LOCUS       NM_170782              11966 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens potassium calcium-activated channel subfamily N member
            3 (KCNN3), transcript variant 2, mRNA.
ACCESSION   NM_170782
VERSION     NM_170782.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11966)
  AUTHORS   Butler,A.S., Hancox,J.C. and Marrion,N.V.
  TITLE     Preferential formation of human heteromeric SK2:SK3 channels limits
            homomeric SK channel assembly and function
  JOURNAL   J Biol Chem 299 (1), 102783 (2023)
   PUBMED   36502918
  REMARK    GeneRIF: Preferential formation of human heteromeric SK2:SK3
            channels limits homomeric SK channel assembly and function.
REFERENCE   2  (bases 1 to 11966)
  AUTHORS   Zhang,D., Zhu,Q., Xia,W., Zhu,C., Zhao,X., Zhang,Y., He,C., Ji,S.,
            Li,X. and Zhang,J.
  TITLE     The role of SK3 in progesterone-induced inhibition of human
            fallopian tubal contraction
  JOURNAL   Reprod Biol Endocrinol 20 (1), 73 (2022)
   PUBMED   35488306
  REMARK    GeneRIF: The role of SK3 in progesterone-induced inhibition of
            human fallopian tubal contraction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11966)
  AUTHORS   Gripp,K.W., Smithson,S.F., Scurr,I.J., Baptista,J., Majumdar,A.,
            Pierre,G., Williams,M., Henderson,L.B., Wentzensen,I.M.,
            McLaughlin,H., Leeuwen,L., Simon,M.E.H., van Binsbergen,E.,
            Dinulos,M.B.P., Kaplan,J.D., McRae,A., Superti-Furga,A., Good,J.M.
            and Kutsche,K.
  TITLE     Syndromic disorders caused by gain-of-function variants in KCNH1,
            KCNK4, and KCNN3-a subgroup of K+ channelopathies
  JOURNAL   Eur J Hum Genet 29 (9), 1384-1395 (2021)
   PUBMED   33594261
  REMARK    GeneRIF: Syndromic disorders caused by gain-of-function variants in
            KCNH1, KCNK4, and KCNN3-a subgroup of K(+) channelopathies.
REFERENCE   4  (bases 1 to 11966)
  AUTHORS   Rahm,A.K., Wieder,T., Gramlich,D., Muller,M.E., Wunsch,M.N., El
            Tahry,F.A., Heimberger,T., Weis,T., Most,P., Katus,H.A., Thomas,D.
            and Lugenbiel,P.
  TITLE     HDAC2-dependent remodeling of KCa2.2 (KCNN2) and KCa2.3 (KCNN3) K+
            channels in atrial fibrillation with concomitant heart failure
  JOURNAL   Life Sci 266, 118892 (2021)
   PUBMED   33310041
  REMARK    GeneRIF: HDAC2-dependent remodeling of KCa2.2 (KCNN2) and KCa2.3
            (KCNN3) K(+) channels in atrial fibrillation with concomitant heart
            failure.
REFERENCE   5  (bases 1 to 11966)
  AUTHORS   Bery,F., Figiel,S., Kouba,S., Fontaine,D., Gueguinou,M.,
            Potier-Cartereau,M., Vandier,C., Guibon,R., Bruyere,F., Fromont,G.
            and Maheo,K.
  TITLE     Hypoxia Promotes Prostate Cancer Aggressiveness by Upregulating
            EMT-Activator Zeb1 and SK3 Channel Expression
  JOURNAL   Int J Mol Sci 21 (13), 4786 (2020)
   PUBMED   32640738
  REMARK    GeneRIF: Hypoxia Promotes Prostate Cancer Aggressiveness by
            Upregulating EMT-Activator Zeb1 and SK3 Channel Expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11966)
  AUTHORS   Wittekindt,O.H., Visan,V., Tomita,H., Imtiaz,F., Gargus,J.J.,
            Lehmann-Horn,F., Grissmer,S. and Morris-Rosendahl,D.J.
