LOCUS       NM_033272               4262 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily H member 7
            (KCNH7), transcript variant 1, mRNA.
ACCESSION   NM_033272
VERSION     NM_033272.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4262)
  AUTHORS   Tas,A., Hayta,E., Karadag,A., Zontul,C., Ozmen,E., Aydin,S. and
            Silig,Y.
  TITLE     Potassium Ion Channel Protein (KCNH) Levels in Patients with
            Fibromyalgia Syndrome
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 451-457 (2022)
   PUBMED   35818223
  REMARK    GeneRIF: Potassium Ion Channel Protein (KCNH) Levels in Patients
            with Fibromyalgia Syndrome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4262)
  AUTHORS   Burton,M.J., Cresser-Brown,J., Thomas,M., Portolano,N., Basran,J.,
            Freeman,S.L., Kwon,H., Bottrill,A.R., Llansola-Portoles,M.J.,
            Pascal,A.A., Jukes-Jones,R., Chernova,T., Schmid,R., Davies,N.W.,
            Storey,N.M., Dorlet,P., Moody,P.C.E., Mitcheson,J.S. and Raven,E.L.
  TITLE     Discovery of a heme-binding domain in a neuronal voltage-gated
            potassium channel
  JOURNAL   J Biol Chem 295 (38), 13277-13286 (2020)
   PUBMED   32723862
  REMARK    GeneRIF: Discovery of a heme-binding domain in a neuronal
            voltage-gated potassium channel.
            Erratum:[J Biol Chem. 2022 Mar;298(3):101754. doi:
            10.1016/j.jbc.2022.101754.. PMID: 35247676]
REFERENCE   3  (bases 1 to 4262)
  AUTHORS   Xiao,K., Sun,Z., Jin,X., Ma,W., Song,Y., Lai,S., Chen,Q., Fan,M.,
            Zhang,J., Yue,W. and Huang,Z.
  TITLE     ERG3 potassium channel-mediated suppression of neuronal intrinsic
            excitability and prevention of seizure generation in mice
  JOURNAL   J Physiol 596 (19), 4729-4752 (2018)
   PUBMED   30016551
  REMARK    GeneRIF: Low ERG3 expression is associated with epilepsy.
REFERENCE   4  (bases 1 to 4262)
  AUTHORS   Perez-Neut,M., Haar,L., Rao,V., Santha,S., Lansu,K., Rana,B.,
            Jones,W.K. and Gentile,S.
  TITLE     Activation of hERG3 channel stimulates autophagy and promotes
            cellular senescence in melanoma
  JOURNAL   Oncotarget 7 (16), 21991-22004 (2016)
   PUBMED   26942884
  REMARK    GeneRIF: we have discovered that, the Kv11.3 (hERG3) a
            plasma-membrane potassium channel plays a critical role in the
            regulation of autophagy in a melanoma cell model
REFERENCE   5  (bases 1 to 4262)
  AUTHORS   Li,X., Anishkin,A., Liu,H., van Rossum,D.B., Chintapalli,S.V.,
            Sassic,J.K., Gallegos,D., Pivaroff-Ward,K. and Jegla,T.
  TITLE     Bimodal regulation of an Elk subfamily K+ channel by
            phosphatidylinositol 4,5-bisphosphate
  JOURNAL   J Gen Physiol 146 (5), 357-374 (2015)
   PUBMED   26503718
REFERENCE   6  (bases 1 to 4262)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   7  (bases 1 to 4262)
  AUTHORS   Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D.,
            Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W.
            and Wang,X.
  TITLE     International Union of Pharmacology. LIII. Nomenclature and
            molecular relationships of voltage-gated potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 473-508 (2005)
   PUBMED   16382104
  REMARK    Review article
REFERENCE   8  (bases 1 to 4262)
  AUTHORS   Akhavan,A., Atanasiu,R., Noguchi,T., Han,W., Holder,N. and
            Shrier,A.
  TITLE     Identification of the cyclic-nucleotide-binding domain as a
            conserved determinant of ion-channel cell-surface localization
  JOURNAL   J Cell Sci 118 (Pt 13), 2803-2812 (2005)
   PUBMED   15961404
  REMARK    GeneRIF: The recombinant wild-type ERG3 protein produced in HEK
            cells generates two prominent bands. When the entire CNBD of ERG3
            protein was deleted, only an EndoH-sensitive band was generated,
            indicating that this band constitutes the immature species.
