LOCUS       NM_025221               2370 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens potassium voltage-gated channel interacting protein 4
            (KCNIP4), transcript variant 1, mRNA.
ACCESSION   NM_025221
VERSION     NM_025221.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2370)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2370)
  AUTHORS   Mosley,J.D., Shaffer,C.M., Van Driest,S.L., Weeke,P.E., Wells,Q.S.,
            Karnes,J.H., Velez Edwards,D.R., Wei,W.Q., Teixeira,P.L.,
            Bastarache,L., Crawford,D.C., Li,R., Manolio,T.A., Bottinger,E.P.,
            McCarty,C.A., Linneman,J.G., Brilliant,M.H., Pacheco,J.A.,
            Thompson,W., Chisholm,R.L., Jarvik,G.P., Crosslin,D.R.,
            Carrell,D.S., Baldwin,E., Ralston,J., Larson,E.B., Grafton,J.,
            Scrol,A., Jouni,H., Kullo,I.J., Tromp,G., Borthwick,K.M.,
            Kuivaniemi,H., Carey,D.J., Ritchie,M.D., Bradford,Y., Verma,S.S.,
            Chute,C.G., Veluchamy,A., Siddiqui,M.K., Palmer,C.N., Doney,A.,
            MahmoudPour,S.H., Maitland-van der Zee,A.H., Morris,A.D.,
            Denny,J.C. and Roden,D.M.
  TITLE     A genome-wide association study identifies variants in KCNIP4
            associated with ACE inhibitor-induced cough
  JOURNAL   Pharmacogenomics J 16 (3), 231-237 (2016)
   PUBMED   26169577
  REMARK    GeneRIF: Results indicate that SNPs in KCNIP4 may modulate ACE
            inhibitor-induced cough risk.
REFERENCE   3  (bases 1 to 2370)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 2370)
  AUTHORS   Kitazawa,M., Kubo,Y. and Nakajo,K.
  TITLE     The stoichiometry and biophysical properties of the Kv4 potassium
            channel complex with K+ channel-interacting protein (KChIP)
            subunits are variable, depending on the relative expression level
  JOURNAL   J Biol Chem 289 (25), 17597-17609 (2014)
   PUBMED   24811166
  REMARK    GeneRIF: Subunit counting by single-molecule imaging revealed that
            the bound number of KChIP4 in each Kv4.2.KChIP4 complex was
            dependent on the expression level of KChIP4.
REFERENCE   5  (bases 1 to 2370)
  AUTHORS   Tang,Y.Q., Liang,P., Zhou,J., Lu,Y., Lei,L., Bian,X. and Wang,K.
  TITLE     Auxiliary KChIP4a suppresses A-type K+ current through endoplasmic
            reticulum (ER) retention and promoting closed-state inactivation of
            Kv4 channels
  JOURNAL   J Biol Chem 288 (21), 14727-14741 (2013)
   PUBMED   23576435
  REMARK    GeneRIF: KChIP4a suppresses A-type Kv4 current via ER retention and
            enhancement of Kv4 closed-state inactivation.
REFERENCE   6  (bases 1 to 2370)
  AUTHORS   Bonne,A., Vreede,L., Kuiper,R.P., Bodmer,D., Jansen,C., Eleveld,M.,
            van Erp,F., Arkesteijn,G., Hoogerbrugge,N., van Ravenswaaij,C.,
            Schoenmakers,E.F. and Geurts van Kessel,A.
  TITLE     Mapping of constitutional translocation breakpoints in renal cell
            cancer patients: identification of KCNIP4 as a candidate gene
  JOURNAL   Cancer Genet Cytogenet 179 (1), 11-18 (2007)
   PUBMED   17981209
  REMARK    GeneRIF: Mutation of KCNIP4 is associated with renal cell
            carcinoma.
REFERENCE   7  (bases 1 to 2370)
  AUTHORS   Chen,C.P., Lee,L. and Chang,L.S.
  TITLE     Effects of metal-binding properties of human Kv channel-interacting
            proteins on their molecular structure and binding with Kv4.2
            channel
  JOURNAL   Protein J 25 (5), 345-351 (2006)
   PUBMED   16951992
  REMARK    GeneRIF: The conformational change with metal-bound KChIP4.1 is
            crucial for its interaction with Kv channel but not for KChIP2.2,
            and that the Mg2+- and Ca2+-binding properties of KChIP2.2 and
            KChIP4.1 have different effects on their molecular structure.
REFERENCE   8  (bases 1 to 2370)
  AUTHORS   Pruunsild,P. and Timmusk,T.
