LOCUS       NM_031460               1524 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens potassium two pore domain channel subfamily K member
            17 (KCNK17), transcript variant 1, mRNA.
ACCESSION   NM_031460 NM_033094
VERSION     NM_031460.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1524)
  AUTHORS   Neelsen,L.C., Riel,E.B., Rinne,S., Schmid,F.R., Jurs,B.C.,
            Bedoya,M., Langer,J.P., Eymsh,B., Kiper,A.K., Cordeiro,S.,
            Decher,N., Baukrowitz,T. and Schewe,M.
  TITLE     Ion occupancy of the selectivity filter controls opening of a
            cytoplasmic gate in the K2P channel TALK-2
  JOURNAL   Nat Commun 15 (1), 7545 (2024)
   PUBMED   39215031
  REMARK    GeneRIF: Ion occupancy of the selectivity filter controls opening
            of a cytoplasmic gate in the K2P channel TALK-2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1524)
  AUTHORS   Khoubza,L., Gilbert,N., Kim,E.J., Chatelain,F.C., Feliciangeli,S.,
            Abelanet,S., Kang,D., Lesage,F. and Bichet,D.
  TITLE     Alkaline-sensitive two-pore domain potassium channels form
            functional heteromers in pancreatic beta-cells
  JOURNAL   J Biol Chem 298 (10), 102447 (2022)
   PUBMED   36063992
REFERENCE   3  (bases 1 to 1524)
  AUTHORS   Chai,S., Wan,X., Ramirez-Navarro,A., Tesar,P.J., Kaufman,E.S.,
            Ficker,E., George,A.L. Jr. and Deschenes,I.
  TITLE     Physiological genomics identifies genetic modifiers of long QT
            syndrome type 2 severity
  JOURNAL   J Clin Invest 128 (3), 1043-1056 (2018)
   PUBMED   29431731
  REMARK    GeneRIF: 2 novel gene variants in REM2 and KCNK17 that provide a
            physiologically plausible explanation for variable expressivity in
            a large subset of patients in a multigenerational long QT syndrome
            type 2 family
REFERENCE   4  (bases 1 to 1524)
  AUTHORS   Suzuki,Y., Tsutsumi,K., Miyamoto,T., Yamamura,H. and Imaizumi,Y.
  TITLE     Heterodimerization of two pore domain K+ channel TASK1 and TALK2 in
            living heterologous expression systems
  JOURNAL   PLoS One 12 (10), e0186252 (2017)
   PUBMED   29016681
  REMARK    GeneRIF: The results suggested that heterodimerization of TASK1 and
            TALK2 provides cells with the ability to make multiple responses to
            a variety of physiological and pharmacological stimuli.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1524)
  AUTHORS   Schewe,M., Nematian-Ardestani,E., Sun,H., Musinszki,M.,
            Cordeiro,S., Bucci,G., de Groot,B.L., Tucker,S.J., Rapedius,M. and
            Baukrowitz,T.
  TITLE     A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P
            K(+) Channels
  JOURNAL   Cell 164 (5), 937-949 (2016)
   PUBMED   26919430
REFERENCE   6  (bases 1 to 1524)
  AUTHORS   Gierten,J., Ficker,E., Bloehs,R., Schlomer,K., Kathofer,S.,
            Scholz,E., Zitron,E., Kiesecker,C., Bauer,A., Becker,R.,
            Katus,H.A., Karle,C.A. and Thomas,D.
  TITLE     Regulation of two-pore-domain (K2P) potassium leak channels by the
            tyrosine kinase inhibitor genistein
  JOURNAL   Br J Pharmacol 154 (8), 1680-1690 (2008)
   PUBMED   18516069
REFERENCE   7  (bases 1 to 1524)
  AUTHORS   Goldstein,S.A., Bayliss,D.A., Kim,D., Lesage,F., Plant,L.D. and
            Rajan,S.
