LOCUS       NM_002245               2061 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens potassium two pore domain channel subfamily K member 1
            (KCNK1), mRNA.
ACCESSION   NM_002245
VERSION     NM_002245.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2061)
  AUTHORS   Bargary,G., Bosten,J.M., Lawrance-Owen,A.J., Goodbourn,P.T. and
            Mollon,J.D.
  TITLE     Evidence for an Association Between a pH-Dependent Potassium
            Channel, TWIK-1, and the Accuracy of Smooth Pursuit Eye Movements
  JOURNAL   Invest Ophthalmol Vis Sci 65 (8), 24 (2024)
   PUBMED   39012638
  REMARK    GeneRIF: Evidence for an Association Between a pH-Dependent
            Potassium Channel, TWIK-1, and the Accuracy of Smooth Pursuit Eye
            Movements.
REFERENCE   2  (bases 1 to 2061)
  AUTHORS   Hou,X., Ouyang,J., Tang,L., Wu,P., Deng,X., Yan,Q., Shi,L., Fan,S.,
            Fan,C., Guo,C., Liao,Q., Li,Y., Xiong,W., Li,G., Zeng,Z. and
            Wang,F.
  TITLE     KCNK1 promotes proliferation and metastasis of breast cancer cells
            by activating lactate dehydrogenase A (LDHA) and up-regulating
            H3K18 lactylation
  JOURNAL   PLoS Biol 22 (6), e3002666 (2024)
   PUBMED   38905316
  REMARK    GeneRIF: KCNK1 promotes proliferation and metastasis of breast
            cancer cells by activating lactate dehydrogenase A (LDHA) and
            up-regulating H3K18 lactylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2061)
  AUTHORS   Zhang,W., Chen,X.S., Wei,Y., Wang,X.M., Chen,X.J., Chi,B.T.,
            Huang,L.Q., He,R.Q., Huang,Z.G., Li,Q., Chen,G., He,J. and Wu,M.
  TITLE     Overexpressed KCNK1 regulates potassium channels affecting
            molecular mechanisms and biological pathways in bladder cancer
  JOURNAL   Eur J Med Res 29 (1), 257 (2024)
   PUBMED   38689322
  REMARK    GeneRIF: Overexpressed KCNK1 regulates potassium channels affecting
            molecular mechanisms and biological pathways in bladder cancer.
            Erratum:[Eur J Med Res. 2024 Jun 20;29(1):342. doi:
            10.1186/s40001-024-01905-5.. PMID: 38902786]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2061)
  AUTHORS   Sun,X., Li,Y., Lan,H., Jiang,T., Wan,X. and Cheng,Y.
  TITLE     Identification of KCNK1 as a potential prognostic biomarker and
            therapeutic target of breast cancer
  JOURNAL   Pathol Res Pract 241, 154286 (2023)
   PUBMED   36566598
  REMARK    GeneRIF: Identification of KCNK1 as a potential prognostic
            biomarker and therapeutic target of breast cancer.
REFERENCE   5  (bases 1 to 2061)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2061)
  AUTHORS   Goldstein,S.A., Wang,K.W., Ilan,N. and Pausch,M.H.
  TITLE     Sequence and function of the two P domain potassium channels:
            implications of an emerging superfamily
  JOURNAL   J Mol Med (Berl) 76 (1), 13-20 (1998)
   PUBMED   9462864
  REMARK    Review article
REFERENCE   7  (bases 1 to 2061)
  AUTHORS   Orias,M., Velazquez,H., Tung,F., Lee,G. and Desir,G.V.
  TITLE     Cloning and localization of a double-pore K channel, KCNK1:
            exclusive expression in distal nephron segments
  JOURNAL   Am J Physiol 273 (4), F663-F666 (1997)
   PUBMED   9362344
REFERENCE   8  (bases 1 to 2061)
  AUTHORS   Lesage,F., Reyes,R., Fink,M., Duprat,F., Guillemare,E. and
            Lazdunski,M.
  TITLE     Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge
  JOURNAL   EMBO J 15 (23), 6400-6407 (1996)
   PUBMED   8978667
REFERENCE   9  (bases 1 to 2061)
  AUTHORS   Lesage,F., Mattei,M., Fink,M., Barhanin,J. and Lazdunski,M.