  TITLE     Structure, alternative splicing, and expression of the human and
            mouse KCNIP gene family
  JOURNAL   Genomics 86 (5), 581-593 (2005)
   PUBMED   16112838
REFERENCE   9  (bases 1 to 2370)
  AUTHORS   Morohashi,Y., Hatano,N., Ohya,S., Takikawa,R., Watabiki,T.,
            Takasugi,N., Imaizumi,Y., Tomita,T. and Iwatsubo,T.
  TITLE     Molecular cloning and characterization of CALP/KChIP4, a novel
            EF-hand protein interacting with presenilin 2 and voltage-gated
            potassium channel subunit Kv4
  JOURNAL   J Biol Chem 277 (17), 14965-14975 (2002)
   PUBMED   11847232
  REMARK    GeneRIF: cloning and investigation of interaction with presenilin 2
            and voltage-gated potassium channel subunit Kv4
REFERENCE   10 (bases 1 to 2370)
  AUTHORS   Holmqvist,M.H., Cao,J., Hernandez-Pineda,R., Jacobson,M.D.,
            Carroll,K.I., Sung,M.A., Betty,M., Ge,P., Gilbride,K.J.,
            Brown,M.E., Jurman,M.E., Lawson,D., Silos-Santiago,I., Xie,Y.,
            Covarrubias,M., Rhodes,K.J., Distefano,P.S. and An,W.F.
  TITLE     Elimination of fast inactivation in Kv4 A-type potassium channels
            by an auxiliary subunit domain
  JOURNAL   Proc Natl Acad Sci U S A 99 (2), 1035-1040 (2002)
   PUBMED   11805342
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113606.3, BI596848.1,
            AF367023.1, BC032520.2, AC097505.2, AC104065.3 and BX648990.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_025221.5.
            
            Summary: This gene encodes a member of the family of voltage-gated
            potassium (Kv) channel-interacting proteins (KCNIPs), which belong
            to the recoverin branch of the EF-hand superfamily. Members of the
            KCNIP family are small calcium binding proteins. They all have
            EF-hand-like domains, and differ from each other in the N-terminus.
            They are integral subunit components of native Kv4 channel
            complexes. They may regulate A-type currents, and hence neuronal
            excitability, in response to changes in intracellular calcium. This
            protein member also interacts with presenilin. Multiple
            alternatively spliced transcript variants encoding distinct
            isoforms have been identified for this gene. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1, also known as KCHIP4.1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.271330.1,
                                           SRR1803611.185942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382152.7/ ENSP00000371587.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC113606.3         77172-77192         c
            22-136              BI596848.1         6-120
            137-226             AF367023.1         46-135
            227-350             BC032520.2         120-243
            351-429             AC097505.2         113366-113444       c
            430-1555            BC032520.2         323-1448
            1556-2057           AC104065.3         66869-67370         c
            2058-2360           BX648990.1         2085-2387
            2361-2370           AC104065.3         66556-66565         c
FEATURES             Location/Qualifiers
     source          1..2370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.31-p15.2"
     gene            1..2370
                     /gene="KCNIP4"
                     /gene_synonym="CALP; KCHIP4"
                     /note="potassium voltage-gated channel interacting protein
                     4"
                     /db_xref="GeneID:80333"
                     /db_xref="HGNC:HGNC:30083"
                     /db_xref="MIM:608182"
     exon            1..202
                     /gene="KCNIP4"
                     /gene_synonym="CALP; KCHIP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..894
                     /gene="KCNIP4"
                     /gene_synonym="CALP; KCHIP4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calsenilin-like protein; a-type potassium channel
                     modulatory protein 4; Kv channel interacting protein 4"
                     /codon_start=1
                     /product="Kv channel-interacting protein 4 isoform 1"
                     /protein_id="NP_079497.2"
                     /db_xref="CCDS:CCDS43216.1"
                     /db_xref="GeneID:80333"
                     /db_xref="HGNC:HGNC:30083"
                     /db_xref="MIM:608182"
                     /translation="MNVRRVESISAQLEEASSTGGFLYAQNSTKRSIKERLMKLLPCS
                     AAKTSSPAIQNSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGV
                     VNEETFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEK
                     LNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDK
                     NKDGVVTIDEFIESCQKDENIMRSMQLFENVI"
     exon            203..304
                     /gene="KCNIP4"
                     /gene_synonym="CALP; KCHIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            305..429
                     /gene="KCNIP4"
                     /gene_synonym="CALP; KCHIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            430..499
                     /gene="KCNIP4"
                     /gene_synonym="CALP; KCHIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            500..570
                     /gene="KCNIP4"
                     /gene_synonym="CALP; KCHIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            571..678
                     /gene="KCNIP4"
                     /gene_synonym="CALP; KCHIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            679..783
                     /gene="KCNIP4"
                     /gene_synonym="CALP; KCHIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            784..846
                     /gene="KCNIP4"
                     /gene_synonym="CALP; KCHIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            847..2370
                     /gene="KCNIP4"
                     /gene_synonym="CALP; KCHIP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2339..2344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNIP4"
                     /gene_synonym="CALP; KCHIP4"
                     /note="hexamer: AATAAA"
     polyA_site      2370
                     /gene="KCNIP4"
                     /gene_synonym="CALP; KCHIP4"
                     /note="major polyA site"
ORIGIN      
        1 gcagccgccg ccgaagctct cgctcccagc gccacggacg cccccgggcc gagcggcggt
       61 gcgctcccgt gcagacccgt ggacagacgc ccctggccgg tggactctcg agtctcgctt
      121 ctgcaccctg cgtccctaga catgaatgtg aggagggtgg aaagcatttc ggctcagctg
      181 gaggaggcca gctctacagg cggtttcctg tacgctcaga acagcaccaa gcgcagcatt
      241 aaagagcggc tcatgaagct cttgccctgc tcagctgcca aaacgtcgtc tcctgctatt
      301 caaaacagcg tggaagatga actggagatg gccaccgtca ggcatcggcc tgaagccctt
      361 gagcttctgg aagcccagag caaatttacc aagaaagagc ttcagatcct ttacagagga
      421 tttaagaatg aatgccccag tggtgttgtt aatgaagaaa ccttcaaaga gatttactcg
      481 cagttctttc cacagggaga ctctacaaca tatgcacatt ttctgttcaa tgcatttgat
      541 acagaccaca atggagctgt gagtttcgag gatttcatca aaggtctttc cattttgctc
      601 cgggggacag tacaagaaaa actcaattgg gcatttaatc tgtatgacat aaataaagat
      661 ggctacatca ctaaagagga aatgcttgat ataatgaaag caatatacga tatgatgggt
      721 aaatgtacat atcctgtcct caaagaagat gctcccagac aacacgttga aacatttttt
      781 cagaaaatgg acaaaaataa agatggggtt gttaccatag atgagttcat tgaaagctgc
      841 caaaaagatg aaaacataat gcgctccatg cagctctttg aaaatgtgat ttaacttgtc
      901 aaatagatcc tgaatccaac agacaaatgt gaactattct accaccctta aagttggagc
      961 taccactttt agcatagatt gctcagcttg acactgaagc atattatgca aacaagcttt
     1021 gttttaatat aaagcaatcc ccaaaagatt tgagctttca gttataaatt tgcatccttt
     1081 tcataatgcc actgagttca ggggatggtc taactcattt catactctgt gaatattcaa
     1141 aagtaataga atctggcata tagttttatt ggttccttag ccatgggatt attgaggctt
     1201 tcacatatca gtgattttaa aatatcagtg ttttttgcta ctcatttgta tgtattcagt
     1261 cctaggattt tgaatggttt tctaatatag tgacatctgc atttaatttc cagaaattaa
     1321 attaattttc atgtttgaat gctgtaattc catttaaatt ccatttatat actttaagga
     1381 aacaagatta caacaattaa aaaaacacat agttccagtt tctatggcct tcccaccttc
     1441 tgttagaaat tagttttatc tggcattttt aaacatttaa aaattattaa acatttaaaa
     1501 attagtttat tatcagatat cagcatatgc ctaataaaac ttattttaat aagcatttaa
     1561 ttttccataa tatgttacag ccaaggccta tataataatt ttggatttgt tcaatctttc
     1621 ttacaggctg ttttctattg tatcaatcat tagtatcaat cattaagtgg aagttgaaga
     1681 aggcatcaaa caaaacaagg atgtttacag acatatgcaa agggtcagga tatctatcct
     1741 ccagtatata gtaatgctta ataacaagta atcctaacag cattaaaggc caaatctgtc
     1801 ctctttcccc tgacttcctt acagcatgtt tatttatatt acaagccatt cagggacaaa
     1861 gaaagaaacc ttgactaccc cactgtctac taagaacaaa cagcaagcaa aattagcaag
     1921 caaaattcac tttgaaagca ccagtggttc cattacattg acaactacta ccaagattta
     1981 gtagaaaata agtgctcaac aactaatcca gattacagta tgatttagct catcataatt
     2041 cagattattt ttaatcatct tagccaaaac tgtaaagttg ccacattact aaagccacac
     2101 acatcgtccc tgttttgtag aaatatcaca aagaccaaga ggctacagaa ggaggaaatt
     2161 tgcaactgtc tttgcaacaa taaatcaggt atctattctg gtgtagagat aggatgttga
     2221 aagctgccct gctatcacca gtgtagaaat taagagtagt acaatacatg tacactgaaa
     2281 tttgccatca cgtgtttgtg taaactcaat gtgcacattt tgtatttcaa aaagaaaaaa
     2341 taaaagcaaa ataaaatgtt tataactcta
//
