LOCUS       NM_004981               1903 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens potassium inwardly rectifying channel subfamily J
            member 4 (KCNJ4), transcript variant 2, mRNA.
ACCESSION   NM_004981
VERSION     NM_004981.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1903)
  AUTHORS   Wu,X.Y. and Yu,X.Y.
  TITLE     Overexpression of KCNJ4 correlates with cancer progression and
            unfavorable prognosis in lung adenocarcinoma
  JOURNAL   J Biochem Mol Toxicol 33 (4), e22270 (2019)
   PUBMED   30512237
  REMARK    GeneRIF: results shed some light on the contribution of KCNJ4
            functioning as a significant player in LADC, implying that KCNJ4
            might be a valuable prognostic biomarker and a potential
            therapeutic target for LADC treatment
REFERENCE   2  (bases 1 to 1903)
  AUTHORS   Sundell,G.N., Arnold,R., Ali,M., Naksukpaiboon,P., Orts,J.,
            Guntert,P., Chi,C.N. and Ivarsson,Y.
  TITLE     Proteome-wide analysis of phospho-regulated PDZ domain interactions
  JOURNAL   Mol Syst Biol 14 (8), e8129 (2018)
   PUBMED   30126976
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1903)
  AUTHORS   Agopian,A.J., Mitchell,L.E., Glessner,J., Bhalla,A.D., Sewda,A.,
            Hakonarson,H. and Goldmuntz,E.
  TITLE     Genome-wide association study of maternal and inherited loci for
            conotruncal heart defects
  JOURNAL   PLoS One 9 (5), e96057 (2014)
   PUBMED   24800985
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1903)
  AUTHORS   Ivarsson,Y., Arnold,R., McLaughlin,M., Nim,S., Joshi,R., Ray,D.,
            Liu,B., Teyra,J., Pawson,T., Moffat,J., Li,S.S., Sidhu,S.S. and
            Kim,P.M.
  TITLE     Large-scale interaction profiling of PDZ domains through proteomic
            peptide-phage display using human and viral phage peptidomes
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), 2542-2547 (2014)
   PUBMED   24550280
REFERENCE   5  (bases 1 to 1903)
  AUTHORS   Cazorla,M., Shegda,M., Ramesh,B., Harrison,N.L. and Kellendonk,C.
  TITLE     Striatal D2 receptors regulate dendritic morphology of medium spiny
            neurons via Kir2 channels
  JOURNAL   J Neurosci 32 (7), 2398-2409 (2012)
   PUBMED   22396414
  REMARK    GeneRIF: Increased excitability and decreased dendritic
            arborization are associated with downregulation of inward rectifier
            potassium channels (Kir2.1/2.3).
REFERENCE   6  (bases 1 to 1903)
  AUTHORS   Coulter,K.L., Perier,F., Radeke,C.M. and Vandenberg,C.A.
  TITLE     Identification and molecular localization of a pH-sensing domain
            for the inward rectifier potassium channel HIR
  JOURNAL   Neuron 15 (5), 1157-1168 (1995)
   PUBMED   7576658
REFERENCE   7  (bases 1 to 1903)
  AUTHORS   Budarf,M.L., Perier,F., Barnoski,B.L., Bell,C.J. and
            Vandenberg,C.A.
  TITLE     Assignment of the human hippocampal inward rectifier potassium
            channel (HIR) gene to 22q13.1
  JOURNAL   Genomics 26 (3), 625-629 (1995)
   PUBMED   7607694
REFERENCE   8  (bases 1 to 1903)
  AUTHORS   Makhina,E.N., Kelly,A.J., Lopatin,A.N., Mercer,R.W. and
            Nichols,C.G.
  TITLE     Cloning and expression of a novel human brain inward rectifier
            potassium channel
  JOURNAL   J Biol Chem 269 (32), 20468-20474 (1994)
   PUBMED   8051145
REFERENCE   9  (bases 1 to 1903)
  AUTHORS   Tang,W. and Yang,X.C.
  TITLE     Cloning a novel human brain inward rectifier potassium channel and
            its functional expression in Xenopus oocytes
  JOURNAL   FEBS Lett 348 (3), 239-243 (1994)
   PUBMED   8034048
REFERENCE   10 (bases 1 to 1903)
  AUTHORS   Perier,F., Radeke,C.M. and Vandenberg,C.A.
  TITLE     Primary structure and characterization of a small-conductance
            inwardly rectifying potassium channel from human hippocampus
  JOURNAL   Proc Natl Acad Sci U S A 91 (13), 6240-6244 (1994)
   PUBMED   8016146
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U07364.1.
            
            On Aug 13, 2020 this sequence version replaced NM_004981.1.
            
            Summary: Several different potassium channels are known to be
            involved with electrical signaling in the nervous system. One class
            is activated by depolarization whereas a second class is not. The
            latter are referred to as inwardly rectifying K+ channels, and they
            have a greater tendency to allow potassium to flow into the cell
            rather than out of it. This asymmetry in potassium ion conductance
            plays a key role in the excitability of muscle cells and neurons.
