LOCUS       NM_171830               1085 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens potassium calcium-activated channel subfamily M
            regulatory beta subunit 3 (KCNMB3), transcript variant 3, mRNA.
ACCESSION   NM_171830
VERSION     NM_171830.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1085)
  AUTHORS   Imari,K., Harada,Y., Zhang,J., Mori,Y. and Hayashi,Y.
  TITLE     KCNMB3 in spinal microglia contributes to the generation and
            maintenance of neuropathic pain in mice
  JOURNAL   Int J Mol Med 44 (4), 1585-1593 (2019)
   PUBMED   31364720
  REMARK    GeneRIF: The results from the present study suggested that BK
            channels modulated the activation state of spinal microglia, and
            that KCNMB3 is a potential therapeutic target for neuropathic pain.
REFERENCE   2  (bases 1 to 1085)
  AUTHORS   Zheng,J.S., Arnett,D.K., Parnell,L.D., Lee,Y.C., Ma,Y., Smith,C.E.,
            Richardson,K., Li,D., Borecki,I.B., Tucker,K.L., Ordovas,J.M. and
            Lai,C.Q.
  TITLE     Polyunsaturated Fatty Acids Modulate the Association between
            PIK3CA-KCNMB3 Genetic Variants and Insulin Resistance
  JOURNAL   PLoS One 8 (6), e67394 (2013)
   PUBMED   23826284
  REMARK    GeneRIF: Single-nucleotide polymorphism in KCNMB3 gene is
            associated with Insulin Resistance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1085)
  AUTHORS   Lee,U.S. and Cui,J.
  TITLE     {beta} subunit-specific modulations of BK channel function by a
            mutation associated with epilepsy and dyskinesia
  JOURNAL   J Physiol 587 (Pt 7), 1481-1498 (2009)
   PUBMED   19204046
  REMARK    GeneRIF: Report beta subunit (KNMB1-4)-specific modulations of BK
            channel function by a Slo1 mutation associated with epilepsy and
            dyskinesia.
REFERENCE   4  (bases 1 to 1085)
  AUTHORS   Dai,X.H., Chen,W.W., Wang,X., Zhu,Q.H., Li,C., Li,L., Liu,M.G.,
            Wang,Q.K. and Liu,J.Y.
  TITLE     A novel genetic locus for familial febrile seizures and epilepsy on
            chromosome 3q26.2-q26.33
  JOURNAL   Hum Genet 124 (4), 423-429 (2008)
   PUBMED   18830713
REFERENCE   5  (bases 1 to 1085)
  AUTHORS   Uebele,V.N., Lagrutta,A., Wade,T., Figueroa,D.J., Liu,Y.,
            McKenna,E., Austin,C.P., Bennett,P.B. and Swanson,R.
  TITLE     Cloning and functional expression of two families of beta-subunits
            of the large conductance calcium-activated K+ channel
  JOURNAL   J Biol Chem 275 (30), 23211-23218 (2000)
   PUBMED   10766764
REFERENCE   6  (bases 1 to 1085)
  AUTHORS   Xia,X.M., Ding,J.P., Zeng,X.H., Duan,K.L. and Lingle,C.J.
  TITLE     Rectification and rapid activation at low Ca2+ of Ca2+-activated,
            voltage-dependent BK currents: consequences of rapid inactivation
            by a novel beta subunit
  JOURNAL   J Neurosci 20 (13), 4890-4903 (2000)
   PUBMED   10864947
REFERENCE   7  (bases 1 to 1085)
  AUTHORS   Behrens,R., Nolting,A., Reimann,F., Schwarz,M., Waldschutz,R. and
            Pongs,O.
  TITLE     hKCNMB3 and hKCNMB4, cloning and characterization of two members of
            the large-conductance calcium-activated potassium channel beta
            subunit family
  JOURNAL   FEBS Lett 474 (1), 99-106 (2000)
   PUBMED   10828459
REFERENCE   8  (bases 1 to 1085)
  AUTHORS   Meera,P., Wallner,M. and Toro,L.
