LOCUS       NM_002246               6191 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens potassium two pore domain channel subfamily K member 3
            (KCNK3), mRNA.
ACCESSION   NM_002246
VERSION     NM_002246.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6191)
  AUTHORS   Rinne,S., Schick,F., Vowinkel,K., Schutte,S., Krasel,C.,
            Kauferstein,S., Schafer,M.K., Kiper,A.K., Muller,T. and Decher,N.
  TITLE     Potassium channel TASK-5 forms functional heterodimers with TASK-1
            and TASK-3 to break its silence
  JOURNAL   Nat Commun 15 (1), 7548 (2024)
   PUBMED   39215006
  REMARK    GeneRIF: Potassium channel TASK-5 forms functional heterodimers
            with TASK-1 and TASK-3 to break its silence.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6191)
  AUTHORS   Huang,D., Shang,W., Xu,M., Wan,Q., Zhang,J., Tang,X., Shen,Y.,
            Wang,Y. and Yu,Y.
  TITLE     Genome-Wide Methylation Analysis Reveals a KCNK3-Prominent Causal
            Cascade on Hypertension
  JOURNAL   Circ Res 135 (3), e76-e93 (2024)
   PUBMED   38841840
  REMARK    GeneRIF: Genome-Wide Methylation Analysis Reveals a KCNK3-Prominent
            Causal Cascade on Hypertension.
REFERENCE   3  (bases 1 to 6191)
  AUTHORS   Wiedmann,F., Paasche,A., Nietfeld,J., Kraft,M., Meyer,A.L.,
            Warnecke,G., Karck,M., Frey,N. and Schmidt,C.
  TITLE     Activation of neurokinin-III receptors modulates human atrial
            TASK-1 currents
  JOURNAL   J Mol Cell Cardiol 184, 26-36 (2023)
   PUBMED   37793594
  REMARK    GeneRIF: Activation of neurokinin-III receptors modulates human
            atrial TASK-1 currents.
REFERENCE   4  (bases 1 to 6191)
  AUTHORS   Yeo,Y., Jeong,H., Kim,M., Choi,Y., Kim,K.L. and Suh,W.
  TITLE     Crosstalk between BMP signaling and KCNK3 in phenotypic switching
            of pulmonary vascular smooth muscle cells
  JOURNAL   BMB Rep 55 (11), 565-570 (2022)
   PUBMED   36016502
  REMARK    GeneRIF: Crosstalk between BMP signaling and KCNK3 in phenotypic
            switching of pulmonary vascular smooth muscle cells.
REFERENCE   5  (bases 1 to 6191)
  AUTHORS   Sormann,J., Schewe,M., Proks,P., Jouen-Tachoire,T., Rao,S.,
            Riel,E.B., Agre,K.E., Begtrup,A., Dean,J., Descartes,M.,
            Fischer,J., Gardham,A., Lahner,C., Mark,P.R., Muppidi,S.,
            Pichurin,P.N., Porrmann,J., Schallner,J., Smith,K., Straub,V.,
            Vasudevan,P., Willaert,R., Carpenter,E.P., Rodstrom,K.E.J.,
            Hahn,M.G., Muller,T., Baukrowitz,T., Hurles,M.E., Wright,C.F. and
            Tucker,S.J.
  TITLE     Gain-of-function mutations in KCNK3 cause a developmental disorder
            with sleep apnea
  JOURNAL   Nat Genet 54 (10), 1534-1543 (2022)
   PUBMED   36195757
  REMARK    GeneRIF: Gain-of-function mutations in KCNK3 cause a developmental
            disorder with sleep apnea.
REFERENCE   6  (bases 1 to 6191)
  AUTHORS   Patel,A.J., Honore,E., Lesage,F., Fink,M., Romey,G. and
            Lazdunski,M.
  TITLE     Inhalational anesthetics activate two-pore-domain background K+
            channels
  JOURNAL   Nat Neurosci 2 (5), 422-426 (1999)
   PUBMED   10321245
REFERENCE   7  (bases 1 to 6191)
  AUTHORS   Manjunath,N.A., Bray-Ward,P., Goldstein,S.A. and Gallagher,P.G.
  TITLE     Assignment of the 2P domain, acid-sensitive potassium channel OAT1
            gene KCNK3 to human chromosome bands 2p24.1-->p23.3 and murine 5B
            by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 242-243 (1999)
   PUBMED   10575216
REFERENCE   8  (bases 1 to 6191)
  AUTHORS   Lesage,F. and Lazdunski,M.
