LOCUS       NM_003740               3783 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens potassium two pore domain channel subfamily K member 5
            (KCNK5), mRNA.
ACCESSION   NM_003740
VERSION     NM_003740.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3783)
  AUTHORS   Liao,K., Zeng,H., Yang,X., He,D., Wang,B. and Yuan,J.
  TITLE     KCNK5 Regulating Potassium Efflux and Inducing Pyroptosis in
            Corneal Epithelial Cells Through TNFSF10-Mediated Autophagy in Dry
            Eye
  JOURNAL   Invest Ophthalmol Vis Sci 65 (1), 34 (2024)
   PUBMED   38236186
  REMARK    GeneRIF: KCNK5 Regulating Potassium Efflux and Inducing Pyroptosis
            in Corneal Epithelial Cells Through TNFSF10-Mediated Autophagy in
            Dry Eye.
REFERENCE   2  (bases 1 to 3783)
  AUTHORS   Khoubza,L., Gilbert,N., Kim,E.J., Chatelain,F.C., Feliciangeli,S.,
            Abelanet,S., Kang,D., Lesage,F. and Bichet,D.
  TITLE     Alkaline-sensitive two-pore domain potassium channels form
            functional heteromers in pancreatic beta-cells
  JOURNAL   J Biol Chem 298 (10), 102447 (2022)
   PUBMED   36063992
REFERENCE   3  (bases 1 to 3783)
  AUTHORS   Jiang,Z., Zhao,L., Zhang,X., Zhang,W., Feng,Y. and Li,T.
  TITLE     Common variants in KCNK5 and FHL5 genes contributed to the
            susceptibility of migraine without aura in Han Chinese population
  JOURNAL   Sci Rep 11 (1), 6807 (2021)
   PUBMED   33762637
  REMARK    GeneRIF: Common variants in KCNK5 and FHL5 genes contributed to the
            susceptibility of migraine without aura in Han Chinese population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3783)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3783)
  AUTHORS   Lenzini,L., Prisco,S., Gallina,M., Kuppusamy,M. and Rossi,G.P.
  TITLE     Mutations of the Twik-Related Acid-Sensitive K+ Channel 2 Promoter
            in Human Primary Aldosteronism
  JOURNAL   Endocrinology 159 (3), 1352-1359 (2018)
   PUBMED   29293917
  REMARK    GeneRIF: mutations in the promoter region of the TWIK-related
            acid-sensitive K(+) channel 2 (TASK-2) gene did not result in
            hypertension or primary aldosteronism (PA) during long-term
            follow-up in healthy participants thus they do not seem to be a
            factor in causing PA by themselves.
REFERENCE   6  (bases 1 to 3783)
  AUTHORS   Niemeyer,M.I., Cid,L.P., Valenzuela,X., Paeile,V. and
            Sepulveda,F.V.
  TITLE     Extracellular conserved cysteine forms an intersubunit disulphide
            bridge in the KCNK5 (TASK-2) K+ channel without having an essential
            effect upon activity
  JOURNAL   Mol Membr Biol 20 (2), 185-191 (2003)
   PUBMED   12851074
REFERENCE   7  (bases 1 to 3783)
  AUTHORS   Morton,M.J., O'Connell,A.D., Sivaprasadarao,A. and Hunter,M.
  TITLE     Determinants of pH sensing in the two-pore domain K(+) channels
            TASK-1 and -2
  JOURNAL   Pflugers Arch 445 (5), 577-583 (2003)
   PUBMED   12634929
  REMARK    GeneRIF: TASK-2 does not possess a histidine residue at homologous
            position. Inclusion of such a residue failed to produce expected
            increase in pH sensitivity; instead, a slight decrease was observed
REFERENCE   8  (bases 1 to 3783)
  AUTHORS   Goldstein,S.A., Bockenhauer,D., O'Kelly,I. and Zilberberg,N.
