LOCUS       NM_021161               7501 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens potassium two pore domain channel subfamily K member
            10 (KCNK10), transcript variant 1, mRNA.
ACCESSION   NM_021161 XM_001723547 XM_001725959 XM_001727026
VERSION     NM_021161.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7501)
  AUTHORS   Sorum,B., Docter,T., Panico,V., Rietmeijer,R.A. and Brohawn,S.G.
  TITLE     Tension activation of mechanosensitive two-pore domain K+ channels
            TRAAK, TREK-1, and TREK-2
  JOURNAL   Nat Commun 15 (1), 3142 (2024)
   PUBMED   38605031
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7501)
  AUTHORS   Kim,S.S., Park,J., Kim,E., Hwang,E.M. and Park,J.Y.
  TITLE     beta-COP Suppresses the Surface Expression of the TREK2
  JOURNAL   Cells 12 (11), 1500 (2023)
   PUBMED   37296621
  REMARK    GeneRIF: beta-COP Suppresses the Surface Expression of the TREK2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7501)
  AUTHORS   Conrad,L.J., Proks,P. and Tucker,S.J.
  TITLE     Effects of ionic strength on gating and permeation of TREK-2 K2P
            channels
  JOURNAL   PLoS One 16 (10), e0258275 (2021)
   PUBMED   34618865
  REMARK    GeneRIF: Effects of ionic strength on gating and permeation of
            TREK-2 K2P channels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7501)
  AUTHORS   Zhuo,R.G., Peng,P., Zheng,J.Q., Zhang,Y.L., Wen,L., Wei,X.L. and
            Ma,X.Y.
  TITLE     The glycine hinge of transmembrane segment 2 modulates the
            subcellular localization and gating properties in TREK channels
  JOURNAL   Biochem Biophys Res Commun 490 (3), 1125-1131 (2017)
   PUBMED   28676394
  REMARK    GeneRIF: The M2-glycine hinge controls the macroscopic currents of
            TREK1 channels.
REFERENCE   5  (bases 1 to 7501)
  AUTHORS   McClenaghan,C., Schewe,M., Aryal,P., Carpenter,E.P., Baukrowitz,T.
            and Tucker,S.J.
  TITLE     Polymodal activation of the TREK-2 K2P channel produces
            structurally distinct open states
  JOURNAL   J Gen Physiol 147 (6), 497-505 (2016)
   PUBMED   27241700
REFERENCE   6  (bases 1 to 7501)
  AUTHORS   Goldstein,S.A., Bayliss,D.A., Kim,D., Lesage,F., Plant,L.D. and
            Rajan,S.
  TITLE     International Union of Pharmacology. LV. Nomenclature and molecular
            relationships of two-P potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 527-540 (2005)
   PUBMED   16382106
  REMARK    Review article
REFERENCE   7  (bases 1 to 7501)
  AUTHORS   Gu,W., Schlichthorl,G., Hirsch,J.R., Engels,H., Karschin,C.,
            Karschin,A., Derst,C., Steinlein,O.K. and Daut,J.
  TITLE     Expression pattern and functional characteristics of two novel
            splice variants of the two-pore-domain potassium channel TREK-2
  JOURNAL   J Physiol 539 (Pt 3), 657-668 (2002)
   PUBMED   11897838
  REMARK    GeneRIF: Expression pattern and functional characteristics of two
            novel splice variants of the two-pore-domain potassium channel
            TREK-2.
REFERENCE   8  (bases 1 to 7501)
  AUTHORS   Goldstein,S.A., Bockenhauer,D., O'Kelly,I. and Zilberberg,N.
  TITLE     Potassium leak channels and the KCNK family of two-P-domain
            subunits
  JOURNAL   Nat Rev Neurosci 2 (3), 175-184 (2001)
   PUBMED   11256078
  REMARK    Review article
REFERENCE   9  (bases 1 to 7501)
  AUTHORS   Lesage,F., Terrenoire,C., Romey,G. and Lazdunski,M.
  TITLE     Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple
            regulations by polyunsaturated fatty acids, lysophospholipids, and
            Gs, Gi, and Gq protein-coupled receptors
  JOURNAL   J Biol Chem 275 (37), 28398-28405 (2000)
   PUBMED   10880510
REFERENCE   10 (bases 1 to 7501)
  AUTHORS   Bang,H., Kim,Y. and Kim,D.
