LOCUS       NM_152868               2065 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens potassium inwardly rectifying channel subfamily J
            member 4 (KCNJ4), transcript variant 1, mRNA.
ACCESSION   NM_152868
VERSION     NM_152868.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2065)
  AUTHORS   Wu,X.Y. and Yu,X.Y.
  TITLE     Overexpression of KCNJ4 correlates with cancer progression and
            unfavorable prognosis in lung adenocarcinoma
  JOURNAL   J Biochem Mol Toxicol 33 (4), e22270 (2019)
   PUBMED   30512237
  REMARK    GeneRIF: results shed some light on the contribution of KCNJ4
            functioning as a significant player in LADC, implying that KCNJ4
            might be a valuable prognostic biomarker and a potential
            therapeutic target for LADC treatment
REFERENCE   2  (bases 1 to 2065)
  AUTHORS   Sundell,G.N., Arnold,R., Ali,M., Naksukpaiboon,P., Orts,J.,
            Guntert,P., Chi,C.N. and Ivarsson,Y.
  TITLE     Proteome-wide analysis of phospho-regulated PDZ domain interactions
  JOURNAL   Mol Syst Biol 14 (8), e8129 (2018)
   PUBMED   30126976
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2065)
  AUTHORS   Agopian,A.J., Mitchell,L.E., Glessner,J., Bhalla,A.D., Sewda,A.,
            Hakonarson,H. and Goldmuntz,E.
  TITLE     Genome-wide association study of maternal and inherited loci for
            conotruncal heart defects
  JOURNAL   PLoS One 9 (5), e96057 (2014)
   PUBMED   24800985
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2065)
  AUTHORS   Ivarsson,Y., Arnold,R., McLaughlin,M., Nim,S., Joshi,R., Ray,D.,
            Liu,B., Teyra,J., Pawson,T., Moffat,J., Li,S.S., Sidhu,S.S. and
            Kim,P.M.
  TITLE     Large-scale interaction profiling of PDZ domains through proteomic
            peptide-phage display using human and viral phage peptidomes
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), 2542-2547 (2014)
   PUBMED   24550280
REFERENCE   5  (bases 1 to 2065)
  AUTHORS   Cazorla,M., Shegda,M., Ramesh,B., Harrison,N.L. and Kellendonk,C.
  TITLE     Striatal D2 receptors regulate dendritic morphology of medium spiny
            neurons via Kir2 channels
  JOURNAL   J Neurosci 32 (7), 2398-2409 (2012)
   PUBMED   22396414
  REMARK    GeneRIF: Increased excitability and decreased dendritic
            arborization are associated with downregulation of inward rectifier
            potassium channels (Kir2.1/2.3).
REFERENCE   6  (bases 1 to 2065)
  AUTHORS   Coulter,K.L., Perier,F., Radeke,C.M. and Vandenberg,C.A.
  TITLE     Identification and molecular localization of a pH-sensing domain
            for the inward rectifier potassium channel HIR
  JOURNAL   Neuron 15 (5), 1157-1168 (1995)
   PUBMED   7576658
REFERENCE   7  (bases 1 to 2065)
  AUTHORS   Budarf,M.L., Perier,F., Barnoski,B.L., Bell,C.J. and
            Vandenberg,C.A.
  TITLE     Assignment of the human hippocampal inward rectifier potassium
            channel (HIR) gene to 22q13.1
  JOURNAL   Genomics 26 (3), 625-629 (1995)
   PUBMED   7607694
REFERENCE   8  (bases 1 to 2065)
  AUTHORS   Makhina,E.N., Kelly,A.J., Lopatin,A.N., Mercer,R.W. and
            Nichols,C.G.
  TITLE     Cloning and expression of a novel human brain inward rectifier
            potassium channel
  JOURNAL   J Biol Chem 269 (32), 20468-20474 (1994)
   PUBMED   8051145
REFERENCE   9  (bases 1 to 2065)
  AUTHORS   Tang,W. and Yang,X.C.
  TITLE     Cloning a novel human brain inward rectifier potassium channel and
            its functional expression in Xenopus oocytes
  JOURNAL   FEBS Lett 348 (3), 239-243 (1994)
   PUBMED   8034048
REFERENCE   10 (bases 1 to 2065)
  AUTHORS   Perier,F., Radeke,C.M. and Vandenberg,C.A.
  TITLE     Primary structure and characterization of a small-conductance
            inwardly rectifying potassium channel from human hippocampus
  JOURNAL   Proc Natl Acad Sci U S A 91 (13), 6240-6244 (1994)
   PUBMED   8016146
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z97056.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_152868.2.
            
            Summary: Several different potassium channels are known to be
            involved with electrical signaling in the nervous system. One class
            is activated by depolarization whereas a second class is not. The
            latter are referred to as inwardly rectifying K+ channels, and they
            have a greater tendency to allow potassium to flow into the cell
            rather than out of it. This asymmetry in potassium ion conductance
            plays a key role in the excitability of muscle cells and neurons.
