LOCUS       NM_022358               2514 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens potassium two pore domain channel subfamily K member
            15 (KCNK15), mRNA.
ACCESSION   NM_022358
VERSION     NM_022358.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2514)
  AUTHORS   Rinne,S., Schick,F., Vowinkel,K., Schutte,S., Krasel,C.,
            Kauferstein,S., Schafer,M.K., Kiper,A.K., Muller,T. and Decher,N.
  TITLE     Potassium channel TASK-5 forms functional heterodimers with TASK-1
            and TASK-3 to break its silence
  JOURNAL   Nat Commun 15 (1), 7548 (2024)
   PUBMED   39215006
  REMARK    GeneRIF: Potassium channel TASK-5 forms functional heterodimers
            with TASK-1 and TASK-3 to break its silence.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2514)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 2514)
  AUTHORS   Goldstein,S.A., Bayliss,D.A., Kim,D., Lesage,F., Plant,L.D. and
            Rajan,S.
  TITLE     International Union of Pharmacology. LV. Nomenclature and molecular
            relationships of two-P potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 527-540 (2005)
   PUBMED   16382106
  REMARK    Review article
REFERENCE   4  (bases 1 to 2514)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   5  (bases 1 to 2514)
  AUTHORS   Karschin,C., Wischmeyer,E., Preisig-Muller,R., Rajan,S., Derst,C.,
            Grzeschik,K.H., Daut,J. and Karschin,A.
  TITLE     Expression pattern in brain of TASK-1, TASK-3, and a tandem pore
            domain K(+) channel subunit, TASK-5, associated with the central
            auditory nervous system
  JOURNAL   Mol Cell Neurosci 18 (6), 632-648 (2001)
   PUBMED   11749039
REFERENCE   6  (bases 1 to 2514)
  AUTHORS   Ashmole,I., Goodwin,P.A. and Stanfield,P.R.
  TITLE     TASK-5, a novel member of the tandem pore K+ channel family
  JOURNAL   Pflugers Arch 442 (6), 828-833 (2001)
   PUBMED   11680614
REFERENCE   7  (bases 1 to 2514)
  AUTHORS   Vega-Saenz de Miera,E., Lau,D.H., Zhadina,M., Pountney,D.,
            Coetzee,W.A. and Rudy,B.
  TITLE     KT3.2 and KT3.3, two novel human two-pore K(+) channels closely
            related to TASK-1
  JOURNAL   J Neurophysiol 86 (1), 130-142 (2001)
   PUBMED   11431495
REFERENCE   8  (bases 1 to 2514)
  AUTHORS   Kim,D. and Gnatenco,C.
  TITLE     TASK-5, a new member of the tandem-pore K(+) channel family
  JOURNAL   Biochem Biophys Res Commun 284 (4), 923-930 (2001)
   PUBMED   11409881
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF257081.1, AF294351.1 and
            BC082981.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022358.3.
            
            Summary: This gene encodes one of the members of the superfamily of
            potassium channel proteins containing two pore-forming P domains.
