LOCUS       NM_013434               2891 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens potassium voltage-gated channel interacting protein 3
            (KCNIP3), transcript variant 1, mRNA.
ACCESSION   NM_013434
VERSION     NM_013434.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2891)
  AUTHORS   Brennan,K., Espin-Perez,A., Chang,S., Bedi,N., Saumyaa,S.,
            Shin,J.H., Plevritis,S.K., Gevaert,O., Sunwoo,J.B. and Gentles,A.J.
  TITLE     Loss of p53-DREAM-mediated repression of cell cycle genes as a
            driver of lymph node metastasis in head and neck cancer
  JOURNAL   Genome Med 15 (1), 98 (2023)
   PUBMED   37978395
  REMARK    GeneRIF: Loss of p53-DREAM-mediated repression of cell cycle genes
            as a driver of lymph node metastasis in head and neck cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2891)
  AUTHORS   Molinaro,P., Sanguigno,L., Casamassa,A., Valsecchi,V.,
            Sirabella,R., Pignataro,G., Annunziato,L. and Formisano,L.
  TITLE     Emerging Role of DREAM in Healthy Brain and Neurological Diseases
  JOURNAL   Int J Mol Sci 24 (11), 9177 (2023)
   PUBMED   37298129
  REMARK    GeneRIF: Emerging Role of DREAM in Healthy Brain and Neurological
            Diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2891)
  AUTHORS   Zhong,J., Lin,R., Wang,G., Lin,L., Ruan,S. and Liu,W.
  TITLE     KCNIP3 silence promotes proliferation and epithelial-mesenchymal
            transition of papillary thyroid carcinoma through activating
            Wnt/beta-catenin pathway
  JOURNAL   Tissue Cell 75, 101739 (2022)
   PUBMED   35066335
  REMARK    GeneRIF: KCNIP3 silence promotes proliferation and
            epithelial-mesenchymal transition of papillary thyroid carcinoma
            through activating Wnt/beta-catenin pathway.
REFERENCE   4  (bases 1 to 2891)
  AUTHORS   Li,J., Kumari,T., Barazia,A., Jha,V., Jeong,S.Y., Olson,A., Kim,M.,
            Lee,B.K., Manickam,V., Song,Z., Clemens,R., Razani,B., Kim,J.,
            Dinauer,M.C. and Cho,J.
  TITLE     Neutrophil DREAM promotes neutrophil recruitment in vascular
            inflammation
  JOURNAL   J Exp Med 219 (1) (2022)
   PUBMED   34751735
  REMARK    GeneRIF: Neutrophil DREAM promotes neutrophil recruitment in
            vascular inflammation.
REFERENCE   5  (bases 1 to 2891)
  AUTHORS   Kim,M.J., Cervantes,C., Jung,Y.S., Zhang,X., Zhang,J., Lee,S.H.,
            Jun,S., Litovchick,L., Wang,W., Chen,J., Fang,B. and Park,J.I.
  TITLE     PAF remodels the DREAM complex to bypass cell quiescence and
            promote lung tumorigenesis
  JOURNAL   Mol Cell 81 (8), 1698-1714 (2021)
   PUBMED   33626321
  REMARK    GeneRIF: PAF remodels the DREAM complex to bypass cell quiescence
            and promote lung tumorigenesis.
REFERENCE   6  (bases 1 to 2891)
  AUTHORS   Leissring,M.A., Yamasaki,T.R., Wasco,W., Buxbaum,J.D., Parker,I.
            and LaFerla,F.M.
  TITLE     Calsenilin reverses presenilin-mediated enhancement of calcium
            signaling
  JOURNAL   Proc Natl Acad Sci U S A 97 (15), 8590-8593 (2000)
   PUBMED   10900016
REFERENCE   7  (bases 1 to 2891)
  AUTHORS   An,W.F., Bowlby,M.R., Betty,M., Cao,J., Ling,H.P., Mendoza,G.,
            Hinson,J.W., Mattsson,K.I., Strassle,B.W., Trimmer,J.S. and
            Rhodes,K.J.
  TITLE     Modulation of A-type potassium channels by a family of calcium
            sensors
  JOURNAL   Nature 403 (6769), 553-556 (2000)
   PUBMED   10676964
REFERENCE   8  (bases 1 to 2891)
  AUTHORS   Carrion,A.M., Link,W.A., Ledo,F., Mellstrom,B. and Naranjo,J.R.
  TITLE     DREAM is a Ca2+-regulated transcriptional repressor
  JOURNAL   Nature 398 (6722), 80-84 (1999)
   PUBMED   10078534
REFERENCE   9  (bases 1 to 2891)
  AUTHORS   Carrion,A.M., Mellstrom,B. and Naranjo,J.R.