  TITLE     TREK-2, a new member of the mechanosensitive tandem-pore K+ channel
            family
  JOURNAL   J Biol Chem 275 (23), 17412-17419 (2000)
   PUBMED   10747911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049834.3, AF279890.1,
            AL133279.7, AI693366.1 and U79244.1.
            
            On Aug 13, 2020 this sequence version replaced NM_021161.4.
            
            Summary: The protein encoded by this gene belongs to the family of
            potassium channel proteins containing two pore-forming P domains.
            This channel is an open rectifier which primarily passes outward
            current under physiological K+ concentrations, and is stimulated
            strongly by arachidonic acid and to a lesser degree by membrane
            stretching, intracellular acidification, and general anaesthetics.
            Several alternatively spliced transcript variants encoding
            different isoforms have been identified for this gene. [provided by
            RefSeq, Sep 2008].
            
            Transcript Variant: This variant (1, also known as TREK2 splice
            variant a) encodes the shortest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF279890.1, EU978938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-441               AL049834.3         31213-31653         c
            442-2126            AF279890.1         457-2141
            2127-2713           AF279890.1         2144-2730
            2714-3646           AL133279.7         85446-86378         c
            3647-4192           AI693366.1         2-547               c
            4193-6637           AL133279.7         82455-84899         c
            6638-7501           U79244.1           1-864
FEATURES             Location/Qualifiers
     source          1..7501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q31.3"
     gene            1..7501
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /note="potassium two pore domain channel subfamily K
                     member 10"
                     /db_xref="GeneID:54207"
                     /db_xref="HGNC:HGNC:6273"
                     /db_xref="MIM:605873"
     exon            1..494
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             458..2074
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; outward rectifying potassium channel protein
                     TREK-2; 2P domain potassium channel TREK2; potassium
                     channel TREK-2; TWIK-related K+ channel 2; TREK-2 K(+)
                     channel subunit; protein phosphatase 1, regulatory subunit
                     97; potassium channel, subfamily K, member 10; potassium
                     channel, two pore domain subfamily K, member 10"
                     /codon_start=1
                     /product="potassium channel subfamily K member 10 isoform
                     1 precursor"
                     /protein_id="NP_066984.1"
                     /db_xref="CCDS:CCDS9880.1"
                     /db_xref="GeneID:54207"
                     /db_xref="HGNC:HGNC:6273"
                     /db_xref="MIM:605873"
                     /translation="MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLS
                     ISSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQK
                     NTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFF
                     AGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVE
                     KVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTT
