LOCUS       NM_170736               8407 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens potassium inwardly rectifying channel subfamily J
            member 15 (KCNJ15), transcript variant 1, mRNA.
ACCESSION   NM_170736
VERSION     NM_170736.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8407)
  AUTHORS   Bentley,S.R., Guella,I., Sherman,H.E., Neuendorf,H.M., Sykes,A.M.,
            Fowdar,J.Y., Silburn,P.A., Wood,S.A., Farrer,M.J. and Mellick,G.D.
  TITLE     Hunting for Familial Parkinson's Disease Mutations in the Post
            Genome Era
  JOURNAL   Genes (Basel) 12 (3), 430 (2021)
   PUBMED   33802862
  REMARK    GeneRIF: Hunting for Familial Parkinson's Disease Mutations in the
            Post Genome Era.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8407)
  AUTHORS   Nakamura,S., Kanda,M., Koike,M., Shimizu,D., Umeda,S., Hattori,N.,
            Hayashi,M., Tanaka,C., Kobayashi,D., Yamada,S., Omae,K. and
            Kodera,Y.
  TITLE     KCNJ15 Expression and Malignant Behavior of Esophageal Squamous
            Cell Carcinoma
  JOURNAL   Ann Surg Oncol 27 (7), 2559-2568 (2020)
   PUBMED   32052303
  REMARK    GeneRIF: KCNJ15 Expression and Malignant Behavior of Esophageal
            Squamous Cell Carcinoma.
REFERENCE   3  (bases 1 to 8407)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 8407)
  AUTHORS   Alves da Silva,A.F., Machado,F.B., Pavarino,E.C.,
            Biselli-Perico,J.M., Zampieri,B.L., da Silva Francisco Junior,R.,
            Mozer Rodrigues,P.T., Terra Machado,D., Santos-Reboucas,C.B., Gomes
            Fernandes,M., Chuva de Sousa Lopes,S.M., Lopes Rios,A.F. and
            Medina-Acosta,E.
  TITLE     Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and
            -Independent Manners
  JOURNAL   PLoS One 11 (4), e0154108 (2016)
   PUBMED   27100087
  REMARK    GeneRIF: RNA-seq evidence of biallelic expression of KCNJ15 and 10
            neighboring genes in at least one primary human tissue tested
            indicates that the expression of KCNJ15 is uncoupled from the
            control of the maternally inherited 5mCpG imprints at the WRB
            differentially methylated region (DMR) in disomic controls or
            trisomy (Down syndrome) individuals.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8407)
  AUTHORS   Nakajima,K.I., Zhu,K., Sun,Y.H., Hegyi,B., Zeng,Q., Murphy,C.J.,
            Small,J.V., Chen-Izu,Y., Izumiya,Y., Penninger,J.M. and Zhao,M.
  TITLE     KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular
            electric fields in galvanotaxis
  JOURNAL   Nat Commun 6, 8532 (2015)
   PUBMED   26449415
  REMARK    GeneRIF: KCNJ15 couples with polyamines in sensing weak electric
            fields.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8407)
  AUTHORS   Pearson,W.L., Dourado,M., Schreiber,M., Salkoff,L. and Nichols,C.G.
  TITLE     Expression of a functional Kir4 family inward rectifier K+ channel
            from a gene cloned from mouse liver
  JOURNAL   J Physiol 514 (Pt 3) (Pt 3), 639-653 (1999)
   PUBMED   9882736
REFERENCE   7  (bases 1 to 8407)
  AUTHORS   Kurschner,C., Mermelstein,P.G., Holden,W.T. and Surmeier,D.J.
  TITLE     CIPP, a novel multivalent PDZ domain protein, selectively interacts
            with Kir4.0 family members, NMDA receptor subunits, neurexins, and
            neuroligins
  JOURNAL   Mol Cell Neurosci 11 (3), 161-172 (1998)
   PUBMED   9647694
REFERENCE   8  (bases 1 to 8407)
  AUTHORS   Gosset,P., Ghezala,G.A., Korn,B., Yaspo,M.L., Poutska,A.,
            Lehrach,H., Sinet,P.M. and Creau,N.