  TITLE     Potassium leak channels and the KCNK family of two-P-domain
            subunits
  JOURNAL   Nat Rev Neurosci 2 (3), 175-184 (2001)
   PUBMED   11256078
  REMARK    Review article
REFERENCE   9  (bases 1 to 3783)
  AUTHORS   Gray,A.T., Zhao,B.B., Kindler,C.H., Winegar,B.D., Mazurek,M.J.,
            Xu,J., Chavez,R.A., Forsayeth,J.R. and Yost,C.S.
  TITLE     Volatile anesthetics activate the human tandem pore domain baseline
            K+ channel KCNK5
  JOURNAL   Anesthesiology 92 (6), 1722-1730 (2000)
   PUBMED   10839924
REFERENCE   10 (bases 1 to 3783)
  AUTHORS   Reyes,R., Duprat,F., Lesage,F., Fink,M., Salinas,M., Farman,N. and
            Lazdunski,M.
  TITLE     Cloning and expression of a novel pH-sensitive two pore domain K+
            channel from human kidney
  JOURNAL   J Biol Chem 273 (47), 30863-30869 (1998)
   PUBMED   9812978
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC060793.1 and BU608155.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003740.3.
            
            Summary: This gene encodes one of the members of the superfamily of
            potassium channel proteins containing two pore-forming P domains.
            The message for this gene is mainly expressed in the cortical
            distal tubules and collecting ducts of the kidney. The protein is
            highly sensitive to external pH and this, in combination with its
            expression pattern, suggests it may play an important role in renal
            potassium transport. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060793.1, AF084830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359534.4/ ENSP00000352527.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3635              BC060793.1         1-3635
            3636-3783           BU608155.1         18-165              c
FEATURES             Location/Qualifiers
     source          1..3783
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..3783
                     /gene="KCNK5"
                     /gene_synonym="K2p5.1; KCNK5b; TASK-2; TASK2"
                     /note="potassium two pore domain channel subfamily K
                     member 5"
                     /db_xref="GeneID:8645"
                     /db_xref="HGNC:HGNC:6280"
                     /db_xref="MIM:603493"
     exon            1..550
                     /gene="KCNK5"
                     /gene_synonym="K2p5.1; KCNK5b; TASK-2; TASK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..1864
                     /gene="KCNK5"
                     /gene_synonym="K2p5.1; KCNK5b; TASK-2; TASK2"
                     /note="potassium channel, subfamily K, member 1 (TASK-2);
                     acid-sensitive potassium channel protein TASK-2;
                     TWIK-related acid-sensitive K+ channel 2; K2P5.1 potassium
                     channel; TWIK-related acid-sensitive K(+) channel 2;
                     potassium channel, subfamily, member 5 (KCNK5); potassium
                     channel, two pore domain subfamily K, member 5;
                     TWIK-related acid-sensitive K+ 2"
                     /codon_start=1
                     /product="potassium channel subfamily K member 5"
                     /protein_id="NP_003731.1"
                     /db_xref="CCDS:CCDS4841.1"
                     /db_xref="GeneID:8645"
