LOCUS       NM_001135105            1557 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens potassium two pore domain channel subfamily K member
            16 (KCNK16), transcript variant 1, mRNA.
ACCESSION   NM_001135105
VERSION     NM_001135105.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1557)
  AUTHORS   Khoubza,L., Gilbert,N., Kim,E.J., Chatelain,F.C., Feliciangeli,S.,
            Abelanet,S., Kang,D., Lesage,F. and Bichet,D.
  TITLE     Alkaline-sensitive two-pore domain potassium channels form
            functional heteromers in pancreatic beta-cells
  JOURNAL   J Biol Chem 298 (10), 102447 (2022)
   PUBMED   36063992
REFERENCE   2  (bases 1 to 1557)
  AUTHORS   Graff,S.M., Johnson,S.R., Leo,P.J., Dadi,P.K., Dickerson,M.T.,
            Nakhe,A.Y., McInerney-Leo,A.M., Marshall,M., Zaborska,K.E.,
            Schaub,C.M., Brown,M.A., Jacobson,D.A. and Duncan,E.L.
  TITLE     A KCNK16 mutation causing TALK-1 gain of function is associated
            with maturity-onset diabetes of the young
  JOURNAL   JCI Insight 6 (13), 138057 (2021)
   PUBMED   34032641
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1557)
  AUTHORS   Vierra,N.C., Dadi,P.K., Milian,S.C., Dickerson,M.T., Jordan,K.L.,
            Gilon,P. and Jacobson,D.A.
  TITLE     TALK-1 channels control beta cell endoplasmic reticulum Ca2+
            homeostasis
  JOURNAL   Sci Signal 10 (497) (2017)
   PUBMED   28928238
  REMARK    GeneRIF: data establish TALK-1 channels as key regulators of beta
            cell ER Ca(2+) and suggest that TALK-1 may be a therapeutic target
            to reduce ER Ca(2+) handling defects in beta cells during the
            pathogenesis of diabetes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1557)
  AUTHORS   Dickerson,M.T., Vierra,N.C., Milian,S.C., Dadi,P.K. and
            Jacobson,D.A.
  TITLE     Osteopontin activates the diabetes-associated potassium channel
            TALK-1 in pancreatic beta-cells
  JOURNAL   PLoS One 12 (4), e0175069 (2017)
   PUBMED   28403169
  REMARK    GeneRIF: The TALK-1/iOPN complex caused Vm hyperpolarization and
            reduced beta-cell glucose-stimulated Ca2+ influx, which is
            predicted to inhibit glucose stimulated insulin secretion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1557)
  AUTHORS   Schewe,M., Nematian-Ardestani,E., Sun,H., Musinszki,M.,
            Cordeiro,S., Bucci,G., de Groot,B.L., Tucker,S.J., Rapedius,M. and
            Baukrowitz,T.
  TITLE     A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P
            K(+) Channels
  JOURNAL   Cell 164 (5), 937-949 (2016)
   PUBMED   26919430
REFERENCE   6  (bases 1 to 1557)
  AUTHORS   Goldstein,S.A., Bayliss,D.A., Kim,D., Lesage,F., Plant,L.D. and
            Rajan,S.
  TITLE     International Union of Pharmacology. LV. Nomenclature and molecular
            relationships of two-P potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 527-540 (2005)
   PUBMED   16382106
  REMARK    Review article
REFERENCE   7  (bases 1 to 1557)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 1557)
  AUTHORS   Han,J., Kang,D. and Kim,D.
  TITLE     Functional properties of four splice variants of a human pancreatic
            tandem-pore K+ channel, TALK-1
  JOURNAL   Am J Physiol Cell Physiol 285 (3), C529-C538 (2003)
   PUBMED   12724142
  REMARK    GeneRIF: at least two functional TALK-1 variants are present and
            may serve as background K+ currents in certain cells of the human
            pancreas.
REFERENCE   9  (bases 1 to 1557)
  AUTHORS   Girard,C., Duprat,F., Terrenoire,C., Tinel,N., Fosset,M., Romey,G.,
            Lazdunski,M. and Lesage,F.
  TITLE     Genomic and functional characteristics of novel human pancreatic 2P
            domain K(+) channels
  JOURNAL   Biochem Biophys Res Commun 282 (1), 249-256 (2001)
   PUBMED   11263999
REFERENCE   10 (bases 1 to 1557)
  AUTHORS   Goldstein,S.A., Bockenhauer,D., O'Kelly,I. and Zilberberg,N.
  TITLE     Potassium leak channels and the KCNK family of two-P-domain
            subunits
  JOURNAL   Nat Rev Neurosci 2 (3), 175-184 (2001)
   PUBMED   11256078
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136087.12, CA843225.1,
            BC111860.1 and BP387644.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001135105.1.
            
            Summary: The protein encoded by this gene belongs to the family of
            potassium channel proteins containing two pore-forming P domains.
            This channel is an open rectifier which primarily passes outward
            current under physiological K+ concentrations. This gene is
            expressed predominantly in the pancreas and is activated at
            alkaline pH. Several alternatively spliced transcript variants
            encoding different isoforms have been identified for this gene.
            [provided by RefSeq, Sep 2008].
