LOCUS       NM_013348               3854 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens potassium inwardly rectifying channel subfamily J
            member 14 (KCNJ14), mRNA.
ACCESSION   NM_013348
VERSION     NM_013348.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3854)
  AUTHORS   Alasiri,G.
  TITLE     Comprehensive Analysis of KCNJ14 Potassium Channel as a Biomarker
            for Cancer Progression and Development
  JOURNAL   Int J Mol Sci 24 (3), 2049 (2023)
   PUBMED   36768373
  REMARK    GeneRIF: Comprehensive Analysis of KCNJ14 Potassium Channel as a
            Biomarker for Cancer Progression and Development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3854)
  AUTHORS   Li,B., Ge,N., Pan,Z., Hou,C., Xie,K., Wang,D., Liu,J., Wan,J.,
            Deng,F., Li,M. and Luo,S.
  TITLE     KCNJ14 knockdown significantly inhibited the proliferation and
            migration of colorectal cells
  JOURNAL   BMC Med Genomics 15 (1), 194 (2022)
   PUBMED   36100894
  REMARK    GeneRIF: KCNJ14 knockdown significantly inhibited the proliferation
            and migration of colorectal cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3854)
  AUTHORS   Yokoyama,K., Urashima,M., Ohkido,I., Kono,T., Yoshida,T.,
            Muramatsu,M., Niu,T. and Hosoya,T.
  TITLE     L-type voltage-dependent calcium channel alpha subunit 1C is a
            novel candidate gene associated with secondary hyperparathyroidism:
            an application of haplotype-based analysis for multiple linked
            single nucleotide polymorphisms
  JOURNAL   Nephron Clin Pract 115 (4), c237-c243 (2010)
   PUBMED   20424473
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3854)
  AUTHORS   Ji,W., Foo,J.N., O'Roak,B.J., Zhao,H., Larson,M.G., Simon,D.B.,
            Newton-Cheh,C., State,M.W., Levy,D. and Lifton,R.P.
  TITLE     Rare independent mutations in renal salt handling genes contribute
            to blood pressure variation
  JOURNAL   Nat Genet 40 (5), 592-599 (2008)
   PUBMED   18391953
REFERENCE   5  (bases 1 to 3854)
  AUTHORS   Tennant,B.P., Cui,Y., Tinker,A. and Clapp,L.H.
  TITLE     Functional expression of inward rectifier potassium channels in
            cultured human pulmonary smooth muscle cells: evidence for a major
            role of Kir2.4 subunits
  JOURNAL   J Membr Biol 213 (1), 19-29 (2006)
   PUBMED   17347781
  REMARK    GeneRIF: Using patch-clamp techniques, we characterized K(IR)
            channels in cultured pulmonary artery smooth muscle cells and
            compared them to cloned Kir2.1 and Kir2.4 channels
REFERENCE   6  (bases 1 to 3854)
  AUTHORS   Kubo,Y., Adelman,J.P., Clapham,D.E., Jan,L.Y., Karschin,A.,
            Kurachi,Y., Lazdunski,M., Nichols,C.G., Seino,S. and
            Vandenberg,C.A.
  TITLE     International Union of Pharmacology. LIV. Nomenclature and
            molecular relationships of inwardly rectifying potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 509-526 (2005)
   PUBMED   16382105
  REMARK    Review article
REFERENCE   7  (bases 1 to 3854)
  AUTHORS   Fang,Y., Schram,G., Romanenko,V.G., Shi,C., Conti,L.,
            Vandenberg,C.A., Davies,P.F., Nattel,S. and Levitan,I.
  TITLE     Functional expression of Kir2.x in human aortic endothelial cells:
            the dominant role of Kir2.2
  JOURNAL   Am J Physiol Cell Physiol 289 (5), C1134-C1144 (2005)
   PUBMED   15958527
  REMARK    GeneRIF: Kir2.2 and Kir2.1 are primary determinants of endogenous
            K(+) conductance in HAECs under resting conditions and that Kir2.2
            provides the dominant conductance in these cells.
