LOCUS       NM_138317               7530 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens potassium two pore domain channel subfamily K member
            10 (KCNK10), transcript variant 2, mRNA.
ACCESSION   NM_138317
VERSION     NM_138317.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7530)
  AUTHORS   Sorum,B., Docter,T., Panico,V., Rietmeijer,R.A. and Brohawn,S.G.
  TITLE     Tension activation of mechanosensitive two-pore domain K+ channels
            TRAAK, TREK-1, and TREK-2
  JOURNAL   Nat Commun 15 (1), 3142 (2024)
   PUBMED   38605031
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7530)
  AUTHORS   Kim,S.S., Park,J., Kim,E., Hwang,E.M. and Park,J.Y.
  TITLE     beta-COP Suppresses the Surface Expression of the TREK2
  JOURNAL   Cells 12 (11), 1500 (2023)
   PUBMED   37296621
  REMARK    GeneRIF: beta-COP Suppresses the Surface Expression of the TREK2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7530)
  AUTHORS   Conrad,L.J., Proks,P. and Tucker,S.J.
  TITLE     Effects of ionic strength on gating and permeation of TREK-2 K2P
            channels
  JOURNAL   PLoS One 16 (10), e0258275 (2021)
   PUBMED   34618865
  REMARK    GeneRIF: Effects of ionic strength on gating and permeation of
            TREK-2 K2P channels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7530)
  AUTHORS   Zhuo,R.G., Peng,P., Zheng,J.Q., Zhang,Y.L., Wen,L., Wei,X.L. and
            Ma,X.Y.
  TITLE     The glycine hinge of transmembrane segment 2 modulates the
            subcellular localization and gating properties in TREK channels
  JOURNAL   Biochem Biophys Res Commun 490 (3), 1125-1131 (2017)
   PUBMED   28676394
  REMARK    GeneRIF: The M2-glycine hinge controls the macroscopic currents of
            TREK1 channels.
REFERENCE   5  (bases 1 to 7530)
  AUTHORS   McClenaghan,C., Schewe,M., Aryal,P., Carpenter,E.P., Baukrowitz,T.
            and Tucker,S.J.
  TITLE     Polymodal activation of the TREK-2 K2P channel produces
            structurally distinct open states
  JOURNAL   J Gen Physiol 147 (6), 497-505 (2016)
   PUBMED   27241700
REFERENCE   6  (bases 1 to 7530)
  AUTHORS   Goldstein,S.A., Bayliss,D.A., Kim,D., Lesage,F., Plant,L.D. and
            Rajan,S.
  TITLE     International Union of Pharmacology. LV. Nomenclature and molecular
            relationships of two-P potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 527-540 (2005)
   PUBMED   16382106
  REMARK    Review article
REFERENCE   7  (bases 1 to 7530)
  AUTHORS   Gu,W., Schlichthorl,G., Hirsch,J.R., Engels,H., Karschin,C.,
            Karschin,A., Derst,C., Steinlein,O.K. and Daut,J.
  TITLE     Expression pattern and functional characteristics of two novel
            splice variants of the two-pore-domain potassium channel TREK-2
  JOURNAL   J Physiol 539 (Pt 3), 657-668 (2002)
   PUBMED   11897838
  REMARK    GeneRIF: Expression pattern and functional characteristics of two
            novel splice variants of the two-pore-domain potassium channel
            TREK-2.
REFERENCE   8  (bases 1 to 7530)
  AUTHORS   Goldstein,S.A., Bockenhauer,D., O'Kelly,I. and Zilberberg,N.
  TITLE     Potassium leak channels and the KCNK family of two-P-domain
            subunits
  JOURNAL   Nat Rev Neurosci 2 (3), 175-184 (2001)
   PUBMED   11256078
  REMARK    Review article
REFERENCE   9  (bases 1 to 7530)
  AUTHORS   Lesage,F., Terrenoire,C., Romey,G. and Lazdunski,M.
  TITLE     Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple
            regulations by polyunsaturated fatty acids, lysophospholipids, and
            Gs, Gi, and Gq protein-coupled receptors
  JOURNAL   J Biol Chem 275 (37), 28398-28405 (2000)
   PUBMED   10880510
REFERENCE   10 (bases 1 to 7530)
  AUTHORS   Bang,H., Kim,Y. and Kim,D.
