LOCUS       NM_139318              11283 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily H member 5
            (KCNH5), transcript variant 1, mRNA.
ACCESSION   NM_139318
VERSION     NM_139318.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11283)
  AUTHORS   Zhang,M., Shan,Y. and Pei,D.
  TITLE     Mechanism underlying delayed rectifying in human voltage-mediated
            activation Eag2 channel
  JOURNAL   Nat Commun 14 (1), 1470 (2023)
   PUBMED   36928654
  REMARK    GeneRIF: Mechanism underlying delayed rectifying in human
            voltage-mediated activation Eag2 channel.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11283)
  AUTHORS   Happ,H.C., Sadleir,L.G., Zemel,M., de Valles-Ibanez,G.,
            Hildebrand,M.S., McConkie-Rosell,A., McDonald,M., May,H., Sands,T.,
            Aggarwal,V., Elder,C., Feyma,T., Bayat,A., Moller,R.S.,
            Fenger,C.D., Klint Nielsen,J.E., Datta,A.N., Gorman,K.M.,
            King,M.D., Linhares,N.D., Burton,B.K., Paras,A., Ellard,S.,
            Rankin,J., Shukla,A., Majethia,P., Olson,R.J., Muthusamy,K.,
            Schimmenti,L.A., Starnes,K., Sedlackova,L., Sterbova,K.,
            Vlckova,M., Lassuthova,P., Jahodova,A., Porter,B.E., Couque,N.,
            Colin,E., Prouteau,C., Collet,C., Smol,T., Caumes,R., Vansenne,F.,
            Bisulli,F., Licchetta,L., Person,R., Torti,E., McWalter,K.,
            Webster,R., Gerard,E.E., Lesca,G., Szepetowski,P., Scheffer,I.E.,
            Mefford,H.C. and Carvill,G.L.
  TITLE     Neurodevelopmental and Epilepsy Phenotypes in Individuals With
            Missense Variants in the Voltage-Sensing and Pore Domains of KCNH5
  JOURNAL   Neurology 100 (6), e603-e615 (2023)
   PUBMED   36307226
  REMARK    GeneRIF: Neurodevelopmental and Epilepsy Phenotypes in Individuals
            With Missense Variants in the Voltage-Sensing and Pore Domains of
            KCNH5.
REFERENCE   3  (bases 1 to 11283)
  AUTHORS   Galan-Vidal,J., Socuellamos,P.G., Baena-Nuevo,M., Contreras,L.,
            Gonzalez,T., Perez-Poyato,M.S., Valenzuela,C., Gonzalez-Lamuno,D.
            and Gandarillas,A.
  TITLE     A novel loss-of-function mutation of the voltage-gated potassium
            channel Kv10.2 involved in epilepsy and autism
  JOURNAL   Orphanet J Rare Dis 17 (1), 345 (2022)
   PUBMED   36068614
  REMARK    GeneRIF: A novel loss-of-function mutation of the voltage-gated
            potassium channel Kv10.2 involved in epilepsy and autism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11283)
  AUTHORS   Gervais,O., Ueno,K., Kawai,Y., Hitomi,Y., Aiba,Y., Ueta,M.,
            Nakamura,M., Tokunaga,K. and Nagasaki,M.
  TITLE     Regional heritability mapping identifies several novel loci (STAT4,
            ULK4, and KCNH5) for primary biliary cholangitis in the Japanese
            population
  JOURNAL   Eur J Hum Genet 29 (8), 1282-1291 (2021)
   PUBMED   33833419
  REMARK    GeneRIF: Regional heritability mapping identifies several novel
            loci (STAT4, ULK4, and KCNH5) for primary biliary cholangitis in
            the Japanese population.
REFERENCE   5  (bases 1 to 11283)
  AUTHORS   Francisco,M.A., Wanggou,S., Fan,J.J., Dong,W., Chen,X., Momin,A.,
            Abeysundara,N., Min,H.K., Chan,J., McAdam,R., Sia,M., Pusong,R.J.,
            Liu,S., Patel,N., Ramaswamy,V., Kijima,N., Wang,L.Y., Song,Y.,
            Kafri,R., Taylor,M.D., Li,X. and Huang,X.
  TITLE     Chloride intracellular channel 1 cooperates with potassium channel
            EAG2 to promote medulloblastoma growth
  JOURNAL   J Exp Med 217 (5) (2020)
   PUBMED   32097463
  REMARK    GeneRIF: Chloride intracellular channel 1 cooperates with potassium
            channel EAG2 to promote medulloblastoma growth.
