LOCUS       NM_001017425            3875 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens potassium two pore domain channel subfamily K member 2
            (KCNK2), transcript variant 3, mRNA.
ACCESSION   NM_001017425
VERSION     NM_001017425.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3875)
  AUTHORS   Sorum,B., Docter,T., Panico,V., Rietmeijer,R.A. and Brohawn,S.G.
  TITLE     Tension activation of mechanosensitive two-pore domain K+ channels
            TRAAK, TREK-1, and TREK-2
  JOURNAL   Nat Commun 15 (1), 3142 (2024)
   PUBMED   38605031
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3875)
  AUTHORS   Li,T., Fei,J., Yu,H., Wang,X., Li,D. and Yin,Z.
  TITLE     Prolonged stretching of rat uteri causes hypoxia and inhibits
            contractility via potassium channel TREK1
  JOURNAL   Reproduction 166 (1), 55-64 (2023)
   PUBMED   37184053
  REMARK    GeneRIF: Prolonged stretching of rat uteri causes hypoxia and
            inhibits contractility via potassium channel TREK1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3875)
  AUTHORS   Wang,J., Li,J., Cheng,D., Zhang,K., Liu,W., Xue,Q., Du,R., Zhou,L.,
            Yeung,Y.T., Bai,R., Huang,H., Cui,J., Xiang,P., Zhi,Y., Liu,K.,
            Li,X. and Dong,Z.
  TITLE     miR-132-3p promotes heat stimulation-induced esophageal squamous
            cell carcinoma tumorigenesis by targeting KCNK2
  JOURNAL   Mol Carcinog 62 (5), 583-597 (2023)
   PUBMED   37014157
  REMARK    GeneRIF: miR-132-3p promotes heat stimulation-induced esophageal
            squamous cell carcinoma tumorigenesis by targeting KCNK2.
REFERENCE   4  (bases 1 to 3875)
  AUTHORS   Li,T., Fei,J., Yu,H., Wang,X., Bai,J., Chen,F., Li,D. and Yin,Z.
  TITLE     High glucose induced HIF-1alpha/TREK1 expression and myometrium
            relaxation during pregnancy
  JOURNAL   Front Endocrinol (Lausanne) 14, 1115619 (2023)
   PUBMED   36909311
  REMARK    GeneRIF: High glucose induced HIF-1alpha/TREK1 expression and
            myometrium relaxation during pregnancy.
            Erratum:[Front Endocrinol (Lausanne). 2023 Apr 13;14:1200774. doi:
            10.3389/fendo.2023.1200774.. PMID: 37124756]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3875)
  AUTHORS   Zyrianova,T., Lopez,B., Zou,K., Gu,C., Pham,D., Talapaneni,S.,
            Waters,C.M., Olcese,R. and Schwingshackl,A.
  TITLE     Activation of TREK-1 (K2P2.1) potassium channels protects against
            influenza A-induced lung injury
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 324 (1), L64-L75 (2023)
   PUBMED   36410022
  REMARK    GeneRIF: Activation of TREK-1 (K2P2.1) potassium channels protects
            against influenza A-induced lung injury.
REFERENCE   6  (bases 1 to 3875)
  AUTHORS   Goldstein,S.A., Bockenhauer,D., O'Kelly,I. and Zilberberg,N.
  TITLE     Potassium leak channels and the KCNK family of two-P-domain
            subunits
  JOURNAL   Nat Rev Neurosci 2 (3), 175-184 (2001)
   PUBMED   11256078
  REMARK    Review article
REFERENCE   7  (bases 1 to 3875)
  AUTHORS   Meadows,H.J., Benham,C.D., Cairns,W., Gloger,I., Jennings,C.,
            Medhurst,A.D., Murdock,P. and Chapman,C.G.
  TITLE     Cloning, localisation and functional expression of the human
            orthologue of the TREK-1 potassium channel
  JOURNAL   Pflugers Arch 439 (6), 714-722 (2000)
   PUBMED   10784345
REFERENCE   8  (bases 1 to 3875)
  AUTHORS   Patel,A.J., Honore,E., Lesage,F., Fink,M., Romey,G. and
            Lazdunski,M.
