LOCUS       NM_033347               1121 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens potassium two pore domain channel subfamily K member 7
            (KCNK7), transcript variant A, mRNA.
ACCESSION   NM_033347
VERSION     NM_033347.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1121)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1121)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1121)
  AUTHORS   Goldstein,S.A., Bayliss,D.A., Kim,D., Lesage,F., Plant,L.D. and
            Rajan,S.
  TITLE     International Union of Pharmacology. LV. Nomenclature and molecular
            relationships of two-P potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 527-540 (2005)
   PUBMED   16382106
  REMARK    Review article
REFERENCE   4  (bases 1 to 1121)
  AUTHORS   Goldstein,S.A., Bockenhauer,D., O'Kelly,I. and Zilberberg,N.
  TITLE     Potassium leak channels and the KCNK family of two-P-domain
            subunits
  JOURNAL   Nat Rev Neurosci 2 (3), 175-184 (2001)
   PUBMED   11256078
  REMARK    Review article
REFERENCE   5  (bases 1 to 1121)
  AUTHORS   Medhurst,A.D., Rennie,G., Chapman,C.G., Meadows,H., Duckworth,M.D.,
            Kelsell,R.E., Gloger,I.I. and Pangalos,M.N.
  TITLE     Distribution analysis of human two pore domain potassium channels
            in tissues of the central nervous system and periphery
  JOURNAL   Brain Res Mol Brain Res 86 (1-2), 101-114 (2001)
   PUBMED   11165377
REFERENCE   6  (bases 1 to 1121)
  AUTHORS   Salinas,M., Reyes,R., Lesage,F., Fosset,M., Heurteaux,C., Romey,G.
            and Lazdunski,M.
  TITLE     Cloning of a new mouse two-P domain channel subunit and a human
            homologue with a unique pore structure
  JOURNAL   J Biol Chem 274 (17), 11751-11760 (1999)
   PUBMED   10206991
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001362.5.
            
            On Aug 5, 2019 this sequence version replaced NM_033347.1.
            
            Summary: This gene encodes a member of the superfamily of potassium
            channel proteins containing two pore-forming P domains. The product
            of this gene has not been shown to be a functional channel;
            however, it may require other non-pore-forming proteins for
            activity. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF110522.1, BC103811.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340313.5/ ENSP00000344820.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-347               AP001362.5         76065-76411         c
            348-746             AP001362.5         74087-74485         c
            747-1121            AP001362.5         73447-73821         c
FEATURES             Location/Qualifiers
     source          1..1121
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1121
                     /gene="KCNK7"
                     /gene_synonym="K2p7.1; TWIK3"
                     /note="potassium two pore domain channel subfamily K
                     member 7"
                     /db_xref="GeneID:10089"
                     /db_xref="HGNC:HGNC:6282"
                     /db_xref="MIM:603940"
     exon            1..347
                     /gene="KCNK7"
                     /gene_synonym="K2p7.1; TWIK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..952
                     /gene="KCNK7"
                     /gene_synonym="K2p7.1; TWIK3"
                     /note="isoform A is encoded by transcript variant A; two
                     pore domain K+ channel; potassium channel, two pore domain
                     subfamily K, member 7"
                     /codon_start=1
                     /product="potassium channel subfamily K member 7 isoform
                     A"
                     /protein_id="NP_203133.1"
                     /db_xref="CCDS:CCDS31608.1"
                     /db_xref="GeneID:10089"
                     /db_xref="HGNC:HGNC:6282"
                     /db_xref="MIM:603940"
                     /translation="MGGLRPWSRYGLLVVAHLLALGLGAVVFQALEGPPACRLQAELR
                     AELAAFQAEHRACLPPGALEELLGTALATQAHGVSTLGNSSEGRTWDLPSALLFAASI
                     LTTTGYGHMAPLSPGGKAFCMVYAALGLPASLALVATLRHCLLPVLSRPRAWVAVHWQ
                     LSPARAALLQAVALGLLVASSFVLLPALVLWGLQGDCSLLGAVYFCFSSLSTIGLEDL
                     LPGRGRSLHPVIYHLGQLALLGYLLLGLLAMLLAVETFSELPQVRAMGKFFRPSGPVT
                     AEDQGGILGQDELALSTLPPAAPASGQAPAC"
     exon            348..746
                     /gene="KCNK7"
                     /gene_synonym="K2p7.1; TWIK3"
                     /inference="alignment:Splign:2.1.0"
     exon            747..1121
                     /gene="KCNK7"
                     /gene_synonym="K2p7.1; TWIK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1086..1091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK7"
                     /gene_synonym="K2p7.1; TWIK3"
                     /note="hexamer: CATAAA"
     polyA_site      1121
                     /gene="KCNK7"
                     /gene_synonym="K2p7.1; TWIK3"
                     /note="major polyA site"
ORIGIN      
        1 agttcccaca gcaccccagc ggcctgccat ggggggtcta aggccctggt cccgatacgg
       61 gctcctggtt gtggcccact tgctggccct ggggcttggg gctgtggtgt tccaggccct
      121 ggaggggcct cctgcatgca ggcttcaggc tgagctcagg gcagagctgg cagccttcca
      181 ggcagagcat agggcctgcc tgccacccgg agctctggaa gagctgctgg gcactgccct
      241 ggccacccag gcccatgggg tctccaccct gggcaacagc tcagagggca ggacctggga
      301 ccttccctca gccctgctct tcgctgccag catcctcacc accacaggtt atggccacat
      361 ggccccacta tcgccaggcg gaaaggcctt ctgcatggtc tatgcagccc tggggctgcc
      421 agcctcctta gctctcgtgg ccaccctgcg ccattgcctg ctgcctgtgc tcagccgccc
      481 acgtgcctgg gtagcggtcc actggcagct gtcaccggcc agggctgcgc tgctgcaggc
      541 agttgcactg ggactgctgg tggccagcag ctttgtgctg ctgccagcgc tggtgctgtg
      601 gggccttcag ggcgactgca gcctgctggg ggccgtctac ttctgcttca gctcgctcag
      661 caccattggc ctggaggact tgctgcccgg ccgcggccgc agcctgcacc ccgtgattta
      721 ccacctgggc cagctcgcac ttcttggtta cttgcttcta ggactcttgg ccatgctgct
      781 ggcagtggag accttctctg agctgccgca ggtccgtgcc atggggaagt tcttcagacc
      841 cagtggtcct gtgactgctg aggaccaagg tggcatccta gggcaggatg aactggctct
      901 gagcaccctg ccgcccgcgg ccccagcttc aggacaagcc cctgcttgct gaagcgtcag
      961 gtgaccgagt tcagctccgt aaggtggcgg cacctgagga ggaagcagcc aggagtggct
     1021 ggggaagaat ctggagatgg agccgcggtg agggtgggcg ggaggcctca gaggatactg
     1081 ttaatcataa aatgagcaac gacttcggct attttcaact a
//