  TITLE     Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK
            (KCNK3) to chromosomes 1q41 and 2p23
  JOURNAL   Genomics 51 (3), 478-479 (1998)
   PUBMED   9721223
REFERENCE   9  (bases 1 to 6191)
  AUTHORS   Duprat,F., Lesage,F., Fink,M., Reyes,R., Heurteaux,C. and
            Lazdunski,M.
  TITLE     TASK, a human background K+ channel to sense external pH variations
            near physiological pH
  JOURNAL   EMBO J 16 (17), 5464-5471 (1997)
   PUBMED   9312005
REFERENCE   10 (bases 1 to 6191)
  AUTHORS   Austin,E.D., Phillips,J.A. III and Loyd,J.E.
  TITLE     Heritable Pulmonary Arterial Hypertension Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015977.9 and AF065163.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002246.2.
            
            Summary: This gene encodes a member of the superfamily of potassium
            channel proteins that contain two pore-forming P domains. The
            encoded protein is an outwardly rectifying channel that is
            sensitive to changes in extracellular pH and is inhibited by
            extracellular acidification. Also referred to as an acid-sensitive
            potassium channel, it is activated by the anesthetics halothane and
            isoflurane. Although three transcripts are detected in northern
            blots, there is currently no sequence available to confirm
            transcript variants for this gene. [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF006823.1, AF065163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302909.4/ ENSP00000306275.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC015977.9         124319-124425
            108-1351            AF065163.1         79-1322
            1352-3969           AC015977.9         160178-162795
            3970-6191           AC015977.9         162796-165017
FEATURES             Location/Qualifiers
     source          1..6191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..6191
                     /gene="KCNK3"
                     /gene_synonym="K2p3.1; OAT1; PPH4; TASK; TASK-1; TASK1;
                     TBAK1"
                     /note="potassium two pore domain channel subfamily K
                     member 3"
                     /db_xref="GeneID:3777"
                     /db_xref="HGNC:HGNC:6278"
                     /db_xref="MIM:603220"
     exon            1..437
                     /gene="KCNK3"
                     /gene_synonym="K2p3.1; OAT1; PPH4; TASK; TASK-1; TASK1;
                     TBAK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1339
                     /gene="KCNK3"
                     /gene_synonym="K2p3.1; OAT1; PPH4; TASK; TASK-1; TASK1;
                     TBAK1"
                     /note="potassium inwardly-rectifying channel, subfamily K,
                     member 3; TWIK-related acid-sensitive K+ 1; acid-sensitive
                     potassium channel protein TASK; two P domain potassium
                     channel; cardiac potassium channel; TWIK-related
                     acid-sensitive K+ channel; potassium channel, two pore
                     domain subfamily K, member 3; two pore K(+) channel KT3.1;
                     two pore potassium channel KT3.1; TWIK-related
                     acid-sensitive K(+) channel 1; acid-sensitive potassium
                     channel protein TASK-1"
                     /codon_start=1
                     /product="potassium channel subfamily K member 3"
                     /protein_id="NP_002237.1"