  TITLE     International Union of Pharmacology. LV. Nomenclature and molecular
            relationships of two-P potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 527-540 (2005)
   PUBMED   16382106
  REMARK    Review article
REFERENCE   8  (bases 1 to 1524)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   9  (bases 1 to 1524)
  AUTHORS   Girard,C., Duprat,F., Terrenoire,C., Tinel,N., Fosset,M., Romey,G.,
            Lazdunski,M. and Lesage,F.
  TITLE     Genomic and functional characteristics of novel human pancreatic 2P
            domain K(+) channels
  JOURNAL   Biochem Biophys Res Commun 282 (1), 249-256 (2001)
   PUBMED   11263999
REFERENCE   10 (bases 1 to 1524)
  AUTHORS   Decher,N., Maier,M., Dittrich,W., Gassenhuber,J., Bruggemann,A.,
            Busch,A.E. and Steinmeyer,K.
  TITLE     Characterization of TASK-4, a novel member of the pH-sensitive,
            two-pore domain potassium channel family
  JOURNAL   FEBS Lett 492 (1-2), 84-89 (2001)
   PUBMED   11248242
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP317866.1, AF358910.1 and
            BC025726.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_031460.3.
            
            Summary: The protein encoded by this gene belongs to the family of
            potassium channel proteins containing two pore-forming P domains.
            This channel is an open rectifier which primarily passes outward
            current under physiological K+ concentrations. This gene is
            activated at alkaline pH. Alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Sep 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025726.1, AY358853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373231.9/ ENSP00000362328.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                BP317866.1         135-233
            100-1098            AF358910.1         1-999
            1099-1524           BC025726.1         1087-1512
FEATURES             Location/Qualifiers
     source          1..1524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..1524
                     /gene="KCNK17"
                     /gene_synonym="K2p17.1; TALK-2; TALK2; TASK-4; TASK4"
                     /note="potassium two pore domain channel subfamily K
                     member 17"
                     /db_xref="GeneID:89822"
                     /db_xref="HGNC:HGNC:14465"
                     /db_xref="MIM:607370"
     exon            1..336
                     /gene="KCNK17"
                     /gene_synonym="K2p17.1; TALK-2; TALK2; TASK-4; TASK4"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1098
                     /gene="KCNK17"
                     /gene_synonym="K2p17.1; TALK-2; TALK2; TASK-4; TASK4"
                     /note="isoform 1 is encoded by transcript variant 1; 2P
                     domain potassium channel Talk-2; TWIK-related alkaline
                     pH-activated K(+) channel 2; TWIK-related acid-sensitive
                     K(+) channel 4; acid-sensitive potassium channel protein
                     TASK-4; potassium channel, two pore domain subfamily K,
                     member 17; TWIK-related acid-sensitive K+ 4"
                     /codon_start=1
                     /product="potassium channel subfamily K member 17 isoform
                     1"
                     /protein_id="NP_113648.2"
                     /db_xref="CCDS:CCDS4842.1"
                     /db_xref="GeneID:89822"
                     /db_xref="HGNC:HGNC:14465"
                     /db_xref="MIM:607370"