  TITLE     TREK-2, a new member of the mechanosensitive tandem-pore K+ channel
            family
  JOURNAL   J Biol Chem 275 (23), 17412-17419 (2000)
   PUBMED   10747911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049834.3, AK313499.1,
            EU978939.1, AF279890.1, AL133279.7, AI693366.1 and U79244.1.
            
            On Jun 2, 2019 this sequence version replaced NM_138317.2.
            
            Summary: The protein encoded by this gene belongs to the family of
            potassium channel proteins containing two pore-forming P domains.
            This channel is an open rectifier which primarily passes outward
            current under physiological K+ concentrations, and is stimulated
            strongly by arachidonic acid and to a lesser degree by membrane
            stretching, intracellular acidification, and general anaesthetics.
            Several alternatively spliced transcript variants encoding
            different isoforms have been identified for this gene. [provided by
            RefSeq, Sep 2008].
            
            Transcript Variant: This variant (2, also known as TREK2 splice
            variant c) has a different 5' terminal exon compared to transcript
            variant 1, and encodes a slightly longer isoform (2) with a
            distinct N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.33356.1,
                                           SRR1803614.141814.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319231.10/ ENSP00000312811.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AL049834.3         27991-28010         c
            21-1145             AK313499.1         1-1125
            1146-2409           EU978939.1         799-2062
            2410-2742           AF279890.1         2398-2730
            2743-3675           AL133279.7         85446-86378         c
            3676-4221           AI693366.1         2-547               c
            4222-6666           AL133279.7         82455-84899         c
            6667-7530           U79244.1           1-864
FEATURES             Location/Qualifiers
     source          1..7530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q31.3"
     gene            1..7530
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /note="potassium two pore domain channel subfamily K
                     member 10"
                     /db_xref="GeneID:54207"
                     /db_xref="HGNC:HGNC:6273"
                     /db_xref="MIM:605873"
     exon            1..523
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             472..2103
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     outward rectifying potassium channel protein TREK-2; 2P
                     domain potassium channel TREK2; potassium channel TREK-2;
                     TWIK-related K+ channel 2; TREK-2 K(+) channel subunit;
                     protein phosphatase 1, regulatory subunit 97; potassium
                     channel, subfamily K, member 10; potassium channel, two
                     pore domain subfamily K, member 10"
                     /codon_start=1
                     /product="potassium channel subfamily K member 10 isoform
                     2"
                     /protein_id="NP_612190.1"
                     /db_xref="CCDS:CCDS9881.1"
                     /db_xref="GeneID:54207"
                     /db_xref="HGNC:HGNC:6273"
                     /db_xref="MIM:605873"
                     /translation="MKFPIETPRKQVNWDPKVAVPAAAPVCQPKSATNGQPPAPAPTP
                     TPRLSISSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPF
                     ESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLG
                     SAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKS
                     IARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVV
                     VTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKT
                     KEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAH
                     SLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIIN
                     KFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEEETEKMCNSDNSSTAM
                     LTDCIQQHAELENGMIPTDTKDREPENNSLLEDRN"
     exon            524..873
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            874..991
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1152
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1339
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1482
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..7530
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4200..4205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /note="hexamer: ATTAAA"
     polyA_site      4225
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /note="major polyA site"
     regulatory      7506..7511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /note="hexamer: AACAAA"
     polyA_site      7530
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /note="major polyA site"
ORIGIN      
        1 aagcgcgcgc ccgggagtgt gtgtgcgggt gtgtgtgtgc gggagtgtgt gcgcacacgc
       61 cttcgggggc tggagtgaca ctgcagtggg cttctccgta gccccagcct tcaggctgcg
      121 cagcccctaa cctgccggca ccgcttttgg gaagcagctt ggctcttcca tctccccaag
      181 ccttcctctc catcctttca tccacccctc gccgatctta ctttttcttt tacccacggg
      241 gccgcggccg gccaccccct ggccggtgca aacacccaag ccctctccag ttctccccca
      301 agctaatatt ttcccacctg tctttttctg gggttcctcc acgagccagt ccaaggctcc
      361 cccatcctcg gaaattgttt tgttggactg ctaaaccgag gcgtgtaaag cttgaggact
      421 ttattattat ttgggttctt ttcatttctt ccccttctgg gcaacgaagc aatgaaattt
      481 ccaatcgaga cgccaagaaa acaggtgaac tgggatccta aagtggccgt tcccgcagca
      541 gcaccggtgt gccagcccaa gagcgccact aacgggcaac ccccggctcc ggctccgact
      601 ccaactccgc gcctgtccat ttcctcccga gccacagtgg tagccaggat ggaaggcacc
      661 tcccaagggg gcttgcagac cgtcatgaag tggaagacgg tggttgccat ctttgtggtt
      721 gtggtggtct accttgtcac tggcggtctt gtcttccggg cattggagca gccctttgag
      781 agcagccaga agaataccat cgccttggag aaggcggaat tcctgcggga tcatgtctgt
      841 gtgagccccc aggagctgga gacgttgatc cagcatgctc ttgatgctga caatgcggga
      901 gtcagtccaa taggaaactc ttccaacaac agcagccact gggacctcgg cagtgccttt
      961 ttctttgctg gaactgtcat tacgaccata gggtatggga atattgctcc gagcactgaa
     1021 ggaggcaaaa tcttttgtat tttatatgcc atctttggaa ttccactctt tggtttctta
     1081 ttggctggaa ttggagacca acttggaacc atctttggga aaagcattgc aagagtggag
     1141 aaggtctttc gaaaaaagca agtgagtcag accaagatcc gggtcatctc aaccatcctg
     1201 ttcatcttgg ccggctgcat tgtgtttgtg acgatccctg ctgtcatctt taagtacatc
     1261 gagggctgga cggccttgga gtccatttac tttgtggtgg tcactctgac cacggtgggc
     1321 tttggtgatt ttgtggcagg gggaaacgct ggcatcaatt atcgggagtg gtataagccc
     1381 ctagtgtggt tttggatcct tgttggcctt gcctactttg cagctgtcct cagtatgatc
     1441 ggagattggc tacgggttct gtccaaaaag acaaaagaag aggtgggtga aatcaaggcc
     1501 catgcggcag agtggaaggc caatgtcacg gctgagttcc gggagacacg gcgaaggctc
     1561 agcgtggaga tccacgataa gctgcagcgg gcggccacca tccgcagcat ggagcgccgg
     1621 cggctgggcc tggaccagcg ggcccactca ctggacatgc tgtcccccga gaagcgctct
     1681 gtctttgctg ccctggacac cggccgcttc aaggcctcat cccaggagag catcaacaac