  TITLE     An apamin- and scyllatoxin-insensitive isoform of the human SK3
            channel
  JOURNAL   Mol Pharmacol 65 (3), 788-801 (2004)
   PUBMED   14978258
REFERENCE   7  (bases 1 to 11966)
  AUTHORS   Dror,V., Shamir,E., Ghanshani,S., Kimhi,R., Swartz,M., Barak,Y.,
            Weizman,R., Avivi,L., Litmanovitch,T., Fantino,E., Kalman,K.,
            Jones,E.G., Chandy,K.G., Gargus,J.J., Gutman,G.A. and Navon,R.
  TITLE     hKCa3/KCNN3 potassium channel gene: association of longer CAG
            repeats with schizophrenia in Israeli Ashkenazi Jews, expression in
            human tissues and localization to chromosome 1q21
  JOURNAL   Mol Psychiatry 4 (3), 254-260 (1999)
   PUBMED   10395215
REFERENCE   8  (bases 1 to 11966)
  AUTHORS   Chandy,K.G., Fantino,E., Wittekindt,O., Kalman,K., Tong,L.L.,
            Ho,T.H., Gutman,G.A., Crocq,M.A., Ganguli,R., Nimgaonkar,V.,
            Morris-Rosendahl,D.J. and Gargus,J.J.
  TITLE     Isolation of a novel potassium channel gene hSKCa3 containing a
            polymorphic CAG repeat: a candidate for schizophrenia and bipolar
            disorder?
  JOURNAL   Mol Psychiatry 3 (1), 32-37 (1998)
   PUBMED   9491810
REFERENCE   9  (bases 1 to 11966)
  AUTHORS   Imbert,G., Saudou,F., Yvert,G., Devys,D., Trottier,Y.,
            Garnier,J.M., Weber,C., Mandel,J.L., Cancel,G., Abbas,N., Durr,A.,
            Didierjean,O., Stevanin,G., Agid,Y. and Brice,A.
  TITLE     Cloning of the gene for spinocerebellar ataxia 2 reveals a locus
            with high sensitivity to expanded CAG/glutamine repeats
  JOURNAL   Nat Genet 14 (3), 285-291 (1996)
   PUBMED   8896557
REFERENCE   10 (bases 1 to 11966)
  AUTHORS   Kohler,M., Hirschberg,B., Bond,C.T., Kinzie,J.M., Marrion,N.V.,
            Maylie,J. and Adelman,J.P.
  TITLE     Small-conductance, calcium-activated potassium channels from
            mammalian brain
  JOURNAL   Science 273 (5282), 1709-1714 (1996)
   PUBMED   8781233
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390204.11, AA284005.1,
            BC042147.1, AL606500.8 and AW135188.1.
            
            On May 31, 2019 this sequence version replaced NM_170782.2.
            
            Summary: Action potentials in vertebrate neurons are followed by an
            afterhyperpolarization (AHP) that may persist for several seconds
            and may have profound consequences for the firing pattern of the
            neuron. Each component of the AHP is kinetically distinct and is
            mediated by different calcium-activated potassium channels. This
            gene belongs to the KCNN family of potassium channels. It encodes
            an integral membrane protein that forms a voltage-independent
            calcium-activated channel, which is thought to regulate neuronal
            excitability by contributing to the slow component of synaptic AHP.
            This gene contains two CAG repeat regions in the coding sequence.
            It was thought that expansion of one or both of these repeats could
            lead to an increased susceptibility to schizophrenia or bipolar
            disorder, but studies indicate that this is probably not the case.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Feb
            2011].