  TITLE     A new inward rectifier potassium channel gene (KCNJ15) localized on
            chromosome 21 in the Down syndrome chromosome region 1 (DCR1)
  JOURNAL   Genomics 44 (2), 237-241 (1997)
   PUBMED   9299242
REFERENCE   9  (bases 1 to 8407)
  AUTHORS   Shuck,M.E., Piser,T.M., Bock,J.H., Slightom,J.L., Lee,K.S. and
            Bienkowski,M.J.
  TITLE     Cloning and characterization of two K+ inward rectifier (Kir) 1.1
            potassium channel homologs from human kidney (Kir1.2 and Kir1.3)
  JOURNAL   J Biol Chem 272 (1), 586-593 (1997)
   PUBMED   8995301
REFERENCE   10 (bases 1 to 8407)
  AUTHORS   Ohira,M., Seki,N., Nagase,T., Suzuki,E., Nomura,N., Ohara,O.,
            Hattori,M., Sakaki,Y., Eki,T., Murakami,Y., Saito,T., Ichikawa,H.
            and Ohki,M.
  TITLE     Gene identification in 1.6-Mb region of the Down syndrome region on
            chromosome 21
  JOURNAL   Genome Res 7 (1), 47-58 (1997)
   PUBMED   9037601
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from D87291.1, BC013327.1,
            AI344546.1, AI453386.1 and AP001422.1.
            
            On Nov 22, 2018 this sequence version replaced NM_170736.2.
            
            Summary: Potassium channels are present in most mammalian cells,
            where they participate in a wide range of physiologic responses.
            The protein encoded by this gene is an integral membrane protein
            and inward-rectifier type potassium channel. The encoded protein
            has a greater tendency to allow potassium to flow into a cell
            rather than out of a cell. Eight transcript variants encoding the
            same protein have been found for this gene. [provided by RefSeq,
            Feb 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All eight variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292812.1, D87291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398938.7/ ENSP00000381911.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-603               D87291.1           44-646
            604-2537            BC013327.1         599-2532
            2538-2871           AI344546.1         5-338               c
            2872-2876           AI453386.1         32-36               c
            2877-8407           AP001422.1         2096-7626
FEATURES             Location/Qualifiers
     source          1..8407
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.13-q22.2"
     gene            1..8407
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
                     /note="potassium inwardly rectifying channel subfamily J
                     member 15"
                     /db_xref="GeneID:3772"
                     /db_xref="HGNC:HGNC:6261"
                     /db_xref="MIM:602106"
     exon            1..195
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
                     /inference="alignment:Splign:2.1.0"
     exon            196..293
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
                     /inference="alignment:Splign:2.1.0"
     exon            294..8407
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1439
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
                     /note="inward rectifier K+ channel KIR4.2; inward
