LOCUS       NM_001386974            3603 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens potassium calcium-activated channel subfamily N member
            1 (KCNN1), transcript variant 2, mRNA.
ACCESSION   NM_001386974
VERSION     NM_001386974.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3603)
  AUTHORS   Charlick,J.N., Bozadzhieva,D., Butler,A.S., Wilkinson,K.A. and
            Marrion,N.V.
  TITLE     A single coiled-coil domain mutation in hIKCa channel subunits
            disrupts preferential formation of heteromeric hSK1:hIKCa channels
  JOURNAL   Eur J Neurosci 59 (1), 3-16 (2024)
   PUBMED   38018635
  REMARK    GeneRIF: A single coiled-coil domain mutation in hIKCa channel
            subunits disrupts preferential formation of heteromeric hSK1:hIKCa
            channels.
REFERENCE   2  (bases 1 to 3603)
  AUTHORS   Xiao,B., Xiang,Q., Deng,Z., Chen,D., Wu,S., Zhang,Y., Liang,Y.,
            Wei,S., Luo,G. and Li,L.
  TITLE     KCNN1 promotes proliferation and metastasis of breast cancer via
            ERLIN2-mediated stabilization and K63-dependent ubiquitination of
            Cyclin B1
  JOURNAL   Carcinogenesis 44 (12), 809-823 (2023)
   PUBMED   37831636
  REMARK    GeneRIF: KCNN1 promotes proliferation and metastasis of breast
            cancer via ERLIN2-mediated stabilization and K63-dependent
            ubiquitination of Cyclin B1.
REFERENCE   3  (bases 1 to 3603)
  AUTHORS   Rahm,A.K., Wieder,T., Gramlich,D., Muller,M.E., Wunsch,M.N., El
            Tahry,F.A., Heimberger,T., Sandke,S., Weis,T., Most,P., Katus,H.A.,
            Thomas,D. and Lugenbiel,P.
  TITLE     Differential regulation of KCa 2.1 (KCNN1) K+ channel expression by
            histone deacetylases in atrial fibrillation with concomitant heart
            failure
  JOURNAL   Physiol Rep 9 (11), e14835 (2021)
   PUBMED   34111326
  REMARK    GeneRIF: Differential regulation of KCa 2.1 (KCNN1) K(+) channel
            expression by histone deacetylases in atrial fibrillation with
            concomitant heart failure.
REFERENCE   4  (bases 1 to 3603)
  AUTHORS   Todesca,L.M., Maskri,S., Brommel,K., Thale,I., Wunsch,B., Koch,O.
            and Schwab,A.
  TITLE     Targeting Kca3.1 Channels in Cancer
  JOURNAL   Cell Physiol Biochem 55 (S3), 131-144 (2021)
   PUBMED   34043300
  REMARK    GeneRIF: Targeting Kca3.1 Channels in Cancer.
            Review article
REFERENCE   5  (bases 1 to 3603)
  AUTHORS   Higham,J., Sahu,G., Wazen,R.M., Colarusso,P., Gregorie,A.,
            Harvey,B.S.J., Goudswaard,L., Varley,G., Sheppard,D.N., Turner,R.W.
            and Marrion,N.V.
  TITLE     Preferred Formation of Heteromeric Channels between Coexpressed SK1
            and IKCa Channel Subunits Provides a Unique Pharmacological Profile
            of Ca2+-Activated Potassium Channels
  JOURNAL   Mol Pharmacol 96 (1), 115-126 (2019)
   PUBMED   31048549
  REMARK    GeneRIF: Data demonstrate that IKCa and SK1 subunits prefer to form
            heteromeric channels when coexpressed in a heterologous system that
            will alter their responsiveness to pharmacological tools typically
            used to define their expression pattern.
REFERENCE   6  (bases 1 to 3603)
  AUTHORS   Rimini,R., Rimland,J.M. and Terstappen,G.C.