            The product of this gene has not been shown to be a functional
            channel, however, it may require other non-pore-forming proteins
            for activity. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF257081.1, AF294350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372861.5/ ENSP00000361952.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AF257081.1         19-64
            47-1235             AF294351.1         1-1189
            1236-2514           BC082981.1         42-1320
FEATURES             Location/Qualifiers
     source          1..2514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..2514
                     /gene="KCNK15"
                     /gene_synonym="dJ781B1.1; K2p15.1; KCNK11; KCNK14; KT3.3;
                     TASK-5; TASK5"
                     /note="potassium two pore domain channel subfamily K
                     member 15"
                     /db_xref="GeneID:60598"
                     /db_xref="HGNC:HGNC:13814"
                     /db_xref="MIM:607368"
     exon            1..329
                     /gene="KCNK15"
                     /gene_synonym="dJ781B1.1; K2p15.1; KCNK11; KCNK14; KT3.3;
                     TASK-5; TASK5"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1039
                     /gene="KCNK15"
                     /gene_synonym="dJ781B1.1; K2p15.1; KCNK11; KCNK14; KT3.3;
                     TASK-5; TASK5"
                     /note="potassium channel, subfamily K, member 14; two pore
                     potassium channel KT3.3; two pore K(+) channel KT3.3;
                     TWIK-related acid-sensitive K(+) channel 5; acid-sensitive
                     potassium channel protein TASK-5; potassium channel, two
                     pore domain subfamily K, member 15; TWIK-related
                     acid-sensitive K+ 5"
                     /codon_start=1
                     /product="potassium channel subfamily K member 15"
                     /protein_id="NP_071753.2"
                     /db_xref="CCDS:CCDS13337.1"
                     /db_xref="GeneID:60598"
                     /db_xref="HGNC:HGNC:13814"
                     /db_xref="MIM:607368"
                     /translation="MRRPSVRAAGLVLCTLCYLLVGAAVFDALESEAESGRQRLLVQK
                     RGALRRKFGFSAEDYRELERLALQAEPHRAGRQWKFPGSFYFAITVITTIEYGHAAPG
                     TDSGKVFCMFYALLGIPLTLVTFQSLGERLNAVVRRLLLAAKCCLGLRWTCVSTENLV
                     VAGLLACAATLALGAVAFSHFEGWTFFHAYYYCFITLTTIGFGDFVALQSGEALQRKL
                     PYVAFSFLYILLGLTVIGAFLNLVVLRFLVASADWPERAARTPSPRPPGAPESRGLWL
                     PRRPARSVGSASVFCHVHKLERCARDNLGFSPPSSPGVVRGGQAPRLGARWKSI"
     exon            330..2514
                     /gene="KCNK15"
                     /gene_synonym="dJ781B1.1; K2p15.1; KCNK11; KCNK14; KT3.3;
                     TASK-5; TASK5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1211..1216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK15"
                     /gene_synonym="dJ781B1.1; K2p15.1; KCNK11; KCNK14; KT3.3;
                     TASK-5; TASK5"
                     /note="hexamer: ATTACA"
     polyA_site      1235
                     /gene="KCNK15"
                     /gene_synonym="dJ781B1.1; K2p15.1; KCNK11; KCNK14; KT3.3;
                     TASK-5; TASK5"
                     /note="major polyA site"
     regulatory      2491..2496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK15"
                     /gene_synonym="dJ781B1.1; K2p15.1; KCNK11; KCNK14; KT3.3;
                     TASK-5; TASK5"
                     /note="hexamer: AATAAA"
     regulatory      2495..2500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK15"