                     rectifier K(+) channel Kir1.3; inward rectifier K(+)
                     channel Kir4.2; potassium channel, inwardly rectifying
                     subfamily J member 15; potassium voltage-gated channel
                     subfamily J member 15"
                     /codon_start=1
                     /product="ATP-sensitive inward rectifier potassium channel
                     15"
                     /protein_id="NP_733932.1"
                     /db_xref="CCDS:CCDS13656.1"
                     /db_xref="GeneID:3772"
                     /db_xref="HGNC:HGNC:6261"
                     /db_xref="MIM:602106"
                     /translation="MDAIHIGMSSTPLVKHTAGAGLKANRPRVMSKSGHSNVRIDKVD
                     GIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPGEPIS
                     NHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFI
                     TGTFLAKIARPKKRAETIKFSHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQ
                     THVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKE
                     FELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIR
                     KSPDCTFYCADSEKQQLEEKYRQEDQRERELRTLLLQQSNV"
     regulatory      1798..1803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
                     /note="hexamer: AATACA"
     polyA_site      1821
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
                     /note="major polyA site"
     regulatory      2843..2848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
                     /note="hexamer: AATAAA"
     polyA_site      2876
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
     regulatory      4150..4155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
                     /note="hexamer: AATAAA"
     polyA_site      4176
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
     regulatory      4721..4726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
                     /note="hexamer: AATAAA"
     polyA_site      4738
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
     regulatory      8383..8388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
                     /note="hexamer: TATAAA"
     polyA_site      8393
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
     polyA_site      8407
                     /gene="KCNJ15"
                     /gene_synonym="IRKK; KIR1.3; KIR4.2"
ORIGIN      
        1 agttcctcca ggtaattctt actcaaactt gtaccaactt gtttttgact gacagtgaac
       61 agtgagagag ttttcttcat tttgaggaac cctaaacacc tatctttccc aaggcaacct
      121 gtctggactg agcatttctc tgacttgaca taacttccca tccagccagg agtctgcact
      181 cttcagtctt tgcaggcagt agcagaatcc catggtagcc aggtgggtga aggggagcga
      241 ggacgttcta cctgccttga agaagacacc tgacctgcgg agtgagtgac cagtgtttcc
      301 agagcctggc aatggatgcc attcacatcg gcatgtccag cacccccctg gtgaagcaca
      361 ctgctggggc tgggctcaag gccaacagac cccgcgtcat gtccaagagt gggcacagca
      421 acgtgagaat tgacaaagtg gatggcatat acctactcta cctgcaagac ctgtggacca
      481 cagttatcga catgaagtgg agatacaaac tcaccctgtt cgctgccact tttgtgatga
      541 cctggttcct ttttggagtc atctactatg ccatcgcgtt tattcatggg gacttagaac
      601 ccggtgagcc catttcaaat cataccccct gcatcatgaa agtggactct ctcactgggg