REFERENCE   8  (bases 1 to 3854)
  AUTHORS   Hughes,B.A., Kumar,G., Yuan,Y., Swaminathan,A., Yan,D., Sharma,A.,
            Plumley,L., Yang-Feng,T.L. and Swaroop,A.
  TITLE     Cloning and functional expression of human retinal kir2.4, a
            pH-sensitive inwardly rectifying K(+) channel
  JOURNAL   Am J Physiol Cell Physiol 279 (3), C771-C784 (2000)
   PUBMED   10942728
REFERENCE   9  (bases 1 to 3854)
  AUTHORS   Topert,C., Doring,F., Derst,C., Daut,J., Grzeschik,K.H. and
            Karschin,A.
  TITLE     Cloning, structure and assignment to chromosome 19q13 of the human
            Kir2.4 inwardly rectifying potassium channel gene (KCNJ14)
  JOURNAL   Mamm Genome 11 (3), 247-249 (2000)
   PUBMED   10723734
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF081466.1 and AC008403.8.
            
            On Jul 17, 2019 this sequence version replaced NM_013348.3.
            
            Summary: Potassium channels are present in most mammalian cells,
            where they participate in a wide range of physiologic responses.
            The protein encoded by this gene is an integral membrane protein
            and inward-rectifier type potassium channel, and probably has a
            role in controlling the excitability of motor neurons. [provided by
            RefSeq, Feb 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF081466.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342291.3/ ENSP00000341479.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2362              AF081466.1         66-2427
            2363-3854           AC008403.8         49003-50494
FEATURES             Location/Qualifiers
     source          1..3854
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..3854
                     /gene="KCNJ14"
                     /gene_synonym="IRK4; KIR2.4"
                     /note="potassium inwardly rectifying channel subfamily J
                     member 14"
                     /db_xref="GeneID:3770"
                     /db_xref="HGNC:HGNC:6260"
                     /db_xref="MIM:603953"
     exon            1..285
                     /gene="KCNJ14"
                     /gene_synonym="IRK4; KIR2.4"
                     /inference="alignment:Splign:2.1.0"
     exon            286..1054
                     /gene="KCNJ14"
                     /gene_synonym="IRK4; KIR2.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..1651
                     /gene="KCNJ14"
                     /gene_synonym="IRK4; KIR2.4"
                     /note="inwardly rectifying potassium channel KIR2.4;
                     inward rectifier K(+) channel Kir2.4; potassium channel,
                     inwardly rectifying subfamily J member 14; potassium
                     voltage-gated channel subfamily J member 14"
                     /codon_start=1
                     /product="ATP-sensitive inward rectifier potassium channel
                     14"
                     /protein_id="NP_037480.1"
                     /db_xref="CCDS:CCDS12721.1"
                     /db_xref="GeneID:3770"
