LOCUS       NM_001365837           11944 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens potassium calcium-activated channel subfamily N member
            3 (KCNN3), transcript variant 4, mRNA.
ACCESSION   NM_001365837
VERSION     NM_001365837.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11944)
  AUTHORS   Butler,A.S., Hancox,J.C. and Marrion,N.V.
  TITLE     Preferential formation of human heteromeric SK2:SK3 channels limits
            homomeric SK channel assembly and function
  JOURNAL   J Biol Chem 299 (1), 102783 (2023)
   PUBMED   36502918
  REMARK    GeneRIF: Preferential formation of human heteromeric SK2:SK3
            channels limits homomeric SK channel assembly and function.
REFERENCE   2  (bases 1 to 11944)
  AUTHORS   Zhang,D., Zhu,Q., Xia,W., Zhu,C., Zhao,X., Zhang,Y., He,C., Ji,S.,
            Li,X. and Zhang,J.
  TITLE     The role of SK3 in progesterone-induced inhibition of human
            fallopian tubal contraction
  JOURNAL   Reprod Biol Endocrinol 20 (1), 73 (2022)
   PUBMED   35488306
  REMARK    GeneRIF: The role of SK3 in progesterone-induced inhibition of
            human fallopian tubal contraction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11944)
  AUTHORS   Gripp,K.W., Smithson,S.F., Scurr,I.J., Baptista,J., Majumdar,A.,
            Pierre,G., Williams,M., Henderson,L.B., Wentzensen,I.M.,
            McLaughlin,H., Leeuwen,L., Simon,M.E.H., van Binsbergen,E.,
            Dinulos,M.B.P., Kaplan,J.D., McRae,A., Superti-Furga,A., Good,J.M.
            and Kutsche,K.
  TITLE     Syndromic disorders caused by gain-of-function variants in KCNH1,
            KCNK4, and KCNN3-a subgroup of K+ channelopathies
  JOURNAL   Eur J Hum Genet 29 (9), 1384-1395 (2021)
   PUBMED   33594261
  REMARK    GeneRIF: Syndromic disorders caused by gain-of-function variants in
            KCNH1, KCNK4, and KCNN3-a subgroup of K(+) channelopathies.
REFERENCE   4  (bases 1 to 11944)
  AUTHORS   Rahm,A.K., Wieder,T., Gramlich,D., Muller,M.E., Wunsch,M.N., El
            Tahry,F.A., Heimberger,T., Weis,T., Most,P., Katus,H.A., Thomas,D.
            and Lugenbiel,P.
  TITLE     HDAC2-dependent remodeling of KCa2.2 (KCNN2) and KCa2.3 (KCNN3) K+
            channels in atrial fibrillation with concomitant heart failure
  JOURNAL   Life Sci 266, 118892 (2021)
   PUBMED   33310041
  REMARK    GeneRIF: HDAC2-dependent remodeling of KCa2.2 (KCNN2) and KCa2.3
            (KCNN3) K(+) channels in atrial fibrillation with concomitant heart
            failure.
REFERENCE   5  (bases 1 to 11944)
  AUTHORS   Bery,F., Figiel,S., Kouba,S., Fontaine,D., Gueguinou,M.,
            Potier-Cartereau,M., Vandier,C., Guibon,R., Bruyere,F., Fromont,G.
            and Maheo,K.
  TITLE     Hypoxia Promotes Prostate Cancer Aggressiveness by Upregulating
            EMT-Activator Zeb1 and SK3 Channel Expression
  JOURNAL   Int J Mol Sci 21 (13), 4786 (2020)
   PUBMED   32640738
  REMARK    GeneRIF: Hypoxia Promotes Prostate Cancer Aggressiveness by
            Upregulating EMT-Activator Zeb1 and SK3 Channel Expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11944)
  AUTHORS   Wittekindt,O.H., Visan,V., Tomita,H., Imtiaz,F., Gargus,J.J.,
            Lehmann-Horn,F., Grissmer,S. and Morris-Rosendahl,D.J.