     1741 cggcccaaca acctgcgcct gaaggggccg gagcagctga acaagcatgg gcagggtgcg
     1801 tccgaggaca acatcatcaa caagttcggg tccacctcca gactcaccaa gaggaaaaac
     1861 aaggacctca aaaagacctt gcccgaggac gttcagaaaa tctacaagac cttccggaat
     1921 tactccctgg acgaggagaa gaaagaggag gagacggaaa agatgtgtaa ctcagacaac
     1981 tccagcacag ccatgctgac ggactgtatc cagcagcacg ctgagttgga gaacggaatg
     2041 atacccacgg acaccaaaga ccgggagccg gagaacaact cattacttga agacagaaac
     2101 taaatgtgaa ggacattggt cttggactga gcgttgtgtg tgtgtgtgtg tgtgttttta
     2161 atattcacac tgagacatgt gccttaaaca gactttttag tccaaaatta catagcattg
     2221 aagaatatat ttcactgtgc cataaacaac tgaaagcttg ctctgccaaa aggaatcaga
     2281 gaacaagaac ttcatttcag atagcaaacg caggacacac caagagtgtc cgtgcacgta
     2341 gccggttctg gccgtacatg ttaagggcat ttcagtggca gtgctgtacc cctgggcagt
     2401 gctacctggg cacacacgta gacaagggca gctattcctt agaccagcct cctgaaagaa
     2461 acaggtgtgt ctttttagtg gagtcgtagt aatatgtgca cacacagaag gggacctgat
     2521 tgggtgggag ctggttatgt gtaactagcg ttggagttga cattttggca tgtgctctga
     2581 gcttgaattt tgataccaac cattcagtgc atcataccta gtctttctat gctccaaatg
     2641 aatgtctgtg gggacctgag agcacctgga atttgttgga agcagatcag agcacacgta
     2701 cgaaaaggtg caattgcttt tctcatgaca aaagaaaaaa aataatcaca aacacatcac
     2761 actgtggata tcaccttaac caatgacaga agcctgctga gtttggtctt tctcacaggg
     2821 gtaggtagtc cacatgaact ggcgagcagt ggtgaaaaca tgacatcaac tgctgcgtgg
     2881 ttaaaggcca atcatgcatt ttcctcagtg ggtgcaatgg tgacaataaa ctgatttgga
     2941 aatgtccatg tactttggtt ataacttgtt ttgataagag gggtagaaat accaaaacaa
     3001 ttgccttgca tgatgccagt ggcttgctgt tctgtctagc tgatcctaca tttttacaaa
     3061 agtagacatc ctgcatttct gagacacact gaggaggacc atggcatctt tccatctcag
     3121 ggctttttgt cccttgggtg tcttagggta gacatagtga taagatccaa tctcgctatc
     3181 tccaaacaaa aagaaaatgt accccttgta cagtaagctt gaaatgtttt tattgcttgc
     3241 agcgtaagtg ccattaattc catttaacaa tgatacttag aaatatttaa aatatttcat
     3301 tttactttta tgtttgggca ttcctttatt ctgaaaaagt caccactgct ccttgcttgt
     3361 ttctacatct cacatcggtt actcactaaa actggaacac cctagactga ttgttcccag
     3421 gcaaacgata agctaacaca tcataattat gattggtctg tgaggctaga acatcccgca
     3481 gaggaaagtc ggggaatggc tagtcatagg ttgcatgatg attttaaatg ggtttgtatc
     3541 agaaagggga aaatacatac tcctgtgtat gcctcagtct ttatcataat tggctggttc
     3601 acagctagct ctttgggcca cacgtgaaag catttggacc tggcaacacc aggcagttgc
     3661 tggttatggg tgttctaggc tcactgctac cttttacaga gttcacggga ttttacgtaa
     3721 ctaacccgca gtgtggattt accaaaagat cacagcacta gcggagactt ccagaaactg
     3781 tctcatgctt tctgacctcc agggaaagtt gtacccacga catcctcaac cactggtacc
     3841 atggaagacc tgtccctgcc catttctcaa aaatgcacag ctcttccctg cctggagcac
     3901 atgaagtccc atctccctgt ccccagacct ttaggctctg ttgaagttct ggcattgctt
     3961 atgagaccct tcctgtccaa ggaaggtcta agtcaactcc tccattggac tggagatgag
     4021 gctcactggt gacatcctgt gtcgactcag taataaatag tcacttggga ggcgatgttt
     4081 atgcaggtgt ggatgttgag ttttactatg ggaatcattc cagcctgaca aaatgtgttt
     4141 taaggaatag gtagataact gggacttcct ctgttattct aacaagtcga agcttcctaa
     4201 ttaaactgtc catggatctc acttatttgg tttccactct gtgttatctg gtacgttctt
     4261 tgtagcagtg tgttaaaatt ccaggcccta cggccaaatc tggcagaggc ttccctctca
     4321 tttatccagt gccttctgtg ggccaggcac aggattaggc actttatgaa cgtcagctca
     4381 ttgaaacttc acgacactat gtgggaagta tttgcaaacc cattatatac acaaggacac
     4441 agaggctcag ggaagctatg ttatttatcc aatggcacac agcaagaaag tggtagagct
     4501 ggtattcaaa gtctgaccaa agtctgcttt caacttcact acagtgtctg tgtcatgcat
     4561 ccttgtgatt gtgtgtgttt gtgtgtatgt gtgtctttct agcttcatgg acacagctta
     4621 cagatgtggg gagcagatat ggtggaatct ccaccaccaa gagggcacaa ggtctttgtg
