LOCUS       NM_173191               2424 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens potassium voltage-gated channel interacting protein 2
            (KCNIP2), transcript variant 2, mRNA.
ACCESSION   NM_173191
VERSION     NM_173191.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2424)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2424)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2424)
  AUTHORS   Murthy,A., Workman,S.W., Jiang,M., Hu,J., Sifa,I., Bernas,T.,
            Tang,W., Deschenes,I. and Tseng,G.N.
  TITLE     Dynamic palmitoylation regulates trafficking of K channel
            interacting protein 2 (KChIP2) across multiple subcellular
            compartments in cardiac myocytes
  JOURNAL   J Mol Cell Cardiol 135, 1-9 (2019)
   PUBMED   31362018
  REMARK    GeneRIF: The palmitoylation status of KChIP2 determines its
            subcellular distribution in cardiac myocytes. Stress promotes
            nuclear entry of KChIP2, diverting it from ion channel modulation
            at the plasma membrane to other functions in the nuclear
            compartment.
REFERENCE   4  (bases 1 to 2424)
  AUTHORS   Murphy,J.G. and Hoffman,D.A.
  TITLE     A polybasic motif in alternatively spliced KChIP2 isoforms prevents
            Ca2+ regulation of Kv4 channels
  JOURNAL   J Biol Chem 294 (10), 3683-3695 (2019)
   PUBMED   30622142
  REMARK    GeneRIF: polybasic motif in alternatively spliced KChIP2 isoforms
            prevents Ca(2+) regulation of Kv4 channels
REFERENCE   5  (bases 1 to 2424)
  AUTHORS   Prechtel,H., Hartmann,S., Minge,D. and Bahring,R.
  TITLE     Somatodendritic surface expression of epitope-tagged and KChIP
            binding-deficient Kv4.2 channels in hippocampal neurons
  JOURNAL   PLoS One 13 (1), e0191911 (2018)
   PUBMED   29385176
  REMARK    GeneRIF: Our results do not support the notion that accessory
            KChIP2 binding is a prerequisite for dendritic trafficking and
            functional surface expression of Kv4.2 channels, however, accessory
            KChIP2 binding may play a potential role in Kv4.2 modulation during
            intrinsic plasticity processes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2424)
  AUTHORS   Bahring,R., Dannenberg,J., Peters,H.C., Leicher,T., Pongs,O. and
            Isbrandt,D.
  TITLE     Conserved Kv4 N-terminal domain critical for effects of Kv
            channel-interacting protein 2.2 on channel expression and gating
  JOURNAL   J Biol Chem 276 (26), 23888-23894 (2001)
   PUBMED   11287421
REFERENCE   7  (bases 1 to 2424)
  AUTHORS   Rosati,B., Pan,Z., Lypen,S., Wang,H.S., Cohen,I., Dixon,J.E. and
            McKinnon,D.
  TITLE     Regulation of KChIP2 potassium channel beta subunit gene expression
            underlies the gradient of transient outward current in canine and
            human ventricle
  JOURNAL   J Physiol 533 (Pt 1), 119-125 (2001)
   PUBMED   11351020
REFERENCE   8  (bases 1 to 2424)
  AUTHORS   Ohya,S., Morohashi,Y., Muraki,K., Tomita,T., Watanabe,M.,
            Iwatsubo,T. and Imaizumi,Y.
  TITLE     Molecular cloning and expression of the novel splice variants of
            K(+) channel-interacting protein 2
  JOURNAL   Biochem Biophys Res Commun 282 (1), 96-102 (2001)
   PUBMED   11263977
REFERENCE   9  (bases 1 to 2424)
  AUTHORS   An,W.F., Bowlby,M.R., Betty,M., Cao,J., Ling,H.P., Mendoza,G.,
            Hinson,J.W., Mattsson,K.I., Strassle,B.W., Trimmer,J.S. and
            Rhodes,K.J.
  TITLE     Modulation of A-type potassium channels by a family of calcium
            sensors
  JOURNAL   Nature 403 (6769), 553-556 (2000)
   PUBMED   10676964
REFERENCE   10 (bases 1 to 2424)
  AUTHORS   Zhu,X.R., Wulf,A., Schwarz,M., Isbrandt,D. and Pongs,O.
