LOCUS       NM_181840               1155 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens potassium two pore domain channel subfamily K member
            18 (KCNK18), mRNA.
ACCESSION   NM_181840
VERSION     NM_181840.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1155)
  AUTHORS   Majethia,P., Harish,R., Narayanan,D.L., B,L. Y, Sharma,S. and
            Shukla,A.
  TITLE     Further evidence of biallelic variants in KCNK18 as a cause of
            intellectual disability and epilepsy with febrile seizure plus
  JOURNAL   Clin Dysmorphol 32 (4), 147-150 (2023)
   PUBMED   37195340
  REMARK    GeneRIF: Further evidence of biallelic variants in KCNK18 as a
            cause of intellectual disability and epilepsy with febrile seizure
            plus.
REFERENCE   2  (bases 1 to 1155)
  AUTHORS   Pavinato,L., Nematian-Ardestani,E., Zonta,A., De Rubeis,S.,
            Buxbaum,J., Mancini,C., Bruselles,A., Tartaglia,M., Pessia,M.,
            Tucker,S.J., D'Adamo,M.C. and Brusco,A.
  TITLE     KCNK18 Biallelic Variants Associated with Intellectual Disability
            and Neurodevelopmental Disorders Alter TRESK Channel Activity
  JOURNAL   Int J Mol Sci 22 (11), 6064 (2021)
   PUBMED   34199759
  REMARK    GeneRIF: KCNK18 Biallelic Variants Associated with Intellectual
            Disability and Neurodevelopmental Disorders Alter TRESK Channel
            Activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1155)
  AUTHORS   Lengyel,M., Hajdu,D., Dobolyi,A., Rosta,J., Czirjak,G., Dux,M. and
            Enyedi,P.
  TITLE     TRESK background potassium channel modifies the TRPV1-mediated
            nociceptor excitability in sensory neurons
  JOURNAL   Cephalalgia 41 (7), 827-838 (2021)
   PUBMED   33525904
  REMARK    GeneRIF: TRESK background potassium channel modifies the
            TRPV1-mediated nociceptor excitability in sensory neurons.
REFERENCE   4  (bases 1 to 1155)
  AUTHORS   Andres-Bilbe,A., Castellanos,A., Pujol-Coma,A., Callejo,G.,
            Comes,N. and Gasull,X.
  TITLE     The Background K+ Channel TRESK in Sensory Physiology and Pain
  JOURNAL   Int J Mol Sci 21 (15), 5206 (2020)
   PUBMED   32717813
  REMARK    GeneRIF: The Background K(+) Channel TRESK in Sensory Physiology
            and Pain.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1155)
  AUTHORS   Imbrici,P., Nematian-Ardestani,E., Hasan,S., Pessia,M., Tucker,S.J.
            and D'Adamo,M.C.
  TITLE     Altered functional properties of a missense variant in the TRESK K+
            channel (KCNK18) associated with migraine and intellectual
            disability
  JOURNAL   Pflugers Arch 472 (7), 923-930 (2020)
   PUBMED   32394190
  REMARK    GeneRIF: Altered functional properties of a missense variant in the
            TRESK K(+) channel (KCNK18) associated with migraine and
            intellectual disability.
REFERENCE   6  (bases 1 to 1155)
  AUTHORS   Goldstein,S.A., Bayliss,D.A., Kim,D., Lesage,F., Plant,L.D. and
            Rajan,S.
  TITLE     International Union of Pharmacology. LV. Nomenclature and molecular
            relationships of two-P potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 527-540 (2005)
   PUBMED   16382106
  REMARK    Review article
REFERENCE   7  (bases 1 to 1155)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   8  (bases 1 to 1155)
  AUTHORS   Kang,D., Mariash,E. and Kim,D.
  TITLE     Functional expression of TRESK-2, a new member of the tandem-pore
            K+ channel family
  JOURNAL   J Biol Chem 279 (27), 28063-28070 (2004)
   PUBMED   15123670
  REMARK    GeneRIF: TRESK-2 is a functional member of the K(2P) channel family
            and contributes to the background K+ conductance in many types of
            cells [TRESK-2]
REFERENCE   9  (bases 1 to 1155)
  AUTHORS   Czirjak,G., Toth,Z.E. and Enyedi,P.
  TITLE     The two-pore domain K+ channel, TRESK, is activated by the
            cytoplasmic calcium signal through calcineurin
  JOURNAL   J Biol Chem 279 (18), 18550-18558 (2004)
   PUBMED   14981085
  REMARK    GeneRIF: TRESK is activated by increased cytoplasmic calcium
            concentration, calcineurin being involved in the regulation; Serine
            276 was identified as the major functional target of calcineurin in
            TRESK
REFERENCE   10 (bases 1 to 1155)
  AUTHORS   Sano,Y., Inamura,K., Miyake,A., Mochizuki,S., Kitada,C., Yokoi,H.,
            Nozawa,K., Okada,H., Matsushime,H. and Furuichi,K.