      661 cgtttctctt ttccctggaa tcccagacaa ccattggcta tggagtccgt tccatcacag
      721 aggaatgtcc tcatgccatc ttcctgttgg ttgctcagtt ggtcatcacg accttgattg
      781 agatcttcat caccggaacc ttcctggcca aaatcgccag acccaaaaag cgggctgaga
      841 ccatcaagtt cagccactgt gcagtcatca ccaagcagaa tgggaagctg tgcttggtga
      901 ttcaggtagc caatatgagg aagagcctct tgattcagtg ccagctctct ggcaagctcc
      961 tgcagaccca cgtcaccaag gagggggagc ggattctcct caaccaagcc actgtcaaat
     1021 tccacgtgga ctcctcctct gagagcccct tcctcattct gcccatgaca ttctaccatg
     1081 tgctggatga gacgagcccc ctgagagacc tcacacccca aaacctaaag gagaaggagt
     1141 ttgagcttgt ggtcctcctc aatgccactg tggaatccac cagcgctgtc tgccagagcc
     1201 gaacatctta tatcccagag gaaatctact ggggttttga gtttgtgcct gtggtatctc
     1261 tctccaaaaa tggaaaatat gtggctgatt tcagtcagtt tgaacagatt cggaaaagcc
     1321 cagattgcac attttactgt gcagattctg agaaacagca actcgaggag aagtacaggc
     1381 aggaggatca gagggaaaga gaactgagga cacttttatt acaacagagc aatgtctgat
     1441 cacaggggcg ccatccaggt ttaaccctgc aagctgtttc cacatcagaa ctcccttcaa
     1501 acacaaagat tgctgtgaaa acgaaaatgt gtagacgcac tctcaaaaac tgcacggaca
     1561 tacaaaatca atcttttcct ttgatcttgt ggctaaacca gcatttctgt gtttgagaga
     1621 tttcctgtta ggtgcttcgt ctgaaagtga actctcataa ttcaaattgt ataaaataaa
     1681 gctacatttc taagagcttg gtgtagggca attggaataa tgtcctgtta gataaacaga
     1741 catttagcaa tcctgacatt aaaaggaaat gtatttctat acaagattat tagctgtaat
     1801 acaagatatt tatttaacca atgaccttat ggctgagagt tgaattgtgg ttcagtattc
     1861 attgatctca ctgctttaaa acatgctctt tttgttcaag caggaaaaat attatatcta
     1921 attatgtcta tgtggtaata cctaaaaaga ggtagagaga ctctatgttc acaaaatata
     1981 gtaatttcat ttttaccttt cttcagtgga ctgaattgta tggaaggaaa ttgatcagat
     2041 ctgtaattca caactgtgga aacctacaca aatggggctg atgccattgt ttcctctatt
     2101 ttattttatt tatttttgaa tccactatct ctttccattc aaaatatttc cattcaaaat
     2161 gtggttcaca gacccgccac atcagcacca tccgagagct tattagtaat gtgtagattc
     2221 tcatgtccca gccagactta cagaattggg gtctgtatct taacaagaac cccagatgat
     2281 ttgtgtacaa atgaaagttc gaaagctgtg ctctggacag tgttctcaaa gcaactttct
     2341 gaagccgtgt ggaaaactga ctctgtgtgg gtcccgtatc cctgtggcat ccagacctgg
     2401 cctctcttca tttcattatt attggccaat atttctttca gccatttcat ttcttatcta
     2461 ttaaaatggc ttgcccataa aggaactgca taggattatc ccctgacatt ccaagagcaa
     2521 aataaagctc ttgagagtaa ttgttgtctc agtcatgctt gctgattaca gttagcacaa
     2581 aagaaaaatt cagctgcctg acaatacagg aaatgttctc agatgctgat gtttgtaagg
     2641 tccggtgggg ccatgaggaa gaagaggagc tgaaggtaag aaactcataa acaagatgac
     2701 tctttgatgc atgaacaaga tttgaaaatc tcaagcctgt aaagaatacc cctgctattt
     2761 aaataaagct cataccaaga ggtaacattt tgccccgggc caaattcagg ggtctagtgc
     2821 cctgcattcc tttgaggcaa aaaataaatg ggctatgact ggttaaatgt ccaaaaggtg
     2881 aattctcatt tcattcaaac aaagacagat ttgcgcattc actcaagcag aatgtggcca
     2941 tgaatattca gcccctgcat acatacaaag atgtacgcat gattcccccc accaagcaca
     3001 cacacagtca cacacgcaca cacacacaca tgcacacacg cgcgtgcaca cacgcacaca
     3061 tgcacacaca catacgcaca cgtaaacaca tgcacacatg cacacacgcg cacacatgca
     3121 cacacgcaca cacttgcaca ggccctggct cttcaagcat aatcatggta gtcatcagtg
     3181 aaagacattt gaggttaaga cagcaagtcc ttgacaaata tgttcatgtc tatttggttc
