LOCUS       NM_004137               4742 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens potassium calcium-activated channel subfamily M
            regulatory beta subunit 1 (KCNMB1), mRNA.
ACCESSION   NM_004137
VERSION     NM_004137.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4742)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4742)
  AUTHORS   Scruggs,A.M., Grabauskas,G. and Huang,S.K.
  TITLE     The Role of KCNMB1 and BK Channels in Myofibroblast Differentiation
            and Pulmonary Fibrosis
  JOURNAL   Am J Respir Cell Mol Biol 62 (2), 191-203 (2020)
   PUBMED   31486669
  REMARK    GeneRIF: that epigenetic upregulation of KCNMB1 contributes to
            increased large-conductance (Big) potassium channel activity in
            idiopathic pulmonary fibrosis fibroblasts
REFERENCE   3  (bases 1 to 4742)
  AUTHORS   Lu,T., Chai,Q., Jiao,G., Wang,X.L., Sun,X., Furuseth,J.D.,
            Stulak,J.M., Daly,R.C., Greason,K.L., Cha,Y.M. and Lee,H.C.
  TITLE     Downregulation of BK channel function and protein expression in
            coronary arteriolar smooth muscle cells of type 2 diabetic patients
  JOURNAL   Cardiovasc Res 115 (1), 145-153 (2019)
   PUBMED   29850792
  REMARK    GeneRIF: Decreased protein expression and altered intrinsic
            properties of BKbeta1 channels mediates abnormal vasodilation in
            the coronary microvasculature of type 2 diabetics.
REFERENCE   4  (bases 1 to 4742)
  AUTHORS   Lorca,R.A., Ma,X. and England,S.K.
  TITLE     The unique N-terminal sequence of the BKCa channel alpha-subunit
            determines its modulation by beta-subunits
  JOURNAL   PLoS One 12 (7), e0182068 (2017)
   PUBMED   28750098
  REMARK    GeneRIF: These results provide further insights into the mechanism
            of modulation of the different N-terminal regions of the BKCa
            channel by beta-subunits.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4742)
  AUTHORS   Li,Y., Wang,X.L., Sun,X., Chai,Q., Li,J., Thompson,B., Shen,W.K.,
            Lu,T. and Lee,H.C.
  TITLE     Regulation of vascular large-conductance calcium-activated
            potassium channels by Nrf2 signalling
  JOURNAL   Diab Vasc Dis Res 14 (4), 353-362 (2017)
   PUBMED   28429615
  REMARK    GeneRIF: Expression of vascular large-conductance calcium-activated
            potassium channel Kcnmb1 is regulated by Nrf2 signaling.
REFERENCE   6  (bases 1 to 4742)
  AUTHORS   Valverde,M.A., Rojas,P., Amigo,J., Cosmelli,D., Orio,P.,
            Bahamonde,M.I., Mann,G.E., Vergara,C. and Latorre,R.
  TITLE     Acute activation of Maxi-K channels (hSlo) by estradiol binding to
            the beta subunit
  JOURNAL   Science 285 (5435), 1929-1931 (1999)
   PUBMED   10489376
REFERENCE   7  (bases 1 to 4742)
  AUTHORS   Jiang,Z., Wallner,M., Meera,P. and Toro,L.
  TITLE     Human and rodent MaxiK channel beta-subunit genes: cloning and
            characterization
  JOURNAL   Genomics 55 (1), 57-67 (1999)
   PUBMED   9888999
REFERENCE   8  (bases 1 to 4742)
  AUTHORS   Tseng-Crank,J., Godinot,N., Johansen,T.E., Ahring,P.K.,
            Strobaek,D., Mertz,R., Foster,C.D., Olesen,S.P. and Reinhart,P.H.
  TITLE     Cloning, expression, and distribution of a Ca(2+)-activated K+
            channel beta-subunit from human brain
  JOURNAL   Proc Natl Acad Sci U S A 93 (17), 9200-9205 (1996)
   PUBMED   8799178
REFERENCE   9  (bases 1 to 4742)
  AUTHORS   Dworetzky,S.I., Boissard,C.G., Lum-Ragan,J.T., McKay,M.C.,
            Post-Munson,D.J., Trojnacki,J.T., Chang,C.P. and Gribkoff,V.K.
  TITLE     Phenotypic alteration of a human BK (hSlo) channel by hSlobeta
            subunit coexpression: changes in blocker sensitivity,
            activation/relaxation and inactivation kinetics, and protein kinase
            A modulation
  JOURNAL   J Neurosci 16 (15), 4543-4550 (1996)
   PUBMED   8764643
REFERENCE   10 (bases 1 to 4742)
  AUTHORS   Meera,P., Wallner,M., Jiang,Z. and Toro,L.