  TITLE     A novel two-pore domain K+ channel, TRESK, is localized in the
            spinal cord
  JOURNAL   J Biol Chem 278 (30), 27406-27412 (2003)
   PUBMED   12754259
  REMARK    GeneRIF: TRESK is a novel two-pore domain K+ channel that may set
            the resting membrane potential of cells in the spinal cord
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB087138.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Potassium channels play a role in many cellular processes
            including maintenance of the action potential, muscle contraction,
            hormone secretion, osmotic regulation, and ion flow. This gene
            encodes a member of the superfamily of potassium channel proteins
            containing two pore-forming P domains and the encoded protein
            functions as an outward rectifying potassium channel. A mutation in
            this gene has been found to be associated with migraine with
            aura.[provided by RefSeq, Jan 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB087138.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2145743,
                                           SAMEA2151119 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334549.1/ ENSP00000334650.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1155
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..1155
                     /gene="KCNK18"
                     /gene_synonym="K2p18.1; MGR13; TRESK; TRESK-2; TRESK2;
                     TRIK"
                     /note="potassium two pore domain channel subfamily K
                     member 18"
                     /db_xref="GeneID:338567"
                     /db_xref="HGNC:HGNC:19439"
                     /db_xref="MIM:613655"
     CDS             1..1155
                     /gene="KCNK18"
                     /gene_synonym="K2p18.1; MGR13; TRESK; TRESK-2; TRESK2;
                     TRIK"
                     /note="TWIK-related spinal cord K+ channel; TWIK-related
                     individual K+ channel; TWIK-related individual potassium
                     channel; TWIK-related spinal cord potassium channel;
                     potassium channel, subfamily K, member 18; potassium
                     channel, two pore domain subfamily K, member 18"
                     /codon_start=1
                     /product="potassium channel subfamily K member 18"
                     /protein_id="NP_862823.1"
                     /db_xref="CCDS:CCDS7598.1"
                     /db_xref="GeneID:338567"
                     /db_xref="HGNC:HGNC:19439"
                     /db_xref="MIM:613655"
                     /translation="MEVSGHPQARRCCPEALGKLFPGLCFLCFLVTYALVGAVVFSAI
                     EDGQVLVAADDGEFEKFLEELCRILNCSETVVEDRKQDLQGHLQKVKPQWFNRTTHWS
                     FLSSLFFCCTVFSTVGYGYIYPVTRLGKYLCMLYALFGIPLMFLVLTDTGDILATILS
                     TSYNRFRKFPFFTRPLLSKWCPKSLFKKKPDPKPADEAVPQIIISAEELPGPKLGTCP
                     SRPSCSMELFERSHALEKQNTLQLPPQAMERSNSCPELVLGRLSYSIISNLDEVGQQV
                     ERLDIPLPIIALIVFAYISCAAAILPFWETQLDFENAFYFCFVTLTTIGFGDTVLEHP
                     NFFLFFSIYIIVGMEIVFIAFKLVQNRLIDIYKNVMLFFAKGKFYHLVKK"
     exon            1..223
                     /gene="KCNK18"
                     /gene_synonym="K2p18.1; MGR13; TRESK; TRESK-2; TRESK2;
                     TRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            224..352
                     /gene="KCNK18"
                     /gene_synonym="K2p18.1; MGR13; TRESK; TRESK-2; TRESK2;
                     TRIK"
                     /inference="alignment:Splign:2.1.0"
     exon            353..1155
                     /gene="KCNK18"
                     /gene_synonym="K2p18.1; MGR13; TRESK; TRESK-2; TRESK2;
                     TRIK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggaggtct cggggcaccc ccaggccagg agatgctgcc cagaggccct gggaaagctc
       61 ttccctggcc tctgcttcct ctgctttctg gtgacctacg ccctggtggg tgctgtggtc
      121 ttctctgcca ttgaggacgg ccaggtcctg gtggcagcag atgatggaga gtttgagaag
      181 ttcttggagg agctctgcag aatcttgaac tgcagtgaaa cagtggtgga agacagaaaa
      241 caggatctcc aggggcatct gcagaaggtg aagcctcagt ggtttaacag gaccacacac
      301 tggtccttcc tgagctcgct ctttttctgc tgcacggtgt tcagcaccgt gggctatggc
      361 tacatctacc ccgtcaccag gcttggcaag tacttgtgca tgctctatgc tctctttggt
      421 atccccctga tgttcctcgt tctcacggac acaggcgaca tcctggcaac catcttatct
      481 acatcttata atcggttccg aaaattccct ttctttaccc gccccctcct ctccaagtgg
      541 tgccccaaat ctctcttcaa gaaaaaaccg gaccccaagc ccgcagatga agctgtccct
      601 cagatcatca tcagtgctga agagcttcca ggccccaaac ttggcacatg tccttcacgc
      661 ccaagctgca gcatggagct gtttgagaga tctcatgcgc tagagaaaca gaacacactg
      721 caactgcccc cacaagccat ggagaggagt aactcgtgtc ccgaactggt gttgggaaga
      781 ctctcatact ccatcatcag caacctggat gaagttggac agcaggtgga gaggttggac
      841 atccccctcc ccatcattgc ccttattgtt tttgcctaca tttcctgtgc agctgccatc
      901 ctccccttct gggagacaca gttggatttc gagaatgcct tctatttctg ctttgtcaca
      961 ctcaccacca ttgggtttgg ggatactgtt ttagaacacc ctaacttctt cctgttcttc
     1021 tccatttata tcatcgttgg aatggagatt gtgttcattg ctttcaagtt ggtgcaaaac
     1081 aggctgattg acatatacaa aaatgttatg ctattctttg caaaagggaa gttttaccac
     1141 cttgttaaaa agtga
//
