduction to NLRP3
            inflammasome activation.
REFERENCE   6  (bases 1 to 1956)
  AUTHORS   Fanger,C.M., Ghanshani,S., Logsdon,N.J., Rauer,H., Kalman,K.,
            Zhou,J., Beckingham,K., Chandy,K.G., Cahalan,M.D. and Aiyar,J.
  TITLE     Calmodulin mediates calcium-dependent activation of the
            intermediate conductance KCa channel, IKCa1
  JOURNAL   J Biol Chem 274 (9), 5746-5754 (1999)
   PUBMED   10026195
REFERENCE   7  (bases 1 to 1956)
  AUTHORS   Ghanshani,S., Coleman,M., Gustavsson,P., Wu,A.C., Gargus,J.J.,
            Gutman,G.A., Dahl,N., Mohrenweiser,H. and Chandy,K.G.
  TITLE     Human calcium-activated potassium channel gene KCNN4 maps to
            chromosome 19q13.2 in the region deleted in diamond-blackfan anemia
  JOURNAL   Genomics 51 (1), 160-161 (1998)
   PUBMED   9693050
REFERENCE   8  (bases 1 to 1956)
  AUTHORS   Logsdon,N.J., Kang,J., Togo,J.A., Christian,E.P. and Aiyar,J.
  TITLE     A novel gene, hKCa4, encodes the calcium-activated potassium
            channel in human T lymphocytes
  JOURNAL   J Biol Chem 272 (52), 32723-32726 (1997)
   PUBMED   9407042
REFERENCE   9  (bases 1 to 1956)
  AUTHORS   Ishii,T.M., Silvia,C., Hirschberg,B., Bond,C.T., Adelman,J.P. and
            Maylie,J.
  TITLE     A human intermediate conductance calcium-activated potassium
            channel
  JOURNAL   Proc Natl Acad Sci U S A 94 (21), 11651-11656 (1997)
   PUBMED   9326665
REFERENCE   10 (bases 1 to 1956)
  AUTHORS   Joiner,W.J., Wang,L.Y., Tang,M.D. and Kaczmarek,L.K.
  TITLE     hSK4, a member of a novel subfamily of calcium-activated potassium
            channels
  JOURNAL   Proc Natl Acad Sci U S A 94 (20), 11013-11018 (1997)
   PUBMED   9380751
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF022797.1 and AF033021.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 6, 2018 this sequence version replaced NM_002250.2.
            
            Summary: The protein encoded by this gene is part of a potentially
            heterotetrameric voltage-independent potassium channel that is
            activated by intracellular calcium. Activation is followed by
            membrane hyperpolarization, which promotes calcium influx. The
            encoded protein may be part of the predominant calcium-activated
            potassium channel in T-lymphocytes. This gene is similar to other
            KCNN family potassium channel genes, but it differs enough to
            possibly be considered as part of a new subfamily. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138512.577803.1,
                                           SRR1163657.85675.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000648319.1/ ENSP00000496939.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1954              AF022797.1         285-2238
            1955-1956           AF033021.1         1972-1973
FEATURES             Location/Qualifiers
     source          1..1956
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..1956
                     /gene="KCNN4"
                     /gene_synonym="DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1;
                     IKCA1; KCa3.1; KCA4; SK4"
                     /note="potassium calcium-activated channel subfamily N
                     member 4"
                     /db_xref="GeneID:3783"
                     /db_xref="HGNC:HGNC:6293"
                     /db_xref="MIM:602754"
     exon            1..271
                     /gene="KCNN4"
                     /gene_synonym="DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1;
                     IKCA1; KCa3.1; KCA4; SK4"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1396
                     /gene="KCNN4"
                     /gene_synonym="DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1;
                     IKCA1; KCa3.1; KCA4; SK4"
                     /note="putative erythrocyte intermediate conductance
                     calcium-activated potassium Gardos channel; SKCa4; SKCa 4;
                     putative Gardos channel; potassium intermediate/small
                     conductance calcium-activated channel, subfamily N, member
                     4; small conductance calcium-activated potassium channel
                     4; potassium channel, calcium activated intermediate/small
                     conductance subfamily N alpha, member 4;
                     intermediate-conductance Ca2+-activated K+ channel,
                     KCa3.1; gardos channel"
                     /codon_start=1
                     /product="intermediate conductance calcium-activated
                     potassium channel protein 4"
                     /protein_id="NP_002241.1"
                     /db_xref="CCDS:CCDS12630.1"
                     /db_xref="GeneID:3783"
                     /db_xref="HGNC:HGNC:6293"
                     /db_xref="MIM:602754"
                     /translation="MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHA
                     EMLWFGGCSWALYLFLVKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTG
                     RQAAQIVLELVVCGLHPAPVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRL
                     YLVPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLT
                     TAWVLSVAERQAVNATGHLSDTLWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVC
                     CTALLVAVVARKLEFNKAEKHVHNFMMDIQYTKEMKESAARVLQEAWMFYKHTRRKES
                     HAARRHQRKLLAAINAFRQVRLKHRKLREQVNSMVDISKMHMILYDLQQNLSSSHRAL
                     EKQIDTLAGKLDALTELLSTALGPRQLPEPSQQSK"
     exon            272..367
                     /gene="KCNN4"
                     /gene_synonym="DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1;
                     IKCA1; KCa3.1; KCA4; SK4"
                     /inference="alignment:Splign:2.1.0"
     exon            368..795
                     /gene="KCNN4"
                     /gene_synonym="DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1;
                     IKCA1; KCa3.1; KCA4; SK4"
                     /inference="alignment:Splign:2.1.0"
     exon            796..931
                     /gene="KCNN4"
                     /gene_synonym="DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1;
                     IKCA1; KCa3.1; KCA4; SK4"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1042
                     /gene="KCNN4"
                     /gene_synonym="DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1;
                     IKCA1; KCa3.1; KCA4; SK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1161
                     /gene="KCNN4"
                     /gene_synonym="DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1;
                     IKCA1; KCa3.1; KCA4; SK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1231
                     /gene="KCNN4"
                     /gene_synonym="DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1;
                     IKCA1; KCa3.1; KCA4; SK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1399
                     /gene="KCNN4"
                     /gene_synonym="DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1;
                     IKCA1; KCa3.1; KCA4; SK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1956
                     /gene="KCNN4"
                     /gene_synonym="DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1;
                     IKCA1; KCa3.1; KCA4; SK4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1937..1942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNN4"
                     /gene_synonym="DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1;
                     IKCA1; KCa3.1; KCA4; SK4"
                     /note="hexamer: AATAAA"
     polyA_site      1956
                     /gene="KCNN4"
                     /gene_synonym="DHS2; hIK1; hIKCa1; hKCa4; hSK4; IK; IK1;
                     IKCA1; KCa3.1; KCA4; SK4"
                     /note="major polyA site"
ORIGIN      
        1 agagccagca gagcaggctg acgacctgca agccacagtg gctgccctgt gcgtgctgcg
       61 aggtggggga ccctgggcag gaagctggct gagccccaag accccggggg ccatgggcgg
      121 ggatctggtg cttggcctgg gggccttgag acgccgaaag cgcttgctgg agcaggagaa
      181 gtctctggcc ggctgggcac tggtgctggc aggaactggc attggactca tggtgctgca
      241 tgcagagatg ctgtggttcg gggggtgctc gtgggcgctc tacctgttcc tggttaaatg
      301 cacgatcagc atttccacct tcttactcct ctgcctcatc gtggcctttc atgccaaaga
      361 ggtccagctg ttcatgaccg acaacgggct gcgggactgg cgcgtggcgc tgaccgggcg
      421 gcaggcggcg cagatcgtgc tggagctggt ggtgtgtggg ctgcacccgg cgcccgtgcg
      481 gggcccgccg tgcgtgcagg atttaggggc gccgctgacc tccccgcagc cctggccggg
      541 attcctgggc caaggggaag cgctgctgtc cctggccatg ctgctgcgtc tctacctggt
      601 gccccgcgcc gtgctcctgc gcagcggcgt cctgctcaac gcttcctacc gcagcatcgg
      661 cgctctcaat caagtccgct tccgccactg gttcgtggcc aagctttaca tgaacacgca
      721 ccctggccgc ctgctgctcg gcctcacgct tggcctctgg ctgaccaccg cctgggtgct
      781 gtccgtggcc gagaggcagg ctgttaatgc cactgggcac ctttcagaca cactttggct
      841 gatccccatc acattcctga ccatcggcta tggtgacgtg gtgccgggca ccatgtgggg
      901 caagatcgtc tgcctgtgca ctggagtcat gggtgtctgc tgcacagccc tgctggtggc
      961 cgtggtggcc cggaagctgg agtttaacaa ggcagagaag cacgtgcaca acttcatgat
     1021 ggatatccag tataccaaag agatgaagga gtccgctgcc cgagtgctac aagaagcctg
     1081 gatgttctac aaacatactc gcaggaagga gtctcatgct gcccgcaggc atcagcgcaa
     1141 gctgctggcc gccatcaacg cgttccgcca ggtgcggctg aaacaccgga agctccggga
     1201 acaagtgaac tccatggtgg acatctccaa gatgcacatg atcctgtatg acctgcagca
     1261 gaatctgagc agctcacacc gggccctgga gaaacagatt gacacgctgg cggggaagct
     1321 ggatgccctg actgagctgc ttagcactgc cctggggccg aggcagcttc cagaacccag
     1381 ccagcagtcc aagtagctgg acccacgagg aggaaccagg ctactttccc cagtactgag
     1441 gtggtggaca tcgtctctgc cactcctgac ccagccctga acaaagcacc tcaagtgcaa
     1501 ggaccaaagg gggccctggc ttggagtggg ttggcttgct gatggctgct ggaggggacg
     1561 ctggctaaag tgggtaggcc ttggcccacc tgaggcccca ggtgggaaca tggtcacccc
     1621 cactctgcat accctcatca aaaacactct cactatgctg ctatggacga cctccagctc
     1681 tcagttacaa gtgcaggcga ctggaggcag gactcctggg tccctgggaa agagggtact
     1741 aggggcccgg atccaggatt ctgggaggct tcagttaccg ctggccgagc tgaagaactg
     1801 ggtatgaggc tggggcgggg ctggaggtgg cgccccctgg tgggacaaca aagaggacac
     1861 catttttcca gagctgcaga gagcacctgg tggggaggaa gaagtgtaac tcaccagcct
     1921 ctgctcttat ctttgtaata aatgttaaag ccagaa
//