                     /db_xref="HGNC:HGNC:6260"
                     /db_xref="MIM:603953"
                     /translation="MGLARALRRLSGALDSGDSRAGDEEEAGPGLCRNGWAPAPVQSP
                     VGRRRGRFVKKDGHCNVRFVNLGGQGARYLSDLFTTCVDVRWRWMCLLFSCSFLASWL
                     LFGLAFWLIASLHGDLAAPPPPAPCFSHVASFLAAFLFALETQTSIGYGVRSVTEECP
                     AAVAAVVLQCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAVVALRDHRLCLMWR
                     VGNLRRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVSPITIVH
                     EIDSASPLYELGRAELARADFELVVILEGMVEATAMTTQCRSSYLPGELLWGHRFEPV
                     LFQRGSQYEVDYRHFHRTYEVPGTPVCSAKELDERAEQASHSLKSSFPGSLTAFCYEN
                     ELALSCCQEEDEDDETEEGNGVETEDGAASPRVLTPTLALTLPP"
     exon            1055..3854
                     /gene="KCNJ14"
                     /gene_synonym="IRK4; KIR2.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3834..3839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNJ14"
                     /gene_synonym="IRK4; KIR2.4"
                     /note="hexamer: ATTAAA"
     polyA_site      3854
                     /gene="KCNJ14"
                     /gene_synonym="IRK4; KIR2.4"
                     /note="major polyA site"
ORIGIN      
        1 gagtcgcagc cagcctggga gctgggccat gttggccgca gatggccccc tggtgaaggt
       61 tcccgttggc tttgggaagt agacaacggg tctgcctcac ggggctgagg tgggactgga
      121 ggatttcgag ggcagaactc tgggaaggaa agaaaggctt aggacccaac cagcattccc
      181 cctggcactg cgggggcctg gccagctcat ggcgttccct gagcctgttc cccaactgtg
      241 aaagggggtg atgatcttca cctcccggca tcctgagcgg ccaagcaggt tgggggcgcc
      301 tgccccccac taggccaagt ggagggggtc cctccgtcca atgggcctgg ccagggccct
      361 acgccgcctc agcggcgccc tggattcggg agacagccgg gcgggcgatg aagaggaggc
      421 cgggcccggg ttgtgccgca acgggtgggc gccggcaccg gtgcagtcac ccgtgggccg
      481 gcgccgcggt cgcttcgtca agaaagacgg gcactgcaac gtgcgtttcg taaacctggg
      541 tggccagggc gcgcgctacc tgagcgacct gttcaccaca tgcgtggacg tgcgctggcg
      601 ctggatgtgc ctgctcttct cctgctcctt cctcgcctcc tggctgctct tcggcctggc
      661 cttctggctc attgcctcgc tgcacggcga cctggccgcc ccgccaccgc ccgcgccctg
      721 cttctcacac gtggccagct tcctggccgc cttcctcttc gcgctggaga cgcagacgtc
      781 catcggctac ggcgtgcgca gcgtcaccga ggagtgcccg gccgctgtgg ccgccgtggt
      841 gctgcagtgc attgccggct gcgtgctcga cgccttcgtc gtgggtgctg tcatggccaa
      901 gatggccaaa cccaagaagc gcaacgagac gctggtcttc agcgagaacg ccgtcgtggc
      961 gctgcgcgac caccgcctct gcctcatgtg gcgcgtcggc aacctgcgcc gcagccacct
     1021 ggtcgaggcc cacgtgcgtg cccagctgct gcagccccgt gtgaccccag agggtgagta
     1081 catcccgctg gaccaccagg atgtggatgt gggctttgat ggaggcaccg atcgtatctt
     1141 cctcgtgtcc cccatcacca tcgtccatga gatcgactct gccagtcctc tgtatgagct
     1201 aggacgtgcc gagctggcca gggctgactt tgagctggtg gtcattctcg aggggatggt
     1261 tgaggccaca gccatgacca cacagtgtcg ctcgtcctac ctccctggtg aactgctctg
     1321 gggccatcgt tttgagccag ttctcttcca gcgtggctcc cagtatgagg tcgactatcg
     1381 ccacttccat cgcacttatg aggtcccagg gacaccggtc tgcagtgcta aggagctgga