                     /gene_synonym="dJ781B1.1; K2p15.1; KCNK11; KCNK14; KT3.3;
                     TASK-5; TASK5"
                     /note="hexamer: AATAAA"
     polyA_site      2509
                     /gene="KCNK15"
                     /gene_synonym="dJ781B1.1; K2p15.1; KCNK11; KCNK14; KT3.3;
                     TASK-5; TASK5"
     polyA_site      2514
                     /gene="KCNK15"
                     /gene_synonym="dJ781B1.1; K2p15.1; KCNK11; KCNK14; KT3.3;
                     TASK-5; TASK5"
ORIGIN      
        1 acacggagca ggttgggacc gcggcgggta ccggggccgg ggcgccatgc ggaggccgag
       61 cgtgcgcgcg gccgggctgg tcctgtgcac cctgtgttac ctgctggtgg gcgctgctgt
      121 cttcgacgcg ctcgagtccg aggcggaaag cggccgccag cgactgctgg tccagaagcg
      181 gggcgctctc cggaggaagt tcggcttctc ggccgaggac taccgcgagc tggagcgcct
      241 ggcgctccag gctgagcccc accgcgccgg ccgccagtgg aagttccccg gctccttcta
      301 cttcgccatc accgtcatca ctaccatcga gtacggccac gccgcgccgg gtacggactc
      361 cggcaaggtc ttctgcatgt tctacgcgct cctgggcatc ccgctgacgc tggtcacttt
      421 ccagagcctg ggcgaacggc tgaacgcggt ggtgcggcgc ctcctgttgg cggccaagtg
      481 ctgcctgggc ctgcggtgga cgtgcgtgtc cacggagaac ctggtggtgg ccgggctgct
      541 ggcgtgtgcc gccaccctgg ccctcggggc cgtcgccttc tcgcacttcg agggctggac
      601 cttcttccac gcctactact actgcttcat caccctcacc accatcggct tcggcgactt
      661 cgtggcactg cagagcggcg aggcgctgca gaggaagctc ccctacgtgg ccttcagctt
      721 cctctacatc ctcctggggc tcacggtcat tggcgccttc ctcaacctgg tggtcctgcg
      781 cttcctcgtt gccagcgccg actggcccga gcgcgctgcc cgcaccccca gcccgcgccc
      841 cccgggggcg cccgagagcc gtggcctctg gctgccccgc cgcccggccc gctccgtggg
      901 ctccgcctct gtcttctgcc acgtgcacaa gctggagagg tgcgcccgcg acaacctggg
      961 cttttcgccc ccctcgagcc cgggggtcgt gcgtggcggg caggctccca ggcttggggc
     1021 ccggtggaag tccatctgac aaccccaccc aggccagggt cgaatctgga atgggagggt
     1081 ctggcttcag ctatcagggc accctcccca gggattggaa acggatgacg ggcctctagg
     1141 cggtcttctg ccacgagcag tttctcatta ctgtctgtgg ctaagtcccc tccctccttt
     1201 ccaaaaatat attacagtca caccataagc acaaaccagg ctccagggtc accctgtagg
     1261 agcaaattcc ttgtagtcca aattgtatga gggcgtggcc acatcagcac ttaggagagg
     1321 ctctgcacag gtccacctca gagccgaccc tccagagcaa cttttctgtt gtgaagaggc
     1381 tggttttctg agtaacggtt gaaatgtgca actttcaaca ctggaatctt cgctgcaatt
     1441 agtgaggtca gatgctcaca ctacgagaag catggggaac aaaggtggac caaatgggac
     1501 cgtgtacagt ccagtgttga caagggggtc aatctcttgc gctaaacgat ctcattctct
     1561 gcccagtgta tagagtggaa tcagcccatg tgtgaatgat ggcctctttc ccccagacag
     1621 ctgatgctct ttgtccctgg ccagccccac ttcaggatga gggaggcctt gctgtcaccc
     1681 acccaccatg tcactggggc cacttggaca cagcagaatg ccatgggacg agctctcttc
     1741 cgggtcctgt caatcaccag caatatgacc ttggagaatc gcatcctctc ccagggcctc
     1801 agtttccaca tctgtagaat gacggggttc atccagaacc ctgctccctc ttacgcatct
     1861 ctggcaggac tttctggaac aggcccctgc accataaggg ggcagagaca aagcccgagg
     1921 tgtggcatcc tggcaccccg tggcactcag ccacttcccc tggcttccca gatagggctg
     1981 tctcaacaca aagcatgaac gagccaggtt agaaaagcca aaaactttaa tttcaacatg
     2041 agctacatgg tcatgaacac aatgcaacgc gaccccactc caacccaagg gccccagaaa
     2101 ccctccctcc ctaaaggcct gggcggctgc tgctccaaga gagggaatga gggaaaggtg
     2161 ggtggatgga gagaggcccc cagcctaagg acccaggctc ctgccttccc accacccgtc
     2221 caggaagcag tcataaagtg aaagggctcc agaggtgatg ctcacagccc tgggttcggc
     2281 tccattctga cctccctgaa gcgctgggtt agacgggcac catcagccca cctcacaggc
     2341 tcggcgtcgg gtgagctcgt ggacgctaat gctttctgtc cactctgagg tgctgctcca
     2401 gatgtggggc cctcccagag ggcctcggag acaccatagg ggaacaggga gaggggctcg
     2461 gtccctgggc ctgacacagc actgctgctc aataaataaa tgcaggtgac cttg
//