  TITLE     Assignment of the human weak inward rectifier K+ channel TWIK-1
            gene to chromosome 1q42-q43
  JOURNAL   Genomics 34 (1), 153-155 (1996)
   PUBMED   8661042
REFERENCE   10 (bases 1 to 2061)
  AUTHORS   Lesage,F., Guillemare,E., Fink,M., Duprat,F., Lazdunski,M.,
            Romey,G. and Barhanin,J.
  TITLE     TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with
            a novel structure
  JOURNAL   EMBO J 15 (5), 1004-1011 (1996)
   PUBMED   8605869
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U90065.1, BC018051.1,
            BQ022191.1 and AL356357.22.
            
            On May 17, 2019 this sequence version replaced NM_002245.3.
            
            Summary: This gene encodes one of the members of the superfamily of
            potassium channel proteins containing two pore-forming P domains.
            The product of this gene has not been shown to be a functional
            channel, however, it may require other non-pore-forming proteins
            for activity. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.183713.1,
                                           SRR1660807.199475.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366621.8/ ENSP00000355580.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                U90065.1           105-154
            51-1108             U90065.1           167-1224
            1109-1823           BC018051.1         1088-1802
            1824-2059           BQ022191.1         19-254              c
            2060-2061           AL356357.22        62699-62700
FEATURES             Location/Qualifiers
     source          1..2061
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.2"
     gene            1..2061
                     /gene="KCNK1"
                     /gene_synonym="DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1;
                     TWIK1"
                     /note="potassium two pore domain channel subfamily K
                     member 1"
                     /db_xref="GeneID:3775"
                     /db_xref="HGNC:HGNC:6272"
                     /db_xref="MIM:601745"
     exon            1..421
                     /gene="KCNK1"
                     /gene_synonym="DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1;
                     TWIK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1077
                     /gene="KCNK1"
                     /gene_synonym="DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1;
                     TWIK1"
                     /note="potassium inwardly-rectifying channel, subfamily K,
                     member 1; potassium channel, two pore domain subfamily K,
                     member 1; potassium channel KCNO1; inward rectifying
                     potassium channel protein TWIK-1; tandem of P domains in a
                     weak inward rectifying K+ channel 1; potassium channel
                     K2P1"
                     /codon_start=1
                     /product="potassium channel subfamily K member 1"
                     /protein_id="NP_002236.1"
                     /db_xref="CCDS:CCDS1599.1"
                     /db_xref="GeneID:3775"
                     /db_xref="HGNC:HGNC:6272"
                     /db_xref="MIM:601745"
                     /translation="MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSV
                     ELPYEDLLRQELRKLKRRFLEEHECLSEQQLEQFLGRVLEASNYGVSVLSNASGNWNW
                     DFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHV
                     TRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYF
                     CFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKF
                     RKMFYVKKDKDEDQVHIIEHDQLSFSSITDQAAGMKEDQKQNEPFVATQSSACVDGPA
                     NH"
     exon            422..817
                     /gene="KCNK1"
                     /gene_synonym="DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1;
                     TWIK1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..2061
                     /gene="KCNK1"
                     /gene_synonym="DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1;
                     TWIK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1761..1766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK1"