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon compared to variant 1, resulting in translation
            initiation from a different start codon, and a shorter isoform (b)
            with a distinct N-terminus compared to isoform a. This isoform
            lacks the two CAG repeat regions.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1624985.1,
                                           SRR14038194.1989367.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL390204.11        75867-75880         c
            15-30               AA284005.1         1-16
            31-49               AL390204.11        75832-75850         c
            50-1995             BC042147.1         17-1962
            1996-11467          AL606500.8         111316-120787       c
            11468-11959         AW135188.1         12-503              c
            11960-11966         AL606500.8         110817-110823       c
FEATURES             Location/Qualifiers
     source          1..11966
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..11966
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /note="potassium calcium-activated channel subfamily N
                     member 3"
                     /db_xref="GeneID:3782"
                     /db_xref="HGNC:HGNC:6292"
                     /db_xref="MIM:602983"
     exon            1..182
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1445
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /note="isoform b is encoded by transcript variant 2; SKCa
                     3; potassium intermediate/small conductance
                     calcium-activated channel, subfamily N, member 3; small
                     conductance calcium-activated potassium channel 3;
                     potassium channel, calcium activated intermediate/small
                     conductance subfamily N alpha, member 3"
                     /codon_start=1
                     /product="small conductance calcium-activated potassium
                     channel protein 3 isoform b"
                     /protein_id="NP_740752.1"
                     /db_xref="CCDS:CCDS1072.1"
                     /db_xref="GeneID:3782"
                     /db_xref="HGNC:HGNC:6292"
                     /db_xref="MIM:602983"
                     /translation="MERPIKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDN
                     GADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIIL
                     SIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLV
                     FSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGV
                     CLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWL
                     IYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMY
                     DLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARG
                     VSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC"
     exon            183..278
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     exon            279..697
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     exon            698..839
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     exon            840..950