  TITLE     Quantitative expression analysis of the small conductance
            calcium-activated potassium channels, SK1, SK2 and SK3, in human
            brain
  JOURNAL   Brain Res Mol Brain Res 85 (1-2), 218-220 (2000)
   PUBMED   11146124
REFERENCE   7  (bases 1 to 3603)
  AUTHORS   Shah,M. and Haylett,D.G.
  TITLE     The pharmacology of hSK1 Ca2+-activated K+ channels expressed in
            mammalian cell lines
  JOURNAL   Br J Pharmacol 129 (4), 627-630 (2000)
   PUBMED   10683185
REFERENCE   8  (bases 1 to 3603)
  AUTHORS   Litt,M., LaMorticella,D., Bond,C.T. and Adelman,J.P.
  TITLE     Gene structure and chromosome mapping of the human
            small-conductance calcium-activated potassium channel SK1 gene
            (KCNN1)
  JOURNAL   Cytogenet Cell Genet 86 (1), 70-73 (1999)
   PUBMED   10516439
REFERENCE   9  (bases 1 to 3603)
  AUTHORS   Ishii,T.M., Maylie,J. and Adelman,J.P.
  TITLE     Determinants of apamin and d-tubocurarine block in SK potassium
            channels
  JOURNAL   J Biol Chem 272 (37), 23195-23200 (1997)
   PUBMED   9287325
REFERENCE   10 (bases 1 to 3603)
  AUTHORS   Kohler,M., Hirschberg,B., Bond,C.T., Kinzie,J.M., Marrion,N.V.,
            Maylie,J. and Adelman,J.P.
  TITLE     Small-conductance, calcium-activated potassium channels from
            mammalian brain
  JOURNAL   Science 273 (5282), 1709-1714 (1996)
   PUBMED   8781233
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020904.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Action potentials in vertebrate neurons are followed by an
            afterhyperpolarization (AHP) that may persist for several seconds
            and may have profound consequences for the firing pattern of the
            neuron. Each component of the AHP is kinetically distinct and is
            mediated by different calcium-activated potassium channels. The
            protein encoded by this gene is activated before membrane
            hyperpolarization and is thought to regulate neuronal excitability
            by contributing to the slow component of synaptic AHP. The encoded
            protein is an integral membrane protein that forms a
            voltage-independent calcium-activated channel with three other
            calmodulin-binding subunits. This gene is a member of the KCNN
            family of potassium channel genes. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC075037.2 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000684775.1/
                                                ENSP00000507021.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AC020904.7         12975-13185
            212-694             AC020904.7         19676-20158
            695-790             AC020904.7         20960-21055
            791-1209            AC020904.7         27577-27995
            1210-1351           AC020904.7         31180-31321
            1352-1462           AC020904.7         34283-34393
            1463-1590           AC020904.7         35584-35711
            1591-1599           AC020904.7         38922-38930
            1600-1669           AC020904.7         39358-39427
            1670-3603           AC020904.7         44020-45953
FEATURES             Location/Qualifiers
     source          1..3603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..3603
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /note="potassium calcium-activated channel subfamily N
                     member 1"
                     /db_xref="GeneID:3780"
                     /db_xref="HGNC:HGNC:6290"
                     /db_xref="MIM:602982"
     exon            1..211
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            212..694
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..1924