  TITLE     Inhalational anesthetics activate two-pore-domain background K+
            channels
  JOURNAL   Nat Neurosci 2 (5), 422-426 (1999)
   PUBMED   10321245
REFERENCE   9  (bases 1 to 3875)
  AUTHORS   Lesage,F. and Lazdunski,M.
  TITLE     Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK
            (KCNK3) to chromosomes 1q41 and 2p23
  JOURNAL   Genomics 51 (3), 478-479 (1998)
   PUBMED   9721223
REFERENCE   10 (bases 1 to 3875)
  AUTHORS   Fink,M., Duprat,F., Lesage,F., Reyes,R., Romey,G., Heurteaux,C. and
            Lazdunski,M.
  TITLE     Cloning, functional expression and brain localization of a novel
            unconventional outward rectifier K+ channel
  JOURNAL   EMBO J 15 (24), 6854-6862 (1996)
   PUBMED   9003761
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099675.2, DR001358.1,
            EF165334.1, BC069462.1, AK123409.1 and AC092804.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001017425.2.
            
            Summary: This gene encodes one of the members of the
            two-pore-domain background potassium channel protein family. This
            type of potassium channel is formed by two homodimers that create a
            channel that leaks potassium out of the cell to control resting
            membrane potential. The channel can be opened, however, by certain
            anesthetics, membrane stretching, intracellular acidosis, and heat.
            Three transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            beginning of the coding region compared to variant 1. The resulting
            isoform (c) is slightly shorter and has a distinct N-terminus
            compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.116604.1, AK291483.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000444842.7/ ENSP00000394033.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               AC099675.2         64094-64573
            481-666             DR001358.1         10-195
            667-2133            EF165334.1         120-1586
            2134-2152           BC069462.1         1454-1472
            2153-2807           AK123409.1         1443-2097
            2808-3875           AC092804.2         93901-94968         c
FEATURES             Location/Qualifiers
     source          1..3875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..3875
                     /gene="KCNK2"
                     /gene_synonym="hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK;
                     TREK-1; TREK1"
                     /note="potassium two pore domain channel subfamily K
                     member 2"
                     /db_xref="GeneID:3776"
                     /db_xref="HGNC:HGNC:6277"
                     /db_xref="MIM:603219"
     exon            1..695
                     /gene="KCNK2"
                     /gene_synonym="hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK;
                     TREK-1; TREK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             650..1930
                     /gene="KCNK2"
                     /gene_synonym="hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK;
                     TREK-1; TREK1"
                     /note="isoform c is encoded by transcript variant 3;
                     potassium inwardly-rectifying channel, subfamily K, member
                     2; TWIK-related potassium channel 1; potassium channel,
                     two pore domain subfamily K, member 2; two-pore potassium
                     channel 1; tandem-pore-domain potassium channel TREK-1;
                     K2P2.1 potassium channel; TREK-1 K(+) channel subunit; two
                     pore potassium channel TPKC1; two pore domain potassium
                     channel TREK-1; outward rectifying potassium channel
                     protein TREK-1; two pore domain potassium channel TREK1"
                     /codon_start=1
                     /product="potassium channel subfamily K member 2 isoform
                     c"