  TITLE     An apamin- and scyllatoxin-insensitive isoform of the human SK3
            channel
  JOURNAL   Mol Pharmacol 65 (3), 788-801 (2004)
   PUBMED   14978258
REFERENCE   7  (bases 1 to 11944)
  AUTHORS   Dror,V., Shamir,E., Ghanshani,S., Kimhi,R., Swartz,M., Barak,Y.,
            Weizman,R., Avivi,L., Litmanovitch,T., Fantino,E., Kalman,K.,
            Jones,E.G., Chandy,K.G., Gargus,J.J., Gutman,G.A. and Navon,R.
  TITLE     hKCa3/KCNN3 potassium channel gene: association of longer CAG
            repeats with schizophrenia in Israeli Ashkenazi Jews, expression in
            human tissues and localization to chromosome 1q21
  JOURNAL   Mol Psychiatry 4 (3), 254-260 (1999)
   PUBMED   10395215
REFERENCE   8  (bases 1 to 11944)
  AUTHORS   Chandy,K.G., Fantino,E., Wittekindt,O., Kalman,K., Tong,L.L.,
            Ho,T.H., Gutman,G.A., Crocq,M.A., Ganguli,R., Nimgaonkar,V.,
            Morris-Rosendahl,D.J. and Gargus,J.J.
  TITLE     Isolation of a novel potassium channel gene hSKCa3 containing a
            polymorphic CAG repeat: a candidate for schizophrenia and bipolar
            disorder?
  JOURNAL   Mol Psychiatry 3 (1), 32-37 (1998)
   PUBMED   9491810
REFERENCE   9  (bases 1 to 11944)
  AUTHORS   Imbert,G., Saudou,F., Yvert,G., Devys,D., Trottier,Y.,
            Garnier,J.M., Weber,C., Mandel,J.L., Cancel,G., Abbas,N., Durr,A.,
            Didierjean,O., Stevanin,G., Agid,Y. and Brice,A.
  TITLE     Cloning of the gene for spinocerebellar ataxia 2 reveals a locus
            with high sensitivity to expanded CAG/glutamine repeats
  JOURNAL   Nat Genet 14 (3), 285-291 (1996)
   PUBMED   8896557
REFERENCE   10 (bases 1 to 11944)
  AUTHORS   Kohler,M., Hirschberg,B., Bond,C.T., Kinzie,J.M., Marrion,N.V.,
            Maylie,J. and Adelman,J.P.
  TITLE     Small-conductance, calcium-activated potassium channels from
            mammalian brain
  JOURNAL   Science 273 (5282), 1709-1714 (1996)
   PUBMED   8781233
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390204.11, AL954342.10 and
            AL606500.8.
            
            Summary: Action potentials in vertebrate neurons are followed by an
            afterhyperpolarization (AHP) that may persist for several seconds
            and may have profound consequences for the firing pattern of the
            neuron. Each component of the AHP is kinetically distinct and is
            mediated by different calcium-activated potassium channels. This
            gene belongs to the KCNN family of potassium channels. It encodes
            an integral membrane protein that forms a voltage-independent
            calcium-activated channel, which is thought to regulate neuronal
            excitability by contributing to the slow component of synaptic AHP.
            This gene contains two CAG repeat regions in the coding sequence.