REFERENCE   6  (bases 1 to 11283)
  AUTHORS   Stevens,L., Ju,M. and Wray,D.
  TITLE     Roles of surface residues of intracellular domains of heag
            potassium channels
  JOURNAL   Eur Biophys J 38 (4), 523-532 (2009)
   PUBMED   19172261
  REMARK    GeneRIF: data suggest that the 'Per-Ant-Sim' (PAS) and cyclic
            nucleotide binding (cNBD) domains at the N- and C-termini form
            interacting oligomers that have roles in channel function
REFERENCE   7  (bases 1 to 11283)
  AUTHORS   Feng,Q., Hawes,S.E., Stern,J.E., Wiens,L., Lu,H., Dong,Z.M.,
            Jordan,C.D., Kiviat,N.B. and Vesselle,H.
  TITLE     DNA methylation in tumor and matched normal tissues from non-small
            cell lung cancer patients
  JOURNAL   Cancer Epidemiol Biomarkers Prev 17 (3), 645-654 (2008)
   PUBMED   18349282
  REMARK    GeneRIF: Methylation of KCNH5 was present in 80% of NSCLC tissues
            but only in 14% of noncancerous tissues.
REFERENCE   8  (bases 1 to 11283)
  AUTHORS   Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D.,
            Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W.
            and Wang,X.
  TITLE     International Union of Pharmacology. LIII. Nomenclature and
            molecular relationships of voltage-gated potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 473-508 (2005)
   PUBMED   16382104
  REMARK    Review article
REFERENCE   9  (bases 1 to 11283)
  AUTHORS   Ju,M. and Wray,D.
  TITLE     Molecular identification and characterisation of the human eag2
            potassium channel
  JOURNAL   FEBS Lett 524 (1-3), 204-210 (2002)
   PUBMED   12135768
  REMARK    GeneRIF: molecular identification and characterisation
REFERENCE   10 (bases 1 to 11283)
  AUTHORS   Schonherr,R., Gessner,G., Lober,K. and Heinemann,S.H.
  TITLE     Functional distinction of human EAG1 and EAG2 potassium channels
  JOURNAL   FEBS Lett 514 (2-3), 204-208 (2002)
   PUBMED   11943152
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL132666.8, BC073979.1,
            AF472412.1 and AL355101.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_139318.4.
            
            Summary: This gene encodes a member of voltage-gated potassium
            channels. Members of this family have diverse functions, including
            regulating neurotransmitter and hormone release, cardiac function,
            and cell volume. This protein is an outward-rectifying,
            noninactivating channel. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC073979.1, AF472412.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322893.12/ ENSP00000321427.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AL132666.8         47222-47441
            221-2504            BC073979.1         1-2284
            2505-2848           AF472412.1         2233-2576
            2849-2849           AL355101.2         99755-99755
            2850-4174           BC073979.1         2630-3954
            4175-11283          AL355101.2         101081-108189
FEATURES             Location/Qualifiers
     source          1..11283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.2"
     gene            1..11283
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /note="potassium voltage-gated channel subfamily H member
                     5"
                     /db_xref="GeneID:27133"
                     /db_xref="HGNC:HGNC:6254"
                     /db_xref="MIM:605716"
     exon            1..345
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..3239