  TITLE     A calcium switch for the functional coupling between alpha (hslo)
            and beta subunits (KV,Ca beta) of maxi K channels
  JOURNAL   FEBS Lett 382 (1-2), 84-88 (1996)
   PUBMED   8612769
  REMARK    Erratum:[FEBS Lett. 1996 Apr 29;385(1-2):127-8. doi:
            10.1016/0014-5793(96)83884-1.. PMID: 8641456]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC134820.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004137.3.
            
            Summary: MaxiK channels are large conductance, voltage and
            calcium-sensitive potassium channels which are fundamental to the
            control of smooth muscle tone and neuronal excitability. MaxiK
            channels can be formed by 2 subunits: the pore-forming alpha
            subunit and the product of this gene, the modulatory beta subunit.
            Intracellular calcium regulates the physical association between
            the alpha and beta subunits. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U25138.1, SRR5189655.201403.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159368 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274629.9/ ENSP00000274629.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC134820.1         11056-11164
            110-267             AC134820.1         14952-15109
            268-439             AC134820.1         16573-16744
            440-4742            AC134820.1         21450-25752
FEATURES             Location/Qualifiers
     source          1..4742
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..4742
                     /gene="KCNMB1"
                     /gene_synonym="BKbeta1; hbeta1; hslo-beta; K(VCA)beta;
                     k(VCA)beta-1; SLO-BETA; slo-beta-1"
                     /note="potassium calcium-activated channel subfamily M
                     regulatory beta subunit 1"
                     /db_xref="GeneID:3779"
                     /db_xref="HGNC:HGNC:6285"
                     /db_xref="MIM:603951"
     exon            1..109
                     /gene="KCNMB1"
                     /gene_synonym="BKbeta1; hbeta1; hslo-beta; K(VCA)beta;
                     k(VCA)beta-1; SLO-BETA; slo-beta-1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..267
                     /gene="KCNMB1"
                     /gene_synonym="BKbeta1; hbeta1; hslo-beta; K(VCA)beta;
                     k(VCA)beta-1; SLO-BETA; slo-beta-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..709
                     /gene="KCNMB1"
                     /gene_synonym="BKbeta1; hbeta1; hslo-beta; K(VCA)beta;
                     k(VCA)beta-1; SLO-BETA; slo-beta-1"
                     /note="large conductance Ca2+-activated K+ channel beta 1
                     subunit; calcium-activated potassium channel, subfamily M
                     subunit beta-1; BK channel subunit beta-1; maxi K channel
                     subunit beta-1; charybdotoxin receptor subunit beta-1;
                     potassium large conductance calcium-activated channel,
                     subfamily M, beta member 1; BK channel beta subunit 1;
                     MaxiK channel beta-subunit 1; big potassium channel beta
                     subunit 1; potassium channel subfamily M regulatory beta
                     subunit 1"
                     /codon_start=1
                     /product="calcium-activated potassium channel subunit
                     beta-1"
                     /protein_id="NP_004128.1"
                     /db_xref="CCDS:CCDS4373.1"
                     /db_xref="GeneID:3779"
                     /db_xref="HGNC:HGNC:6285"
                     /db_xref="MIM:603951"
                     /translation="MVKKLVMAQKRGETRALCLGVTMVVCAVITYYILVTTVLPLYQK
                     SVWTQESKCHLIETNIRDQEELKGKKVPQYPCLWVNVSAAGRWAVLYHTEDTRDQNQQ