                     VGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVG
                     EIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDML
                     SPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGST
                     SRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEEETEKMCNSDNSSTAMLTDCI
                     QQHAELENGMIPTDTKDREPENNSLLEDRN"
     exon            495..844
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..962
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1123
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1310
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1453
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..7501
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4171..4176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /note="hexamer: ATTAAA"
     polyA_site      4196
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /note="major polyA site"
     regulatory      7477..7482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /note="hexamer: AACAAA"
     polyA_site      7501
                     /gene="KCNK10"
                     /gene_synonym="K2p10.1; PPP1R97; TREK-2; TREK2"
                     /note="major polyA site"
ORIGIN      
        1 acgcggcagg catcgtctcc tccggtctca cagctacccc gggctggagc gtggggaggg
       61 ggtaagggag ccagccaact cggggaaact tcgttgccag agatgactgg ggttttcggg
      121 ctttcccagc cttcccatgc cgggccacac ggcattcatt aaagtggtgg ggcaactatt
      181 ggtgcgctcc agccgggcag gttttgagct gcagagaccc gtgcccggta gcagcgcttt
      241 gccaccgagt gcacccagga cgcagtggcc gccagcccgg gtctcctgct gggggccggc
      301 gagtgcaggg agactttgcg ccacgatgtt ttgttttcct gccgcaggaa cgctaggcag
      361 tctctttcca ccagacttaa cccgcctgaa gcaatagcca tggaagttgc ggcggcacag
      421 agggagacag aaccgcttgg agcggcatct ttcttggatg ttttttctct acacagactt
      481 ctttctttcc ttggtggccg ttcccgcagc agcaccggtg tgccagccca agagcgccac
      541 taacgggcaa cccccggctc cggctccgac tccaactccg cgcctgtcca tttcctcccg
      601 agccacagtg gtagccagga tggaaggcac ctcccaaggg ggcttgcaga ccgtcatgaa
      661 gtggaagacg gtggttgcca tctttgtggt tgtggtggtc taccttgtca ctggcggtct
      721 tgtcttccgg gcattggagc agccctttga gagcagccag aagaatacca tcgccttgga
      781 gaaggcggaa ttcctgcggg atcatgtctg tgtgagcccc caggagctgg agacgttgat
      841 ccagcatgct cttgatgctg acaatgcggg agtcagtcca ataggaaact cttccaacaa
      901 cagcagccac tgggacctcg gcagtgcctt tttctttgct ggaactgtca ttacgaccat
      961 agggtatggg aatattgctc cgagcactga aggaggcaaa atcttttgta ttttatatgc
     1021 catctttgga attccactct ttggtttctt attggctgga attggagacc aacttggaac
     1081 catctttggg aaaagcattg caagagtgga gaaggtcttt cgaaaaaagc aagtgagtca
     1141 gaccaagatc cgggtcatct caaccatcct gttcatcttg gccggctgca ttgtgtttgt
     1201 gacgatccct gctgtcatct ttaagtacat cgagggctgg acggccttgg agtccattta
     1261 ctttgtggtg gtcactctga ccacggtggg ctttggtgat tttgtggcag ggggaaacgc
     1321 tggcatcaat tatcgggagt ggtataagcc cctagtgtgg ttttggatcc ttgttggcct
     1381 tgcctacttt gcagctgtcc tcagtatgat cggagattgg ctacgggttc tgtccaaaaa
     1441 gacaaaagaa gaggtgggtg aaatcaaggc ccatgcggca gagtggaagg ccaatgtcac
     1501 ggctgagttc cgggagacac ggcgaaggct cagcgtggag atccacgata agctgcagcg
     1561 ggcggccacc atccgcagca tggagcgccg gcggctgggc ctggaccagc gggcccactc
     1621 actggacatg ctgtcccccg agaagcgctc tgtctttgct gccctggaca ccggccgctt
     1681 caaggcctca tcccaggaga gcatcaacaa ccggcccaac aacctgcgcc tgaaggggcc
     1741 ggagcagctg aacaagcatg ggcagggtgc gtccgaggac aacatcatca acaagttcgg
     1801 gtccacctcc agactcacca agaggaaaaa caaggacctc aaaaagacct tgcccgagga
