LOCUS       NM_012284               4023 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily H member 3
            (KCNH3), transcript variant 1, mRNA.
ACCESSION   NM_012284 XM_035483
VERSION     NM_012284.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4023)
  AUTHORS   Li,X., Anishkin,A., Liu,H., van Rossum,D.B., Chintapalli,S.V.,
            Sassic,J.K., Gallegos,D., Pivaroff-Ward,K. and Jegla,T.
  TITLE     Bimodal regulation of an Elk subfamily K+ channel by
            phosphatidylinositol 4,5-bisphosphate
  JOURNAL   J Gen Physiol 146 (5), 357-374 (2015)
   PUBMED   26503718
REFERENCE   2  (bases 1 to 4023)
  AUTHORS   Herrmann,M., Ruprecht,K., Sauter,M., Martinez,J., van Heteren,P.,
            Glas,M., Best,B., Meyerhans,A., Roemer,K. and Mueller-Lantzsch,N.
  TITLE     Interaction of human immunodeficiency virus gp120 with the
            voltage-gated potassium channel BEC1
  JOURNAL   FEBS Lett 584 (16), 3513-3518 (2010)
   PUBMED   20638388
  REMARK    GeneRIF: report on the binding of HIV-1 gp120 to the cytoplasmic
            C-terminus of the voltage-gated potassium channel BEC1, an
            interaction that can result in the repression of BEC's activity and
            the inhibition of HIV-1 particle-release
REFERENCE   3  (bases 1 to 4023)
  AUTHORS   Miyake,A., Takahashi,S., Nakamura,Y., Inamura,K., Matsumoto,S.,
            Mochizuki,S. and Katou,M.
  TITLE     Disruption of the ether-a-go-go K+ channel gene BEC1/KCNH3 enhances
            cognitive function
  JOURNAL   J Neurosci 29 (46), 14637-14645 (2009)
   PUBMED   19923296
  REMARK    GeneRIF: BEC1 is negatively involved in cognitive functions with no
            abnormal behaviors such as spontaneous seizures or motor
            dysfunction.
REFERENCE   4  (bases 1 to 4023)
  AUTHORS   Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D.,
            Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W.
            and Wang,X.
  TITLE     International Union of Pharmacology. LIII. Nomenclature and
            molecular relationships of voltage-gated potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 473-508 (2005)
   PUBMED   16382104
  REMARK    Review article
REFERENCE   5  (bases 1 to 4023)
  AUTHORS   Zou,A., Lin,Z., Humble,M., Creech,C.D., Wagoner,P.K., Krafte,D.,
            Jegla,T.J. and Wickenden,A.D.
  TITLE     Distribution and functional properties of human KCNH8 (Elk1)
            potassium channels
  JOURNAL   Am J Physiol Cell Physiol 285 (6), C1356-C1366 (2003)
   PUBMED   12890647
REFERENCE   6  (bases 1 to 4023)
  AUTHORS   Miyake,A., Mochizuki,S., Yokoi,H., Kohda,M. and Furuichi,K.
  TITLE     New ether-a-go-go K(+) channel family members localized in human
            telencephalon
  JOURNAL   J Biol Chem 274 (35), 25018-25025 (1999)
   PUBMED   10455180
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020612.40, AB033108.1 and
            AW248597.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012284.2.