            It was thought that expansion of one or both of these repeats could
            lead to an increased susceptibility to schizophrenia or bipolar
            disorder, but studies indicate that this is probably not the case.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Feb
            2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.307594.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AL390204.11        83953-84074         c
            123-218             AL390204.11        38093-38188         c
            219-637             AL954342.10        14323-14741         c
            638-682             AL606500.8         150406-150450       c
            683-824             AL606500.8         146365-146506       c
            825-935             AL606500.8         139278-139388       c
            936-1063            AL606500.8         128238-128365       c
            1064-1133           AL606500.8         126826-126895       c
            1134-11944          AL606500.8         110824-121634       c
FEATURES             Location/Qualifiers
     source          1..11944
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..11944
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /note="potassium calcium-activated channel subfamily N
                     member 3"
                     /db_xref="GeneID:3782"
                     /db_xref="HGNC:HGNC:6292"
                     /db_xref="MIM:602983"
     exon            1..122
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     exon            123..218
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1430
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /note="isoform d is encoded by transcript variant 4; SKCa
                     3; potassium intermediate/small conductance
                     calcium-activated channel, subfamily N, member 3; small
                     conductance calcium-activated potassium channel 3;
                     potassium channel, calcium activated intermediate/small
                     conductance subfamily N alpha, member 3"
                     /codon_start=1
                     /product="small conductance calcium-activated potassium
                     channel protein 3 isoform d"
                     /protein_id="NP_001352766.1"
                     /db_xref="GeneID:3782"
                     /db_xref="HGNC:HGNC:6292"
                     /db_xref="MIM:602983"
                     /translation="MFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIA
                     MTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRL
                     YLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWII
                     AAWTVRVCESPESPAQPSGSSLPAWYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPH
                     TYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAAN
                     VLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLS
                     KMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLS
                     AIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC"
     exon            219..637