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1078
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1148
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..11966
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11929..11934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /note="hexamer: AACAAG"
     regulatory      11945..11950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /note="hexamer: ACTAAA"
     polyA_site      11959
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /note="major polyA site"
     polyA_site      11966
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /note="major polyA site"
ORIGIN      
        1 aaaggacagg agtgctgctc agtgtcaaat taacaggaaa gtcagcttaa aggacactcc
       61 ttgcagggac tgagctggca cctactcctt agagcttgct gataccaggc ctgccacgcg
      121 acatctgcaa ggacagttgt ttggtgtttt gcttcaggtt atagatggag agacctataa
      181 aggactccat gttttcgttg gccctgaaat gccttatcag tctgtccacc atcatccttt
      241 tgggcttgat catcgcctac cacacacgtg aagtccagct cttcgtgatc gacaatggcg
      301 cggatgactg gcggatagcc atgacctacg agcgcatcct gtacatcagc ctggagatgc
      361 tggtgtgcgc catccacccc attcctggcg agtacaagtt cttctggacg gcacgcctgg
      421 ccttctccta cacaccctcc cgggcggagg ccgatgtgga catcatcctg tctatcccca
      481 tgttcctgcg cctgtacctg atcgcccgag tcatgctgct gcacagcaag ctcttcaccg
      541 atgcctcgtc ccgcagcatc ggggccctca acaagatcaa cttcaacacc cgctttgtca
      601 tgaagacgct catgaccatc tgccctggca ctgtgctgct cgtgttcagc atctctctgt
      661 ggatcattgc tgcctggacc gtccgtgtct gtgaaaggta ccatgaccag caggacgtaa
      721 ctagtaactt tctgggtgcc atgtggctca tctccatcac attcctttcc attggttatg
      781 gggacatggt gccccacaca tactgtggga aaggtgtctg tctcctcact ggcatcatgg
      841 gtgcaggctg cactgccctt gtggtggccg tggtggcccg aaagctggaa ctcaccaaag
      901 cggagaagca cgttcataac ttcatgatgg acactcagct caccaagcgg atcaagaatg
      961 ctgcagccaa tgtccttcgg gaaacatggt taatctataa acacacaaag ctgctaaaga
     1021 agattgacca tgccaaagtg aggaaacacc agaggaagtt cctccaagct atccaccagt
     1081 tgaggagcgt caagatggaa cagaggaagc tgagtgacca agccaacact ctggtggacc
     1141 tttccaagat gcagaatgtc atgtatgact taatcacaga actcaatgac cggagcgaag
     1201 acctggagaa gcagattggc agcctggagt cgaagctgga gcatctcacc gccagcttca
     1261 actccctgcc gctgctcatc gccgacaccc tgcgccagca gcagcagcag ctcctgtctg
     1321 ccatcatcga ggcccggggt gtcagcgtgg cagtgggcac cacccacacc ccaatctccg
     1381 atagccccat tggggtcagc tccacctcct tcccgacccc gtacacaagt tcaagcagtt
     1441 gctaaataaa tctccccact ccagaagcat tacccatagg tcttaagatg caaatcaact
     1501 ctctcctggt cgctttgcca tcaagaaaca ttcagaccag ggaacggaaa gaagagagac
     1561 cgagctaatt aactaactca tgttcattca gcgtgcttgg tccgacatgc cttgaaacca
     1621 gaaatctaat ctctgtttag gtgcctctac ttgggagcgg gaagaggaga tgacaggaag
     1681 cgacgcctct ggcagggccc ttgctgcaga gttggtggag aacagaaatc cacgctcaat
     1741 ctcaggtctt cacgcggggg gtgggggtca gatgcactga agtagccaac agcgaagcca
     1801 gtccagaaga ggggtccgct gggagggagg gttgtgtcag gcttggggga tgggctcttc
     1861 gccatggggg tctttgaaca cacctctctc ctttcctttt gtctacggaa gcctctgggt
     1921 gacaaaagta aaagagagct gcccacaact tgccaaaaca gatatactcg aatcagactg