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ether-a-go-go-related potassium channel 2; potassium
                     voltage-gated channel, subfamily H (eag-related), member
                     5; potassium channel, voltage gated eag related subfamily
                     H, member 5; voltage-gated potassium channel subunit
                     Kv10.2; ether-a-go-go 2; voltage-gated delayed rectifier
                     potassium channel KCNH5"
                     /codon_start=1
                     /product="voltage-gated delayed rectifier potassium
                     channel KCNH5 isoform 1"
                     /protein_id="NP_647479.2"
                     /db_xref="CCDS:CCDS9756.1"
                     /db_xref="GeneID:27133"
                     /db_xref="HGNC:HGNC:6254"
                     /db_xref="MIM:605716"
                     /translation="MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSN
                     DGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNR
                     TPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSR
                     SVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWD
                     WVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGE
                     VISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV
                     ARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQL
                     ALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSV
                     AMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDY
                     IVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEF
                     QTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLA
                     HACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDV
                     KKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSTQGDPERNQLQVESRS
                     LQNGASITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRDAMELKPNGGADQKCLKVN
                     SPIRMKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLLSEDPKSSDSENSVTKN
                     PLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYPIPEQALQTTLQEVK
                     HELKEDIQLLSCRMTALEKQVAEILKILSEKSVPQASSPKSQMPLQVPPQIPCQDIFS
                     VSRPESPESDKDEIHF"
     exon            346..469
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /inference="alignment:Splign:2.1.0"
     exon            470..576
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..705
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..821
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1214
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1641
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1841
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..2094
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2291
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..11283
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11261..11266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /note="hexamer: AATAAA"
     polyA_site      11283
                     /gene="KCNH5"
                     /gene_synonym="DEE112; EAG2; H-EAG2; hEAG2; Kv10.2"
                     /note="major polyA site"
ORIGIN      
        1 gcagttcccg agccccgtgt gcggcaccgc cacagtctgg gcagcggcgg ccgggggagc
       61 gctactacca tgaactgcct ggtcctcctc cccagagctg ctcatccggg tcgggctgga
      121 gacacagtca ggggaccccg tcgccgccgc cgcgccccct cttctttcgg ctcaatcttc
