LOCUS       NM_001282534            2393 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens potassium two pore domain channel subfamily K member 9
            (KCNK9), transcript variant 1, mRNA.
ACCESSION   NM_001282534
VERSION     NM_001282534.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2393)
  AUTHORS   Rinne,S., Schick,F., Vowinkel,K., Schutte,S., Krasel,C.,
            Kauferstein,S., Schafer,M.K., Kiper,A.K., Muller,T. and Decher,N.
  TITLE     Potassium channel TASK-5 forms functional heterodimers with TASK-1
            and TASK-3 to break its silence
  JOURNAL   Nat Commun 15 (1), 7548 (2024)
   PUBMED   39215006
  REMARK    GeneRIF: Potassium channel TASK-5 forms functional heterodimers
            with TASK-1 and TASK-3 to break its silence.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2393)
  AUTHORS   Lin,H., Li,J., Zhang,Q., Yang,H. and Chen,S.
  TITLE     C-type inactivation and proton modulation mechanisms of the TASK3
            channel
  JOURNAL   Proc Natl Acad Sci U S A 121 (17), e2320345121 (2024)
   PUBMED   38630723
  REMARK    GeneRIF: C-type inactivation and proton modulation mechanisms of
            the TASK3 channel.
REFERENCE   3  (bases 1 to 2393)
  AUTHORS   Saito,M., Tanaka,C., Toyoda,H. and Kang,Y.
  TITLE     Subcellular Localization of Homomeric TASK3 Channels and Its
            Presumed Functional Significances in Trigeminal Motoneurons
  JOURNAL   Int J Mol Sci 24 (1), 344 (2022)
   PUBMED   36613787
  REMARK    GeneRIF: Subcellular Localization of Homomeric TASK3 Channels and
            Its Presumed Functional Significances in Trigeminal Motoneurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2393)
  AUTHORS   Ruf,N., Bahring,S., Galetzka,D., Pliushch,G., Luft,F.C.,
            Nurnberg,P., Haaf,T., Kelsey,G. and Zechner,U.
  TITLE     Sequence-based bioinformatic prediction and QUASEP identify genomic
            imprinting of the KCNK9 potassium channel gene in mouse and human
  JOURNAL   Hum Mol Genet 16 (21), 2591-2599 (2007)
   PUBMED   17704508
  REMARK    GeneRIF: KCNK9 gene is imprinted in human and mouse, exhibiting
            preferential expression from the maternal allele in brain.
REFERENCE   5  (bases 1 to 2393)
  AUTHORS   Vega-Saenz de Miera,E., Lau,D.H., Zhadina,M., Pountney,D.,
            Coetzee,W.A. and Rudy,B.
  TITLE     KT3.2 and KT3.3, two novel human two-pore K(+) channels closely
            related to TASK-1
  JOURNAL   J Neurophysiol 86 (1), 130-142 (2001)
   PUBMED   11431495
REFERENCE   6  (bases 1 to 2393)
  AUTHORS   Meadows,H.J. and Randall,A.D.
  TITLE     Functional characterisation of human TASK-3, an acid-sensitive
            two-pore domain potassium channel
  JOURNAL   Neuropharmacology 40 (4), 551-559 (2001)
   PUBMED   11249964
REFERENCE   7  (bases 1 to 2393)
  AUTHORS   Chapman,C.G., Meadows,H.J., Godden,R.J., Campbell,D.A.,
            Duckworth,M., Kelsell,R.E., Murdock,P.R., Randall,A.D., Rennie,G.I.
            and Gloger,I.S.
  TITLE     Cloning, localisation and functional expression of a novel human,
            cerebellum specific, two pore domain potassium channel
  JOURNAL   Brain Res Mol Brain Res 82 (1-2), 74-83 (2000)
   PUBMED   11042359
REFERENCE   8  (bases 1 to 2393)
  AUTHORS   Rajan,S., Wischmeyer,E., Xin Liu,G., Preisig-Muller,R., Daut,J.,
            Karschin,A. and Derst,C.
  TITLE     TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An
            extracellular histiding as pH sensor
  JOURNAL   J Biol Chem 275 (22), 16650-16657 (2000)
   PUBMED   10747866
REFERENCE   9  (bases 1 to 2393)
  AUTHORS   Kim,Y., Bang,H. and Kim,D.