                     CSYIPGSVDNYQTARADVEKVRAKFQEQQVFYCFSAPRGNETSVLFQRLYGPQALLFS
                     LFWPTFLLTGGLLIIAMVKSNQYLSILAAQK"
     exon            268..439
                     /gene="KCNMB1"
                     /gene_synonym="BKbeta1; hbeta1; hslo-beta; K(VCA)beta;
                     k(VCA)beta-1; SLO-BETA; slo-beta-1"
                     /inference="alignment:Splign:2.1.0"
     exon            440..4742
                     /gene="KCNMB1"
                     /gene_synonym="BKbeta1; hbeta1; hslo-beta; K(VCA)beta;
                     k(VCA)beta-1; SLO-BETA; slo-beta-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1227..1232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNMB1"
                     /gene_synonym="BKbeta1; hbeta1; hslo-beta; K(VCA)beta;
                     k(VCA)beta-1; SLO-BETA; slo-beta-1"
                     /note="hexamer: AATAAA"
     polyA_site      1249
                     /gene="KCNMB1"
                     /gene_synonym="BKbeta1; hbeta1; hslo-beta; K(VCA)beta;
                     k(VCA)beta-1; SLO-BETA; slo-beta-1"
                     /note="major polyA site"
     regulatory      4722..4727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNMB1"
                     /gene_synonym="BKbeta1; hbeta1; hslo-beta; K(VCA)beta;
                     k(VCA)beta-1; SLO-BETA; slo-beta-1"
                     /note="hexamer: AATAAA"
     polyA_site      4742
                     /gene="KCNMB1"
                     /gene_synonym="BKbeta1; hbeta1; hslo-beta; K(VCA)beta;
                     k(VCA)beta-1; SLO-BETA; slo-beta-1"
ORIGIN      
        1 gaggccaaac ttcctgctga agctctgtgg cctcttttgg ggtgggggcg ggggtccagg
       61 cagaaagaaa ctgtctgctg ctcaagaccc acaggacgcc gggaagacta aatgatcact
      121 gcccccagtg aatatggtga agaagctggt gatggcccag aagcggggag agacacgagc
      181 cctttgcctg ggtgtaacca tggtggtgtg tgccgtcatc acctactaca tcctggtcac
      241 gactgtgctg cccctctacc agaaaagcgt gtggacccag gaatccaagt gccacctgat
      301 tgagaccaac atcagggacc aggaggagct gaagggcaag aaggtgcccc agtacccatg
      361 cctgtgggtc aacgtgtcag ctgccggcag gtgggctgtg ctgtaccaca cggaggacac
      421 tcgggaccag aaccagcagt gctcctacat cccaggcagc gtggacaatt accagacggc
      481 ccgggccgac gtggagaagg tcagagccaa attccaagag cagcaggtct tctactgctt
      541 ctccgcacct cgggggaacg aaaccagcgt cctattccag cgcctctacg ggccccaggc
      601 cctcctcttc tccctcttct ggcccacctt cctgctgacc ggtggcctcc tcattatcgc
      661 catggtgaag agcaaccagt acctgtccat cctggcggcc cagaagtaga gccatccatc
      721 catgccatac cacttgtcag ggcacagggg actggctggg cccccagggc tgctccccac
      781 ttgcagcaca atgccttctc cacctgccct cccactcttc cagtccaatc cacgctgtct
      841 tctgttgcag gactaacctt tgagaaatcc ttttgtgaag tcattgcctg ctcaagaatg
      901 tacagtggct ccccaatgcc ttggaggcca taaggccagc cagttctagc tctctattac
      961 ctgtccccac tcaactgact catacctgtt tccggctgca tcactatgtg ccccacagag
     1021 aacgatgatc gtcacctctg tgcctgagtt ctccctgttg tctcaaagcg gtacccatcc
     1081 tcccccagaa gctgtcccca gcgagcctcc cttctttgtt tgaattctct aataagagca
     1141 acagcagctc ccatttctag aacacattta cagtattact attttctagg atataaagtg
     1201 ccatatatat ttttaattcc aatattaata aatgtatgcc aaacaacaat cagctgcaag
     1261 gaaacacatg agaactcatc aaaattttag cggtgggatg gtggttaatt tctgttttct
     1321 tccttatccc ctttttattt ttgctgcttt tctaaatttt tgattatagg aagggtgtgt
     1381 ttcgtttgct tttaatcaga aaagccatgg tagatgccat tttggaaaag ttgaaagagt
     1441 gtgtccccct cacagaaaaa gatggaagtg ggtctgggga cggagttggg ttccagtcag
     1501 agacaggcca ttcagaacac acaatcttaa aaacccctct gggccgggcg cggtggctca
     1561 ctcctgtaat cccagcactt tgggaggccg aggctggtgg atcacgaggt caggagatca
     1621 agaccatcct ggctaacatg gtgaaacccc gtctctacta aaaatacaaa aaattagcca
     1681 ggcgtggtgg tgggcacctg tggtcccagc tactcaggag gctgaggcag gagaatggcg