            The protein encoded by this gene is an integral membrane protein
            and member of the inward rectifier potassium channel family. The
            encoded protein has a small unitary conductance compared to other
            members of this protein family. Two transcript variants encoding
            the same protein have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U24056.1, CR456507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303592.3/ ENSP00000306497.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               Z97056.1           66164-66383         c
            221-2065            Z97056.1           37510-39354         c
FEATURES             Location/Qualifiers
     source          1..2065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2065
                     /gene="KCNJ4"
                     /gene_synonym="HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3"
                     /note="potassium inwardly rectifying channel subfamily J
                     member 4"
                     /db_xref="GeneID:3761"
                     /db_xref="HGNC:HGNC:6265"
                     /db_xref="MIM:600504"
     exon            1..220
                     /gene="KCNJ4"
                     /gene_synonym="HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            221..2065
                     /gene="KCNJ4"
                     /gene_synonym="HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1597
                     /gene="KCNJ4"
                     /gene_synonym="HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3"
                     /note="hippocampal inward rectifier potassium channel;
                     potassium channel, inwardly rectifying subfamily J, member
                     4; inward rectifier K(+) channel Kir2.3; potassium
                     voltage-gated channel subfamily J member 4"
                     /codon_start=1
                     /product="inward rectifier potassium channel 4"
                     /protein_id="NP_690607.1"
                     /db_xref="CCDS:CCDS13971.1"
                     /db_xref="GeneID:3761"
                     /db_xref="HGNC:HGNC:6265"
                     /db_xref="MIM:600504"
                     /translation="MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMA
                     DIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAG
                     GGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVG
                     CVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAH
                     VRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGK
                     EELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYS
                     RFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAA
                     AAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI"
     regulatory      2037..2042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNJ4"
                     /gene_synonym="HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3"
                     /note="hexamer: TATAAA"
     polyA_site      2065
                     /gene="KCNJ4"
                     /gene_synonym="HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3"
                     /note="major polyA site"
ORIGIN      
        1 gggagcggcg cgggacggcc gggacgcgcg gagaccccaa gacccacgcg cagaccgagc
       61 ggcagccggg gaggggagcg cgggccggcc ggccgagttc gcgggcaggg ggcgccggga
      121 ctcccctttc cgcgcccggg acgccgcccg ccggatcgcg ccttgggatg tagcgcccgc
      181 tcgccgcctc ccggactctc gtcggaccct ccgcccagcg gccctgcgtc ttcccaggtg
      241 accacgccgg cttcaggaca tgcacggaca cagccgcaac ggccaggccc acgtgccccg
      301 gcggaagcgc cgcaaccgct tcgtcaagaa gaacggccaa tgcaacgtgt acttcgccaa
      361 cctgagcaac aagtcgcagc gctacatggc ggacatcttc accacctgcg tggacacgcg
      421 ctggcgctac atgctcatga tcttctccgc ggccttcctt gtctcctggc tctttttcgg
      481 cctcctcttc tggtgtatcg ccttcttcca cggtgacctg gaggccagcc caggggtgcc
      541 tgcggcgggg ggcccggcgg cgggtggtgg cggagcagcc ccggtggccc ccaagccctg
      601 catcatgcac gtgaacggct tcctgggtgc cttcctgttc tcggtggaga cgcagacgac
      661 catcggctat gggttccggt gcgtgacaga ggagtgcccg ctggcagtca tcgctgtggt
      721 ggtccagtcc atcgtgggct gcgtcatcga ctccttcatg attggcacca tcatggccaa
      781 gatggcgcgg cccaagaagc gggcgcagac gttgctgttc agccaccacg cggtcatttc
      841 ggtgcgcgac ggcaagctct gcctcatgtg gcgcgtgggc aacctgcgca agagccacat
      901 tgtggaggcc cacgtgcggg cccagctcat caagccctac atgacccagg agggcgagta
      961 cctgcccctg gaccagcggg acctcaacgt gggctatgac atcggcctgg accgcatctt
     1021 cctggtgtcg cccatcatca ttgtccacga gatcgacgag gacagcccgc tttatggcat
     1081 gggcaaggag gagctggagt cggaggactt tgagatcgtg gtcatcctgg agggcatggt
     1141 ggaggccacg gccatgacca cccaggcccg cagctcctac ctggccagcg agatcctgtg
     1201 gggccaccgc tttgagcctg tggtcttcga ggagaagagc cactacaagg tggactactc
     1261 acgttttcac aagacctacg aggtggccgg cacgccctgc tgctcggccc gggagctgca
     1321 ggagagtaag atcaccgtgc tgcccgcccc accgccccct cccagtgcct tctgctacga
     1381 gaacgagctg gcccttatga gccaggagga agaggagatg gaggaggagg cagctgcggc
     1441 ggccgcggtg gccgcaggcc tgggcctgga ggcgggttcc aaggaggagg cgggcatcat
     1501 ccggatgctg gagttcggca gccacctgga cctggagcgc atgcaggctt ccctcccgct
     1561 ggacaacatc tcctaccgca gggagtctgc catctgacct ccaggcccgg ccctcaccac
     1621 tgcccacaag agcctctgcc gggggtggga tgccaggaca ccccctccca cactcaggac
     1681 agagccaacc ctggctccgt ggaccttctg gaggaaggtg ggggtttcaa agactggggg
     1741 accccttcct cctgactcca gcacccaggc ctgggaagag ctcggccccg atcagcctga
     1801 gttccgccag cgcctacttc tggtggctct aggtccccgg atccaccacc cttcccccac
     1861 tgactcttca aggacgtgcc ctctttgctc tcagaacctt ggggaaggtg gctggactgc
     1921 tgggcggggg acatctcggg gtttcagggt gggcaggggg ttagtttggg gagggggggg
     1981 tgcgtttctt ttgcatgact gtggcctgtt gctcatgact ttcttttgta aatatctata
     2041 aatggagaca gatggagaca ccaaa
//