     1981 aaaaaaaaaa aaaaagacac agacaaataa aaagccagat tttccactcg atattaatac
     2041 ccacataaac ctgtgtgttt gcaaacgtgt acatgtacac acatacacat cccacgttcg
     2101 cttcaggtcc tttcttattt gagcttaatc caaataaaaa gggacttgac accttaccct
     2161 gcatacaata ggcacccctt acatgtgttt tgagttggtc tgaatctgaa catggggtgc
     2221 tttcagttca ggtagttagc tagttctggc cacattctga gtttcactga agatgtggat
     2281 cccttcagac ataatgcaca ttgctttgtc ctggatatgc accttgcttg atttgaaatg
     2341 gatgccaagc caaaattgtt ggcattcagg agggataagc aggcttctaa aaataacagc
     2401 atctgcagag ttttcttctt ccatccaaac aagttgtgtt tcgatggtcc acatgaccag
     2461 gtgtatgtct gtaagtgtgg agggagagga caagaaattg tgcatgtgtg tgcagacatg
     2521 cacaaacagg agcaatccaa taacacctta gtgaatagaa atatggttgg ggatttgctg
     2581 agctgtattt atccagcaac aggtttccag ccccagatgt tagtagtgca aaagggccaa
     2641 gtgcctcaat tgtgagcctc tgagctagga ggagaagtga tgaagagtgg cctatgtggt
     2701 cccttctacc tgaccttaag tcatctcaaa atgaaatatt gtgagaatga agggaaccct
     2761 tagggaacct tgtgggtaag gtaagtggac atggatttgt cagtagcctg ttcctactgt
     2821 gccatgttaa tcttggtgcg aaaaactatt ccaatacatc tcaaactcca agagacttca
     2881 gaaacatcaa gatttagtgt aatgagcggc gcagaaaaat gttttcattg ctccataatc
     2941 tgaccacacg taacatttgt gacgtgaaaa ccatgacttt ctcattctga ggtctttggt
     3001 ttctgcctgt gggaaattga atggcactgt atggactatt tcatctgttg atggtaaaac
     3061 aaaagggtga tttttttgct tgtggttgtc atcttgggtt tacctttgta agaagacatc
     3121 atcaccattc tgaaggcagt ggcttggcat ggagattttt attctgtagc actgggcctg
     3181 ttcttctaag gacagcacaa ggtagacaat tgtagagcca aggccacttt ttcaggaaga
     3241 tctagtctct tgctaaccct cttctttctc tcttgctatt gctgctgctc ttttgatggt
     3301 ttatagtctt aatggcctgc cttgataatt cctttgaaca ctttcattag ttgttttgca
     3361 taccagagat gccgcacctg ctgttggctt atttttttac ttgttctatt aactgttgat
     3421 tatctgaatg tttcccctcc tccttgtttc atgtcccaag aatggtgctc ctgttttcag
     3481 tgacagttca gctgaacata taagcagatg tgtaaacaga tgaagtaacc atgcagtttc
     3541 cttgtggcat tagttccatt tcacaaagtg aagaccactg gtgggctgat ctgagtgtgc
     3601 caatcctgat catttaaacc tacagccttc aactggtgat tcctacccac cgttttcatt
     3661 ctgctataac cctgtgatat gtgtgcgtgt gggtgtgagt gtgggtgtgt gcacatatag
     3721 agatttagtc ttaatttcaa ccaaatgaca tgcaagattc cactgccact cttcctggcc
     3781 aaaagtgtgc acagactgtg atttattcat tgtggtctgt gactttaacc catcattgat
     3841 gctctcactt aggtaaaccc taaagaccaa actagcaaca ctagtcaagg gagtgactgg
     3901 agttatttct ggtagcagta gccactggca tcctagaaac acatggacat ttgtagcatg
     3961 aattgaccta ttggtagtgc aatagctata catgattttt attcttggca aaagaaaatg
     4021 cttcaaaaaa aaagtgatca aacctgcaca ttgatcctgt aatagcaaat ggaaggctat
     4081 ttctctgtac tagcatttca gctttatgtg ggaaagttac ccgttctcct gcaagtacaa
     4141 tcaacccttg atgacttaag tattaattat tctgggtgta gctcacccaa gttttcttcc
     4201 tacatctttt ggctaattcc accacacctc agcatcacag tcagatggga aaaggggcag
     4261 gtggattctc atgtcatgcc ttcttgtacc ttattttcaa gttttgtggt ggaggaggtt
     4321 taattatctg ctcaagaatc tggtatatat agccaggtgc ggtggctcat gcctgtaatc
     4381 ccaggacttt gggcaaggcg agaggatcac ctgaggtcag gagttcaaga ccagcctggc