     1741 tgaacccggg gttcggagct tgcagtgagc cgagattgtg ccactgcact ccagcctggt
     1801 gatagaacaa gactccgtct caaaaaaaaa acaaaaaaca aaaaatgaaa aacaaccctc
     1861 tggaggaaag gtcatgatat agaggaggat ttgttattta aattgagggt atggactctg
     1921 gcactgagcc tgctggggaa gcctatctca gatttgaaaa gggcaaaatg ggaagaagcc
     1981 atcaccttta ccattcccac tccaggaagt tttcctagaa cgatgactgt ccaagtgtgg
     2041 tccctgggcc agcagcatca ggatcctgtg gcagcttgtg agaaatgcac actctcaggc
     2101 ccctgtccca gccccaccac gccagaagcc ctgcacgggg tgggggtagc aatgttctgt
     2161 gttctaacaa tgcgtagggg attctgtggc acacctcgag ccagagaact accggtgtag
     2221 gaagtgagcg tcctgtcgcg aggattttca gagcaggtga gtgaccattc ggcagggcca
     2281 gtcctgagct gggtgtgaag ttaggctggt gtctgaagtt tcttccagtg ttgtgagtcc
     2341 aagatgcaga tcttgggttt gaatcctgtc tctactctgc ccgatttcat ctctttgatt
     2401 cttagttttt tcatctataa aagaaggact ctttctggat agttgggagg gctgaaggaa
     2461 tgtttgacac atcataggtg tttaaaatgg caactatagt tttttttgtt tgttttgtgt
     2521 gtgtgttttt ttcttaactt tcattttaag ttgcagggta cacgttcagg tttgttacat
     2581 aggtacactt gtgtcaaggg agtttgttgt gcagattatt tcatcaccca ggtattaagt
     2641 ctagtaccca ttattaaaga aaatgtggta cgtatacgtc atggaatatt atgcagccat
     2701 aaaaaggaag gagatcatgt cctttgcagg gacatggatg gagctggagg ccaaatatta
     2761 tccttagcaa actaacacag ggacacaaaa ctaaatactg tatattctca cttataagtg
     2821 ggagctaaat gatgaaaaca catggacaca aagaggggaa caacacacac tgaggcctat
     2881 tggagggcgg gaggtaggag gagggagagg atcagggaaa aagagctatt gttagtaaca
     2941 agaaaaagtc ggccgggcgt ggtggctcac acctgtaatc ccagcacttt gggaggccga
     3001 ggtgggcaga tcacgaggtc aggagatcga gaccatcctg gctaacacgg tgaaaccctg
     3061 tctctactaa aaaatagaaa aaatcatagc cgggcgtggt ggtagccgcc tgtagtccca
     3121 gctgctcagg aggctgaggc agaagaatgg cgtgaacccg ggaggcggag cttgcagtga
     3181 gccgagatcg cgccacggca ctccagcctg ggtaacagag caagactctg tctcaaaaaa
     3241 aaaaaaaaaa aaaaaaaaaa aagaataagt catgaatact cagaaacttc cagaagttat
     3301 actgacaatg ttatctggca tgtatgggtg cttatttatt ctgtgccagg cactgtacta
     3361 attagtttgc cttggaaaaa aaaatgagat actcctgaac ctgcctcaca gatgatgaga
     3421 agcaacagag gacagtggct aagtatgtgg acttgggatg tgcactgttt gggttcaaat
     3481 tccagctgtg ctgttcacaa gctgggtgac tttggacgaa taacctttct gtgcctgttt
     3541 cctcgtttgc aaaacgaaac tgataatagt atctttccat agagttttgg catgaaacaa
     3601 atttttatgt aaatttccta ggatagtgac atatggtaag tgctatctaa gttactatga
     3661 aaaactgagg ctgtaagagg taactggcca aggccatctg taaagtgagg ggctaggact
     3721 caagcctgga gctgtgtgtt ccagtacctg gcatctcaac cacagaactc agcagagcca
     3781 gctgtgaagg gctgagggac agagccagct gtgaagggct gaggggcaga gccagctgtg
     3841 aagggctgag gggcagagcc agctgtgaag ggctgaggga cacagccact caaagccaca
     3901 ggggccaggc agggagctgc gttgcatccc tggaacccag gtgccctcat gcaggttgga
     3961 gttctgaggg gaggccctgg catctgcacc agcatctgcc aattccagcc agggagccca
     4021 gaggtatccc tgtggcctcc agtttcttac ctggtggacc ttccttccaa aggcaggcag
     4081 ctcatcattc cctggaattt tttccttctg gggtcaggga agtctcaaag gtcctcatgt
     4141 gagtctttta agaaagtctt aattgtaata ttgtactata gttttgcaaa atattaaata
     4201 ttaccattgg ggacattagg tagagggggc acggaatgtc tctgtattat ttcgtaaagc
     4261 ttcatgtgaa tctacaatta tctcaaaaat ttaagttaaa aaaggaagaa aaataagaaa
     4321 ggaagtccca acttggagtc tgatttaaag ggtctatttt gtcaatggtt tccatgcacc
     4381 tgaatttggg actaaaatac acagaaactc agaataccca aacaatccct gcaggggaaa
     4441 aggccatgtt cctctagaaa aattagtatg tgaggatgcc taacccccac tgtcccataa
     4501 attattaatg atgaccttca tttgcttgag atagatgttc tcctcctgtc aataaagact
     4561 ggccttctag caaatgccac aactgtctgc tgctcacaga actttatgca cgggataagc
     4621 atgaaataat gggaatttag gcatgatgga gttagaccct gtgcctacgt gtttttttgc
     4681 aataatatct gcctgggagc agagaacctt catcagttct taataaacca ctctgctaat
     4741 ga
//