                     /db_xref="CCDS:CCDS1727.1"
                     /db_xref="GeneID:3777"
                     /db_xref="HGNC:HGNC:6278"
                     /db_xref="MIM:603220"
                     /translation="MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELR
                     QQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPS
                     TDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMV
                     LIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQP
                     QYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGG
                     GSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLS
                     TSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRS
                     SV"
     exon            438..6191
                     /gene="KCNK3"
                     /gene_synonym="K2p3.1; OAT1; PPH4; TASK; TASK-1; TASK1;
                     TBAK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2448..2453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK3"
                     /gene_synonym="K2p3.1; OAT1; PPH4; TASK; TASK-1; TASK1;
                     TBAK1"
                     /note="hexamer: AATAAA"
     polyA_site      2465
                     /gene="KCNK3"
                     /gene_synonym="K2p3.1; OAT1; PPH4; TASK; TASK-1; TASK1;
                     TBAK1"
                     /note="major polyA site"
     regulatory      3944..3949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK3"
                     /gene_synonym="K2p3.1; OAT1; PPH4; TASK; TASK-1; TASK1;
                     TBAK1"
                     /note="hexamer: AATAAA"
     polyA_site      3969
                     /gene="KCNK3"
                     /gene_synonym="K2p3.1; OAT1; PPH4; TASK; TASK-1; TASK1;
                     TBAK1"
                     /note="major polyA site"
     regulatory      5100..5105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK3"
                     /gene_synonym="K2p3.1; OAT1; PPH4; TASK; TASK-1; TASK1;
                     TBAK1"
                     /note="hexamer: TATAAA"
     polyA_site      5127
                     /gene="KCNK3"
                     /gene_synonym="K2p3.1; OAT1; PPH4; TASK; TASK-1; TASK1;
                     TBAK1"
     regulatory      6162..6167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK3"
                     /gene_synonym="K2p3.1; OAT1; PPH4; TASK; TASK-1; TASK1;
                     TBAK1"
                     /note="hexamer: AATAAA"
     polyA_site      6191
                     /gene="KCNK3"
                     /gene_synonym="K2p3.1; OAT1; PPH4; TASK; TASK-1; TASK1;
                     TBAK1"
ORIGIN      
        1 ggcggcggcg gccccgggcg ctgagcgggt gcccggcgcg gagagcggcg agcgcagcca
       61 tgccccaggc cgcctccggg gcagcagcag cggcggccgg ggccgaggcg cgggccgggg
      121 gcgccggggg gccggcggcg gcccgggcgg gacgatgaag cggcagaacg tgcgcacgct
      181 ggcgctcatc gtgtgcacct tcacctacct gctggtgggc gccgcggtct tcgacgcgct
      241 ggagtcggag cccgagctga tcgagcggca gcggctggag ctgcggcagc aggagctgcg
      301 ggcgcgctac aacctcagcc agggcggcta cgaggagctg gagcgcgtcg tgctgcgcct
      361 caagccgcac aaggccggcg tgcagtggcg cttcgccggc tccttctact tcgccatcac
      421 cgtcatcacc accatcggct acgggcacgc ggcacccagc acggatggcg gcaaggtgtt
      481 ctgcatgttc tacgcgctgc tgggcatccc gctcacgctc gtcatgttcc agagcctggg
      541 cgagcgcatc aacaccttgg tgaggtacct gctgcaccgc gccaagaagg ggctgggcat
      601 gcggcgcgcc gacgtgtcca tggccaacat ggtgctcatc ggcttcttct cgtgcatcag