                     /protein_id="NP_001017425.2"
                     /db_xref="CCDS:CCDS41467.1"
                     /db_xref="GeneID:3776"
                     /db_xref="HGNC:HGNC:6277"
                     /db_xref="MIM:603219"
                     /translation="MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVL
                     ASRVESDTTINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTF
                     ISQHSCVNSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGF
                     GNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQ
                     TKIRIISTIIFILFGCVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGG
                     SDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTA
                     NVTAEFKETRRRLSVEIYDKFQRATSIKRKLSAELAGNHNQELTPCRRTLSVNHLTSE
                     RDVLPPLLKTESIYLNGLTPHCAGEEIAVIENIK"
     exon            696..1006
                     /gene="KCNK2"
                     /gene_synonym="hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK;
                     TREK-1; TREK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1124
                     /gene="KCNK2"
                     /gene_synonym="hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK;
                     TREK-1; TREK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1285
                     /gene="KCNK2"
                     /gene_synonym="hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK;
                     TREK-1; TREK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1472
                     /gene="KCNK2"
                     /gene_synonym="hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK;
                     TREK-1; TREK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1612
                     /gene="KCNK2"
                     /gene_synonym="hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK;
                     TREK-1; TREK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..3875
                     /gene="KCNK2"
                     /gene_synonym="hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK;
                     TREK-1; TREK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3006..3011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK2"
                     /gene_synonym="hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK;
                     TREK-1; TREK1"
                     /note="hexamer: AATAAA"
     polyA_site      3032
                     /gene="KCNK2"
                     /gene_synonym="hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK;
                     TREK-1; TREK1"
     regulatory      3853..3858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK2"
                     /gene_synonym="hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK;
                     TREK-1; TREK1"
                     /note="hexamer: AATAAA"
     polyA_site      3875
                     /gene="KCNK2"
                     /gene_synonym="hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK;
                     TREK-1; TREK1"
                     /note="major polyA site"
ORIGIN      
        1 aaacgagccg gcaaggggcg acaggagcga gccgggaagg gagagcagcg gagggctgca
       61 gagctgcggg cgcccggacc gtgccacaca ccccccgcgg ggcacggagg gcattgcggg
      121 gggagacaca caaagacatg cgaagagggg ctgaacgagg ctcgcgcaca aagacgccgg
      181 ggcgcacggc agctggggct gcacccaccg cccccgcgcc gcgccgtgcc ggggccgggc
      241 cagcgagcag cccggggctg agcgcgtggc ggcggcggcg gcggcggcgg cggcgggcag
      301 gcgcgggacc cgggtcgccc gcgctctccg ggtgacccgg gcccggcagc aggcgcgcgc
      361 gggggcggcg gcgcccaagc ccaacttggc ctccgcctcg ccctctgccc agcccgccgg
      421 tgtcccctcc ttcccgcgat ttcgtttctt ctcacgctcc cccccccgcc ccctcccgcg
      481 tccagccccg ctctccccac cttgtaaaac aaagccgggg aaaatgcctg cccgtgcagc
      541 tcggagcgcg cagcccgtct ctgaataaga agtgagtaca atggcgtgtt tgtaaaaaaa
      601 agcttcaagt ccgtcttttt caaaaaacat tttgaatgct gcatgcctca tgcttcccag
      661 cgcctcgcgg gagagacccg gctatagagc aggagtggcg gcacctgact tgctggatcc