      181 tcttccacct tttcctcctc ttcctccacc ttctttgcct gcatcccccc ctcccccgcc
      241 gcggatcctg gccgctgctc tccagaccca ggatgccggg gggcaagaga gggctggtgg
      301 caccgcagaa cacatttttg gagaacatcg tcaggcgctc cagtgaatca agtttcttac
      361 tgggaaatgc ccagattgtg gattggcctg tagtttatag taatgacggt ttttgtaaac
      421 tctctggata tcatcgagct gacgtcatgc agaaaagcag cacttgcagt tttatgtatg
      481 gggaattgac tgacaagaag accattgaga aagtcaggca aacttttgac aactacgaat
      541 caaactgctt tgaagttctt ctgtacaaga aaaacagaac ccctgtttgg ttttatatgc
      601 aaattgcacc aataagaaat gaacatgaaa aggtggtctt gttcctgtgt actttcaagg
      661 atattacgtt gttcaaacag ccaatagagg atgattcaac aaaaggttgg acgaaatttg
      721 cccgattgac acgggctttg acaaatagcc gaagtgtttt gcagcagctc acgccaatga
      781 ataaaacaga ggtggtccat aaacattcaa gactagctga agttcttcag ctgggatcag
      841 atatccttcc tcagtataaa caagaagcgc caaagacgcc accacacatt attttacatt
      901 attgtgcttt taaaactact tgggattggg tgattttaat tcttaccttc tacaccgcca
      961 ttatggttcc ttataatgtt tccttcaaaa caaagcagaa caacatagcc tggctggtac
     1021 tggatagtgt ggtggacgtt atttttctgg ttgacatcgt tttaaatttt cacacgactt
     1081 tcgtggggcc cggtggagag gtcatttctg accctaagct cataaggatg aactatctga
     1141 aaacttggtt tgtgatcgat ctgctgtctt gtttacctta tgacatcatc aatgcctttg
     1201 aaaatgtgga tgagggaatc agcagtctct tcagttcttt aaaagtggtg cgtctcttac
     1261 gactgggccg tgtggctagg aaactggacc attacctaga atatggagca gcagtcctcg
     1321 tgctcctggt gtgtgtgttt ggactggtgg cccactggct ggcctgcata tggtatagca
     1381 tcggagacta cgaggtcatt gatgaagtca ctaacaccat ccaaatagac agttggctct
     1441 accagctggc tttgagcatt gggactccat atcgctacaa taccagtgct gggatatggg
     1501 aaggaggacc cagcaaggat tcattgtacg tgtcctctct ctactttacc atgacaagcc
     1561 ttacaaccat aggatttgga aacatagctc ctaccacaga tgtggagaag atgttttcgg
     1621 tggctatgat gatggttggc tctcttcttt atgcaactat ttttggaaat gttacaacaa
     1681 ttttccagca aatgtatgcc aacaccaacc gataccatga gatgctgaat aatgtacggg
     1741 acttcctaaa actctatcag gtcccaaaag gccttagtga gcgagtcatg gattatattg
     1801 tctcaacatg gtccatgtca aaaggcattg atacagaaaa ggtcctctcc atctgtccca
     1861 aggacatgag agctgatatc tgtgttcatc taaaccggaa ggtttttaat gaacatcctg
     1921 cttttcgatt ggccagcgat gggtgtctgc gcgccttggc ggtagagttc caaaccattc
     1981 actgtgctcc cggggacctc atttaccatg ctggagaaag tgtggatgcc ctctgctttg
     2041 tggtgtcagg atccttggaa gtcatccagg atgatgaggt ggtggctatt ttagggaagg
     2101 gtgatgtatt tggagacatc ttctggaagg aaaccaccct tgcccatgca tgtgcgaacg
     2161 tccgggcact gacgtactgt gacctacaca tcatcaagcg ggaagccttg ctcaaagtcc
     2221 tggactttta tacagctttt gcaaactcct tctcaaggaa tctcactctt acttgcaatc
     2281 tgaggaaacg gatcatcttt cgtaagatca gtgatgtgaa gaaagaggag gaggagcgcc
     2341 tccggcagaa gaatgaggtg accctcagca ttcccgtgga ccacccagtc agaaagctct
     2401 tccagaagtt caagcagcag aaggagctgc ggaatcaggg ctcaacacag ggtgaccctg
     2461 agaggaacca actccaggta gagagccgct ccttacagaa tggagcctcc atcaccggaa
     2521 ccagcgtggt gactgtgtca cagattactc ccattcagac gtctctggcc tatgtgaaaa
     2581 ccagtgaatc ccttaagcag aacaaccgtg atgccatgga actcaagccc aacggcggtg
     2641 ctgaccaaaa atgtctcaaa gtcaacagcc caataagaat gaagaatgga aatggaaaag
     2701 ggtggctgcg actcaagaat aatatgggag cccatgagga gaaaaaggaa gactggaata
     2761 atgtcactaa agctgagtca atggggctat tgtctgagga ccccaagagc agtgattcag
     2821 agaacagtgt gaccaaaaac ccactaagaa aaacagattc ttgtgacagt ggaattacaa
     2881 aaagtgacct tcgtttggat aaggctgggg aggcccgaag tccgctagag cacagtccca