     1441 tgaacgggca gagcaggctt cccacagcct caagtctagt ttccccggct ctctgactgc
     1501 attttgttat gagaatgaac ttgctctgag ctgctgccag gaggaagatg aggacgatga
     1561 gactgaggaa gggaatgggg tggaaacaga agatggggct gctagccccc gagttctcac
     1621 accaaccctg gcgctgaccc tgcctccatg atgcaaactg atgtcccctt ccccgtgtat
     1681 gcccccttcc ccaaggtagc aagatggagg gatggggctc tctcctggga tgggggcagg
     1741 tgttcctgaa taccgacagg cctgctgggt aaatgactag gtggtaaggt tctgccatgc
     1801 ctggtgaccc accatggaca tactggacct taattcctct gcttctgtgc tccctcctga
     1861 gaacccttta tgagcctgat tcctcagtct caccagaatt ctggatcacc caagaggaaa
     1921 agactggcag ttctagattc ctctatatgg ggagacctgg attgttgacc agggtgagaa
     1981 gccaatggta tagactgcct ctggggaagc aagttggcag ttcttgaaca gcatcagata
     2041 tcaagagttt gtaggtctgg attcacctaa gattcaaggg agtgttgctt ctcaactcag
     2101 ccaactgagt agcaaatcat ttgttctaga ccacctaagg agggaaggtt atggaatgcc
     2161 ccaagtattc aagatcatct tgattgacca aagaccaaaa aaaaaaaaaa gacctgtggt
     2221 tccagaaagc tcattagttg agattctgtg agtctaggtt gaccacagag gcaagcactg
     2281 gtgagtctag gacagatttt acgtggagag ttgaactact ccagaaacta aagagtaatg
     2341 tttctagaat gcacaaaaca ttgttagtct gtgggtttag aaagactgaa gtgacagatt
     2401 aagagttctt gatattagat aactccaact tctggctgta gagcacccag ccaagagaat
     2461 aagcagtgct ttgaaaggat ccactgggtg ggttgttttt ttttaaagtg ccattctaga
     2521 atgtccaaag ggaatcagga ttctgtggct gtagactgat cacagagtca aggaagcagt
     2581 ggcaattcta gatatctgag attttgctgg ttccagtttg cccaatggag ttgagaatct
     2641 caatgattct agatgacttc ttgtggttct gtaatgccaa aaggaatgaa ggctccaggg
     2701 atacagagtt gtccattacc aaagcctgga agttctcatc acctccaggt ggactgcttg
     2761 gcagtgctag gaggtggact caggacttca gaagcaacat ttctggcctg acctggaagg
     2821 tgaaggtgaa ggtgagaccc tgtagggcac agggctaatt agtggacaag ggaaggggga
     2881 ggcccagggc tggtgagtct agaatgctct ggaaccctac acctagtgat gtgtgtctat
     2941 ttctttttct ttttcttttt tttttttttt tgagactgag tctcgctctg ccgcccaggc
     3001 tggagtgcaa tggcgtgatc tcagctcact gcaacctccg cctcccggct tcaagtgttt
     3061 ctcctgcctc agtctcctga gtcgctggga ttacaggcat gagccactat gcctggctaa
     3121 tttttgtatt tttagtagag acggggtttc gccatgttgg cgaggttggt cttgaactcc
     3181 cgacctcaga tgatccacct gcctcggtct cccaaagtgc tgggattacg ggtgtgagcc
     3241 accatgccca gccgtgtgtc tgtttcttaa agatattata catatgtata ttatatatat
     3301 gtaatataaa tacagatatc tatctatttt ttcccttggt ccctacaaca ggcttagaga
     3361 tggagtgcta gctaattgga atgaggtcct tttcaaggac cccagaagct ttgctctaaa
     3421 tcccaatgct gccccaactt actgtgtcac tttggactcc tcttcatgtc agtttcccca
     3481 tctgtaaaaa cgggatattg gaacttgaag ttcttcaggg gcctttccag caggatgagt
     3541 cctcactaca ccaagggtgg gatgggcatt cgagtcctgg ggatttccct cctctcccca
     3601 gtgctggatc atacggcctt ccaggagacg ctgggatgta agatactctt ggaggctggc
     3661 tctgaactcg ggtgtctgaa tcacagggca agggtaggcg tgggctgtgg ctaacagcca
     3721 gagtcacttc cctggcctag cttggggacc tggggaggag gaggtagctc tggacaccag
     3781 ggttcttccc attgtgggag agtgagtgtt ttagggggag acctgtcccc cagattaaag
     3841 aactgggagc ccta
//