  TITLE     Characterization of human Kv4.2 mediating a rapidly-inactivating
            transient voltage-sensitive K+ current
  JOURNAL   Recept Channels 6 (5), 387-400 (1999)
   PUBMED   10551270
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK094668.1, BC034685.1,
            AF367021.1, AJ276317.1 and AL136722.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_173191.2.
            
            Summary: This gene encodes a member of the family of voltage-gated
            potassium (Kv) channel-interacting proteins (KCNIPs), which belongs
            to the recoverin branch of the EF-hand superfamily. Members of the
            KCNIP family are small calcium binding proteins. They all have
            EF-hand-like domains, and differ from each other in the N-terminus.
            They are integral subunit components of native Kv4 channel
            complexes. They may regulate A-type currents, and hence neuronal
            excitability, in response to changes in intracellular calcium.
            Multiple alternatively spliced transcript variants encoding
            distinct isoforms have been identified from this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2), also known as KChIP2.4 or
            KChIP2L, lacks an in-frame segment in the coding region, as
            compared to variant 1. Isoform 2 is thus shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.253311.1,
                                           SRR1660809.212154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159607 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356640.7/ ENSP00000349055.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AK094668.1         121-287
            168-401             BC034685.1         151-384
            402-1045            AF367021.1         170-813
            1046-1058           AJ276317.1         179-191
            1059-1105           AL136722.1         724-770
            1106-2327           AJ276317.1         238-1459
            2328-2424           AL136722.1         1993-2089
FEATURES             Location/Qualifiers
     source          1..2424
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..2424
                     /gene="KCNIP2"
                     /gene_synonym="KCHIP2"
                     /note="potassium voltage-gated channel interacting protein
                     2"
                     /db_xref="GeneID:30819"
                     /db_xref="HGNC:HGNC:15522"
                     /db_xref="MIM:604661"
     exon            1..305
                     /gene="KCNIP2"
                     /gene_synonym="KCHIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..1045
                     /gene="KCNIP2"
                     /gene_synonym="KCHIP2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     A-type potassium channel modulatory protein 2; potassium
                     channel-interacting protein 2; cardiac voltage-gated
                     potassium channel modulatory subunit; Kv channel
                     interacting protein 2; A-type potassium channel modulatory
                     protein KCNIP2"
                     /codon_start=1
                     /product="A-type potassium channel modulatory protein
                     KCNIP2 isoform 2"
                     /protein_id="NP_775283.1"
                     /db_xref="CCDS:CCDS7522.1"
                     /db_xref="GeneID:30819"
                     /db_xref="HGNC:HGNC:15522"
                     /db_xref="MIM:604661"
                     /translation="MRGQGRKESLSDSRDLDGSYDQLTGHPPGPTKKALKQRFLKLLP
                     CCGPQALPSVSETLAAPASLRPHRPRLLDPDSVDDEFELSTVCHRPEGLEQLQEQTKF
                     TRKELQVLYRGFKNECPSGIVNEENFKQIYSQFFPQGDSSTYATFLFNAFDTNHDGSV
                     SFEDFVAGLSVILRGTVDDRLNWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYP
                     ALREEAPREHVESFFQKMDRNKDGVVTIEEFIESCQKDENIMRSMQLFDNVI"
     exon            306..401
                     /gene="KCNIP2"
                     /gene_synonym="KCHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            402..455
                     /gene="KCNIP2"
                     /gene_synonym="KCHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            456..580
                     /gene="KCNIP2"