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     exon            638..682
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     exon            683..824
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     exon            825..935
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1063
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1133
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..11944
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11914..11919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /note="hexamer: AACAAG"
     polyA_site      11944
                     /gene="KCNN3"
                     /gene_synonym="hSK3; KCa2.3; SK3; SKCA3; ZLS3"
                     /note="major polyA site"
ORIGIN      
        1 ccggatggag aacagcaggc actggcttta gcggggagct ggccccactg ctccagcctc
       61 tcagtccagc cccaagacgg aggagggggt ttccctccca gagggagtgg agatggagga
      121 aggactccat gttttcgttg gccctgaaat gccttatcag tctgtccacc atcatccttt
      181 tgggcttgat catcgcctac cacacacgtg aagtccagct cttcgtgatc gacaatggcg
      241 cggatgactg gcggatagcc atgacctacg agcgcatcct gtacatcagc ctggagatgc
      301 tggtgtgcgc catccacccc attcctggcg agtacaagtt cttctggacg gcacgcctgg
      361 ccttctccta cacaccctcc cgggcggagg ccgatgtgga catcatcctg tctatcccca
      421 tgttcctgcg cctgtacctg atcgcccgag tcatgctgct gcacagcaag ctcttcaccg
      481 atgcctcgtc ccgcagcatc ggggccctca acaagatcaa cttcaacacc cgctttgtca
      541 tgaagacgct catgaccatc tgccctggca ctgtgctgct cgtgttcagc atctctctgt
      601 ggatcattgc tgcctggacc gtccgtgtct gtgaaagtcc tgaatcacca gcccagcctt
      661 ctggctcatc acttcctgct tggtaccatg accagcagga cgtaactagt aactttctgg
      721 gtgccatgtg gctcatctcc atcacattcc tttccattgg ttatggggac atggtgcccc
      781 acacatactg tgggaaaggt gtctgtctcc tcactggcat catgggtgca ggctgcactg
      841 cccttgtggt ggccgtggtg gcccgaaagc tggaactcac caaagcggag aagcacgttc
      901 ataacttcat gatggacact cagctcacca agcggatcaa gaatgctgca gccaatgtcc
      961 ttcgggaaac atggttaatc tataaacaca caaagctgct aaagaagatt gaccatgcca
     1021 aagtgaggaa acaccagagg aagttcctcc aagctatcca ccagttgagg agcgtcaaga
     1081 tggaacagag gaagctgagt gaccaagcca acactctggt ggacctttcc aagatgcaga
     1141 atgtcatgta tgacttaatc acagaactca atgaccggag cgaagacctg gagaagcaga
     1201 ttggcagcct ggagtcgaag ctggagcatc tcaccgccag cttcaactcc ctgccgctgc
     1261 tcatcgccga caccctgcgc cagcagcagc agcagctcct gtctgccatc atcgaggccc
     1321 ggggtgtcag cgtggcagtg ggcaccaccc acaccccaat ctccgatagc cccattgggg
     1381 tcagctccac ctccttcccg accccgtaca caagttcaag cagttgctaa ataaatctcc
     1441 ccactccaga agcattaccc ataggtctta agatgcaaat caactctctc ctggtcgctt
     1501 tgccatcaag aaacattcag accagggaac ggaaagaaga gagaccgagc taattaacta
     1561 actcatgttc attcagcgtg cttggtccga catgccttga aaccagaaat ctaatctctg
     1621 tttaggtgcc tctacttggg agcgggaaga ggagatgaca ggaagcgacg cctctggcag
     1681 ggcccttgct gcagagttgg tggagaacag aaatccacgc tcaatctcag gtcttcacgc
     1741 ggggggtggg ggtcagatgc actgaagtag ccaacagcga agccagtcca gaagaggggt
     1801 ccgctgggag ggagggttgt gtcaggcttg ggggatgggc tcttcgccat gggggtcttt
     1861 gaacacacct ctctcctttc cttttgtcta cggaagcctc tgggtgacaa aagtaaaaga