  TITLE     Protein kinase A-dependent derepression of the human prodynorphin
            gene via differential binding to an intragenic silencer element
  JOURNAL   Mol Cell Biol 18 (12), 6921-6929 (1998)
   PUBMED   9819380
REFERENCE   10 (bases 1 to 2891)
  AUTHORS   Buxbaum,J.D., Choi,E.K., Luo,Y., Lilliehook,C., Crowley,A.C.,
            Merriam,D.E. and Wasco,W.
  TITLE     Calsenilin: a calcium-binding protein that interacts with the
            presenilins and regulates the levels of a presenilin fragment
  JOURNAL   Nat Med 4 (10), 1177-1181 (1998)
   PUBMED   9771752
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX491997.1, BI755669.1 and
            BC012850.1.
            
            On Sep 7, 2018 this sequence version replaced NM_013434.4.
            
            Summary: This gene encodes a member of the family of voltage-gated
            potassium (Kv) channel-interacting proteins, which belong to the
            recoverin branch of the EF-hand superfamily. Members of this family
            are small calcium binding proteins containing EF-hand-like domains.
            They are integral subunit components of native Kv4 channel
            complexes that may regulate A-type currents, and hence neuronal
            excitability, in response to changes in intracellular calcium. The
            encoded protein also functions as a calcium-regulated
            transcriptional repressor, and interacts with presenilins.
            Alternatively spliced transcript variants encoding different
            isoforms have been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.168528.1,
                                           SRR1803613.45045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295225.10/ ENSP00000295225.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BX491997.1         25-33
            10-58               BI755669.1         64-112
            59-1020             BC012850.1         1-962
            1021-2891           BC012850.1         965-2835
FEATURES             Location/Qualifiers
     source          1..2891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.1"
     gene            1..2891
                     /gene="KCNIP3"
                     /gene_synonym="CSEN; DREAM; KCHIP3"
                     /note="potassium voltage-gated channel interacting protein
                     3"
                     /db_xref="GeneID:30818"
                     /db_xref="HGNC:HGNC:15523"
                     /db_xref="MIM:604662"
     exon            1..107
                     /gene="KCNIP3"
                     /gene_synonym="CSEN; DREAM; KCHIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..863
                     /gene="KCNIP3"
                     /gene_synonym="CSEN; DREAM; KCHIP3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calsenilin, presenilin-binding protein, EF hand
                     transcription factor; DRE-antagonist modulator; A-type
                     potassium channel modulatory protein 3; potassium channel
                     interacting protein 3; kv channel-interacting protein 3;
                     Kv channel interacting protein 3, calsenilin"
                     /codon_start=1
                     /product="calsenilin isoform 1"
                     /protein_id="NP_038462.1"
                     /db_xref="CCDS:CCDS2013.1"
                     /db_xref="GeneID:30818"
                     /db_xref="HGNC:HGNC:15523"
                     /db_xref="MIM:604662"
                     /translation="MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMR
                     CCLVKWILSSTAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKN
                     ECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLR
                     GTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERF
                     FEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI"
     exon            108..273
                     /gene="KCNIP3"
                     /gene_synonym="CSEN; DREAM; KCHIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            274..398
                     /gene="KCNIP3"
                     /gene_synonym="CSEN; DREAM; KCHIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            399..468
                     /gene="KCNIP3"
                     /gene_synonym="CSEN; DREAM; KCHIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            469..539
                     /gene="KCNIP3"
                     /gene_synonym="CSEN; DREAM; KCHIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            540..647
                     /gene="KCNIP3"