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /note="isoform 1 is encoded by transcript variant 2; small
                     conductance calcium-activated potassium channel protein 1;
                     potassium intermediate/small conductance calcium-activated
                     channel, subfamily N, member 1; small conductance
                     calcium-activated potassium channel 1; potassium channel,
                     calcium activated intermediate/small conductance subfamily
                     N alpha, member 1"
                     /codon_start=1
                     /product="small conductance calcium-activated potassium
                     channel protein 1 isoform 1"
                     /protein_id="NP_001373903.1"
                     /db_xref="CCDS:CCDS67611.1"
                     /db_xref="GeneID:3780"
                     /db_xref="HGNC:HGNC:6290"
                     /db_xref="MIM:602982"
                     /translation="MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQV
                     VVAKSEPARPSPGSPRGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEK
                     RKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLY
                     HAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYA
                     PSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKT
                     LMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYG
                     DMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVK
                     NAAANVLRETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQ
                     ANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALPGLIAQAIR
                     PPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG"
     exon            695..790
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1209
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1351
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1462
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1590
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1599
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1669
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..3603
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2206..2211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /note="hexamer: AATAAA"
     polyA_site      2225
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /note="major polyA site"
     polyA_site      2642
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /note="major polyA site"
     regulatory      2775..2780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /note="hexamer: AGTAAA"
     polyA_site      2799
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
     regulatory      3567..3572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
                     /note="hexamer: AATAAA"
     polyA_site      3603
                     /gene="KCNN1"
                     /gene_synonym="hSK1; KCa2.1; SK1; SKCA1"
ORIGIN      
        1 gggcgctcgc cccccgccgg gcccgtggac tgggcggcgg gggatgcgcc tgccgccgcc
       61 gcccccggcc ccgccgcccc cgggccccgc gcccgctcgc tgctgcccgc cccgtccgcg
      121 accccggctc cggctcccga ctgggggtcc gcggccgcgc gggaccctct cccctccagc
      181 cttgtccgcc cgctcgggcc gagccccgca ggtcagtgca ggagcccagc cgctgagcca
      241 tgccgggccc cgggcggcct gcagcgagcc caacccctgc acccaggtag tcatgaacag
      301 ccacagctac aatggcagcg tggggcggcc gctgggcagc gggccgggcg ccctgggacg
      361 agaccctccg gaccctgagg ccggccaccc cccacaaccc ccgcacagcc cgggcctcca
      421 ggtggtagtg gccaagagtg agccagcccg gccctcaccc ggcagccccc gggggcagcc
      481 ccaggaccag gacgatgacg aggatgatga ggaagatgag gccggcaggc agagagcctc
      541 ggggaaaccc tcaaatgtgg gccaccgcct gggccaccgg cgggcgctct tcgagaagcg