     1921 gagctgccca caacttgcca aaacagatat actcgaatca gactgaaaaa aaaaaaaaaa
     1981 gacacagaca aataaaaagc cagattttcc actcgatatt aatacccaca taaacctgtg
     2041 tgtttgcaaa cgtgtacatg tacacacata cacatcccac gttcgcttca ggtcctttct
     2101 tatttgagct taatccaaat aaaaagggac ttgacacctt accctgcata caataggcac
     2161 cccttacatg tgttttgagt tggtctgaat ctgaacatgg ggtgctttca gttcaggtag
     2221 ttagctagtt ctggccacat tctgagtttc actgaagatg tggatccctt cagacataat
     2281 gcacattgct ttgtcctgga tatgcacctt gcttgatttg aaatggatgc caagccaaaa
     2341 ttgttggcat tcaggaggga taagcaggct tctaaaaata acagcatctg cagagttttc
     2401 ttcttccatc caaacaagtt gtgtttcgat ggtccacatg accaggtgta tgtctgtaag
     2461 tgtggaggga gaggacaaga aattgtgcat gtgtgtgcag acatgcacaa acaggagcaa
     2521 tccaataaca ccttagtgaa tagaaatatg gttggggatt tgctgagctg tatttatcca
     2581 gcaacaggtt tccagcccca gatgttagta gtgcaaaagg gccaagtgcc tcaattgtga
     2641 gcctctgagc taggaggaga agtgatgaag agtggcctat gtggtccctt ctacctgacc
     2701 ttaagtcatc tcaaaatgaa atattgtgag aatgaaggga acccttaggg aaccttgtgg
     2761 gtaaggtaag tggacatgga tttgtcagta gcctgttcct actgtgccat gttaatcttg
     2821 gtgcgaaaaa ctattccaat acatctcaaa ctccaagaga cttcagaaac atcaagattt
     2881 agtgtaatga gcggcgcaga aaaatgtttt cattgctcca taatctgacc acacgtaaca
     2941 tttgtgacgt gaaaaccatg actttctcat tctgaggtct ttggtttctg cctgtgggaa
     3001 attgaatggc actgtatgga ctatttcatc tgttgatggt aaaacaaaag ggtgattttt
     3061 ttgcttgtgg ttgtcatctt gggtttacct ttgtaagaag acatcatcac cattctgaag
     3121 gcagtggctt ggcatggaga tttttattct gtagcactgg gcctgttctt ctaaggacag
     3181 cacaaggtag acaattgtag agccaaggcc actttttcag gaagatctag tctcttgcta
     3241 accctcttct ttctctcttg ctattgctgc tgctcttttg atggtttata gtcttaatgg
     3301 cctgccttga taattccttt gaacactttc attagttgtt ttgcatacca gagatgccgc
     3361 acctgctgtt ggcttatttt tttacttgtt ctattaactg ttgattatct gaatgtttcc
     3421 cctcctcctt gtttcatgtc ccaagaatgg tgctcctgtt ttcagtgaca gttcagctga
     3481 acatataagc agatgtgtaa acagatgaag taaccatgca gtttccttgt ggcattagtt
     3541 ccatttcaca aagtgaagac cactggtggg ctgatctgag tgtgccaatc ctgatcattt
     3601 aaacctacag ccttcaactg gtgattccta cccaccgttt tcattctgct ataaccctgt
     3661 gatatgtgtg cgtgtgggtg tgagtgtggg tgtgtgcaca tatagagatt tagtcttaat
     3721 ttcaaccaaa tgacatgcaa gattccactg ccactcttcc tggccaaaag tgtgcacaga
     3781 ctgtgattta ttcattgtgg tctgtgactt taacccatca ttgatgctct cacttaggta
     3841 aaccctaaag accaaactag caacactagt caagggagtg actggagtta tttctggtag
     3901 cagtagccac tggcatccta gaaacacatg gacatttgta gcatgaattg acctattggt
     3961 agtgcaatag ctatacatga tttttattct tggcaaaaga aaatgcttca aaaaaaaagt
     4021 gatcaaacct gcacattgat cctgtaatag caaatggaag gctatttctc tgtactagca
     4081 tttcagcttt atgtgggaaa gttacccgtt ctcctgcaag tacaatcaac ccttgatgac
     4141 ttaagtatta attattctgg gtgtagctca cccaagtttt cttcctacat cttttggcta
     4201 attccaccac acctcagcat cacagtcaga tgggaaaagg ggcaggtgga ttctcatgtc
     4261 atgccttctt gtaccttatt ttcaagtttt gtggtggagg aggtttaatt atctgctcaa
     4321 gaatctggta tatatagcca ggtgcggtgg ctcatgcctg taatcccagg actttgggca
     4381 aggcgagagg atcacctgag gtcaggagtt caagaccagc ctggccaaca tggcaaaacc