  TITLE     TASK-3, a new member of the tandem pore K(+) channel family
  JOURNAL   J Biol Chem 275 (13), 9340-9347 (2000)
   PUBMED   10734076
REFERENCE   10 (bases 1 to 2393)
  AUTHORS   Zadeh,N. and Graham,J.M. Jr.
  TITLE     KCNK9 Imprinting Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   28333430
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007869.2, AF248241.1,
            AF212829.1, DA416784.1, BX092753.1 and AW085193.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001282534.1.
            
            Summary: This gene encodes a protein that contains multiple
            transmembrane regions and two pore-forming P domains and functions
            as a pH-dependent potassium channel. Amplification and
            overexpression of this gene have been observed in several types of
            human carcinomas. This gene is imprinted in the brain, with
            preferential expression from the maternal allele. A mutation in
            this gene was associated with Birk-Barel dysmorphism syndrome.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jul 2017].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.325644.1,
                                           SRR1660809.181174.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 17704508
            MANE Ensembl match     :: ENST00000520439.3/ ENSP00000430676.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC007869.2         33418-33484
            68-131              AF248241.1         1-64
            132-767             AF212829.1         1-636
            768-1299            AF248241.1         701-1232
            1300-1859           DA416784.1         15-574
            1860-2156           BX092753.1         442-738
            2157-2393           AW085193.1         6-242               c
FEATURES             Location/Qualifiers
     source          1..2393
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2393
                     /gene="KCNK9"
                     /gene_synonym="BIBARS; K2p9.1; KT3.2; TASK-3; TASK3;
                     TASK32"
                     /note="potassium two pore domain channel subfamily K
                     member 9"
                     /db_xref="GeneID:51305"
                     /db_xref="HGNC:HGNC:6283"
                     /db_xref="MIM:605874"
     exon            1..414
                     /gene="KCNK9"
                     /gene_synonym="BIBARS; K2p9.1; KT3.2; TASK-3; TASK3;
                     TASK32"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1256
                     /gene="KCNK9"
                     /gene_synonym="BIBARS; K2p9.1; KT3.2; TASK-3; TASK3;
                     TASK32"
                     /note="acid-sensitive potassium channel protein TASK-3;
                     two pore K(+) channel KT3.2; potassium channel, two pore
                     domain subfamily K, member 9; two pore potassium channel
                     KT3.2; TWIK-related acid-sensitive K(+) channel 3;
                     TWIK-related acid-sensitive K+ 3; potassium 2-pore domain
                     leak channel TASK3"
                     /codon_start=1
                     /product="potassium channel subfamily K member 9
                     precursor"
                     /protein_id="NP_001269463.1"
                     /db_xref="CCDS:CCDS6377.1"
                     /db_xref="GeneID:51305"
                     /db_xref="HGNC:HGNC:6283"
                     /db_xref="MIM:605874"
                     /translation="MKRQNVRTLSLIVCTFTYLLVGAAVFDALESDHEMREEEKLKAE
                     EIRIKGKYNISSEDYRQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPG
                     TDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMV
                     TVGFFSCMGTLCIGAAAFSQCEEWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKP
                     LYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNSEDERRDAEERASLAGNRNSMVIHIP