     3241 tagttctata aaaatatgaa cattgggact cagagaaaat ggggaaaata aagtggattc
     3301 aggttatcag tgaaatgatg gtatagatta cagcaaatct ggatatatat tgatgttact
     3361 gcatttgcaa atgtcctccc attaaacaga aaatgtggct aaaatccctg gcctggaact
     3421 gaactagttt aaggcaggtg taagaatagt gggaggaaag tttgtgaaag tttaaagaat
     3481 gccctcaatc catgaacgag agggaggatg ttgtctttaa ttatttagaa ggtttttttt
     3541 tccttgtctg ttgataattt tatggaaggt tgctttagat ctccattcct taaaaaaata
     3601 ttacatgtca gtgtagttag atattatctc ttttagttat tatacttgct atttttactg
     3661 tatagtgtgg tataatcaac aaaaaataat gccacgggca tgtttacacc ttttctgttg
     3721 cactattaaa ttcttttcac agtattcata tcaatgctaa tttgaatgtg atgccaatta
     3781 aaaatcttgt tcatttatat tgtatatggt acaaggacgt agcataagat ccaaaaaaaa
     3841 ttttgtattg tcatttagca tatcaatttc agccaaattt ggaagacttg atcatcttat
     3901 cttttgctct acacactcaa aacaaatatt gcagcagaaa tatcacctta aaaatatctt
     3961 attttatatt tagataatat tgaaatcaca gtctattaaa attggaaatt taattcaaat
     4021 aaaaatcaaa caaaatagtt gtttcaattt atctaaatat ctggtcttaa gagtgcctta
     4081 agagtgtctc gtttttaaga gtgtcttaaa aaccaatata tgtataagtc aacaaatcat
     4141 ataatattca ataaatagct ctgaagttgt atctgatttg aaacttacca ttttcctgga
     4201 accttaacta ttattacttt gtacgtaata ctttcatgtt actatgctaa caaaggattt
     4261 aggtagccaa cttaatttat tatatctggt cggtcttctg cttgaaacag attcacactc
     4321 aacacccaac taaggaggag ccaaagtagt ggagtattcc tgacccaaaa aggcttttga
     4381 attttgaaac atttctaatg tgttaggttt tctcaatgag accattaaaa aacgttgtgt
     4441 tccatttgag aaaccagagt caacagcagt aaatcagtgt gccccacaag ccacgtctta
     4501 ttcagcaata aaatagtgct cacatggtgc ctggcagaca gtggctctgg acagcaaagc
     4561 actgagtcac ccaaccccac tcctttggga tggggttggg agtcatgcat tggctccctt
     4621 tttcatcctg gggaaattac aacacaacgc agagtgtcca gaaatctaaa gagctggttt
     4681 aaggtgaaaa aaatgccatg aatgaatgaa ccagatgttt aataaatcaa aacaactatt
     4741 ttgttggatt tttatttgaa ttaaatttcc caatttttaa tagactgtga tttcaatatt
     4801 atcgaaatgt aaacaaagat atatttttaa ggtggcattt ctactccagc atgaaaaaaa
     4861 tagtggcatt tgcactctag cattattctg tctcccttat ttgagtcttc aatatatatg
     4921 cccagctgga gggagaagaa gagaaaaatg aaagcactag gcctttgact aggtttggtt
     4981 ctatatgctg tcatgatgtt caaaatgtca gacatttgac cacatggcac agtgaatact
     5041 ctcacgctct caattttggc tttcattctt gctagacttt tcttctatta aatttctgaa
     5101 ataactagtt tttttttttt gaacttgaaa atcagctttt tatttttttt aattttatta
     5161 ttattatact ttaagtttta gggtacatgt gcacaacgtg caggtttgtt acatatgtat
     5221 acatgtgcca tgttggtgtg ctgcacccat taactcgtca tttagcatta ggtatatctc
     5281 ctaatgctat ccctcccccc tccccccacc ccacaacagt ccccggtgtg tgatgttccc
     5341 cttcctgtgt ccatgtgttc tcattgttca atttccacct atgagtgaga acatgcggtg
     5401 tttggttttc tgtccttgag atagtttgct gagaatgatg gtttccagtt tcatccaata
     5461 actagtttta tcatagcttt ccatgatgta attttttaag cgaaaggtac taacatttcc
     5521 agtcttgatt tccaagtttt gtggtgtgca ctcgaaatct agtctctgat tgttaaactc
     5581 tgggtaggta caagaggctc ttaattttct tcctcccagg aggacttact tacacttaaa
     5641 ggtcaaaagc ttaacattca cttctaaatg gttaactgca tacactttac cctttgtaaa
     5701 cttcaattta tctttttttt tttttttttt tttttttttt tttgatactg ggtctcgctc
     5761 tgtcgcccag gctgctagag tgcagtggcg cgatttcggc tcactgcaag tccgcttcca