     4441 ccatctctac taaaaataca aaaattagct gggtttggtg gtggacacct gtagtcccag
     4501 ctacttggga ggctgcggca ggagaatcac ttgaaccccg gaagtggagg ttgcagtgag
     4561 ccaagatcgt gccattgcac tccagcttgg gtgaccgagc aagactccgt ctcaaaaaaa
     4621 aaaaaaaaat cggctatatg taaaaactat taattatgta acctcactcc aatactgtac
     4681 tgatcaagat ctgcccactc ctagaggact gacccaatgg cagatcccct actataatct
     4741 ttctgacaac tcagtgacag gtaaaatcac tctaatattc ctaaaatatc tagacacttg
     4801 aattagaaat acagaaccac ccccacccct gccattgctt aagccatatt aaagcttcat
     4861 gtactgtaaa gtcagggatg tactgtgata ctttaagacc actaatctca gtggaatttc
     4921 aggacatagc attagttggt aaattacacc agactagggg ctcactcctc cttagattga
     4981 agtccaaata aaagtcttca cctttggatc aaaggccaca tatatatgat catcatcaat
     5041 aaattgtcat aaagtgtcta tgaactgctc ttgccatctt cctaatacgt aacttcatga
     5101 catcatgtct ctagaagtgc ttaatacaat ccaaaagaac aaggggggaa ggccccaagt
     5161 caccactgac cgacctcagc aggggccagt ggtagaacaa caatcttgtg aattaggaga
     5221 catagaaaat gtacgcaaaa gtaaattcca agcgctgagc atgtacaagc tatttttatt
     5281 attaaaagcc aagaaggaag agcattgaag aagtaatgat tttaatatag tgggggattt
     5341 cccccttaaa tttttataat ttccttgtga ataaacaatc atggaaaaga agaaacctag
     5401 tcatacaaaa tcagaataaa taaaaatctt aagactggat ccacatcttt ggccaattca
     5461 tataagcacc taatacatca atttctctgt acttaaaatg aagagaataa ttaatattct
     5521 taagtacaat gttttcaata gagaacaaat gaaatcacct ttgtcatcaa cagcagccca
     5581 gactgactgt atctagatca caccttgatg ttacgtttga atgcagtcag tagttaccaa
     5641 aaagtaatta gtgcacatta aatagtggta aaatcagcag ggagaaatat gggattagca
     5701 cgtagttcca gaaccttcct cctcctccag agtgcaactc aacaaacagt acactccaaa
     5761 ttaagaatca atgtttcatc ccaggacaaa cggtgttgct cccatcacag taccacaact
     5821 gagatactgt gaagtcattg cactaccagt aggttactac tcttttgaag ttactgtttt
     5881 taaatcctaa aatatgtccc cagttttcta cattcattct tcttccccta agagttgcta
     5941 gaagcagatg aaggatccct attgactctg cagggtttga tttcagtacc ttagacagct
     6001 atctggtgac ttcccagtag gcacgaacaa ccccttctct ccccttgcag tcggtgggct
     6061 tgatgacgcc ccagacagta tcctttcctt ctctactgcc gccaaaataa acattaggga
     6121 aatgggatca ttaacaccac tgagaaagga gtttacaggg atcgcaatag taactgtctg
     6181 cttgtggtag tagaaagctt gtgccaggct gcatgaatag aaattaatgt taaactcctg
     6241 ttagacgagt aatatgtaga tttttattga aacagaccac agcttattaa aaagtactca
     6301 gtgcaatggt atatacatat atacagatag aaaaaaatat aactgtgatc tttttgtctt
     6361 acgccattac tggaaacacc caaacgtgaa ctggagttcc ctctgaacaa aaccattgtc
     6421 aaatcttcaa catatgacct ccaaatctag gtgccaagtg ccctgtgaca gttgtttaca
     6481 cacctgaaaa atgtatcctg gaagctgtaa tcttgggcct gggctatgtg ttgaaacaag
     6541 caaaagagac acatcgtgac caaccaagct ggtggaggaa aagcacaaaa ttcaactcca
     6601 acctgcagtt aggatcccaa agagatgttg acatttatag ccaaaaagaa aaagtacata
     6661 tatatatata tatatatata tatatatata tatatatata tatatctgaa tcagatcgaa
     6721 gcagccaacg tccagcttca ctcaagaagg acaaggaata aacaacattc tctagctgtg
     6781 tcatgttgtc tcagtttttg aatctcaacc aggactgatc caccttcatc agatacgttt
     6841 tttaatggcg caacaactca attttggtcc cagactctcc attctgcact ggccacgaga
     6901 acaacaagag aatgacagga tgttaatgga ggaaacattt tcatggcaag ctcagaaact