     4441 caacatggca aaaccccatc tctactaaaa atacaaaaat tagctgggtt tggtggtgga
     4501 cacctgtagt cccagctact tgggaggctg cggcaggaga atcacttgaa ccccggaagt
     4561 ggaggttgca gtgagccaag atcgtgccat tgcactccag cttgggtgac cgagcaagac
     4621 tccgtctcaa aaaaaaaaaa aaaatcggct atatgtaaaa actattaatt atgtaacctc
     4681 actccaatac tgtactgatc aagatctgcc cactcctaga ggactgaccc aatggcagat
     4741 cccctactat aatctttctg acaactcagt gacaggtaaa atcactctaa tattcctaaa
     4801 atatctagac acttgaatta gaaatacaga accaccccca cccctgccat tgcttaagcc
     4861 atattaaagc ttcatgtact gtaaagtcag ggatgtactg tgatacttta agaccactaa
     4921 tctcagtgga atttcaggac atagcattag ttggtaaatt acaccagact aggggctcac
     4981 tcctccttag attgaagtcc aaataaaagt cttcaccttt ggatcaaagg ccacatatat
     5041 atgatcatca tcaataaatt gtcataaagt gtctatgaac tgctcttgcc atcttcctaa
     5101 tacgtaactt catgacatca tgtctctaga agtgcttaat acaatccaaa agaacaaggg
     5161 gggaaggccc caagtcacca ctgaccgacc tcagcagggg ccagtggtag aacaacaatc
     5221 ttgtgaatta ggagacatag aaaatgtacg caaaagtaaa ttccaagcgc tgagcatgta
     5281 caagctattt ttattattaa aagccaagaa ggaagagcat tgaagaagta atgattttaa
     5341 tatagtgggg gatttccccc ttaaattttt ataatttcct tgtgaataaa caatcatgga
     5401 aaagaagaaa cctagtcata caaaatcaga ataaataaaa atcttaagac tggatccaca
     5461 tctttggcca attcatataa gcacctaata catcaatttc tctgtactta aaatgaagag
     5521 aataattaat attcttaagt acaatgtttt caatagagaa caaatgaaat cacctttgtc
     5581 atcaacagca gcccagactg actgtatcta gatcacacct tgatgttacg tttgaatgca
     5641 gtcagtagtt accaaaaagt aattagtgca cattaaatag tggtaaaatc agcagggaga
     5701 aatatgggat tagcacgtag ttccagaacc ttcctcctcc tccagagtgc aactcaacaa
     5761 acagtacact ccaaattaag aatcaatgtt tcatcccagg acaaacggtg ttgctcccat
     5821 cacagtacca caactgagat actgtgaagt cattgcacta ccagtaggtt actactcttt
     5881 tgaagttact gtttttaaat cctaaaatat gtccccagtt ttctacattc attcttcttc
     5941 ccctaagagt tgctagaagc agatgaagga tccctattga ctctgcaggg tttgatttca
     6001 gtaccttaga cagctatctg gtgacttccc agtaggcacg aacaacccct tctctcccct
     6061 tgcagtcggt gggcttgatg acgccccaga cagtatcctt tccttctcta ctgccgccaa
     6121 aataaacatt agggaaatgg gatcattaac accactgaga aaggagttta cagggatcgc
     6181 aatagtaact gtctgcttgt ggtagtagaa agcttgtgcc aggctgcatg aatagaaatt
     6241 aatgttaaac tcctgttaga cgagtaatat gtagattttt attgaaacag accacagctt
     6301 attaaaaagt actcagtgca atggtatata catatataca gatagaaaaa aatataactg
     6361 tgatcttttt gtcttacgcc attactggaa acacccaaac gtgaactgga gttccctctg
     6421 aacaaaacca ttgtcaaatc ttcaacatat gacctccaaa tctaggtgcc aagtgccctg
     6481 tgacagttgt ttacacacct gaaaaatgta tcctggaagc tgtaatcttg ggcctgggct
     6541 atgtgttgaa acaagcaaaa gagacacatc gtgaccaacc aagctggtgg aggaaaagca
     6601 caaaattcaa ctccaacctg cagttaggat cccaaagaga tgttgacatt tatagccaaa
     6661 aagaaaaagt acatatatat atatatatat atatatatat atatatatat atatatatat
     6721 ctgaatcaga tcgaagcagc caacgtccag cttcactcaa gaaggacaag gaataaacaa
     6781 cattctctag ctgtgtcatg ttgtctcagt ttttgaatct caaccaggac tgatccacct
     6841 tcatcagata cgttttttaa tggcgcaaca actcaatttt ggtcccagac tctccattct
     6901 gcactggcca cgagaacaac aagagaatga caggatgtta atggaggaaa cattttcatg