                     /translation="MYRPRARAAPEGRVRGCAVPSTVLLLLAYLAYLALGTGVFWTLE
                     GRAAQDSSRSFQRDKWELLQNFTCLDRPALDSLIRDVVQAYKNGASLLSNTTSMGRWE
                     LVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVVLNRLGHLMQQGVN
                     HWASRLGGTWQDPDKARWLAGSGALLSGLLLFLLLPPLLFSHMEGWSYTEGFYFAFIT
                     LSTVGFGDYVIGMNPSQRYPLWYKNMVSLWILFGMAWLALIIKLILSQLETPGRVCSC
                     CHHSSKEDFKSQSWRQGPDREPESHSPQQGCYPEGPMGIIQHLEPSAHAAGCGKDS"
     exon            337..451
                     /gene="KCNK17"
                     /gene_synonym="K2p17.1; TALK-2; TALK2; TASK-4; TASK4"
                     /inference="alignment:Splign:2.1.0"
     exon            452..612
                     /gene="KCNK17"
                     /gene_synonym="K2p17.1; TALK-2; TALK2; TASK-4; TASK4"
                     /inference="alignment:Splign:2.1.0"
     exon            613..787
                     /gene="KCNK17"
                     /gene_synonym="K2p17.1; TALK-2; TALK2; TASK-4; TASK4"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1524
                     /gene="KCNK17"
                     /gene_synonym="K2p17.1; TALK-2; TALK2; TASK-4; TASK4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1500..1505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK17"
                     /gene_synonym="K2p17.1; TALK-2; TALK2; TASK-4; TASK4"
                     /note="hexamer: AATAAA"
     polyA_site      1524
                     /gene="KCNK17"
                     /gene_synonym="K2p17.1; TALK-2; TALK2; TASK-4; TASK4"
                     /note="major polyA site"
ORIGIN      
        1 aggcgtttgc gagaggagat acgagctgga cgcctggccc ttccctccca ccgggtccta
       61 gtccaccgct cccggcgccg gctccccgcc tctcccgcta tgtaccgacc gcgagcccgg
      121 gcggctcccg agggcagggt ccggggctgc gcggtgccca gcaccgtgct cctgctgctc
      181 gcctacctgg cttacctggc gctgggcacc ggcgtgttct ggacgctgga gggccgcgcg
      241 gcgcaggact ccagccgcag cttccagcgc gacaagtggg agctgttgca gaacttcacg
      301 tgtctggacc gcccggcgct ggactcgctg atccgggatg tcgtccaagc atacaaaaac
      361 ggagccagcc tcctcagcaa caccaccagc atggggcgct gggagctcgt gggctccttc
      421 ttcttttctg tgtccaccat caccaccatt ggctatggca acctgagccc caacacgatg
      481 gctgcccgcc tcttctgcat cttctttgcc cttgtgggga tcccactcaa cctcgtggtg
      541 ctcaaccgac tggggcatct catgcagcag ggagtaaacc actgggccag caggctgggg
      601 ggcacctggc aggatcctga caaggcgcgg tggctggcgg gctctggcgc cctcctctcg
      661 ggcctcctgc tcttcctgct gctgccaccg ctgctcttct cccacatgga gggctggagc
      721 tacacagagg gcttctactt cgccttcatc accctcagca ccgtgggctt cggcgactac
      781 gtgattggaa tgaacccctc ccagaggtac ccactgtggt acaagaacat ggtgtccctg
      841 tggatcctct ttgggatggc atggctggcc ttgatcatca aactcatcct ctcccagctg
      901 gagacgccag ggagggtatg ttcctgctgc caccacagct ctaaggaaga cttcaagtcc
      961 caaagctgga gacagggacc tgaccgggag ccagagtccc actccccaca gcaaggatgc
     1021 tatccagagg gacccatggg aatcatacag catctggaac cttctgctca cgctgcaggc
     1081 tgtggcaagg acagctagtt atactccatt ctttggtcgt cgtcctcggt agcaagaccc
     1141 ctgattttaa gctttgcaca tgtccaccca aactaaagac tacattttcc atccacccta
     1201 gaggctgggt gcagctatat gattaattct gcccaatagg gtatacagag acatgtcctg
     1261 ggtgacatgg gatgtgactt tcgggtgtcg gggcagcatg cccttctccc ccacttcctt
     1321 actttagcgg gctgcaatgc cgccgatatg atggctggga gctctggcag ccatacggca
     1381 ccatgaagta gcggcaatgt ttgagcggca caataagata ggaagagtct ggatctctga
     1441 tgatcacaga gccatcctaa caaacggaat atcacccgac ctcctttatg tgagagagaa
     1501 ataaacatct tatgtaaaat acca
//