     6961 gaagtgttta tattcagaat cagatgagct ttaatatgaa tttgcatctt gcctctgtac
     7021 tgcttgctat tttttaatga taggagaaag cataacagtt tattttaaat atgaaatata
     7081 ttgatatatt ataaaatata ttgtaacttt caattaacat tttgtatcaa actagtgttt
     7141 agcaggtcca ctgtcagcct gctctcccaa tgactgtttc tgagtacaca tcactgttag
     7201 tgattgccgg gcacccagaa aaagggtcct cctaccacag cctactgaac tgccatattc
     7261 taattctcca aggcctgggt attagagaca aaagaacatt attccaagag tagaggaata
     7321 attctaccct aaattctatc aagccatttc agaagagatt ttaaaagcca tcactccttt
     7381 agtagctctg caaagccagt ttaataaaag ttcaggctct ttctatataa attcaaaggc
     7441 ctcattacat aaattatata agtctcaaac ctagccaacc agttttcctt tgacaatgtc
     7501 agaattggac ataagaaaga gtcctgtttt cctgtaactt aaaatactca aaatcctagg
     7561 cattctgagt ttctccatgt acgtgaaacc ggggtcggct ttccaaacta cacaaggccc
     7621 aacaagagtc cagtgtgcag atgtgctttt ctaaattggc aatacccttg agggagcaag
     7681 gttcccacat gtttatcaag gacatggagc ccagctccta agggagtgat gggaggagcc
     7741 ggcaggacat gaacagccag agccagcaaa gagccgggct gccttttctg ctagcttcct
     7801 ctagctggga ggaaataaag ggttcccgtt gagatattgt cctttatagc aaaattaagc
     7861 aactcatgga atctacaccc ctctttctct acagagcagc tgagacatac atgtagaagt
     7921 tctcagttcc ctccttcata tggctaaggc actacttcta gatgaaaaca ggatgtgttc
     7981 ggttacagaa taaagatttt ctagaatcag tgagcctctt ctcacctggg accctcactt
     8041 gctgttgttg ctttggtgca atattgtaca ggtgcaaacc aggttgcatc ggggcagatt
     8101 aactgagcct atgtgtctct tcccttccca agccctgaaa attcacatag atttacagat
     8161 agtgcaaaac aacaagtttt ctcctgggaa aaggctggaa tccttcaaat ttcaatttat
     8221 atgagcttaa aggtatataa gtcatggggc tcactgacat taggtattca tgctgtttga
     8281 aagagaaatg tctaaatgcc cgttttcagt ctgtttgtgt agctgagccc taacttgtac
     8341 acaagttttc ttgttatgga gctaaattct ctcagtgcct gtattactcc tcagttatat
     8401 gttaggccga gctccactaa agccatctga actccagggc acttgttttt atcaggttac
     8461 ttactcaccg gataatggaa attggcttat tttcaatttt acaattgact gatgaatgta
     8521 ttggtggtaa ttgatttatt tcttcacttt tttttgctac taaatgattt tttctttttt
     8581 aaaattatta ttattattat tttgagatgg agtctcactc tgtcgcccag gctggagtgc
     8641 agtggcgcca tctcagctca ctgcaagctc tgcctcctgg gttcatgcaa ttctcctgcc
     8701 tcagcctccc gagtagctgg gattacaggt gcgtgccacc acgaccagct aatttttttg
     8761 tatttttagt agagacaggg tttcatcatg ttaaccagga tggtctcgat ctcctgacct
     8821 cgtgatccac ctgcctgggc ctcccaaagt gagccactgt gcctggccca gtaagtgctt
     8881 ttttcttttg gtttttcctt ctaacactgc tcagaccaag acttacattt ataaagagca
     8941 aatatattct gacctttccc ctcaaagttg tattccatct agaatcaagg aaacaaatgc
     9001 aaattcatca tttggggaaa gcagacctct tgacagtaat tcaagtccat ggctatatgc
     9061 taacccttgc tactcaaagt gtggtccaca gaccagcagc gttagcatca tctgtaagct
     9121 tgttagaaat gcagaatctc aggccccaca tcaaaccttc ttcatcagaa ttggcctttt
     9181 aacaaatccc caggtgacct gtatgcacca gaaatattga taagcactgg cctcacctca
     9241 ccgtagtgat aactaacctc gttaataatt agagaatgaa gctatctctt ccttgagtct
     9301 catttacaga attatttgaa gatgtgaagg tcctgaatga tcataaggat taaaaaaatg
     9361 catctttaaa ttccacttga ggttatataa cttggatggt ctacatcaaa cataataaag
     9421 tcaataagag atagtctttt tccggtctta cctaaatagc actccatatc cttgagccac