      661 cacgctgtgc atcggcgccg ccgccttctc ccactacgag cactggacct tcttccaggc
      721 ctactactac tgcttcatca ccctcaccac catcggcttc ggcgactacg tggcgctgca
      781 gaaggaccag gccctgcaga cgcagccgca gtacgtggcc ttcagcttcg tctacatcct
      841 tacgggcctc acggtcatcg gcgccttcct caacctcgtg gtgctgcgct tcatgaccat
      901 gaacgccgag gacgagaagc gcgacgccga gcaccgcgcg ctgctcacgc gcaacgggca
      961 ggcgggcggc ggcggagggg gtggcagcgc gcacactacg gacaccgcct catccacggc
     1021 ggcagcgggc ggcggcggct tccgcaacgt ctacgcggag gtgctgcact tccagtccat
     1081 gtgctcgtgc ctgtggtaca agagccgcga gaagctgcag tactccatcc ccatgatcat
     1141 cccgcgggac ctctccacgt ccgacacgtg cgtggagcag agccactcgt cgccgggagg
     1201 gggcggccgc tacagcgaca cgccctcgcg acgctgcctg tgcagcgggg cgccacgctc
     1261 cgccatcagc tcggtgtcca cgggtctgca cagcctgtcc accttccgcg gcctcatgaa
     1321 gcgcaggagc tccgtgtgac tgccccgagg ggcctggagc acctgggggc gcgggcgggg
     1381 gacccctgct gggaggccag gagactgccc ctgctgcctt ctgcccagtg ggaccccgca
     1441 caacatccct caccactctc ccccagcacc cccatctccg actgtgcctg cttgcaccag
     1501 ccggcaggag gccgggctct gaggacccct ggggccccca tcggagccct gcaaattccg
     1561 agaaatgtga aacttggtgg ggtcagggag gaaaggcaga agctgggagc ctcccttccc
     1621 tttgaaaatc taagaagctc ccagtcctca gagaccctgc tggtacccag acccccacct
     1681 tcggagggga cttcatgttc cgtgtacgtt tgcatctcta tttatacctc tgtcctgcta
     1741 ggtctcccac cttcccttgg ttccaaaagc cagggtgtct atgtccaagt cacccctact
     1801 cagccccact ccccttcctc atccccagct gtgtctccca acctcccttc gtgttgtttt
     1861 gcatggcttt gcagttatgg agaaagtgga aacccagcag tccctaaagc tggtccccag
     1921 aaagcaggac agaaagaagg agggacaggc aggcagcagg aggggcgagc tgggaggcag
     1981 gaggcagcgg cctgtcagtc tgcagaatgg tcgcactgga ggttcaagct aactggcctc
     2041 cagccacatt ctcatagcag gtaggacttc agccttccag acactgccct tagaatctgg
     2101 aacagaagac ttcagactca ccataattgc tgataattac ccactcttaa atttgtcgag
     2161 tgatttttag cctctgaaaa ctctatgctg gccactgatt cctttgagtc tcacaaaacc
     2221 ctacttaggt catcagggca ggagttctca ctcccatttt acagatgaga atactgaggc
     2281 ctggacaggt gaagtgacca gagagcaaaa ggcaaagggg tgggggctgg gtgcagtggc
     2341 tcacacctgt attcccaaca cttttggagg ctgaggttgg aggattgctt gagcccagga
     2401 atttgagacc agcctaggtg acatagtgag accccatctc tacaaaaaat aaaaaattaa
     2461 ccaggtgtgg tggcacgtgc ctgggagtcc cagcgacttg ggaggctgag gtgggaggat
     2521 tgtttgagcc tgggaggtcg aggctgtagt gagccctgat tgcaccactg tactccagcc
     2581 tgggtgacag ggcaagaccc tgtctcaaaa aaaaaaaaaa aaatggcaaa gggagacaag
     2641 agcccagcct gcttgttgct agccaaagtg ttctttcctt ccagcttggc ctgctcttaa
     2701 aagcaaagct cctgcagtgt acatcctggc attgtgtggc tacctgggtt ttaaaccaga
     2761 atcagaagtc ccggatcaga gggcactgct gaggttcagc ctcttctctt cttggccagg
     2821 aggcagcagc tctgaatggg cccctgaggc tgcacagggg cctttgtcac tggggcgcat
     2881 gcttacaaac agtgcagttc ttgggaccga ggtaagcagg gctgggtctc atggcagaaa
     2941 ggccaggatc tggggctcta ggaatttggg aattgggcag agtggccaag aaagctggca
     3001 ggcatatcct atgggacatc acacctggca ccattgtcat tgttggtgcc tgtgtcccaa
     3061 gtagctagtg ataagctgag gctgcagcaa gaaacaccct tcccaggtgg gggagtttgg
     3121 accagaggtg ccctctgccc accacacctg caacccagaa gcccagatgg aacgcagctg
     3181 acgaaggtga tgcttgaggc tcacttttgg ggccccacag ctggagccgg tataatgact
     3241 gggacaacat caaggggtgg atgaggggcc tctcctcccg caacactgcc ttcccatgct
     3301 gttcccctgc cagctcctta acactgccga ccaaggccag ccctggcatt cagggaaatt
     3361 ggagggcagc acccgtaggg tggccagcct caggccccac cccagctgtg tcctctagtc