     1861 cgttcagaaa atctacaaga ccttccggaa ttactccctg gacgaggaga agaaagagga
     1921 ggagacggaa aagatgtgta actcagacaa ctccagcaca gccatgctga cggactgtat
     1981 ccagcagcac gctgagttgg agaacggaat gatacccacg gacaccaaag accgggagcc
     2041 ggagaacaac tcattacttg aagacagaaa ctaaatgtga aggacattgg tcttggactg
     2101 agcgttgtgt gtgtgtgtgt gtgtgttttt aatattcaca ctgagacatg tgccttaaac
     2161 agacttttta gtccaaaatt acatagcatt gaagaatata tttcactgtg ccataaacaa
     2221 ctgaaagctt gctctgccaa aaggaatcag agaacaagaa cttcatttca gatagcaaac
     2281 gcaggacaca ccaagagtgt ccgtgcacgt agccggttct ggccgtacat gttaagggca
     2341 tttcagtggc agtgctgtac ccctgggcag tgctacctgg gcacacacgt agacaagggc
     2401 agctattcct tagaccagcc tcctgaaaga aacaggtgtg tctttttagt ggagtcgtag
     2461 taatatgtgc acacacagaa ggggacctga ttgggtggga gctggttatg tgtaactagc
     2521 gttggagttg acattttggc atgtgctctg agcttgaatt ttgataccaa ccattcagtg
     2581 catcatacct agtctttcta tgctccaaat gaatgtctgt ggggacctga gagcacctgg
     2641 aatttgttgg aagcagatca gagcacacgt acgaaaaggt gcaattgctt ttctcatgac
     2701 aaaagaaaaa aaataatcac aaacacatca cactgtggat atcaccttaa ccaatgacag
     2761 aagcctgctg agtttggtct ttctcacagg ggtaggtagt ccacatgaac tggcgagcag
     2821 tggtgaaaac atgacatcaa ctgctgcgtg gttaaaggcc aatcatgcat tttcctcagt
     2881 gggtgcaatg gtgacaataa actgatttgg aaatgtccat gtactttggt tataacttgt
     2941 tttgataaga ggggtagaaa taccaaaaca attgccttgc atgatgccag tggcttgctg
     3001 ttctgtctag ctgatcctac atttttacaa aagtagacat cctgcatttc tgagacacac
     3061 tgaggaggac catggcatct ttccatctca gggctttttg tcccttgggt gtcttagggt
     3121 agacatagtg ataagatcca atctcgctat ctccaaacaa aaagaaaatg taccccttgt
     3181 acagtaagct tgaaatgttt ttattgcttg cagcgtaagt gccattaatt ccatttaaca
     3241 atgatactta gaaatattta aaatatttca ttttactttt atgtttgggc attcctttat
     3301 tctgaaaaag tcaccactgc tccttgcttg tttctacatc tcacatcggt tactcactaa
     3361 aactggaaca ccctagactg attgttccca ggcaaacgat aagctaacac atcataatta
     3421 tgattggtct gtgaggctag aacatcccgc agaggaaagt cggggaatgg ctagtcatag
     3481 gttgcatgat gattttaaat gggtttgtat cagaaagggg aaaatacata ctcctgtgta
     3541 tgcctcagtc tttatcataa ttggctggtt cacagctagc tctttgggcc acacgtgaaa
     3601 gcatttggac ctggcaacac caggcagttg ctggttatgg gtgttctagg ctcactgcta
     3661 ccttttacag agttcacggg attttacgta actaacccgc agtgtggatt taccaaaaga
     3721 tcacagcact agcggagact tccagaaact gtctcatgct ttctgacctc cagggaaagt
     3781 tgtacccacg acatcctcaa ccactggtac catggaagac ctgtccctgc ccatttctca
     3841 aaaatgcaca gctcttccct gcctggagca catgaagtcc catctccctg tccccagacc
     3901 tttaggctct gttgaagttc tggcattgct tatgagaccc ttcctgtcca aggaaggtct
     3961 aagtcaactc ctccattgga ctggagatga ggctcactgg tgacatcctg tgtcgactca
     4021 gtaataaata gtcacttggg aggcgatgtt tatgcaggtg tggatgttga gttttactat
     4081 gggaatcatt ccagcctgac aaaatgtgtt ttaaggaata ggtagataac tgggacttcc
     4141 tctgttattc taacaagtcg aagcttccta attaaactgt ccatggatct cacttatttg
     4201 gtttccactc tgtgttatct ggtacgttct ttgtagcagt gtgttaaaat tccaggccct
     4261 acggccaaat ctggcagagg cttccctctc atttatccag tgccttctgt gggccaggca
     4321 caggattagg cactttatga acgtcagctc attgaaactt cacgacacta tgtgggaagt
     4381 atttgcaaac ccattatata cacaaggaca cagaggctca gggaagctat gttatttatc
     4441 caatggcaca cagcaagaaa gtggtagagc tggtattcaa agtctgacca aagtctgctt
     4501 tcaacttcac tacagtgtct gtgtcatgca tccttgtgat tgtgtgtgtt tgtgtgtatg
     4561 tgtgtctttc tagcttcatg gacacagctt acagatgtgg ggagcagata tggtggaatc
     4621 tccaccacca agagggcaca aggtctttgt gtaaacatgg ctcaaagggt tgcccctgca