     6961 gcaagctcag aaactgaagt gtttatattc agaatcagat gagctttaat atgaatttgc
     7021 atcttgcctc tgtactgctt gctatttttt aatgatagga gaaagcataa cagtttattt
     7081 taaatatgaa atatattgat atattataaa atatattgta actttcaatt aacattttgt
     7141 atcaaactag tgtttagcag gtccactgtc agcctgctct cccaatgact gtttctgagt
     7201 acacatcact gttagtgatt gccgggcacc cagaaaaagg gtcctcctac cacagcctac
     7261 tgaactgcca tattctaatt ctccaaggcc tgggtattag agacaaaaga acattattcc
     7321 aagagtagag gaataattct accctaaatt ctatcaagcc atttcagaag agattttaaa
     7381 agccatcact cctttagtag ctctgcaaag ccagtttaat aaaagttcag gctctttcta
     7441 tataaattca aaggcctcat tacataaatt atataagtct caaacctagc caaccagttt
     7501 tcctttgaca atgtcagaat tggacataag aaagagtcct gttttcctgt aacttaaaat
     7561 actcaaaatc ctaggcattc tgagtttctc catgtacgtg aaaccggggt cggctttcca
     7621 aactacacaa ggcccaacaa gagtccagtg tgcagatgtg cttttctaaa ttggcaatac
     7681 ccttgaggga gcaaggttcc cacatgttta tcaaggacat ggagcccagc tcctaaggga
     7741 gtgatgggag gagccggcag gacatgaaca gccagagcca gcaaagagcc gggctgcctt
     7801 ttctgctagc ttcctctagc tgggaggaaa taaagggttc ccgttgagat attgtccttt
     7861 atagcaaaat taagcaactc atggaatcta cacccctctt tctctacaga gcagctgaga
     7921 catacatgta gaagttctca gttccctcct tcatatggct aaggcactac ttctagatga
     7981 aaacaggatg tgttcggtta cagaataaag attttctaga atcagtgagc ctcttctcac
     8041 ctgggaccct cacttgctgt tgttgctttg gtgcaatatt gtacaggtgc aaaccaggtt
     8101 gcatcggggc agattaactg agcctatgtg tctcttccct tcccaagccc tgaaaattca
     8161 catagattta cagatagtgc aaaacaacaa gttttctcct gggaaaaggc tggaatcctt
     8221 caaatttcaa tttatatgag cttaaaggta tataagtcat ggggctcact gacattaggt
     8281 attcatgctg tttgaaagag aaatgtctaa atgcccgttt tcagtctgtt tgtgtagctg
     8341 agccctaact tgtacacaag ttttcttgtt atggagctaa attctctcag tgcctgtatt
     8401 actcctcagt tatatgttag gccgagctcc actaaagcca tctgaactcc agggcacttg
     8461 tttttatcag gttacttact caccggataa tggaaattgg cttattttca attttacaat
     8521 tgactgatga atgtattggt ggtaattgat ttatttcttc actttttttt gctactaaat
     8581 gattttttct tttttaaaat tattattatt attattttga gatggagtct cactctgtcg
     8641 cccaggctgg agtgcagtgg cgccatctca gctcactgca agctctgcct cctgggttca
     8701 tgcaattctc ctgcctcagc ctcccgagta gctgggatta caggtgcgtg ccaccacgac
     8761 cagctaattt ttttgtattt ttagtagaga cagggtttca tcatgttaac caggatggtc
     8821 tcgatctcct gacctcgtga tccacctgcc tgggcctccc aaagtgagcc actgtgcctg
     8881 gcccagtaag tgcttttttc ttttggtttt tccttctaac actgctcaga ccaagactta
     8941 catttataaa gagcaaatat attctgacct ttcccctcaa agttgtattc catctagaat
     9001 caaggaaaca aatgcaaatt catcatttgg ggaaagcaga cctcttgaca gtaattcaag
     9061 tccatggcta tatgctaacc cttgctactc aaagtgtggt ccacagacca gcagcgttag
     9121 catcatctgt aagcttgtta gaaatgcaga atctcaggcc ccacatcaaa ccttcttcat
     9181 cagaattggc cttttaacaa atccccaggt gacctgtatg caccagaaat attgataagc
     9241 actggcctca cctcaccgta gtgataacta acctcgttaa taattagaga atgaagctat
     9301 ctcttccttg agtctcattt acagaattat ttgaagatgt gaaggtcctg aatgatcata
     9361 aggattaaaa aaatgcatct ttaaattcca cttgaggtta tataacttgg atggtctaca
     9421 tcaaacataa taaagtcaat aagagatagt ctttttccgg tcttacctaa atagcactcc