            
            Transcript Variant: This variant (1, also known as TALK-1c) encodes
            the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111860.1, AY253146.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2153347
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AL136087.12        75415-75562         c
            149-162             CA843225.1         1-14
            163-1434            BC111860.1         1-1272
            1435-1557           BP387644.1         93-215
FEATURES             Location/Qualifiers
     source          1..1557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..1557
                     /gene="KCNK16"
                     /gene_synonym="K2p16.1; TALK-1; TALK1"
                     /note="potassium two pore domain channel subfamily K
                     member 16"
                     /db_xref="GeneID:83795"
                     /db_xref="HGNC:HGNC:14464"
                     /db_xref="MIM:607369"
     exon            1..375
                     /gene="KCNK16"
                     /gene_synonym="K2p16.1; TALK-1; TALK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..1131
                     /gene="KCNK16"
                     /gene_synonym="K2p16.1; TALK-1; TALK1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TWIK-related alkaline pH-activated K(+) channel 1; 2P
                     domain potassium channel Talk-1; pancreatic potassium
                     channel Talk-1; potassium channel, subfamily K, member 16;
                     potassium channel, two pore domain subfamily K, member 16"
                     /codon_start=1
                     /product="potassium channel subfamily K member 16 isoform
                     1"
                     /protein_id="NP_001128577.1"
                     /db_xref="CCDS:CCDS47421.1"
                     /db_xref="GeneID:83795"
                     /db_xref="HGNC:HGNC:14464"
                     /db_xref="MIM:607369"
                     /translation="MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSR
                     DQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFA
                     GTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDR
                     PRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDY
                     VVGHPLNFITPSGLLPSQEPFQTPHGKPESQQIPGSFQKVSSMNVWPLSGMHSPGLAF
                     PLPDCNIPDQERFRPLHPGAWKFWPLPLPSSNSKWAPMWLGSSAQV"
     exon            376..490
                     /gene="KCNK16"
                     /gene_synonym="K2p16.1; TALK-1; TALK1"
                     /inference="alignment:Splign:2.1.0"
     exon            491..657
                     /gene="KCNK16"
                     /gene_synonym="K2p16.1; TALK-1; TALK1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..823
                     /gene="KCNK16"
                     /gene_synonym="K2p16.1; TALK-1; TALK1"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1557
                     /gene="KCNK16"
                     /gene_synonym="K2p16.1; TALK-1; TALK1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcactgttca aacagtctcc ccagcctcca gacacctgtg ccgaggagga gggcagggca
       61 ggcggcagcc tgggcacagg cccctaggtg cttactcctc acctgtttcc cacctctccc
      121 ccatagccag ccccacggcc ctggcagggt cctggccaca gcatgcccag tgctgggctc
      181 tgcagctgct ggggtggccg ggtgctgccc ctgctgctgg cctatgtctg ctacctgctg
      241 ctcggtgcca ctatcttcca gctgctagag aggcaggcgg aggctcagtc cagggaccag
      301 tttcagttgg agaagctgcg cttcctggag aactacacct gcctggacca gtgggccatg
      361 gagcagtttg tgcaggtcat catggaagcc tgggtgaaag gtgtgaaccc caaaggcaac
      421 tctaccaacc ccagcaactg ggactttggc agcagtttct tctttgcagg cacagtcgtc
      481 actaccatag gatatgggaa cctggcaccc agcacagagg caggtcaggt cttctgtgtc
      541 ttctatgccc tgttgggcat cccgcttaac gtgatcttcc tcaaccacct gggcacaggg
      601 ctgcgtgccc atctggccgc cattgaaaga tgggaggacc gtcccaggcg ctcccaggta
      661 ctgcaagtcc tgggcctggc tctgttcctg accctgggga cgctggtcat tctcatcttc
      721 ccacccatgg tcttcagcca tgtggagggc tggagcttca gcgagggctt ctactttgct
      781 ttcatcactc tcagcaccat tggctttggg gactatgttg ttggccaccc ccttaacttc
      841 atcactccct ctgggctcct gccttctcaa gagcctttcc aaacacccca tgggaagcca
      901 gagagccagc agatcccagg atccttccag aaagtgagct ccatgaacgt ctggcctctc
      961 tcaggaatgc attctccagg tctggccttt cccctgccag actgcaacat ccctgaccag
     1021 gagagattta gaccactcca tcccggggcc tggaaatttt ggcctttgcc tctcccatca
     1081 tccaacagca agtgggctcc tatgtggctg ggttcctctg cacaggtctg aggcaaggct
     1141 gtggagccaa ggcggctcca ggcaggagac ccaggagagg ctctacagca gcaagaggag
     1201 tccaagtcac accccaggac ttccccatat ccaagaaagg actgggaagc tgaggaccca
     1261 cggactcttc acacagccta gacgcttcct ccactccagg tagagggatt tcgggggcct
     1321 tctcagaagc aaggagtgga caagcctctt ggttaaggct cctcttacct cccaagctca
     1381 tggacaagtg gcaatcagct ggggtccctc ttttggggta caaaggaaag gacagaggtg
     1441 tgggagaccc aaggtggtct tgagattgac agacagcaag tccttggaga tagcccccga
     1501 gtccaagaac ttaggcaggg gccccaagac aataaagttg gtctctacta tctccta
//