     4681 gacacctact gtacatttat ttggttttgg aaattttgta tgtggcaccc tttaaaaaat
     4741 gccctttgaa agcactcttt tgcactttac ttgctaactt tgtagaaact ctgcatacag
     4801 caggaataaa atagttcaaa gcactaagct gcatactcta ccaaatggaa caggtgcatg
     4861 tgttggtatg tgcatagatg cttccccaaa tgagtcaaat cagtcacaca gagggatcaa
     4921 acataacctt gggctggggg tgggaaaatt ttctacataa cccattccct gagacatttg
     4981 gccaagaatg tgatgaacaa aatcaaagaa gatcctctat ggtgattgat cgattaaata
     5041 tgtgtgcaaa gtgtttagaa acctatgaaa tactctcgca aagatgctga gagagaataa
     5101 gaggttggat tcctcttcat ataaactaat tttggaggag gccagttggt ttgaagttac
     5161 ttgaatgtta ccttttttag atggggccaa atggcatgta gaatacacgt gataggtcaa
     5221 agctgctaca cattctatac atgcatcagc acagcccccc ctttccaatc tgcactccca
     5281 ttccagcata aacctaggag aaatgtttcg atttcacaca aagaaagagc acacgtccac
     5341 catcttcagt gggggctgtc ttttgcttca ctggcaagca ggcactgaat ttttcttgca
     5401 tgacaaatct ggaggtttac tggtgagaga gccaatgggc attttttcct ggaaagagta
     5461 cagctccata cccagtccta acccaacagt gatatttatc actttggggc agggctgtat
     5521 agagtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgcgggttgg
     5581 ggtggtgttg ggccatctct ggcctgttac taaggtaact aggactattt gtgttccagc
     5641 agtcatagcc tgtgattgtg ggtgcatcag ttctctgcct agatctcttg ttaccttgtc
     5701 tgcacatcaa gggagggagt tgagcacaga tacttgtcaa gggccattgt agttgtgcag
     5761 ttctctaatg aaacactccc tagtccatga gttcacaaaa tttattaaga ttaaattata
     5821 agttggattt gtgaataatg actaattaat tgtcttgccc attttaggtt aaggtgagag
     5881 cttagtctct tgccctttgg gatttgtctt ttgggggatt aatggagacc agatgtactt
     5941 gggagactgg tgtccaaatt cggatcatgc cctgtgtagg ctctctctat cctcccttat
     6001 agctctttag tgtactgtca ccgggagggc tcatgctgtg agggcatttt ttgcatggtg
     6061 ttaagactag ttaaagaaat tttaagctgt tgttatttgc agtcaattgt agtacttcat
     6121 gtatcatgaa ttcaagtact atgatcagac agacatctct ctctctctca cacacacaca
     6181 cacacacaca cacgcacaca tacacacaca cacacacacc tgaggaaatg gctgctttgg
     6241 gttctataag gaccattcca tgtttaaagt cctagttgag ctgaatgcta agaacctgcc
     6301 cccttgcctc cctctgagat gatatcattt cctggcttcg tcaatgctgc ctgtctattt
     6361 gcatgctggg ttctgaggac tagtgagaag gtgaccagag tttgggtggg gctggttttt
     6421 acccactgga tttggtgaga atatgaagca tccagtgtgt accagggttt ctgaaccacg
     6481 ggaaaggcgt aggaaaacaa acattcagag cccctgtaaa acgagaaagg aaaaaccagc
     6541 cagtgttgca ttccacatct ctgcttgttg cattttgcta atatggggtt attctttctc
     6601 actgttagga tgcaattgtg tgcaaagaca gtggctgagt gaacagtaag agctggctag
     6661 taatggcctt aaaaagaaaa agggtaactc tctgaaacaa agatcacttt agtgtggcat
     6721 tgtggatgct gttaattctg catagggaaa ctttggaaca gcatgctaat tacatggctg
     6781 taagcaaagc cctgtcctct gtctctgcac cataccttca ttggacttca ccaacccatc
     6841 catactccat gtaaacctca gttctctcat gcctgcccta agtcagttga catcagtgca
     6901 gtggcattga ggagaaatga gaggtgtctc tgattttact gaaagttatt atcattttca
     6961 caggtgcctg agatttggta tctactttgt gttcttgatt cttaggtgaa aaatctgaaa
     7021 tagttccctg tgcattaaaa taaattattt tgagaggact cctgctccgt cgattcagca
     7081 gacctatgct gcagaaggta actgcggaag ctctcttttg ctgtcagggc tctgagcttg
     7141 aagggagaag gtgcagtggt gcctagaagt gatatgcaaa ccacctcaca tgccagcctc
     7201 tggcctcctt cccatcccag agtcacagac aggggaccca gtgacaatga tgataaatcc
     7261 atgtgtggag gtgttttact tatttttctt tccgtaggat ttcatggtgc tttaaaaaaa
     7321 aaggcatttt acagaaaata atgtgggggg agggagattt cataatgttc ttagggaaag
     7381 tacaaaacaa atttgcttgt gacatttcaa taagctgtgc tgctattgtc tttatttgat
     7441 gatgtaattt ttttttcaat gatggagaaa aattgcaaca aagaccttct ggaagatcca
     7501 a
//