                     /gene_synonym="KCHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..650
                     /gene="KCNIP2"
                     /gene_synonym="KCHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            651..721
                     /gene="KCNIP2"
                     /gene_synonym="KCHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            722..829
                     /gene="KCNIP2"
                     /gene_synonym="KCHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            830..934
                     /gene="KCNIP2"
                     /gene_synonym="KCHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            935..997
                     /gene="KCNIP2"
                     /gene_synonym="KCHIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            998..2424
                     /gene="KCNIP2"
                     /gene_synonym="KCHIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2403..2408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNIP2"
                     /gene_synonym="KCHIP2"
                     /note="hexamer: AATAAA"
     polyA_site      2424
                     /gene="KCNIP2"
                     /gene_synonym="KCHIP2"
                     /note="major polyA site"
ORIGIN      
        1 agctccgctc tgcctccggc tctgcgctca cctgctgcct agtgttccct ctcctgctcc
       61 aggacctccg ggtagacctc agaccccggg cccattccca gactcagcct cagcccggac
      121 ttccccagcc ccgacagcac agtaggccgc cagggggcgc cgtgtgagcg ccctatcccg
      181 gccacccggc gccccctccc acggcccggg cgggagcggg gcgccggggg ccatgcgggg
      241 ccagggccgc aaggagagtt tgtccgattc ccgagacctg gacggctcct acgaccagct
      301 cacgggccac cctccagggc ccactaaaaa agcgctgaag cagcgattcc tcaagctgct
      361 gccgtgctgc gggccccaag ccctgccctc agtcagtgaa acattagccg ccccagcctc
      421 cctccgcccc cacagacccc gcctgctgga cccagacagc gtggacgatg aatttgaatt
      481 gtccaccgtg tgtcaccggc ctgagggtct ggagcagctg caggagcaaa ccaaattcac
      541 gcgcaaggag ttgcaggtcc tgtaccgggg cttcaagaac gaatgtccca gcggaattgt
      601 caatgaggag aacttcaagc agatttactc ccagttcttt cctcaaggag actccagcac
      661 ctatgccact tttctcttca atgcctttga caccaaccat gatggctcgg tcagttttga
      721 ggactttgtg gctggtttgt ccgtgattct tcggggaact gtagatgaca ggcttaattg
      781 ggccttcaac ctgtatgacc ttaacaagga cggctgcatc accaaggagg aaatgcttga
      841 catcatgaag tccatctatg acatgatggg caagtacacg taccctgcac tccgggagga
      901 ggccccaagg gaacacgtgg agagcttctt ccagaagatg gacagaaaca aggatggtgt
      961 ggtgaccatt gaggaattca ttgagtcttg tcaaaaggat gagaacatca tgaggtccat
     1021 gcagctcttt gacaatgtca tctagccccc aggagagggg gtcagtgttt cctgggggga
     1081 ccatgctcta accctagtcc aggcggacct cacccttctc ttcccaggtc tatcctcatc
     1141 ctacgcctcc ctgggggctg gagggatcca agagcttggg gattcagtag tccagatctc
     1201 tggagctgaa ggggccagag agtgggcaga gtgcatctcg gggggtgttc ccaactccca
     1261 ccagctctca cccccttcct gcctgacacc cagtgttgag agtgcccctc ctgtaggaat
     1321 tgagcggttc cccacctcct acccctactc tagaaacaca ctagacagat gtctcctgct
     1381 atggtgcttc ccccatccct gacctcataa acatttcccc taagactccc ctctcagaga
     1441 gaatgctcca ttcttggcac tggctggctt ctcagaccag ccattgagag ccctgtggga
     1501 gggggacaag aatgtatagg gagaaatctt gggcctgagt caatggatag gtcctaggag
     1561 gtggctgggg ttgagaatag aagggcctgg acagattatg attgctcagg cataccaggt
     1621 tatagctcca agttccacag gtctgctacc acaggccatc aaaatataag tttccaggct
     1681 ttgcagaaga ccttgtctcc ttagaaatgc cccagaaatt ttccacaccc tcctcggtat
     1741 ccatggagag cctggggcca gatatctggc tcatctctgg cattgcttcc tctccttcct
     1801 tcctgcatgt gttggtggtg gttgtggtgg gggaatgtgg atgggggatg tcctggctga
     1861 tgcctgccaa aatttcatcc caccctcctt gcttatcgtc cctgttttga gggctatgac
     1921 ttgagttttt gtttcccatg ttctctatag acttgggacc ttcctgaact tggggcctat
     1981 cactccccac agtggatgcc ttagaaggga gagggaagga gggaggcagg catagcatct
     2041 gaacccagtg tgggggcatt cactagaatc ttcaatcaac ctgggctctc cccaccccac
     2101 cccagataac ctcctcagtt ccctagggtc tcttcttgct tgactcaatc tacccagaga
     2161 tgccccttag cacacctaga gggcagggac cataggaccc aggttccaac cccattgtca
     2221 gcaccccagc catgcggcca ccccttagca cacctgctcg tcccatttag cttaccctcc
     2281 cagttggcca gaatctgagg ggagagcccc cagagagccc ccttccccat cagaagactg
     2341 ttgactgctt tgcattttgg gctcttctat atattttgta aagtaagaaa tataccagat
     2401 ctaataaaac acaatggcta tgca
//