     2941 tccaggctga tgccaagcac cccttttatc ccatccccga gcaggcctta cagaccacac
     3001 tgcaggaagt caaacacgaa ctcaaagagg acatccagct gctcagctgc agaatgactg
     3061 ccctagaaaa gcaggtggca gaaattttaa aaatactgtc ggaaaaaagc gtaccccagg
     3121 cctcatctcc caaatcccaa atgccactcc aagtaccccc ccagatacca tgtcaggata
     3181 tttttagtgt ctcaaggcct gaatcacctg aatctgacaa agatgaaatc cacttttaat
     3241 atatatacat atatatttgt taatatatta aaacagtata tacatatgtg tgtatataca
     3301 gtatatacat atatatattt tcacttgctt tcaagatgat gaccacacat ggattttgat
     3361 atgtaaatat tgcatgtcca gctggattct ggcctgccaa agaagatgat gattaaaaac
     3421 atagatattg cttgtatatt atgcagttga ctgcatgcac actttacatt tatttataat
     3481 ctctattcta taataaaaga gtatgatttt tgttacccaa ggcaatgtaa tatttgaaga
     3541 atcagggtcc aacctgccaa tgttgccatg acaaatttga tctcaggctg agtatgtata
     3601 tcgagctatc attttctcac tgttctgtta agttaaaagt atagattaat gccaaggaag
     3661 agttcagtct tttaaactat tagtaccatg ttatgatctc tttccatagg atatttttct
     3721 gtaacttagt gttaggttct tttcccctac aggcagtgtt tgctccattt aaatgactgt
     3781 ttagttgcct aagtcagata agagtgtggg atattgaaaa cttattgcta tgggttttgt
     3841 gcatgaatta catttttgat caactatacc tctcgttttt taacattata cttagatagt
     3901 aatcattagc tcttatgtaa ggaaatccct actccctcct tcttggagaa cagctgccat
     3961 cttgtaagct gacattatca acatcataaa tactaaacta ttaatataga gtatgttatt
     4021 atagaaacac tgcaccacag ggtataaggg ccttttgaca attcatgtaa gagatgctga
     4081 atttccaaag ctgataaatg ctctaaattt gtatttccaa aacatgttca agagtgacat
     4141 tgaaaggctt gttagcaaag aaacatacaa aaaataaagc atttaagtaa tcatatcaaa
     4201 atgctaacta ttatggtata aaataaaaaa gaatgtaaac agatagataa atttttgtgg
     4261 catgtatata acttagaaag aatgaaacac tggtacggat tgttgacaca tgaatcctag
     4321 tgtttgtagt gataacacat gaaatgtggt aaaacaaaca aaccaaccaa ccaagaagta
     4381 gacattaagt tgctcgactc agataactgc ttttctatca ttttattgtg gttatagttt
     4441 tttaaagctt tttgcacaca gttctactgc tggacttctg ctgagttgat tcaataagct
     4501 attgtggctc aggcaggtcc atttgtgaaa gggggatact aaagactgaa ttttagtctt
     4561 ttgaattcaa atcctctttg tagaaagtgc ctattatcaa gtttttaaaa aaagtcacaa
     4621 agagttgtcc tgtatatagc tagtccctta aatgataagg attgagaata aaatacacat
     4681 tcacttgtaa gaacccagga gaacttattt cttttgacta aactgtattt taggaagtcg
     4741 ttcagggaag catacttttc agtcagtgca tgcacagcat ttaatatggg gagcagggga
     4801 gttagtgttt gcatgaagtt gaaaaaaatg tgtgagtaat ttatatatta cgggaccatc
     4861 tgtacatata tgttaacaat atgcaaaaga tgatggcaaa atcgaaggag atatcttgat
     4921 ctattatacc catttgtatg agcttttcta tctcccagta ttcccaacca aagccactag
     4981 aactgaaaga catgttatca cattcagact tgagaagtgc aaaacagtga tttataaaaa
     5041 cagttgctat tttagaattt ctattgaact tcacatgccc acaagatgtg cctctttaat
     5101 ctaggagtct caaaacatat gagccatggg ctccattttc ctttctttat gcgtataact
     5161 tccattaacc ataatggaag ttttcagggg aacacgtctc catgtaatgc tacaatatct
     5221 acctaccaca aacacaagaa aatgaaataa ttatggagta aagaatcagc cttgaaattg
     5281 gaattttgtt gctttcatgg tgaggatgat atctttttcg tgacctctga catttattga
     5341 atttcagggt atttttctat ttgtttaagt caagtttggc ttaagctttt aaaggtgaat
     5401 gtgtggttaa aataagaatc tgattataga agttgttagt ttaactttag ccagtgcttc
     5461 aaaactaact attggtgtaa agctataaaa gaatgactgt gaacaacatg atgatttgaa
     5521 gttctaattc atggctttgc atattagtgg tgcaaatatt tactgtgttc tgacattgac
     5581 gtagagtttc acctaatcga cctacaatgt tattgttcat atatgtgaga aacataatgg
     5641 ttttgaatta ctccagattg ttaggaagga gggaaagtat caattgttta attatggtgc
     5701 agttatcata gtgtcttttc agccatctct gttctctgtg tgcatgatat gaagaggtgc