     4681 taaacatggc tcaaagggtt gcccctgcag acacctactg tacatttatt tggttttgga
     4741 aattttgtat gtggcaccct ttaaaaaatg ccctttgaaa gcactctttt gcactttact
     4801 tgctaacttt gtagaaactc tgcatacagc aggaataaaa tagttcaaag cactaagctg
     4861 catactctac caaatggaac aggtgcatgt gttggtatgt gcatagatgc ttccccaaat
     4921 gagtcaaatc agtcacacag agggatcaaa cataaccttg ggctgggggt gggaaaattt
     4981 tctacataac ccattccctg agacatttgg ccaagaatgt gatgaacaaa atcaaagaag
     5041 atcctctatg gtgattgatc gattaaatat gtgtgcaaag tgtttagaaa cctatgaaat
     5101 actctcgcaa agatgctgag agagaataag aggttggatt cctcttcata taaactaatt
     5161 ttggaggagg ccagttggtt tgaagttact tgaatgttac cttttttaga tggggccaaa
     5221 tggcatgtag aatacacgtg ataggtcaaa gctgctacac attctataca tgcatcagca
     5281 cagccccccc tttccaatct gcactcccat tccagcataa acctaggaga aatgtttcga
     5341 tttcacacaa agaaagagca cacgtccacc atcttcagtg ggggctgtct tttgcttcac
     5401 tggcaagcag gcactgaatt tttcttgcat gacaaatctg gaggtttact ggtgagagag
     5461 ccaatgggca ttttttcctg gaaagagtac agctccatac ccagtcctaa cccaacagtg
     5521 atatttatca ctttggggca gggctgtata gagtgtgtgt gtgtgtgtgt gtgtgtgtgt
     5581 gtgtgtgtgt gtgtgtgtgt gcgggttggg gtggtgttgg gccatctctg gcctgttact
     5641 aaggtaacta ggactatttg tgttccagca gtcatagcct gtgattgtgg gtgcatcagt
     5701 tctctgccta gatctcttgt taccttgtct gcacatcaag ggagggagtt gagcacagat
     5761 acttgtcaag ggccattgta gttgtgcagt tctctaatga aacactccct agtccatgag
     5821 ttcacaaaat ttattaagat taaattataa gttggatttg tgaataatga ctaattaatt
     5881 gtcttgccca ttttaggtta aggtgagagc ttagtctctt gccctttggg atttgtcttt
     5941 tgggggatta atggagacca gatgtacttg ggagactggt gtccaaattc ggatcatgcc
     6001 ctgtgtaggc tctctctatc ctcccttata gctctttagt gtactgtcac cgggagggct
     6061 catgctgtga gggcattttt tgcatggtgt taagactagt taaagaaatt ttaagctgtt
     6121 gttatttgca gtcaattgta gtacttcatg tatcatgaat tcaagtacta tgatcagaca
     6181 gacatctctc tctctctcac acacacacac acacacacac acgcacacat acacacacac
     6241 acacacacct gaggaaatgg ctgctttggg ttctataagg accattccat gtttaaagtc
     6301 ctagttgagc tgaatgctaa gaacctgccc ccttgcctcc ctctgagatg atatcatttc
     6361 ctggcttcgt caatgctgcc tgtctatttg catgctgggt tctgaggact agtgagaagg
     6421 tgaccagagt ttgggtgggg ctggttttta cccactggat ttggtgagaa tatgaagcat
     6481 ccagtgtgta ccagggtttc tgaaccacgg gaaaggcgta ggaaaacaaa cattcagagc
     6541 ccctgtaaaa cgagaaagga aaaaccagcc agtgttgcat tccacatctc tgcttgttgc
     6601 attttgctaa tatggggtta ttctttctca ctgttaggat gcaattgtgt gcaaagacag
     6661 tggctgagtg aacagtaaga gctggctagt aatggcctta aaaagaaaaa gggtaactct
     6721 ctgaaacaaa gatcacttta gtgtggcatt gtggatgctg ttaattctgc atagggaaac
     6781 tttggaacag catgctaatt acatggctgt aagcaaagcc ctgtcctctg tctctgcacc
     6841 ataccttcat tggacttcac caacccatcc atactccatg taaacctcag ttctctcatg
     6901 cctgccctaa gtcagttgac atcagtgcag tggcattgag gagaaatgag aggtgtctct
     6961 gattttactg aaagttatta tcattttcac aggtgcctga gatttggtat ctactttgtg
     7021 ttcttgattc ttaggtgaaa aatctgaaat agttccctgt gcattaaaat aaattatttt
     7081 gagaggactc ctgctccgtc gattcagcag acctatgctg cagaaggtaa ctgcggaagc
     7141 tctcttttgc tgtcagggct ctgagcttga agggagaagg tgcagtggtg cctagaagtg
     7201 atatgcaaac cacctcacat gccagcctct ggcctccttc ccatcccaga gtcacagaca
     7261 ggggacccag tgacaatgat gataaatcca tgtgtggagg tgttttactt atttttcttt
     7321 ccgtaggatt tcatggtgct ttaaaaaaaa aggcatttta cagaaaataa tgtgggggga
     7381 gggagatttc ataatgttct tagggaaagt acaaaacaaa tttgcttgtg acatttcaat
     7441 aagctgtgct gctattgtct ttatttgatg atgtaatttt tttttcaatg atggagaaaa
     7501 attgcaacaa agaccttctg gaagatccaa
//