     5821 ggttcacgcc attctctccc tcagcctccc gagtagctgg gactacaggc gctcgccacc
     5881 atgcccggct aattttgttt ttgtgttttt agtagagacg gggtttcacc gtgttaacca
     5941 ggatggtctc gatctcatga cctcgtgatc tgcccgccta caagccaggt gtggtggtgc
     6001 gtgcctgtaa tcccagctac tcaggagact gaggcaggag attcgcttga acccgggagg
     6061 tggacgttgc agtgagctaa gatcgcgcca ctgcactcca gcctgggcaa caaaagtaaa
     6121 actccgtctc aaaaaaaaaa aaaaaaagaa aaagaaaaag aaaagaaaag aaaataaacg
     6181 tggcaaaact agaccttcag acacttcact tcacttaacc ctatggccct ccttatcttg
     6241 cacccaattt cttttcaaca tcatacatgc ttggttgact gtttcttcat atttgctgtt
     6301 cattctataa agtcaaatag attggtgggt taaaaaataa tcaattcaaa ttcaaattag
     6361 gaatttatgg acattcagat atccacatat ttgagggcag gaatttttac ttttcaattg
     6421 gtatgttggc agtgtgtaaa aatagaagac caagagaagg cggttgattg gagttgatac
     6481 ttaatagcta ataaaaatta caagaaagga tggtggaagt caaaggacag aactgataca
     6541 cgagtataaa agccaacgat gtcatatatg taggcaaagt ctttgtaatc tgaatataat
     6601 gccagagagc tagggctgcc aggcactctg tatgtgcaga atatgtccta tatggagtaa
     6661 ttttttattt gtgtagactt ttttaggata ccttaaatgt cttacatgca accttttttt
     6721 ccccatatat tacaaaattg ccttggaaat tagacaaatc ttcaaactta actgaaactc
     6781 ctgtcctgaa tagttatttg ccaaatctga caaatttaca aagagtgttc acataatccc
     6841 aaactatgcc catttctaca agagaaatac atgcctcttt atttggagtt tatgatattc
     6901 atacaactag tagtagagtc agggagtatt ccagaaacat atttccctgg cttgcccaat
     6961 tatcaaggga aaatttcagc tgaacacggg gaacccagtc tttgacactc ctgtgtgcag
     7021 tgtggagcag cgtgcactgt ctgagtctcc atagtgagga atggtcttcc ctggggcatc
     7081 accctagaag gatgggctca aagtcgccct ccacgtgggt gcacaggagc ccagattctc
     7141 aagccccagt tgcagaatta ggctgatggt tttacaaaag agtcctccta aaagtccatc
     7201 actaagtttt gtttggttag caacccttgc cacatgatgt agtacttagc tataatttta
     7261 tttttattca aggccaaatc ttatctggtg tccatgcctt cccacctact taaaatttca
     7321 aatttcaccc tcaaaaatat ttcagtaaat aaaagttaga tctactcaaa attagactcc
     7381 aagggaatta ctatagttga ttatagagta tctatttcct taaaaaaaaa aaaccataag
     7441 ttgttgactc tgagctagga aatgcgtgat ctctcagctg acttacttta tgcaaattta
     7501 cttaatatta tagaagagta aagagcttcc aagaaggtga ttggagggaa gttcaaaggg
     7561 aagatttttt tcattcactg tagttttagc tgtattcttt catctgcaat caaatctcag
     7621 gattaaggat gtcgtattac atcaaatcat tacaggaagt atgactgtat cagcggcttt
     7681 ttacaaaaac aaacctccag atcacaaaag gaagctgtgt ttgtgtactg acacgaagtg
     7741 ttacgtagca gccaggagag gaaggatagc agccgacttg gatccatttt tgaggaatta
     7801 tttctgtaag gtgtcatgga attgtaagtt acaaaaataa ggcttttgta aacagaatct
     7861 ccattccaga aggacggact ccaaaatgct acttaatgaa attcatggga atgttatggt
     7921 gatggaaatc ccaaatgaca tgtagatttt atatgcaaac aatcccactg cttgtaactc
     7981 ctggcagtgt gtacttacca aaatcttgat cacacttagg tctcttgcta tatatagaac
     8041 cacatctgat ccttatacag tgttgcaaga tatatgtcct tgctttccca tggttcttaa
     8101 gtgagtctta agcttggatt tgctccagca gaatggtggt ttgtgtttct caaggctgag
     8161 ctactatttg gtgcatgtcg gaaatctcac actaactgtg gatactctgt catcactgaa
     8221 cccaatcata caatgaccag acagctttaa atacctactt ttgtatgcta tgaattcatc
     8281 cgtttacttg tcaaatcctt tatttccata tgtgtctcca tcaccttttt tttctctccg
     8341 gataaatgga attactgtaa cttgtgaaac aatggcaaac actataaagc taattttaca
     8401 gtcttga
//