      721 taaatctgcc gctcagaact ccaaaccgag gctctcgttt tccacgaaac ccacagtgct
      781 tgcttcccgg gtggagagtg acacgaccat taatgttatg aaatggaaga cggtctccac
      841 gatattcctg gtggttgtcc tctatctgat catcggagcc accgtgttca aagcattgga
      901 gcagcctcat gagatttcac agaggaccac cattgtgatc cagaagcaaa cattcatatc
      961 ccaacattcc tgtgtcaatt cgacggagct ggatgaactc attcagcaaa tagtggcagc
     1021 aataaatgca gggattatac cgttaggaaa cacctccaat caaatcagtc actgggattt
     1081 gggaagttcc ttcttctttg ctggcactgt tattacaacc ataggatttg gaaacatctc
     1141 accacgcaca gaaggcggca aaatattctg tatcatctat gccttactgg gaattcccct
     1201 ctttggtttt ctcttggctg gagttggaga tcagctaggc accatatttg gaaaaggaat
     1261 tgccaaagtg gaagatacgt ttattaagtg gaatgttagt cagaccaaga ttcgcatcat
     1321 ctcaacaatc atatttatac tatttggctg tgtactcttt gtggctctgc ctgcgatcat
     1381 attcaaacac atagaaggct ggagtgccct ggacgccatt tattttgtgg ttatcactct
     1441 aacaactatt ggatttggtg actacgttgc aggtggatcc gatattgaat atctggactt
     1501 ctataagcct gtcgtgtggt tctggatcct tgtagggctt gcttactttg ctgctgtcct
     1561 gagcatgatt ggagattggc tccgagtgat atctaaaaag acaaaagaag aggtgggaga
     1621 gttcagagca cacgctgctg agtggacagc caacgtcaca gccgaattca aagaaaccag
     1681 gaggcgactg agtgtggaga tttatgacaa gttccagcgg gccacctcca tcaagcggaa
     1741 gctctcggca gaactggctg gaaaccacaa tcaggagctg actccttgta ggaggaccct
     1801 gtcagtgaac cacctgacca gcgagaggga tgtcttgcct cccttactga agactgagag
     1861 tatctatctg aatggtttga cgccacactg tgctggtgaa gagattgctg tgattgagaa
     1921 catcaaatag ccctctcttt aaataacctt aggcatagcc ataggtgagg acttctctat
     1981 gctctttatg actgttgctg gtagcatttt ttaaattgtg catgagctca aagggggaac
     2041 aaaatagata cacccatcat ggtcatctat catcaagaga atttggaatt ctgagccagc
     2101 actttctttc tgatgatgct tgttgaacgg tccactttct ttgatgagtg gaatgacaag
     2161 caatgtctga tgcctttttg tgcccagact gttttcctct ctctttccct aatgtgccat
     2221 aaggcctcag aatgaatgag aattgtttct ggtaacaatg tagctttgag ggatcagttc
     2281 ttaacttttc agggtctacc taactgagcc tagatatgga ccatttatgg atgacaacaa
     2341 tttttttttt gtaaatgaca agaaattctt atgcagcctt ttacctaaga aattttctgt
     2401 cagtgcctta tcttatgaag aaacagaacc tctctagcta atgtgtggtt tctccttccc
     2461 tgcccccacc cctaggctca cctctgcagt cttttacccc agttctccca tttgaatacc
     2521 ataccttgct ggaaacagtg tgtaaaatga ctgaagtgat gatgcccgaa gatgaaatag
     2581 atgccaaatt agatggacat tgaagcaaca ctcagcgttg cctagcgtta aaggcactgc
     2641 agagaaatga ggtgcagagg tggcccctct gagtatttat ttgactcagg taccagtggt
     2701 acatatatac agtgtaatta tgaccaggct ggtaaaattg gctgctcgca aacaatcccc
     2761 ttttttcctg gcagtatttg gaatttatca tttattaata actatacatt tttaaaggca
     2821 gaagaagaaa atctatctat ctatctatct atctatctat ctatctatct atctatctat
     2881 ctaaatgacc tgacagaaga aaactgttaa aaatggatat tattggaggg gatttaaaac
     2941 agtgggtgtg aattatcatt ctgatggaaa gaaaatagca aaacaatgtg ttacaagtat
     3001 ttgctaataa acagtatact gccagcttct aattgctttt tgatgtatga aaggcttata
     3061 taattttctt ttcgttgggt gacttttgcc agatgagagg aggtggcaca gtggtgagtg
     3121 cagggcacag tcctagcctt ctgtgggtat acttttggag ttgtgacttg gctgtgaggg
     3181 cagaagttga agttgggatc actgtgactt tgcacatgga aaaatgcaga ttgcaggcat
     3241 aattcatctc tgacattaga gaaaaagctg ttatagcaca atttaaattt tgagagtttg
     3301 ctgtgttttt ttttcacata aaagaggctg attattcttt ttagtttaat tttatatcct
     3361 gtaattcttt ggatggttcc aagattcaga aaaaattcag taaatgcacc ccgtaaattg
     3421 ctaccctttc ctttattttc atacttagat ctgctgtaca ttgtatatat atataatttt
     3481 taaaatgcag aaagaaaata atttccctaa atataattgc aaactgattt cttttacttt
     3541 tttgtgtgtg ggggtgggag ctgtatctga ataagtggca ttcagattag ggtcttgaaa
     3601 aataaaccca gaatctttaa aagaagcaaa taaactaata gacgcttatt ttccaaaatt
     3661 taaatttaag ctagaaatgt aaatattcaa ttaatttgtt aaaagtactt ttataaagtt
     3721 aaaaaaaatc caaccaaaat tttagaaagt caggctcttt tagaaagaaa gctacaccca
     3781 tttcctcaaa taactgttcc gaaaatttat atggtggaat gcgccatgta taaactgtga
     3841 attgtattga caaataaagt ttgtaattaa agtca
//
