LOCUS       NM_022054               2289 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens potassium two pore domain channel subfamily K member
            13 (KCNK13), mRNA.
ACCESSION   NM_022054
VERSION     NM_022054.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2289)
  AUTHORS   Tateyama,M. and Kubo,Y.
  TITLE     Regulation of the two-pore domain potassium channel, THIK-1 and
            THIK-2, by G protein coupled receptors
  JOURNAL   PLoS One 18 (4), e0284962 (2023)
   PUBMED   37099539
  REMARK    GeneRIF: Regulation of the two-pore domain potassium channel,
            THIK-1 and THIK-2, by G protein coupled receptors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2289)
  AUTHORS   Sakamaki,K., Ishii,T.M., Sakata,T., Takemoto,K., Takagi,C.,
            Takeuchi,A., Morishita,R., Takahashi,H., Nozawa,A., Shinoda,H.,
            Chiba,K., Sugimoto,H., Saito,A., Tamate,S., Satou,Y., Jung,S.K.,
            Matsuoka,S., Koyamada,K., Sawasaki,T., Nagai,T. and Ueno,N.
  TITLE     Dysregulation of a potassium channel, THIK-1, targeted by caspase-8
            accelerates cell shrinkage
  JOURNAL   Biochim Biophys Acta 1863 (11), 2766-2783 (2016)
   PUBMED   27566292
  REMARK    GeneRIF: Dysregulation of a potassium channel, THIK-1, targeted by
            caspase-8, accelerates cell shrinkage.
REFERENCE   3  (bases 1 to 2289)
  AUTHORS   Blin,S., Chatelain,F.C., Feliciangeli,S., Kang,D., Lesage,F. and
            Bichet,D.
  TITLE     Tandem pore domain halothane-inhibited K+ channel subunits THIK1
            and THIK2 assemble and form active channels
  JOURNAL   J Biol Chem 289 (41), 28202-28212 (2014)
   PUBMED   25148687
  REMARK    GeneRIF: In cell and tissues co-expressing THIK1 and THIK2,
            heterodimeric channels may contribute to cell excitability.
REFERENCE   4  (bases 1 to 2289)
  AUTHORS   Chatelain,F.C., Bichet,D., Feliciangeli,S., Larroque,M.M.,
            Braud,V.M., Douguet,D. and Lesage,F.
  TITLE     Silencing of the tandem pore domain halothane-inhibited K+ channel
            2 (THIK2) relies on combined intracellular retention and low
            intrinsic activity at the plasma membrane
  JOURNAL   J Biol Chem 288 (49), 35081-35092 (2013)
   PUBMED   24163367
REFERENCE   5  (bases 1 to 2289)
  AUTHORS   Wojczynski,M.K., Li,M., Bielak,L.F., Kerr,K.F., Reiner,A.P.,
            Wong,N.D., Yanek,L.R., Qu,L., White,C.C., Lange,L.A.,
            Ferguson,J.F., He,J., Young,T., Mosley,T.H., Smith,J.A., Kral,B.G.,
            Guo,X., Wong,Q., Ganesh,S.K., Heckbert,S.R., Griswold,M.E.,
            O'Leary,D.H., Budoff,M., Carr,J.J., Taylor,H.A. Jr., Bluemke,D.A.,
            Demissie,S., Hwang,S.J., Paltoo,D.N., Polak,J.F., Psaty,B.M.,
            Becker,D.M., Province,M.A., Post,W.S., O'Donnell,C.J., Wilson,J.G.,
            Harris,T.B., Kavousi,M., Cupples,L.A., Rotter,J.I., Fornage,M.,
            Becker,L.C., Peyser,P.A., Borecki,I.B. and Reilly,M.P.
  TITLE     Genetics of coronary artery calcification among African Americans,
            a meta-analysis
  JOURNAL   BMC Med Genet 14, 75 (2013)
   PUBMED   23870195
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2289)
  AUTHORS   Theilig,F., Goranova,I., Hirsch,J.R., Wieske,M., Unsal,S.,
            Bachmann,S., Veh,R.W. and Derst,C.
  TITLE     Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1)
            K channels in the mammalian kidney
  JOURNAL   Cell Physiol Biochem 21 (1-3), 63-74 (2008)
   PUBMED   18209473
  REMARK    GeneRIF: THIK-1 and THIK-2 are abundantly expressed in the proximal
            and distal nephron of the mammalian kidney.
REFERENCE   7  (bases 1 to 2289)
  AUTHORS   Fearon,I.M., Campanucci,V.A., Brown,S.T., Hudasek,K., O'Kelly,I.M.
            and Nurse,C.A.