                     /gene_synonym="DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1;
                     TWIK1"
                     /note="hexamer: AATAAA"
     polyA_site      1786
                     /gene="KCNK1"
                     /gene_synonym="DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1;
                     TWIK1"
                     /note="major polyA site"
     regulatory      1799..1804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK1"
                     /gene_synonym="DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1;
                     TWIK1"
                     /note="hexamer: AATAAA"
     polyA_site      1825
                     /gene="KCNK1"
                     /gene_synonym="DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1;
                     TWIK1"
                     /note="major polyA site"
     regulatory      1894..1899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK1"
                     /gene_synonym="DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1;
                     TWIK1"
                     /note="hexamer: ATTAAA"
     polyA_site      1911
                     /gene="KCNK1"
                     /gene_synonym="DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1;
                     TWIK1"
     regulatory      2038..2043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNK1"
                     /gene_synonym="DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1;
                     TWIK1"
                     /note="hexamer: AATAAA"
     polyA_site      2061
                     /gene="KCNK1"
                     /gene_synonym="DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1;
                     TWIK1"
ORIGIN      
        1 agaagaggcg gcgggccgcg ctccggccgg tctgcggcgt tggccttggc ggcggcggtg
       61 gagaagatgc tgcagtccct ggccggcagc tcgtgcgtgc gcctggtgga gcggcaccgc
      121 tcggcctggt gcttcggctt cctggtgctg ggctacttgc tctacctggt cttcggcgca
      181 gtggtcttct cctcggtgga gctgccctat gaggacctgc tgcgccagga gctgcgcaag
      241 ctgaagcgac gcttcttgga ggagcacgag tgcctgtctg agcagcagct ggagcagttc
      301 ctgggccggg tgctggaggc cagcaactac ggcgtgtcgg tgctcagcaa cgcctcgggc
      361 aactggaact gggacttcac ctccgcgctc ttcttcgcca gcaccgtgct ctccaccaca
      421 ggttatggcc acaccgtgcc cttgtcagat ggaggtaagg ccttctgcat catctactcc
      481 gtcattggca ttcccttcac cctcctgttc ctgacggctg tggtccagcg catcaccgtg
      541 cacgtcaccc gcaggccggt cctctacttc cacatccgct ggggcttctc caagcaggtg
      601 gtggccatcg tccatgccgt gctccttggg tttgtcactg tgtcctgctt cttcttcatc
      661 ccggccgctg tcttctcagt cctggaggat gactggaact tcctggaatc cttttatttt
      721 tgttttattt ccctgagcac cattggcctg ggggattatg tgcctgggga aggctacaat
      781 caaaaattca gagagctcta taagattggg atcacgtgtt acctgctact tggccttatt
      841 gccatgttgg tagttctgga aaccttctgt gaactccatg agctgaaaaa attcagaaaa
      901 atgttctatg tgaagaagga caaggacgag gatcaggtgc acatcataga gcatgaccaa
      961 ctgtccttct cctcgatcac agaccaggca gctggcatga aagaggacca gaagcaaaat
     1021 gagccttttg tggccaccca gtcatctgcc tgcgtggatg gccctgcaaa ccattgagcg
     1081 taggatttgt tgcattatgc tagagcacca gggtcagggt gcaaggaaga ggcttaagta
     1141 tgttcatttt tatcagaatg caaaagcgaa aattatgtca ctttaagaaa tagctactgt
     1201 ttgcaatgtc ttattaaaaa acaacaaaaa aagacaaatg gaacaaagaa gctgtgaccc
     1261 cagcaggatg tctaatatgt gaggaaatga gatgtccacc taaaattcat atgtgacaaa
     1321 attatctcga ccttacatag gaggagaata cttgaagcag tatgctgctg tggttagaag
     1381 cagattttat acttttaact ggaaactttg gggtttgcat ttagatcatt tagctgatgg
     1441 ctaaatagca aaatttatat ttagaagcaa aaaaaaaaag catagagatg tgttttataa
     1501 ataggtttat gtgtactggt ttgcatgtac ccacccaaaa tgattatttt tgtagaatct
     1561 aagttaaact tactatttat aatgcatagg taaccattaa ctatgtacat ataaagtata
     1621 aatatgttta tattctgtac atatggttta ggtcaccaga tcctagtgta gttctgaaac
     1681 taagactata gatattttgt ttcttttgat ttctctttat actaaagaat ccagagttgc
     1741 tacaataaaa taaggggaat aataaacttg agagtgaata accatagtat tctgctgcaa
     1801 taaatgtttc taccctcttg cgatagaatg gtgtcagatg tctaacatgt ttataaacat
     1861 ttttttgaat tgaacaggtt atgaaaagga tttattaaaa ggttaagata ctttgttttg
     1921 aaagtacatt gtgatttgca gccacctagc actaaagcat agaacttaaa cacgaatccc
     1981 taaatgaaca gattatgtta cattaatctg agaattttaa atttagaagc taaaataaat
     2041 aaaaatcaca gctggttgta a
//