            The protein encoded by this gene is an integral membrane protein
            and member of the inward rectifier potassium channel family. The
            encoded protein has a small unitary conductance compared to other
            members of this protein family. Two transcript variants encoding
            the same protein have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U07364.1, S72503.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMN03465406
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1903              U07364.1           1-1903
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..1903
                     /gene="KCNJ4"
                     /gene_synonym="HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3"
                     /note="potassium inwardly rectifying channel subfamily J
                     member 4"
                     /db_xref="GeneID:3761"
                     /db_xref="HGNC:HGNC:6265"
                     /db_xref="MIM:600504"
     exon            1..58
                     /gene="KCNJ4"
                     /gene_synonym="HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3"
                     /inference="alignment:Splign:2.1.0"
     exon            59..1903
                     /gene="KCNJ4"
                     /gene_synonym="HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1435
                     /gene="KCNJ4"
                     /gene_synonym="HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3"
                     /note="hippocampal inward rectifier potassium channel;
                     potassium channel, inwardly rectifying subfamily J, member
                     4; inward rectifier K(+) channel Kir2.3; potassium
                     voltage-gated channel subfamily J member 4"
                     /codon_start=1
                     /product="inward rectifier potassium channel 4"
                     /protein_id="NP_004972.1"
                     /db_xref="CCDS:CCDS13971.1"
                     /db_xref="GeneID:3761"
                     /db_xref="HGNC:HGNC:6265"
                     /db_xref="MIM:600504"
                     /translation="MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMA
                     DIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAG
                     GGGAAPVAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVG
                     CVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAH
                     VRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGK
                     EELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYS
                     RFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAA
                     AAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQASLPLDNISYRRESAI"
     regulatory      1875..1880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNJ4"
                     /gene_synonym="HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3"
                     /note="hexamer: TATAAA"
     polyA_site      1903
                     /gene="KCNJ4"
                     /gene_synonym="HIR; HIRK2; HRK1; IRK-3; IRK3; Kir2.3"
                     /note="major polyA site"
ORIGIN      
        1 gagaatttca accagaaaga acagccagtg caaaggccca gagacaggaa taaacttggc
       61 cctgcgtctt cccaggtgac cacgccggct tcaggacatg cacggacaca gccgcaacgg
      121 ccaggcccac gtgccccggc ggaagcgccg caaccgcttc gtcaagaaga acggccaatg
      181 caacgtgtac ttcgccaacc tgagcaacaa gtcgcagcgc tacatggcgg acatcttcac
      241 cacctgcgtg gacacgcgct ggcgctacat gctcatgatc ttctccgcgg ccttccttgt
      301 ctcctggctc tttttcggcc tcctcttctg gtgtatcgcc ttcttccacg gtgacctgga
      361 ggccagccca ggggtgcctg cggcgggggg cccggcggcg ggtggtggcg gagcagcccc
      421 ggtggccccc aagccctgca tcatgcacgt gaacggcttc ctgggtgcct tcctgttctc
      481 ggtggagacg cagacgacca tcggctatgg gttccggtgc gtgacagagg agtgcccgct
      541 ggcagtcatc gctgtggtgg tccagtccat cgtgggctgc gtcatcgact ccttcatgat
      601 tggcaccatc atggccaaga tggcgcggcc caagaagcgg gcgcagacgt tgctgttcag
      661 ccaccacgcg gtcatttcgg tgcgcgacgg caagctctgc ctcatgtggc gcgtgggcaa
      721 cctgcgcaag agccacattg tggaggccca cgtgcgggcc cagctcatca agccctacat
      781 gacccaggag ggcgagtacc tgcccctgga ccagcgggac ctcaacgtgg gctatgacat
      841 cggcctggac cgcatcttcc tggtgtcgcc catcatcatt gtccacgaga tcgacgagga
      901 cagcccgctt tatggcatgg gcaaggagga gctggagtcg gaggactttg agatcgtggt
      961 catcctggag ggcatggtgg aggccacggc catgaccacc caggcccgca gctcctacct
     1021 ggccagcgag atcctgtggg gccaccgctt tgagcctgtg gtcttcgagg agaagagcca
     1081 ctacaaggtg gactactcac gttttcacaa gacctacgag gtggccggca cgccctgctg
     1141 ctcggcccgg gagctgcagg agagtaagat caccgtgctg cccgccccac cgccccctcc
     1201 cagtgccttc tgctacgaga acgagctggc ccttatgagc caggaggaag aggagatgga
     1261 ggaggaggca gctgcggcgg ccgcggtggc cgcaggcctg ggcctggagg cgggttccaa
     1321 ggaggaggcg ggcatcatcc ggatgctgga gttcggcagc cacctggacc tggagcgcat
     1381 gcaggcttcc ctcccgctgg acaacatctc ctaccgcagg gagtctgcca tctgacctcc
     1441 aggcccggcc ctcaccactg cccacaagag cctctgccgg gggtgggatg ccaggacacc
     1501 ccctcccaca ctcaggacag agccaaccct ggctccgtgg accttctgga ggaaggtggg
     1561 ggtttcaaag actgggggac cccttcctcc tgactccagc acccaggcct gggaagagct
     1621 cggccccgat cagcctgagt tccgccagcg cctacttctg gtggctctag gtccccggat
     1681 ccaccaccct tcccccactg actcttcaag gacgtgccct ctttgctctc agaaccttgg
     1741 ggaaggtggc tggactgctg ggcgggggac atctcggggt ttcagggtgg gcagggggtt
     1801 agtttgggga ggggggggtg cgtttctttt gcatgactgt ggcctgttgc tcatgacttt
     1861 cttttgtaaa tatctataaa tggagacaga tggagacacc aaa
//