  TITLE     Acute hypoxic regulation of recombinant THIK-1 stably expressed in
            HEK293 cells
  JOURNAL   Adv Exp Med Biol 580, 203-8 (2006)
   PUBMED   16683720
  REMARK    GeneRIF: expression in cell hypoxia
REFERENCE   8  (bases 1 to 2289)
  AUTHORS   Goldstein,S.A., Bayliss,D.A., Kim,D., Lesage,F., Plant,L.D. and
            Rajan,S.
  TITLE     International Union of Pharmacology. LV. Nomenclature and molecular
            relationships of two-P potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 527-540 (2005)
   PUBMED   16382106
  REMARK    Review article
REFERENCE   9  (bases 1 to 2289)
  AUTHORS   Rajan,S., Wischmeyer,E., Karschin,C., Preisig-Muller,R.,
            Grzeschik,K.H., Daut,J., Karschin,A. and Derst,C.
  TITLE     THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+
            channels
  JOURNAL   J Biol Chem 276 (10), 7302-7311 (2001)
   PUBMED   11060316
REFERENCE   10 (bases 1 to 2289)
  AUTHORS   Goldstein,S.A., Bockenhauer,D., O'Kelly,I. and Zilberberg,N.
  TITLE     Potassium leak channels and the KCNK family of two-P-domain
            subunits
  JOURNAL   Nat Rev Neurosci 2 (3), 175-184 (2001)
   PUBMED   11256078
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC012779.2, EU978942.1 and
            AW117567.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022054.3.
            
            Summary: Potassium channels represent the most complex class of
            voltage-gated ion channels from both functional and structural
            standpoints. Their diverse functions include regulating
            neurotransmitter release, heart rate, insulin secretion, neuronal
            excitability, epithelial electrolyte transport, smooth muscle
            contraction, and cell volume. This gene encodes a potassium channel
            containing two pore-forming domains. This protein is an open
            channel that can be stimulated by arachidonic acid and inhibited by
            the anesthetic halothane. [provided by RefSeq, Jul 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012779.2, SRR1660807.150449.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282146.5/ ENSP00000282146.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1448              BC012779.2         230-1677
            1449-1762           EU978942.1         1420-1733
            1763-2131           BC012779.2         1992-2360
            2132-2261           AW117567.1         32-161              c
            2262-2289           BC012779.2         2491-2518
FEATURES             Location/Qualifiers
     source          1..2289
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.11"
     gene            1..2289
                     /gene="KCNK13"
                     /gene_synonym="K2p13.1; THIK-1; THIK1"
                     /note="potassium two pore domain channel subfamily K
                     member 13"
                     /db_xref="GeneID:56659"
                     /db_xref="HGNC:HGNC:6275"
                     /db_xref="MIM:607367"
     exon            1..546
                     /gene="KCNK13"
                     /gene_synonym="K2p13.1; THIK-1; THIK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1439
                     /gene="KCNK13"
                     /gene_synonym="K2p13.1; THIK-1; THIK1"
                     /note="tandem pore domain potassium channel THIK-1;
                     K2P13.1 potassium channel; tandem pore domain
                     halothane-inhibited potassium channel 1; potassium
                     channel, subfamily K, member 13; potassium channel, two
                     pore domain subfamily K, member 13"
                     /codon_start=1
                     /product="potassium channel subfamily K member 13"
                     /protein_id="NP_071337.2"
                     /db_xref="CCDS:CCDS9889.1"
                     /db_xref="GeneID:56659"
                     /db_xref="HGNC:HGNC:6275"
                     /db_xref="MIM:607367"
                     /translation="MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELA
                     HERQAKQRWEERLANFSRGHNLSRDELRGFLRHYEEATRAGIRVDNVRPRWDFTGAFY
                     FVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCSSTILFFNLFLERLITIIAYIMKSC
                     HQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTP
                     IEGWSYFDSLYFCFVAFSTIGFGDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLF
                     NVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVRNRCNISIETDGVAE
                     SDTDGRRLSGEMISMKDLLAANKASLAILQKQLSEMANGCPHQTSTLARDNEFSGGVG
                     AFAIMNNRLAETSGDR"
     exon            547..2289
                     /gene="KCNK13"
                     /gene_synonym="K2p13.1; THIK-1; THIK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2269..2274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK13"
                     /gene_synonym="K2p13.1; THIK-1; THIK1"
                     /note="hexamer: AATAAA"
     polyA_site      2289
                     /gene="KCNK13"
                     /gene_synonym="K2p13.1; THIK-1; THIK1"
                     /note="major polyA site"
ORIGIN      
        1 gaggacgtgg ggagctggcg ccacaggagc taccgaggcg gcggccgggg gagcctcgcg
       61 gcctgcggga gagcccggcg gtcatgggcg agccggcggt ggggcgcccg ggagctggct
      121 gagcgccggg gcccttattt cccgggggtg tgggcgagac tccgccgacg cccggtgccg
      181 tgggcctggg ggctgccccc gggggcccgg ccatggctgg ccggggtttc agctggggcc
      241 cgggccacct gaacgaggac aacgcgcgct ttctgctgct ggccgcgctc atcgtgctct
      301 acctgctggg cggcgccgcc gtcttctccg cgctggagct ggcgcacgag cgccaggcca
      361 agcagcgctg ggaggagcgc ctggccaact tcagccgcgg ccacaacctg agccgcgacg
      421 agctgcgcgg cttcctccgc cactacgagg aggccactcg ggccggcatc cgcgtggaca
      481 acgtccgccc gcgctgggac ttcaccggcg ccttctactt cgtgggcacc gtcgtttcca
      541 ccatagggtt tgggatgaca actccggcga cagtaggagg aaaaatcttt ctgatctttt
      601 acggccttgt tgggtgttcc agcaccatct tgttcttcaa cctcttcctg gagcgcctga
      661 tcaccatcat cgcctacatc atgaagtcgt gccaccagcg gcagctccgg agacgagggg
      721 ccctgcccca ggagagcctg aaggatgcgg ggcagtgtga ggtggacagc ctggccggct
      781 ggaagccctc cgtgtactac gtcatgctga tcctatgcac agcctccatc ctcatctctt
      841 gctgcgcctc agccatgtac acccccattg aaggctggag ctactttgac tcactctact
      901 tctgttttgt ggctttcagc accattggct ttggggacct ggtcagcagc cagaacgccc
      961 actatgagag ccaaggcctc tatcgctttg ccaacttcgt cttcatcctc atgggtgtct
     1021 gctgcatcta ctccttgttc aatgtcatct ctatcctcat caaacagtcc ttgaactgga
     1081 tcctgaggaa aatggacagc gggtgctgcc cgcaatgcca gagaggactc ttgcgatcac
     1141 gcaggaacgt ggtgatgcca ggcagcgtcc ggaaccgctg caacatctcc atagagacag
     1201 acggggtggc agagagtgac acggacgggc gccggctctc aggggagatg atctccatga
     1261 aggacttgct ggcagccaac aaggcctcgt tggccatcct gcagaagcaa ctgtctgaga
     1321 tggccaacgg ctgcccccac cagaccagca cactggcccg ggacaatgaa ttctcagggg
     1381 gggtgggagc ctttgcaatc atgaacaaca ggttggcaga gaccagtggg gacaggtaga
     1441 agccaggagt ggatgctggg cagaggccag agtagaatgg aggatgattg ccgcccaggg
     1501 gacgagctca gccctgcgcc ttggctctgt tccttctggg agctgttccc gggagcctcc
     1561 gcaagcatct ttagaaatct gatctcggct ccaaccaaca gccaccttcc agggatgggg
     1621 ggcctgaagc ctcgatgctt gtctcctgat ccttattctt taagtctaaa ttcagtcttt
     1681 tcaaaacaaa tcacaaaagc agcattagac attgccttgt ttcattaatc ttgtttcaga
     1741 gctttagctg cctgaggaga taggttttcc ttaagccttg atttcctgaa gctctctctg
     1801 ttccttattt gggaacaaaa attgcgaaga ctcatctttc cctagaactc tgaatggatg
     1861 aatttttaaa agtggggaga atgtttgggg atgtgtctgg gctttctttt tgccaggctt
     1921 ccttcaaagc atacctgcca atggtgtctg catagggaaa atgtctgttg tactctttat
     1981 acctgtttct gttttttgtt gtccctttct ttttattttt aaggccttaa tgcctggctg
     2041 tggcgtctgt gagacctcaa tgtaataaga aaattaaatt cagcttcagg cctttaaact
     2101 gcagcaagat ggtggtgtag gggtgtggga cggggagaga ctcacttttg taactaaaga
     2161 acatagctta acattttccc tttgaatggt cacacagacc atttcatttt taccagggct
     2221 tggggaccca atgcaaagat gatgactatt taataaaatg gaaaatttaa taaatcctca
     2281 ttttattaa
//