     3421 tctggggacc cctgggggga agaagtctac cctgcttgtg agtcccgtct cagtgtggag
     3481 gaactggctg cacgtgggac ctgaaggtgc cctctgtgtt tatgttgggg gtgggggggc
     3541 agtgctggct gcctctgtcc tgtgtgtgac cctgccctcg aagggtcctg tcctgtcagt
     3601 cccgagggag ccacaaccaa agctgcggag agaaggtggg gaagggtgca gaatggccgt
     3661 ggggcacagc gtggcagact gttcagtctc tgctgggtct ttcctaggga cctggaaggc
     3721 cagtgttgct tccccctcac tccctttcac tgcaggcagc ctctctgctt ccccaatgcc
     3781 ttatgcctgg gcacactgcc acagaatatg caatatgtgt gggtgaccat gccctcacga
     3841 ccacaccccc accccgggca gcccccggac tccaaaggtc gtggctgcca cagcctccct
     3901 cagctcttcc tgcctatctg tcttcacact gagaatggcg cccaataaat gctatccacg
     3961 gagaccaggc tcaggctcca gctgcctctg tcatcgtatg cccttgctgc tgccagggag
     4021 gggccatctc ccaccccctc ccctgccggg gtctacaaac atatctagct gctgggtgcc
     4081 gtggctcaca cctatagtca cagcactagg cgggcagatc acctgaggtc agaagttcaa
     4141 gaccagcctg gccaacatgg taaaaccccg tctctactaa aaatacaaaa attagctgag
     4201 cgtggtggcg catgtctgta gtcccagcta ctcggctact caggaggctg acgcacgaga
     4261 atcgcttgaa cccgggaggc ggaggttgca gtgagctgag atcgtgccac tgcactccag
     4321 cctgagcgac agagtgagac cctgtctaaa aaaaaacaat aataataaaa taaaataaca
     4381 tacctagctg actcgccatg ggctcgctgg cctgtgggcg acactggctt cccttttggg
     4441 atttcccaga agatccagat tttcttaagt ccccttggaa cagactaaga aaggatcacc
     4501 ttagaaatca cctggtccta ttgtcccccc cgtacatgag taactgaggc ccacagagag
     4561 caaatcgcct gcctgagtca cacagcagtg agtggcagac ctaggctagg aactaggact
     4621 ggggattgct attccagtgc tccccatcct cacacagact gcacagtccg cctggacaca
     4681 ccccagctga cagtggtacc tcccagtcag ccaggagaat ggattccttc tcctgcagta
     4741 ggggccccct ggctgagtgg cctgattgac taaaacatat gtctttgaag gagagtgcat
     4801 cacaagcacc tttctttggg gtagattttt ctctgggtct agagggacag ctcaggcttg
     4861 ggactgggcc tcagaaccta cgacagaccg tgagagcaga cccaccttat ccatctggtg
     4921 ccagctcccc aggtcagcta cagcgacccc cggacttcat agagtacaat ccacagtaat
     4981 agcacacagc tctgtaccta tctagctcca tgcctatcta tctgcctacc tttcacaaaa
     5041 taattcttag caaccctgct acagccaatg attctaatac gttctgttct attgcatgtt
     5101 ataaaatgct ggtcacgatc cactaaattg atgtctctac ctgctaatgg tttaatacct
     5161 gcagattgaa atatactgga gaaataaaga gagtgggagt agggacactt tctcccagtg
     5221 cccacaccgc ccctcgttac ccgcataggt caactgaaag atacagagag ggaagctttg
     5281 atggggggtt cagagttcaa aggaagaaat gatggcacct gcactccctg cccccagagg
     5341 caggacacag ccagccctcc tgtgacagca ctcctggcag ctccttgttg gcctgcagcc
     5401 ctcagggggc ttagttgcca ttgactcacc cactcctaag gccaccacat caaaatctga
     5461 ggcttactgc cctgtcccac ctgcctctgt ctttcttaaa acagctaaat gcaacaatag
     5521 cagaaattag cttgtttttg aggttggcaa tgaccagttc aaggtgactc ttattttctt
     5581 aagcagtgct tgcaggacat aaatgtgatg acacttgccc tcctttcttt atcgcctggg
     5641 acagacttta caaacagacc tgggagaagt cccctaaggg gctgcattta tccccatctc
     5701 cctaggggtg atcagcattg tgacagctgg gcagagcagt ggtgaactgc acccatgtcc
     5761 ctgctcacat ctcctaagat ctcagaattg cctgaggttc tagcgtgggc tccttctctc
     5821 cagatgatgc catccccacc cccctcattt ccacacagca tctgaggcat cctgcactaa
     5881 aagatatatg tacagcaaaa caaaaataga aaaccagcac agcagagtgg aggtggggta
     5941 taaatatacc cagatccccg ctgatttggt tactcggggt gagcatcaga tggaaataga
     6001 agtttccggg ggccaagaga gaaagaggga tgtaacgaca attcttttca aaacgtgtcc
     6061 catggtatgc ctcgtggaaa aaatggttcg ttggtcaaat gaatttggga aaatgctgtc
     6121 aatatcaccg actcatggag cttcgcaagg catcttagct taataaaggt tatgaaaagt
     6181 cttgcagcaa a
//