     5761 tgaatgcacc ctgctgtttt cagcaggaat gcatgttttc agcaaacatt gtatatagag
     5821 tagtctttta ggttcccaga ttccacaaat cttagcagtt gaatttactc agatttgaat
     5881 gaagggagaa tatttgcttt aatacatgca ataatgataa aatcatgttc tatgttgcct
     5941 caactagcac atagacagta gatgctcttt tgaggaccag ataactgcat gttttattcc
     6001 tacactgtat agatgctctt ggtgcatcca gaataaaaat tttaatatta tatttctaaa
     6061 taatatatta ataggagtaa atggatatgt attagaaatc caaacatttt ccaaagcaat
     6121 ttacacacct tcaatatttt tctatgatgt tattaatagg taagatcaga tgctgtatcc
     6181 tcgacaggtg gttgtaacaa aatagcaaaa gtcaaattag aatggaaatg tgagtgatgt
     6241 atcataatgg caggttttat cagtctgtat caggatattg ttgcactaaa tgtgatctag
     6301 cagatggaag agattatgat aaaaagcaaa taggcacaca aaagccagat gacaatacca
     6361 aagctatatg aatggtactg aaaatggttc aggcacagtg gttgaattga atgacgtggt
     6421 tgaatacagg cccatgcttc attgttaaaa tggaaaattt ttatgacact agttgcatct
     6481 tgcattaagt ataggactaa aaatgtccta agtatttttt acaaacaact ttatgtatat
     6541 cagagaaaaa aatggaaaat ctggggtttg aaattgctct agaaaaaatg tgtacttctg
     6601 ttgtactcaa cactttaata ggaaaattag ttgtgaccgc taactaaagt accattatca
     6661 aaattaacct tattggagcc caaatgaaaa tcacattttc ccttctgttt aaggagattt
     6721 tgttcaccct gtgatatctg gtccatttga tatcttattt taaatagcta aagtcatttg
     6781 gaattttttt taatattagc cttcagagca gtgactgttt tgaagtgtgc agtggcagat
     6841 atttgtgaaa ttattcatca tatttctaat gaattccact atcttgtata atttttatct
     6901 tttaagcaat tttctatgag tttgttttcc aaaattccat gtaggtaatg agaacattta
     6961 tctagaatgt gcatatcata catggataac tttcaaatat gaatatttta taatcatgtg
     7021 aatgttgtgc tataattttt tctattaggt gtaaaagtat ttctcttctc atcttaatgg
     7081 aaagggggaa aagacaaaaa cagtcttttg gaaaacacct taagtcttag tatctgagct
     7141 ttgtcttgtg ttctgaattt agctttacca caaactagaa gtgtaattat gggcaagtta
     7201 acctttccta gtgtaccaaa tggtaccatt tccccgccaa taaataagaa aacaaagata
     7261 acagctgttg cttccttata tcaacatgct attggtcaat gaaaaaatta tctttcttgc
     7321 aggtgaaaat cacattatga caagtgatca ctttttcatt ctttcataga agagtatcca
     7381 cgatgtactc tctatcaaaa tattcttcta gattttagaa gagatttcag ggattgacgg
     7441 tgatgtgatt tttatctaaa tattctttta ggttttagaa gagatttatc tggtcagagg
     7501 ttaatggaga gaggcatagt ttgctagtgg caggtaagca taaaacttca tacttatgtg
     7561 ggaatttaga actacaaatc aaataaacgt ggaaagaatg aagctccttt gacagaagag
     7621 agagagaaga gaaagatagg taaattttgt gatttttctt atttctactt aatcatactg
     7681 cttggcagaa attctcaatt ttgtgaaaaa attggtaagt ggccaaggta tagagtagtt
     7741 caccaatgta tctatgtaac aaaactgaat gtgtacccct taaatttata caaataaaaa
     7801 ctagagtagt tcatccttca actttttata ttaaaataat catgacctgt tcaagatata
     7861 tgattccaca tgggcagaca ctcttataac aaaattctta actatgtgct atgtgttgta
     7921 agttttggcc tatattctga cttgagattt tctatcactt catttgtagg ataagacccc
     7981 tgtgtttgca ttctttatga gggtcaggac cactgaggat ttggactggg aactagaaag
     8041 atgatgaagg caagggttga gaaaagactg attagaatct atctgcttct ttactcttag
     8101 gcttagaagt taaataagtt aactaagctt atatttacca aggtctcact atgataagca
     8161 ttttatttag gttatcaaat ttaattcttg cagcaacccc atgaaggtat aggttaagga
     8221 acttgtccag gatggcatac ttgttacatg gtaaagttga gtttctaaca caggcagtca
     8281 gaccttaggg agaaaccttt attttgtaga atactgacat tacaagaact atctagttca
     8341 accatctagt ctaggttttt ccagacacat acttttaaag atttcttaaa ataattctta
     8401 aaaattgcac tcgataatgt gaatgtaaat gtttggtttt tcttgatagg tcagagtcaa
     8461 tgacagagtt tgaaatcata ctgtcttaag caaaaggtgc cctgtcccaa cagtggaatt