                     /gene_synonym="CSEN; DREAM; KCHIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            648..752
                     /gene="KCNIP3"
                     /gene_synonym="CSEN; DREAM; KCHIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            753..815
                     /gene="KCNIP3"
                     /gene_synonym="CSEN; DREAM; KCHIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            816..2891
                     /gene="KCNIP3"
                     /gene_synonym="CSEN; DREAM; KCHIP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2874..2879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNIP3"
                     /gene_synonym="CSEN; DREAM; KCHIP3"
                     /note="hexamer: AATAAA"
     polyA_site      2891
                     /gene="KCNIP3"
                     /gene_synonym="CSEN; DREAM; KCHIP3"
                     /note="major polyA site"
ORIGIN      
        1 aaacatgagg cagctgccag ccggcctggg cagtcttgtc tgcctcggct gtgaagtggg
       61 gaggctggca acagttttct tcagcgccca ggatgcagcc ggctaaggaa gtgacaaagg
      121 cgtcggacgg cagcctcctg ggggacctcg ggcacacacc acttagcaag aaggagggta
      181 tcaagtggca gaggccgagg ctcagccgcc aggctttgat gagatgctgc ctggtcaagt
      241 ggatcctgtc cagcacagcc ccacagggct cagatagcag cgacagtgag ctggagctgt
      301 ccacggtgcg ccaccagcca gaggggctgg accagctgca ggcccagacc aagttcacca
      361 agaaggagct gcagtctctc tacaggggct ttaagaatga gtgtcccacg ggcctggtgg
      421 acgaagacac cttcaaactc atttacgcgc agttcttccc tcagggagat gccaccacct
      481 atgcacactt cctcttcaac gcctttgatg cggacgggaa cggggccatc cactttgagg
      541 actttgtggt tggcctctcc atcctgctgc ggggcacagt ccacgagaag ctcaagtggg
      601 cctttaatct ctacgacatt aacaaggatg gctacatcac caaagaggag atgctggcca
      661 tcatgaagtc catctatgac atgatgggcc gccacaccta ccccatcctg cgggaggacg
      721 cgccggcgga gcacgtggag aggttcttcg agaaaatgga ccggaaccag gatggggtag
      781 tgaccattga agagttcctg gaggcctgtc agaaggatga gaacatcatg agctccatgc
      841 agctgtttga gaatgtcatc taggacacgt ccaaaggagt gcatggccac agccacctcc
      901 acccccaaga aacctccatc ctgccaggag cagcctccaa gaaactttta aaaaatagat
      961 ttgcaaaaag tgaacagatt gctacacaca cacacacaca cacacacaca cacacacaca
     1021 gccattcatc tgggctggca gaggggacag agttcaggga ggggctgagt ctggctaggg
     1081 gccgagtcca ggagccccag ccagcccttc ccaggccagc gaggcgaggc tgcctctggg
     1141 tgagtggctg acagagcagg tctgcaggcc accagctgct ggatgtcacc aagaaggggc
     1201 tcgagtgccc ctgcagggga gggtccaatc tccggtgtga gcccacctcg tcccgttctc
     1261 cattctgctt tcttgccaca cagtgggccg gccccaggct cccctggtct cctccccgta
     1321 gccactctct gcccactacc tatgcttcta gaaagcccct cacctcagga ccccagaggg
     1381 accagctggg gggcaggggg gagagggggt aatggaggcc aagcctgcag ctttctggaa
     1441 attcttccct gggggtccca ggatcccctg ctactccact gacctggaag agctgggtac
     1501 caggccaccc actgtggggc aagcctgagt ggtgaggggc cactgggccc cattctccct
     1561 ccatggcagg aaggcggggg atttcaagtt tagggattgg gtcgtggtgg agaatctgag
     1621 ggcactctct gccagctcca cagggtggga tgagcctctc cttgccccag tcctggttca
     1681 gtgggaatgc agtgggtggg gctgtacaca ccctccagca cagactgttc cctccaaggt
     1741 cctcttaggt cccgggagga acgtggttca gagactggca gccagggagc ccggggcaga
     1801 gctcagagga gtctgggaag gggcgtgtcc ctcctcttcc tgtagtgccc ctcccatggc
     1861 ccagcagctt ggctgagccc cctctcctga agcagtgtcg ccgtccctct gccttgcaca
     1921 aaaagcacaa gcattcctta gcagctcagg cgcagcccta gtgggagccc agcacactgc
     1981 ttctcggagg ccaggccctc ctgctggctg aggcttgggc ccagtagccc caatatggtg
     2041 gccctgggga agaggccttg ggggtctgct ctgtgcctgg gatcagtggg gccccaaagc
     2101 ccagcccggc tgaccaacat tcaaaagcac aaaccctggg gactctgctt ggctgtcccc
     2161 tccatctggg gatggagaat gccagcccaa agctggagcc aatggtgagg gctgagaggg
     2221 ctgtggctgg gtggtcagca gaaaccccca ggaggagaga gatgctgctc ccgcctgatt
     2281 ggggcctcac ccagaaggaa cccggtccca ggccgcatgg cccctccagg aacattccca
     2341 cataatacat tccatcacag ccagcccagc tccactcagg gctggcccgg ggagtccccg
     2401 tgtgccccaa gaggctagcc ccagggtgag cagggccctc agaggaaagg cagtatggcg
     2461 gaggccatgg gggcccctcg gcattcacac acagcctggc ctcccctgcg gagctgcatg
     2521 gacgcctggc tccaggctcc aggctgactg ggggcctctg cctccaggag ggcatcagct
     2581 ttccctggct cagggatctt ctccctcccc tcacccgctg cccagccctc ccagctggtg
     2641 tcactctgcc tctaaggcca aggcctcagg agagcatcac caccacaccc ctgccggcct
     2701 tggccttggg gccagactgg ctgcacagcc caaccaggag gggtctgcct cccacgctgg
     2761 gacacagacc ggccgcatgt ctgcatggca gaagcgtctc ccttggccac ggcctgggag
     2821 ggtggttcct gttctcagca tccactaata ttcagtcctg tatattttaa taaaataaac
     2881 ttgacaaagg a
//