     9481 ctcaaagccc ccatttttaa gttttagtct tttttttttt agaccagact agcaaagcca
     9541 tcagaatatc aggtggaacc tcagggcagg tcctctggaa ggctacagga gtctctgctt
     9601 agcatagtac agaaattgtt gtgtttctcg atccttgtgt tcttcccttg aggaactcag
     9661 catctcacca gtaagaactc ccctccccta gaggaaaata gcaagagaag ttagtttaac
     9721 catctagaaa cattgctaat ctccttgaaa gccaattctc ttactcattg caccaacaag
     9781 aaacactcca aggtgggcaa ggaaagacgt gaattctgat attggcgcca taactcgata
     9841 tgtacccaga aacagttatg ttctaaatta atggctttaa cctgttcatt gtaaaaagtg
     9901 ccttggactt caatctaaag aggtcagtat aaatatgtat gtgtgtgtgt gacgtgtatg
     9961 taggcaaata tttacagatt tatacataca taggtgcaca cacatatacc cgcacattca
    10021 tatataatat atacatacat atataaatgc ttcataatat atcatattgc tattcacagc
    10081 tccatttctt ttgtctggtc ctatgtttat ttgtttagtg agacctttac atagagaggt
    10141 tctattcgga acattgatgt attttttgtt tgttttttac tttttattaa aaaggtaaag
    10201 gatattaaaa aaaaaaaaaa aagtcaagtg cctgaaggtt ttgaatggag ttacggtaaa
    10261 ctttctcagg tcaccaaaga ggaaacattt ttcctttgga aaacattttt ctgtttcagt
    10321 gactttgttt tcccttggtg gtaatgcata aataagagtg gttaaagtga ttttgtaagt
    10381 tttatttcaa tccatttctg tggttcccat aaggcaatag ctaaaaattt gttcagtcta
    10441 gtgcccagtt ttctccacac atcagcatca gaagggcccg gtcttcacat gctctgtgtg
    10501 gttttgttcg cgttgttact gtgttcctta ctaaggaaag gcaaatgaaa ttgcaggggc
    10561 tggagcttag accagctcca aatatggctt ccttttggta acacacacag aaggtggact
    10621 agtgggaagt ctctctccct gaagcaggtg ggaacctgtg tcttagaagg cagaggagtc
    10681 ccagtgaact ctccacagct ccatgggccc tgcctgtcta cagttataca actgcctgta
    10741 tgagtcagcc tttctctacc ttagccaaag gtcttctctt tctgtggtgt gacagcttgt
    10801 aatgaaccaa cttgctctgg ttagaagtcc ctagagctcc aggaagagtc gccaggtttc
    10861 cattgctgtg ctcaaagctc aaggacacat tatacttctt taaaccaact aaatctctct
    10921 agctccctgc ccccatggtg acactttcat aataggcagg gccaagtcag agaggtcatg
    10981 ccctgtatac agtgtcaatc agaagagaca ctgcaaaatg tcagaggtga ccagaaagac
    11041 aacagatctc tccagctgtc ctcacagctg caggcacatt tgtggaattg tgagtaggaa
    11101 ggcttggcag ccaggggatg ggaaatgaat ttccccaagt tgaaaaccct gtacccttac
    11161 tttccttccc ataaattttt ctgtagttct aggtaaataa taataataat aaaaatgcaa
    11221 attaggtgct ttagaaggag tatgtaatat ctgggacttt ttctaagttg gtagacctaa
    11281 aaaatgtttt caaaaatata tctagctgca tttctactgc tgtcattcct taaagctctt
    11341 cctccaaaaa ctccatatga atgaatacat ttaccaactc agtgattact aaataatagt
    11401 actttatact tatacacagt aatacctttc atctaaggat ctcaaatgcc aatatattag
    11461 tcatcaccct gtaaggtgga tgacatatta ttcccattat tccaatggga aaattgggcc
    11521 atagaaaact gaggagcaaa tgactcatct acaggaatta aatggaaaaa acaggctagg
    11581 atttctcagc acactttagg agtgaatgaa aacttacagg cttcagttct actgctggcc
    11641 accattggat ttgtaagatc caggatgtgt attgaccaca tgtgtccaga cccaggctta
    11701 gggcatctgg aatgagagtg gtgggctggt gtgtgggtct gaggatctgg atgggagact
    11761 gcattttctt ctctgtgcaa aatatggaag tgtgaccttg aaggtgggct tagtctatgg
    11821 ccttccccac tcctgcttga actgaagctg gagagaatgg gcatttttaa atgttacggc
    11881 atatgctaat ataatattat ggcattaaat aaaaacaaga agagaactga ctaaaaccaa
    11941 aaaa
//