     9481 atatccttga gccacctcaa agcccccatt tttaagtttt agtctttttt tttttagacc
     9541 agactagcaa agccatcaga atatcaggtg gaacctcagg gcaggtcctc tggaaggcta
     9601 caggagtctc tgcttagcat agtacagaaa ttgttgtgtt tctcgatcct tgtgttcttc
     9661 ccttgaggaa ctcagcatct caccagtaag aactcccctc ccctagagga aaatagcaag
     9721 agaagttagt ttaaccatct agaaacattg ctaatctcct tgaaagccaa ttctcttact
     9781 cattgcacca acaagaaaca ctccaaggtg ggcaaggaaa gacgtgaatt ctgatattgg
     9841 cgccataact cgatatgtac ccagaaacag ttatgttcta aattaatggc tttaacctgt
     9901 tcattgtaaa aagtgccttg gacttcaatc taaagaggtc agtataaata tgtatgtgtg
     9961 tgtgtgacgt gtatgtaggc aaatatttac agatttatac atacataggt gcacacacat
    10021 atacccgcac attcatatat aatatataca tacatatata aatgcttcat aatatatcat
    10081 attgctattc acagctccat ttcttttgtc tggtcctatg tttatttgtt tagtgagacc
    10141 tttacataga gaggttctat tcggaacatt gatgtatttt ttgtttgttt tttacttttt
    10201 attaaaaagg taaaggatat taaaaaaaaa aaaaaaagtc aagtgcctga aggttttgaa
    10261 tggagttacg gtaaactttc tcaggtcacc aaagaggaaa catttttcct ttggaaaaca
    10321 tttttctgtt tcagtgactt tgttttccct tggtggtaat gcataaataa gagtggttaa
    10381 agtgattttg taagttttat ttcaatccat ttctgtggtt cccataaggc aatagctaaa
    10441 aatttgttca gtctagtgcc cagttttctc cacacatcag catcagaagg gcccggtctt
    10501 cacatgctct gtgtggtttt gttcgcgttg ttactgtgtt ccttactaag gaaaggcaaa
    10561 tgaaattgca ggggctggag cttagaccag ctccaaatat ggcttccttt tggtaacaca
    10621 cacagaaggt ggactagtgg gaagtctctc tccctgaagc aggtgggaac ctgtgtctta
    10681 gaaggcagag gagtcccagt gaactctcca cagctccatg ggccctgcct gtctacagtt
    10741 atacaactgc ctgtatgagt cagcctttct ctaccttagc caaaggtctt ctctttctgt
    10801 ggtgtgacag cttgtaatga accaacttgc tctggttaga agtccctaga gctccaggaa
    10861 gagtcgccag gtttccattg ctgtgctcaa agctcaagga cacattatac ttctttaaac
    10921 caactaaatc tctctagctc cctgccccca tggtgacact ttcataatag gcagggccaa
    10981 gtcagagagg tcatgccctg tatacagtgt caatcagaag agacactgca aaatgtcaga
    11041 ggtgaccaga aagacaacag atctctccag ctgtcctcac agctgcaggc acatttgtgg
    11101 aattgtgagt aggaaggctt ggcagccagg ggatgggaaa tgaatttccc caagttgaaa
    11161 accctgtacc cttactttcc ttcccataaa tttttctgta gttctaggta aataataata
    11221 ataataaaaa tgcaaattag gtgctttaga aggagtatgt aatatctggg actttttcta
    11281 agttggtaga cctaaaaaat gttttcaaaa atatatctag ctgcatttct actgctgtca
    11341 ttccttaaag ctcttcctcc aaaaactcca tatgaatgaa tacatttacc aactcagtga
    11401 ttactaaata atagtacttt atacttatac acagtaatac ctttcatcta aggatctcaa
    11461 atgccaatat attagtcatc accctgtaag gtggatgaca tattattccc attattccaa
    11521 tgggaaaatt gggccataga aaactgagga gcaaatgact catctacagg aattaaatgg
    11581 aaaaaacagg ctaggatttc tcagcacact ttaggagtga atgaaaactt acaggcttca
    11641 gttctactgc tggccaccat tggatttgta agatccagga tgtgtattga ccacatgtgt
    11701 ccagacccag gcttagggca tctggaatga gagtggtggg ctggtgtgtg ggtctgagga
    11761 tctggatggg agactgcatt ttcttctctg tgcaaaatat ggaagtgtga ccttgaaggt
    11821 gggcttagtc tatggccttc cccactcctg cttgaactga agctggagag aatgggcatt
    11881 tttaaatgtt acggcatatg ctaatataat attatggcat taaataaaaa caagaagaga
    11941 actgactaaa accaaaaaac caaaaa
//