                     /db_xref="HGNC:HGNC:6280"
                     /db_xref="MIM:603493"
                     /translation="MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLH
                     LLKEFPCLGQEGLDKILEVVSDAAGQGVAITGNQTFNNWNWPNAMIFAATVITTIGYG
                     NVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTKRGVSLRKAQI
                     TCTVIFIVWGVLVHLVIPPFVFMVTEGWNYIEGLYYSFITISTIGFGDFVAGVNPSAN
                     YHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKA
                     LQVKGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGL
                     PALPPSLVPLVVYSKNRVPTLEEVSQTLRSKGHVSRSPDEEAVARAPEDSSPAPEVFM
                     NQLDRISEECEPWDAQDYHPLIFQDASITFVNTEAGLSDEETSKSSLEDNLAGEESPQ
                     QGAEAKAPLNMGEFPSSSESTFTSTESELSVPYEQLMNEYNKANSPKGT"
     exon            551..662
                     /gene="KCNK5"
                     /gene_synonym="K2p5.1; KCNK5b; TASK-2; TASK2"
                     /inference="alignment:Splign:2.1.0"
     exon            663..829
                     /gene="KCNK5"
                     /gene_synonym="K2p5.1; KCNK5b; TASK-2; TASK2"
                     /inference="alignment:Splign:2.1.0"
     exon            830..998
                     /gene="KCNK5"
                     /gene_synonym="K2p5.1; KCNK5b; TASK-2; TASK2"
                     /inference="alignment:Splign:2.1.0"
     exon            999..3783
                     /gene="KCNK5"
                     /gene_synonym="K2p5.1; KCNK5b; TASK-2; TASK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3759..3764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK5"
                     /gene_synonym="K2p5.1; KCNK5b; TASK-2; TASK2"
                     /note="hexamer: AATAAA"
     polyA_site      3783
                     /gene="KCNK5"
                     /gene_synonym="K2p5.1; KCNK5b; TASK-2; TASK2"
                     /note="major polyA site"
ORIGIN      
        1 gcatactgct agtggcgcgc ggaggagcga cgcgtggaga agcggcccac gtgtctgccc
       61 agagtcaagt cctgtgttct tcccgctcct tacgcatccg cggtccaggg cgccctttca
      121 gccccgctgg tgttcgccca ccccgggccg cgtgagtggg gccccacgca gctccccgca
      181 ctccgtgggc caacttggcc aagcaactct gtccggggag cggtgcttgc ggggggtgag
      241 taccgggcac tgcgcatgcg gagctccaaa ttcaaacagc tgttttcaga ggctggaggg
      301 cgggcggact ggtagcagct ggggctagga gaggctttct ctaggaggcg gccgctcggg
      361 agccatggtg gaccggggcc ctctgctcac ctcggccatc atcttctacc tggccatcgg
      421 ggcggcgatc ttcgaagtgc tggaggagcc acactggaag gaggccaaga aaaactacta
      481 cacacagaag ctgcatctgc tcaaggagtt cccgtgcctg ggtcaggagg gcctggacaa
      541 gatcctagag gtggtatctg atgctgcagg acagggtgtg gccatcacag ggaaccagac
      601 cttcaacaac tggaactggc ccaatgcaat gatttttgca gcgaccgtca ttaccaccat
      661 tggatatggc aatgtggctc ccaagacccc cgccggtcgc ctcttctgtg ttttctatgg
      721 tctcttcggg gtgccgctct gcctgacgtg gatcagtgcc ctgggcaagt tcttcggggg
      781 acgtgccaag agactagggc agttccttac caagagaggt gtgagtctgc ggaaggcgca
      841 gatcacgtgc acagtcatct tcatcgtgtg gggcgtccta gtccacctgg tgatcccacc
      901 cttcgtattc atggtgactg aggggtggaa ctacatcgag ggcctctact actccttcat
      961 caccatctcc accatcggct tcggtgactt tgtggccggt gtgaacccca gcgccaacta
     1021 ccacgccctg taccgctact tcgtggagct ctggatctac ttggggctgg cctggctgtc
     1081 cctttttgtc aactggaagg tgagcatgtt tgtggaagtc cacaaagcca ttaagaagcg