      601 gaagcgcctc agcgactatg ccctcatttt cggcatgttt ggcatcgtcg tcatggtgac
      661 ggagaccgag ctgtcctggg gggtgtacac caaggagtct ctgtactcat tcgcactcaa
      721 atgcctcatc agcctctcca cggccatcct gctgggtctc gttgtcctct accatgcccg
      781 ggagatccag ctgttcatgg tggacaacgg ggctgatgac tggcgcatcg ccatgacctg
      841 cgagcgcgtg ttcctcatct cgctagagct ggcagtgtgc gccattcacc cggtgcccgg
      901 ccactaccgc ttcacgtgga cggcgcggct ggccttcacg tacgcgccct cggtggccga
      961 ggccgacgtg gacgtgctgc tgtccatccc catgttcctg cgcctctacc tgctgggccg
     1021 ggtgatgcta ctgcacagca aaatcttcac ggacgcctcg agccgcagca tcggggccct
     1081 caacaagatc accttcaaca cgcgcttcgt catgaagaca ctcatgacca tctgccccgg
     1141 caccgtgctg ctggtcttca gcatctcctc ctggatcatc gcagcctgga ccgtgcgcgt
     1201 ctgcgagagg taccacgaca agcaggaagt gaccagcaac ttcctggggg ccatgtggct
     1261 gatttccatc accttcctct ccattggcta cggcgacatg gtgccccaca cctactgcgg
     1321 gaagggtgtg tgcctgctca ctggcatcat gggagctggc tgtaccgcgc tcgtggtggc
     1381 tgtggtggct cggaagctgg agctcaccaa ggctgagaag cacgtgcaca acttcatgat
     1441 ggacactcag ctcaccaagc gggtaaaaaa cgccgctgct aacgttctca gggagacgtg
     1501 gctcatctac aaacatacca ggctggtgaa gaagccagac caagcccggg ttcggaaaca
     1561 ccagcgtaag ttcctccaag ccatccatca ggctcagaag ctccggagtg tgaagatcga
     1621 gcaagggaag ctgaacgacc aggctaacac gcttaccgac ctagccaaga cccagaccgt
     1681 catgtacgac cttgtatcgg agctgcacgc tcagcacgag gagctggagg cccgcctggc
     1741 caccctggaa agccgcttgg atgcgctggg tgcctctcta caggccctgc ctggcctcat
     1801 cgcccaagcc atacgcccac ccccgcctcc cctgcctccc aggcccggcc ccggccccca
     1861 agaccaggca gcccggagct ccccctgccg gtggacgccc gtggccccct cggactgcgg
     1921 gtgacggccc tgcccgccac cagaccccta aatcttggcc atcgtgtggc cgccacctcc
     1981 gggaagcctt gtacagtggc gcctcttgga gttcaagaag ccaacgctga gtcaggctga
     2041 gtggactgag gcctgccccg cccagactgc ccaggcagag ggcagggctg gaccatgggt
     2101 gagggcaggg gagcccggag cttcctctgg tcacctggtc ccccgactct ccccaggccc
     2161 ccggtgggca tggagcagcc cggggagggg tccgtgctgg ttctgaataa agcaggaccc
     2221 gcctagtggc tgcctgtgtg catggctgga aggcactggt gatgtcccag gaggtagacc
     2281 tccagccctg ggtaccaaga tgaatgtggg aatcagaaaa acctgttccc atcaccggcc
     2341 tagcctagaa tcctagccta gaagccctct ctccctctgg gctggagctc agtgagggac
     2401 aactctctag ggacacctgt accagcccca cctggcgctg agatccctca gacagcatgg
     2461 cccagccctg gccagaagca tcgctcccct tcaaccaacc gcgttgatgg acacccactg
     2521 tgtgccaggc cccagcgggg cccatggggg aggtgacctg ggtgaggaag gtcatttggg
     2581 tttttgtgag atttgtattg agcacctgct gtctacagag aatgtgatga tgtcaattac
     2641 cacactgatt cctcatcaga acttgaccat ggtgggatgg gggggaaact gaggcccaga
     2701 gaggtgaatc tacctacctg ggaccacact gcgaggaagg atggtgcatt caaactggaa
     2761 atcccctagg ccaaagtaaa gaaccggact ggctgggcac agtggctcac acctgtaatc
     2821 ccagcacttt gggagggtaa agcgggcgga tcacctgagg tcaggagttc aagaccagcc
     2881 tgggcaacat ggtgaaaccc tgtctctact aaaaatataa aaattagctg ggtgtggtgg
     2941 tgcacgcctg taatcccagc tacttgggag gctgaggcag gataatcgct tgaacccagg
     3001 aggtggaggt tgcagtgaga aaaaacctgg acttggtgga agggactcca tggaggagcc
     3061 atggggacgt caggaggagg ggttatttgg tgacatccag gggtcagaga gacccttcag
     3121 gggtgggcta caggggaggg ttccagacac aagtagaatc agaaaggtcc ctggaggcca
     3181 tgggcttggg tgctgggagc aacaggcatt tacttggcag atgctgagcc ctgggtgggg
     3241 cgaggaggcc tggctcctgg ggagacgacg ctgtgcatag ccgaggagcc ccaggtcctg
     3301 gcagcctctg ataaggccat ccatcgcctg gctcaacgag ataactaggc cgtggctggt
     3361 gcatgaatga ccagcttggg cccacgcacg agaagggtat gaggaggtgc tggtcagacc
     3421 cgggttcgag tcctgactct gccactgctg ggtgactctg agcagtggct gcccctctgg
     3481 ggccttggtt gtttcatctg taaaatgggg tgacagtcta tttaaccaga actccctaaa
     3541 aagggccagg caactggtag gtgctcaata aatgctcctt cccgcctgag ggatcacact
     3601 gga
//