REFERENCE   9  (bases 1 to 4262)
  AUTHORS   Bauer,C.K., Wulfsen,I., Schafer,R., Glassmeier,G., Wimmers,S.,
            Flitsch,J., Ludecke,D.K. and Schwarz,J.R.
  TITLE     HERG K(+) currents in human prolactin-secreting adenoma cells
  JOURNAL   Pflugers Arch 445 (5), 589-600 (2003)
   PUBMED   12634931
  REMARK    GeneRIF: Transcripts for HERG1 were present in all adenomas and
            although transcripts for HERG2 and HERG3 were also detected, their
            expression level was more variable.
REFERENCE   10 (bases 1 to 4262)
  AUTHORS   Ganetzky,B., Robertson,G.A., Wilson,G.F., Trudeau,M.C. and
            Titus,S.A.
  TITLE     The eag family of K+ channels in Drosophila and mammals
  JOURNAL   Ann N Y Acad Sci 868, 356-369 (1999)
   PUBMED   10414305
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104822.5, DR002425.1,
            BC035815.1, AF032897.1, AC007740.2 and AC010876.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_033272.3.
            
            Summary: Voltage-gated potassium (Kv) channels represent the most
            complex class of voltage-gated ion channels from both functional
            and structural standpoints. Their diverse functions include
            regulating neurotransmitter release, heart rate, insulin secretion,
            neuronal excitability, epithelial electrolyte transport, smooth
            muscle contraction, and cell volume. This gene encodes a member of
            the potassium channel, voltage-gated, subfamily H. This member is a
            pore-forming (alpha) subunit. There are at least two alternatively
            spliced transcript variants derived from this gene and encoding
            distinct isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF032897.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267763, SAMN03465402
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332142.10/ ENSP00000331727.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC104822.5         19514-19533         c
            21-37               DR002425.1         7-23
            38-183              BC035815.1         1-146
            184-1568            AF032897.1         35-1419
            1569-2403           BC035815.1         1511-2345
            2404-2548           AF032897.1         2255-2399
            2549-2640           AC007740.2         23362-23453         c
            2641-4252           AF032897.1         2492-4103
            4253-4262           AC010876.2         89781-89790         c
FEATURES             Location/Qualifiers
     source          1..4262
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.2"
     gene            1..4262
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /note="potassium voltage-gated channel subfamily H member
                     7"
                     /db_xref="GeneID:90134"
                     /db_xref="HGNC:HGNC:18863"
                     /db_xref="MIM:608169"
     exon            1..325
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..3840
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     potassium channel subunit HERG-3; potassium channel,
                     voltage gated eag related subfamily H, member 7; ERG-3;
                     eag-related protein 3; ether-a-go-go-related protein 3;
                     ether-a-go-go-related gene potassium channel 3;
                     voltage-gated potassium channel subunit Kv11.3;
                     voltage-gated inwardly rectifying potassium channel KCNH7"
                     /codon_start=1
                     /product="voltage-gated inwardly rectifying potassium
                     channel KCNH7 isoform 1"
                     /protein_id="NP_150375.2"
                     /db_xref="CCDS:CCDS2219.1"
                     /db_xref="GeneID:90134"
                     /db_xref="HGNC:HGNC:18863"
                     /db_xref="MIM:608169"
                     /translation="MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYC
                     NDGFCEMTGFSRPDVMQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKN
                     GSTFICNTHIIPVKNQEGVAMMFIINFEYVTDNENAATPERVNPILPIKTVNRKFFGF
                     KFPGLRVLTYRKQSLPQEDPDVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEADDTKA
                     LIQPSKCSPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLSHSRSRESLCSIRRASSV
                     HDIEGFGVHPKNIFRDRHASEDNGRNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQ
                     LTLNFSEVKTEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQT
                     PRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSP
                     LNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFD
                     LLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWL
                     ACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSS
                     LTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLR
                     VKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLL
                     QNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIV
                     VAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFL
                     TNLELTFNLRHESAKADLLRSQSMNDSEGDNCKLRRRKLSFESEGEKENSTNDPEDSA
                     DTIRHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSGIVDSSPGIGKASGLDFEETVP
                     TSGRMHIDKRSHSCKDITDMRSWERENAHPQPEDSSPSALQRAAWGISETESDLTYGE
                     VEQRLDLLQEQLNRLESQMTTDIQTILQLLQKQTTVVPPAYSMVTAGSEYQRPIIQLM
                     RTSQPEASIKTDRSFSPSSQCPEFLDLEKSKLKSKESLSSGVHLNTASEDNLTSLLKQ
                     DSDLSLELHLRQRKTYVHPIRHPSLPDSSLSTVGIVGLHRHVSDPGLPGK"
     exon            326..556
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            557..712
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            713..1141
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1162
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1377
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1803
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2203
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2403
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2656
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2657..2862
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..2959
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3211
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..3380
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3381..3573
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
     exon            3574..4262
                     /gene="KCNH7"
                     /gene_synonym="ERG3; HERG3; Kv11.3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccccaaac cctctcaccc gcggcagtcc ggtgcgaggc cccctccgga aggtgagggg
       61 aatggattgg actccggtgg ggaaagcggg tgtctagaag tggtgctaat gggaagagaa
      121 ttctggtttc aaaagaggat gctctgccac aaagagcggc tcgcgcgctg gcctgggctc
      181 tagccgagga gagatcccgg gagaactcca gagctccggg ggagcgctcc tcggaagacc
      241 ggggccaaca tgcctgtgcg cagggggcat gtggcaccac aaaatacatt tctggggacc
      301 atcattcgga aatttgaagg gcaaaataaa aaatttatca ttgcaaatgc cagagtgcag
      361 aactgtgcca tcatttattg caacgatggg ttctgtgaga tgactggttt ctccaggcca
      421 gatgtcatgc aaaagccatg cacctgcgac tttctccatg gacccgagac caagaggcat
      481 gatattgccc aaattgccca ggcattgctg gggtcagaag agaggaaagt ggaggtcacc
      541 tactatcaca aaaatgggtc cacttttatt tgtaacactc acataattcc agtgaaaaac
      601 caagagggcg tggctatgat gttcatcatt aattttgaat atgtgacgga taatgaaaac
      661 gctgccaccc cagagagggt aaacccaata ttaccaatca aaactgtaaa ccggaaattt
      721 tttgggttca aattccctgg tctgagagtt ctcacttaca gaaagcagtc cttaccacaa
      781 gaagaccccg atgtggtggt catcgattca tctaaacaca gtgatgattc agtagccatg
      841 aagcatttta agtctcctac aaaagaaagc tgcagcccct ctgaagcaga tgacacaaaa
      901 gctttgatac agcccagcaa atgttctccc ttggtgaata tatccggacc tcttgaccat
      961 tcctctccca aaaggcaatg ggaccgactc taccctgaca tgctgcagtc aagttcccag
     1021 ctgtcccatt ccagatcaag ggaaagctta tgtagtatac ggagagcatc ttcggtccat