     1141 gcggcggcga cggaaggagt cctttgagag ctccccacac tcccggaagg ccctgcaggt
     1201 gaaggggagc acagcctcca aggacgtcaa catcttcagc tttctttcca agaaggaaga
     1261 gacctacaac gacctcatca agcagatcgg gaagaaggcc atgaagacaa gcgggggtgg
     1321 ggagacgggc ccgggcccag ggctggggcc tcaaggcggt gggctcccag cactgccccc
     1381 ttccctggtg cccctggtag tctactccaa gaaccgggtg cccaccttgg aagaggtgtc
     1441 acagacactg aggagcaaag gccacgtatc aaggtcccca gatgaggagg ctgtggcacg
     1501 ggcccctgaa gacagctccc ctgcccccga ggtgttcatg aaccagctgg accgcatcag
     1561 cgaggaatgc gagccatggg acgcccagga ctaccaccca ctcatcttcc aggacgccag
     1621 catcaccttc gtgaacacgg aggctggcct ctcagacgag gagacctcca agtcctcgct
     1681 agaggacaac ttggcagggg aggagagccc ccagcagggg gctgaagcca aggcgcccct
     1741 gaacatgggc gagttcccct cctcctccga gtccaccttc accagcactg agtctgagct
     1801 ctctgtgcct tacgaacagc tgatgaatga gtacaacaag gctaacagcc ccaagggcac
     1861 atgaggcagg gccggctccc caccccacct ttgatggcct cttcccccct caccctaggg
     1921 tgtcccgaga tgaccgggac gcctggcccc tggtgggggg gcagcctcgg aactgggagt
     1981 ggggggccag gggccttcct aaccttccat catcctcagc tagatgtatg cccgggacag
     2041 ggcctctgtt ctccagctga accataccct ggctgtgggg gcatctgtcc tgagcttggc
     2101 tggtgtatct cacaatgcaa agacatgctg gctggcggga caggtgggca ggactgaccc
     2161 tgaggaggcc ttgcctgcag ggtctttgtc tcaccatttg gtggagtatc acacggttct
     2221 ctgaggtctg gggcctcagc tgtttaagtt taccggtatt actgagctcg gcatttggag
     2281 agggagctct gaagtgtctg gggaggtacc gctgtgcgtg gggtcaggtg tttccgtacc
     2341 acagcaggag cagggcccgc ccgcatccca gctgtgggcc tgccggtcag gtcgggcacc
     2401 tactacaaac cgtagtgggg tggaggctgc tggaggtggg agtgaggaga tgagggcagg
     2461 gtctcaaaca gtcctgactc acagggcctg gaaacaagtc ctatgtgggc ctggggcctg
     2521 gggtcctcat cctccttgtt ggtctactca ggcccagccc agagctgtgt tccctgtctc
     2581 aggtcaagca gtggcagacg caaggctttc tgtgggcccc caagtggtag gagggagagt
     2641 agcagagcat gggttactgg aagccgggac tgctagggct ggtggccagg gagctgcaag
     2701 agtgaggctc agctctggct ggttctgccc ttacccctcc tgcccgcctg agaactgcac
     2761 accctgcccg ctggccccag gacctgcact cccaatcctg ctgtcttctc cttccctgtg
     2821 ccctgaacaa ggacctcact gcccgccttc ccctcccacc agcccccttg ggccaggcag
     2881 ggtgaggcca aattgctctt ggcccacaaa tgggtgatgg tcagatatgt gaatcaagct
     2941 cctttctcta gctagtgttt gatgtgcacg tgtgtgtgca cagtgcgtgt gtgcacacgc
     3001 acacctgtgc actcgtgtgt gtttaagaaa ggaaaggatt tgggctgggg agcaaaagat
     3061 aatgtgaaac tgttggtgga ctctctggtg aggggtgggc agaacttgct gctactagag
     3121 ttcttgggtt ctccatgatg ttcaccctgg ggctggccca ctgtgtcctg aatgtttttg
     3181 ttattttttg ttttattttt taaacaaact gctgttttta tatacctgga atctgttgtt
     3241 ggcttcagag ccagtggtta aagagcaggg tcccaaggat tgggagatct agtgtctgcc
     3301 ctcctgccct gcaactcaat tgggcctttt tcggtgacct catccaaggc catgatgtca
     3361 agggccatgt ccccaagcag aggtggagaa ggggacactg aggtgagcaa aagcaggaag
     3421 gggcatccac tgcgggtgac tggaggccgg gcaggaagca agtcatcaga gccgctcagc
     3481 tccgttcact ctctgccttc tgccccacta ctgtggggca gtggggccag agcccacctc
     3541 cccaacatgt gaagacagtg atgggcacgt gcccacaccc ccacttctct agccgtttgc
     3601 agaggccgcc acccagcagg ggcctgaaaa ggagcagcct cgtatttttc tgtgaaatgt
     3661 tttaatgaac catgttgttg ctggttgtcc tggcatcgcg cacactgtat gtacatactg
     3721 gcaacgatgt caaatgtaat ttattttaac atttttacaa taaaacatga ggtggacagg
     3781 cca
//