  TITLE     A neuronal beta subunit (KCNMB4) makes the large conductance,
            voltage- and Ca2+-activated K+ channel resistant to charybdotoxin
            and iberiotoxin
  JOURNAL   Proc Natl Acad Sci U S A 97 (10), 5562-5567 (2000)
   PUBMED   10792058
REFERENCE   9  (bases 1 to 1085)
  AUTHORS   Brenner,R., Jegla,T.J., Wickenden,A., Liu,Y. and Aldrich,R.W.
  TITLE     Cloning and functional characterization of novel large conductance
            calcium-activated potassium channel beta subunits, hKCNMB3 and
            hKCNMB4
  JOURNAL   J Biol Chem 275 (9), 6453-6461 (2000)
   PUBMED   10692449
REFERENCE   10 (bases 1 to 1085)
  AUTHORS   Riazi,M.A., Brinkman-Mills,P., Johnson,A., Naylor,S.L.,
            Minoshima,S., Shimizu,N., Baldini,A. and McDermid,H.E.
  TITLE     Identification of a putative regulatory subunit of a
            calcium-activated potassium channel in the dup(3q) syndrome region
            and a related sequence on 22q11.2
  JOURNAL   Genomics 62 (1), 90-94 (1999)
   PUBMED   10585773
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007823.38 and AC076966.25.
            
            On May 6, 2021 this sequence version replaced NM_171830.1.
            
            Summary: MaxiK channels are large conductance, voltage and
            calcium-sensitive potassium channels which are fundamental to the
            control of smooth muscle tone and neuronal excitability. MaxiK
            channels can be formed by 2 subunits: the pore-forming alpha
            subunit and the modulatory beta subunit. The protein encoded by
            this gene is an auxiliary beta subunit which may partially
            inactivate or slightly decrease the activation time of MaxiK alpha
            subunit currents. Alternative splicing results in multiple
            transcript variants. A related pseudogene has been identified on
            chromosome 22. [provided by RefSeq, Jul 2009].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and 5'
            coding region, and uses an alternate translational start codon,
            compared to variant 4. The resulting isoform (c) has a distinct
            N-terminus and is shorter than isoform d.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113851.1, AF139471.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2162568,
                                           SAMEA2467144 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392685.7/ ENSP00000376451.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-372               AC007823.38        3011-3382           c
            373-571             AC076966.25        131872-132070       c
            572-1085            AC076966.25        130148-130661       c
FEATURES             Location/Qualifiers
     source          1..1085
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.32"
     gene            1..1085
                     /gene="KCNMB3"
                     /gene_synonym="BKBETA3; HBETA3; K(VCA)BETA-3; KCNMB2;
                     KCNMBL; SLO-BETA-3; SLOBETA3"
                     /note="potassium calcium-activated channel subfamily M
                     regulatory beta subunit 3"
                     /db_xref="GeneID:27094"
                     /db_xref="HGNC:HGNC:6287"
                     /db_xref="MIM:605222"
     exon            1..372
                     /gene="KCNMB3"
                     /gene_synonym="BKBETA3; HBETA3; K(VCA)BETA-3; KCNMB2;
                     KCNMBL; SLO-BETA-3; SLOBETA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..952
                     /gene="KCNMB3"
                     /gene_synonym="BKBETA3; HBETA3; K(VCA)BETA-3; KCNMB2;
                     KCNMBL; SLO-BETA-3; SLOBETA3"
                     /note="isoform c is encoded by transcript variant 3; large
                     conductance, voltage and Ca2+ activated potassium channel