                     EEPRPSRPRYKADVPDLQSVCSCTCYRSQDYGGRSVAPQNSFSAKLAPHYFHSISYKI
                     EEISPSTLKNSLFPSPISSISPGLHSFTDHQRLMKRRKSV"
     exon            415..2393
                     /gene="KCNK9"
                     /gene_synonym="BIBARS; K2p9.1; KT3.2; TASK-3; TASK3;
                     TASK32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2372..2377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK9"
                     /gene_synonym="BIBARS; K2p9.1; KT3.2; TASK-3; TASK3;
                     TASK32"
                     /note="hexamer: AATACA"
     polyA_site      2393
                     /gene="KCNK9"
                     /gene_synonym="BIBARS; K2p9.1; KT3.2; TASK-3; TASK3;
                     TASK32"
                     /note="major polyA site"
ORIGIN      
        1 gcttacaact tggaggcggc ggcggcggcg gcggaggagg aggcggcggc ggccgccggg
       61 cgctgcagtg ggacgcgcgc ggctgtgagc ctgcgggaca tgccccccgc gccggctcct
      121 tgctggcggc catgaagagg cagaacgtgc ggactctgtc cctcatcgtc tgcaccttca
      181 cctacctgct ggtgggcgcc gccgtgttcg acgccctcga gtcggaccac gagatgcgcg
      241 aggaggagaa actcaaagcc gaggagatcc ggatcaaggg gaagtacaac atcagcagcg
      301 aggactaccg gcagctggag ctggtgatcc tgcagtcgga accgcaccgc gccggcgtcc
      361 agtggaaatt cgccggctcc ttctactttg cgatcacggt catcaccacc ataggttatg
      421 ggcacgctgc acctggcacc gatgcgggca aggccttctg catgttctac gccgtgctgg
      481 gcatcccgct gacactggtc atgttccaga gcctgggcga gcgcatgaac accttcgtgc
      541 gctacctgct gaagcgcatt aagaagtgct gtggcatgcg caacactgac gtgtctatgg
      601 agaacatggt gactgtgggc ttcttctcct gcatggggac gctgtgcatc ggggcggccg
      661 ccttctccca gtgtgaggag tggagcttct tccacgccta ctactactgc ttcatcacgt
      721 tgactaccat tgggttcggg gactacgtgg ccctgcagac caagggtgcc ctgcagaaga
      781 agccgctcta cgtggccttt agctttatgt atatcctggt ggggctgacg gtcatcgggg
      841 ccttcctcaa cctggtcgtc ctcaggttct tgaccatgaa cagtgaggat gagcggcggg
      901 atgctgaaga gagggcatcc ctcgccggaa accgcaacag catggtcatt cacatccctg
      961 aggagccgcg gcccagccgg cccaggtaca aggcggacgt cccggacctg cagtctgtgt
     1021 gctcctgcac ctgctaccgc tcgcaggact atggcggccg ctcggtggca ccgcagaact
     1081 ccttcagcgc caagcttgcc ccccactact tccactccat ctcttacaag atcgaggaga
     1141 tctcaccaag cacattaaaa aacagcctct tcccatcgcc tattagctcc atctctcctg
     1201 ggttacacag ctttaccgac caccagaggc tgatgaaacg ccggaagtcc gtttaggtgt
     1261 ggggagggaa atgggacaga aaagtcattt gtcatagttg gtgttaattt ccattggtcc
     1321 aactcgtctt ttcttattta tttattatta ttattgtcat cattattact ttctctcctt
     1381 cctcctttct tggtctcttg gtctcatttt cccccacctt tccagccaga cagagcaggc
     1441 caaagggaaa tacaggccca tcctcctctg aaactcacat ctgagcatga agcatggatc
     1501 tcctccttcc ttcccagcag actatgcctt acatttctca ccccacccac cccatcatct
     1561 ctgcagtggt tttcccggga cagatgtgag accaagacca cggagacaga gctgagagga
     1621 tacccacccc aaagctgcac atcacgctca gccttcaatc gcctaccctt agtggtgtct
     1681 ctgacctaac tcctttctct tttcctaagg actgagtgac tgtgtgtgtg ttgtgtgtgt
     1741 gcttctgtgt gcacgtgtgt cgtgacaaaa cgggaagtat taggtattcc gttttctttc
     1801 ccatcacaca tcatagcctg cttttggctg cttccaaaca aaacgggaag acaaaaccca
     1861 caaggttttt gatttatcgt attttgccaa atcaagcatg tttcattaag cagttcttat
     1921 ccctgatgtg tcatggccat attttctaaa tgctaggttc taaattatat taatgttttt
     1981 taggggcggg tgggcaagac gacccaaacc atcttagctt gccagttcag acatttttta
     2041 aaaagcatgc actttgttaa actggtatgc gctatcaaca aaaaaactag aaatggaata
     2101 atccaaagcc aataacatta acttataaaa gacattttta attttgtcac ctccagttcc
     2161 aacaatttac catgcaactg gaattgtcag gggaaacggg aaaattgttg gaaccccaga
     2221 gtatctattt ccctcttatt gatgattttg tgcagcacct accctgcata aataagaatt
     2281 atagtgttgg aatgcttggg tgagaatggg tattagtatg tggctgtggt tccttttcct
     2341 catgaaaatt gacagggcat tcctcattaa aaatacatat ctatttcaag aaa
//