     8521 ttcctttact tctcctaaca gttgaaagac atcggccaaa gtaaactgtc aaatgtggta
     8581 tgtttgatat atggtcactg gtatcaacat tttcttttcc agttgaattt taacctaaag
     8641 aggtaatgcc taatggttaa ggaaagcaag agtcattcag gatttttttt ctataatttc
     8701 tttttctttt taatagtggg atttggatga gactccagaa tttattttta aaatttattt
     8761 tttgactcat tgggttttaa gtagattatt cagatatttt tattgattgc actgatgttg
     8821 gcttcttggc caaaccacta ttaaatacat tatccaaatg aactatttct gtttagaatg
     8881 gcaacttgta tccttatttc caaaattaat gagctcacag tatgtatatt tacttcagag
     8941 agtttcaata attttctcta atgaaaaaat gttaattttc tgaatgtgat ttatttgttc
     9001 taccctttga gatttctaaa gcaagtgtct tgagataagg agaaaaaaac aagatattac
     9061 aacactacat gctggaatct tcagcccaaa ccatcttgtt ttcacttggc taataactga
     9121 gccagaggta atcatagaaa ggaagaatcc tacttttaaa ataatgactg tgaaggaccc
     9181 cactgacacc atccaaagct ttttatagtc agctcacttc catcctggct tttacattac
     9241 cactgcatga ttatttaaat gaggtcatgt cttgtactac ttgtaaaggc acttggtcaa
     9301 agaagagtaa accaaaaagt gcagcttatg accagagtta taactgagga aaaaggagtg
     9361 tggagaaggg acagcagttg cttcctttta atgagttttc tgtatgtggt gccttttaaa
     9421 tagcttttgt ttatttgttt ttaagatgac acattgtcat taaggtttta acaaaaacct
     9481 ttggaagcag tttgaaagct tgtcaaatgc tggggccttc tttagaaata agtgttctcc
     9541 caccaaccaa tgagtttaga acctctggtt ctgacctaca aacccaatcc cctaagcact
     9601 tggctggttg ggctgcattt tgatgggagg aaacaaaaag atctgatcac tctctctcat
     9661 tcatgcggaa tcactgactg ttgaatgacc aaagcagtca aagccaaaat attcaccttg
     9721 aagcttcaat aaaccagatt gagtatccat aataactaat ttaagtaatt ttatccccat
     9781 tctctgctaa atcatatttc ataatataaa atgtaaccac ttccctctat ccaaagcttt
     9841 tggtcagact ctccattgag ttagagaaat tggactttgg caaaaagcaa cataaagatt
     9901 attgttgttc ctagaaccat tgttgccatg gacccctcat ttgctcctca actttttcaa
     9961 ccaaattata gcgggaaaga ttcctgatga agccaagact gcaaacagga agaataccta
    10021 gctagtaaac tatgcaaaat cacaacaaag attcatttat aattccatgt tacagtgttt
    10081 gatagtccta agtatttaat attggtatat tatgtcacag ccatgaactg tcaacttaca
    10141 caaaatccaa acgcactttc atttaaaatc aagattagcc tatttcattt tcaggaaaaa
    10201 acagttgtca gaattgcttt tttgacctct gcagggatgt tttcacattg ctattcttat
    10261 gaccctttat cagagaggga ataagtgtag tgttcacttt catctcctta gggttgactg
    10321 caccagcatc ttccatcaag cagtcgcctt ccaccttaga acctgttcac agttaataaa
    10381 gcaaggggga atatgcattt catattagga acagatttct taagtgattg ttatgaaaag
    10441 tggaaaccag tttagaacca tttttttacc ctaaaacatc cattgtagtt tgttgaaaga
    10501 gcaatgactt ttagaagtgc ttggtactca aacaacacaa aatgtgcaga ttcacgatat
    10561 attgaaaatt atagagttct ttttagtcta tgttctagtg actttgttta cactagttgt
    10621 ggcattttgt atactacaat gtaaattcta ctataacact aatgttacta tgggaattaa
    10681 ttttgcaact tcttaaatgt ttttgtcact gcaaccatat tggtgagata ttgggggtat
    10741 taaaaatgcc tctgccttta agggttaatt caccagaaat aattgattca tgcattgaca
    10801 aaggaaacaa tgcaaaaatt tcatgtggga tgtttttaat accattatgc taagcagtac
    10861 ttgttggctt ttttcaaaat ctgattcatg ctaagcagat ccttttttct acttaaacaa
    10921 agatactgca atgtataata tagaaatttt gtatgtactg ttgacctatc acctgactgc
    10981 tgacaggatg tgtgaaaata ttttaacttt gtgactttag ggtcaattat gaaacaattg
    11041 tgatcaaaat tcagttgctt ctgggaagtt tgtggtgatt atcactttat ttaacgtttg
    11101 ttctcaaaaa atggtcattt tgaaaagtga attggcaggt ggaagctttt agcccaaaag
    11161 aaatctgggt ttcagcacaa taaactgtat ttcatcaggg aggactaact ttgctttttt
    11221 tcacacttta tttaaatgtg gatatttttt catgatacag aataaaatgt gcattttatg
    11281 gaa
//