                     Maxi K beta 3 subunit; BK channel subunit beta-3;
                     charybdotoxin receptor subunit beta-3; calcium-activated
                     potassium channel regulatory subunit; potassium large
                     conductance calcium-activated channel, subfamily M beta
                     member 3; BK channel beta subunit 3; MaxiK channel
                     beta-subunit 3; big potassium channel beta subunit 3;
                     potassium channel subfamily M regulatory beta subunit 3;
                     maxi K channel subunit beta-3; calcium-activated potassium
                     channel, subfamily M subunit beta-3"
                     /codon_start=1
                     /product="calcium-activated potassium channel subunit
                     beta-3 isoform c"
                     /protein_id="NP_741981.1"
                     /db_xref="CCDS:CCDS43173.1"
                     /db_xref="GeneID:27094"
                     /db_xref="HGNC:HGNC:6287"
                     /db_xref="MIM:605222"
                     /translation="MFPLLYELTAVSPSPFPQRTAFPASGKKRETDYSDGDPLDVHKR
                     LPSSAGEDRAVMLGFAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDW
                     LDCAFTCGVHCHGQGKYPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDR
                     NDLLNSALDIKEFFDHKNGTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLL
                     GGALIVGMVRLTQHLSLLCEKYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS"
     exon            373..571
                     /gene="KCNMB3"
                     /gene_synonym="BKBETA3; HBETA3; K(VCA)BETA-3; KCNMB2;
                     KCNMBL; SLO-BETA-3; SLOBETA3"
                     /inference="alignment:Splign:2.1.0"
     exon            572..1085
                     /gene="KCNMB3"
                     /gene_synonym="BKBETA3; HBETA3; K(VCA)BETA-3; KCNMB2;
                     KCNMBL; SLO-BETA-3; SLOBETA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1054..1059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNMB3"
                     /gene_synonym="BKBETA3; HBETA3; K(VCA)BETA-3; KCNMB2;
                     KCNMBL; SLO-BETA-3; SLOBETA3"
                     /note="hexamer: ATTAAA"
     polyA_site      1085
                     /gene="KCNMB3"
                     /gene_synonym="BKBETA3; HBETA3; K(VCA)BETA-3; KCNMB2;
                     KCNMBL; SLO-BETA-3; SLOBETA3"
                     /note="major polyA site"
ORIGIN      
        1 agcttattta gatggacttt tcaccaagct ctgaactggg atttcatttt gttgcattca
       61 tcctgctcac gagacacagg taggcagcaa atgagattat ccctccagtc cccatggatt
      121 ggaaatgttc ccccttcttt atgagctcac tgcagtatct ccttctccct ttccccaaag
      181 gacagccttt cctgcctcag ggaagaagag agagacagac tacagtgatg gagacccact
      241 agatgtgcac aagaggctgc catccagtgc tggagaggac cgagccgtga tgctggggtt
      301 tgccatgatg ggcttctcag tcctaatgtt cttcttgctc ggaacaacca ttctaaagcc
      361 ttttatgctc agcattcaga gagaagaatc gacctgcact gccatccaca cagatatcat
      421 ggacgactgg ctggactgtg ccttcacctg tggtgtgcac tgccacggtc aggggaagta
      481 cccgtgtctt caggtgtttg tgaacctcag ccatccaggt cagaaagctc tcctacatta
      541 taatgaagag gctgtccaga taaatcccaa gtgcttttac acacctaagt gccaccaaga
      601 tagaaatgat ttgctcaaca gtgctctgga cataaaagaa ttcttcgatc acaaaaatgg
      661 aacccccttt tcatgcttct acagtccagc cagccaatct gaagatgtca ttcttataaa
      721 aaagtatgac caaatggcta tcttccactg tttattttgg ccttcactga ctctgctagg
      781 tggtgccctg attgttggca tggtgagatt aacacaacac ctgtccttac tgtgtgaaaa
      841 atatagcact gtagtcagag atgaggtagg tggaaaagta ccttatatag aacagcatca
      901 gttcaaactg tgcattatga ggaggagcaa aggaagagca gagaaatctt aagacggtgg
      961 ccaaattaaa gtgctggcct tcagatgtct gtgatttctg caactgagga cctaattatg
     1021 cctgtctgca aactaataat gtaaaaggta ataattaaag tatcatattt tcatgtggga
     1081 aaaaa
//