     1081 gatatagaag gattcggcgt ccaccccaag aacatattta gagaccgaca tgccagcgaa
     1141 gacaatggtc gcaatgtcaa agggcctttt aatcatatca agtcaagcct cctgggatcc
     1201 acatcagatt caaacctcaa caaatacagc accattaaca agattccaca gctcactctg
     1261 aatttttcag aggtcaaaac tgagaaaaag aattcatcac ctccttcttc agataaaacc
     1321 attattgcac ccaaggttaa agatcgaaca cacaatgtga ctgagaaagt gacccaggtt
     1381 ctctctttag gagcagatgt cctacctgaa tacaaactgc agacaccacg catcaacaag
     1441 tttacgatat tgcactacag ccctttcaag gcagtctggg actggcttat cctgctgttg
     1501 gtcatataca ctgctatatt tactccctac tctgcagcct tcctcctcaa tgacagagaa
     1561 gaacagaaaa gacgagaatg tggctattct tgtagccctt tgaatgtggt agacttgatt
     1621 gtggatatta tgtttatcat agatatttta ataaacttca gaacaacata tgtaaatcag
     1681 aatgaagaag tggtaagtga tcccgccaaa atagcaatac actacttcaa aggctggttc
     1741 ctgattgaca tggttgcagc aattcctttt gacttgctga tttttggatc aggttctgat
     1801 gagacaacaa cattaattgg tcttttgaag actgcccgac tcctccgtct tgtgcgcgtg
     1861 gccaggaaac tggatcgata ttcagaatat ggcgctgctg ttctaatgct cttaatgtgc
     1921 atctttgccc tgattgctca ctggctggct tgcatttggt atgcgattgg gaatgtagaa
     1981 aggccttacc tgactgacaa aatcggatgg ttggattcct taggacagca aattgggaaa
     2041 cgttacaatg acagtgactc aagttctgga ccatccatta aagacaaata cgtcacagca
     2101 ctttatttta ccttcagcag tttaaccagt gtaggattcg ggaatgtgtc tcctaacacg
     2161 aattcggaga aaatcttttc aatttgtgtc atgttgattg gctcactaat gtatgcaagc
     2221 atttttggga atgtatctgc aattatccaa agactatact cgggaactgc caggtaccac
     2281 atgcagatgc tgcgagtaaa agagttcatt cgctttcacc aaatccccaa ccctctgagg
     2341 caacgtcttg aagaatattt ccagcacgca tggacttaca ccaatggcat tgacatgaac
     2401 atggtcctaa agggtttccc agaatgctta caagcagaca tttgtctaca tctcaaccag
     2461 acattgctgc aaaactgcaa agcctttcgg ggggcaagta aaggttgcct tagagctttg
     2521 gcaatgaagt tcaaaaccac ccatgcacct ccaggagaca ccctcgttca ctgtggggat
     2581 gtcctcactg cactttattt cttatccaga ggctccattg aaattctcaa agatgacatt
     2641 gtggtggcta ttctgggaaa aaatgatata tttggagaaa tggttcatct ttatgccaaa
     2701 cctggaaagt ctaatgcaga tgtaagagcc ctcacatact gtgacttgca taagattcag
     2761 cgagaagact tgttagaggt tttggatatg tatcctgagt tttctgatca ctttctaaca
     2821 aacctagagt tgactttcaa cctaaggcat gagagcgcaa aggctgatct cctacgatca
     2881 caatccatga atgattcaga aggagacaac tgtaaactaa gaagaaggaa attgtcattt
     2941 gaaagtgaag gagagaaaga aaacagtaca aatgatcctg aagactctgc agataccata
     3001 agacattatc agagttccaa gagacacttt gaagagaaaa aaagcagatc ctcatctttc
     3061 atctcctcca ttgatgatga acaaaagccg ctcttctcag gaatagtaga ctcttctcca
     3121 ggaataggga aagcatctgg gctcgatttt gaagaaacag tgcccacctc aggaagaatg
     3181 cacatagata aaagaagtca ctcttgcaaa gatatcactg acatgcgaag ctgggaacga
     3241 gaaaatgcac atccccagcc tgaagactcc agtccatctg cacttcagcg agctgcctgg
     3301 ggtatctctg aaaccgaaag cgacctcacc tacggggaag tggaacaaag attagatctg
     3361 ctccaggagc aacttaacag gcttgaatcc caaatgacca ctgacatcca gaccatctta
     3421 cagttgctgc agaaacaaac cactgtggtc cccccagcct acagtatggt aacagcagga
     3481 tcagaatatc agagacccat catccagctg atgagaacca gtcaaccgga agcatccatc
     3541 aaaactgacc gaagtttcag cccttcctca caatgtcctg aatttctaga ccttgaaaaa
     3601 tctaaactta aatccaaaga atccctttca agtggggtgc atctgaacac agcttcagaa
     3661 gacaacttga cttcactttt aaaacaagac agtgatctct ctttagagct tcacctgcgg
     3721 caaagaaaaa cttacgttca tccaattagg catccttctt tgccagattc atccctaagc
     3781 actgtaggaa tcgtgggtct tcataggcat gtttctgatc ctggtcttcc agggaaataa
     3841 tcattttgta ctatttactc cacatacaat gtaagtgctt ttaatggctg ttttcctttt
     3901 tctatttaaa tcctctctac ttgactcagg ggctcacaag gtaccattat atgcaaaagt
     3961 actgtatatt ttcctaaatt gaagcttgta aggtaaaact gagcagttag gatgtaaata
     4021 tacataagaa cttttggttc caaatgttaa aactgccagc atctcacggc accttatttt
     4081 ttatttttat tttttaaatc acatgcatgt taggaaactc caatttctct tgcatggaga
     4141 ctcctattta ctgcttttac taaaccagta cttcgttatg aaaatgcctt ccacgcaaat
     4201 aagaaaccaa gggataaaac tgttcatgga tgcaactcaa attcagatga tcctcaactc
     4261 at
//