            
            Summary: The protein encoded by this gene is a voltage-gated
            potassium channel alpha subunit predominantly expressed in the
            forebrain. Studies in mice have found that cognitive function
            increases when this gene is knocked out. In humans, the encoded
            protein has been shown to be capable of binding glycoprotein 120 of
            the human immunodeficiency virus type 1 (HIV-1) envelope. Two
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033108.1, BC150602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257981.7/ ENSP00000257981.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AC020612.40        13220-13346
            128-3980            AB033108.1         1-3853
            3981-3998           AW248597.1         11-28               c
            3999-4023           AC020612.40        32503-32527
FEATURES             Location/Qualifiers
     source          1..4023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..4023
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /note="potassium voltage-gated channel subfamily H member
                     3"
                     /db_xref="GeneID:23416"
                     /db_xref="HGNC:HGNC:6252"
                     /db_xref="MIM:604527"
     exon            1..463
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..3639
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ether-a-go-go K(+) channel family member; ELK channel 2;
                     brain-specific eag-like channel 1; potassium voltage-gated
                     channel, subfamily H (eag-related), member 3;
                     ether-a-go-go-like potassium channel 2; potassium channel,
                     voltage gated eag related subfamily H, member 3;
                     voltage-gated potassium channel subunit Kv12.2;
                     voltage-gated inwardly rectifying potassium channel KCNH3"
                     /codon_start=1
                     /product="voltage-gated inwardly rectifying potassium
                     channel KCNH3 isoform 1"
                     /protein_id="NP_036416.1"
                     /db_xref="CCDS:CCDS8786.1"
                     /db_xref="GeneID:23416"
                     /db_xref="HGNC:HGNC:6252"
                     /db_xref="MIM:604527"
                     /translation="MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVY
                     CSDGFCDLTGFSRAEVMQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRK
                     SGLPFWCLLDVIPIKNEKGEVALFLVSHKDISETKNRGGPDRWKETGGGRRRYGRARS
                     KGFNANRRRSRAVLYHLSGHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILL
                     HCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDI
                     VLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLL
                     KTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQREIESSESE
                     LPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGTGLELLGGPSLRS
                     AYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMY
                     ARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELR
                     ADIAMHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCS
                     GSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLTYCVLQCLQLAGLHDSL
                     ALYPEFAPRFSRGLRGELSYNLGAGGGSAEVDTSSLSGDNTLMSTLEEKETDGEQGPT
                     VSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPGRAGALKAEAGPS
                     APPRALEGLRLPPMPWNVPPDLSPRVVDGIEDGCGSDQPKFSFRVGQSGPECSSSPSP
                     GPESGLLTVPHGPSEARNTDTLDKLRQAVTELSEQVLQMREGLQSLRQAVQLVLAPHR
                     EGPCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGTWPHPRPGPPPLM
                     APWPWGPPASQSSPWPRATAFWTSTSDSEPPASGDLCSEPSTPASPPPSEEGARTGPA
                     EPVSQAEATSTGEPPPGSGGLALPWDPHSLEMVLIGCHGSGTVQWTQEEGTGV"
     exon            464..697
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..832
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..966
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1210
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1368
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1576
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1855
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..2055
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2305
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2523
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..2855
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2856..2962
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3039
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..4023
                     /gene="KCNH3"
                     /gene_synonym="BEC1; ELK2; Kv12.2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctgcagc ttctccccga cagacggagg gagctgccga gagccggcgc cgagcgaagc
       61 cgagcggaag cccacccgca gccgacacgc gagccgctgc cgcggcggga ggtgctgaga
      121 gcgcggcggc cgcggggcct ggagcccggg atttgtgggc ggcgagggcg cgaggggccg
      181 cgcgccatgc tccgggcccc gacggcgcgg acgccccctc gcgcgccagc gtccggcgcg
      241 accccggatc ccggtctgcg cattgccccc cgacggctgc gctagggagc gcggggcccg
      301 gcggggggcg gccgagctgg gcgccctccc ccggcgcgga gtccccgcac cccggaggga
      361 tggggcgggc agccgcgggc gcctaagatg ccggccatgc ggggcctcct ggcgccgcag
      421 aacaccttcc tggacaccat cgctacgcgc ttcgacggca cgcacagtaa cttcgtgctg
      481 ggcaacgccc aggtggcggg gctcttcccc gtggtctact gctctgatgg cttctgtgac
      541 ctcacgggct tctcccgggc tgaggtcatg cagcggggct gtgcctgctc cttcctttat
      601 gggccagaca ccagtgagct cgtccgccaa cagatccgca aggccctgga cgagcacaag
      661 gagttcaagg ctgagctgat cctgtaccgg aagagcgggc tcccgttctg gtgtctcctg
      721 gatgtgatac ccataaagaa tgagaaaggg gaggtggctc tcttcctagt ctctcacaag
      781 gacatcagcg aaaccaagaa ccgagggggc cccgacagat ggaaggagac aggtggtggc
      841 cggcgccgat atggccgggc acgatccaaa ggcttcaatg ccaaccggcg gcggagccgg
      901 gccgtgctct accacctgtc cgggcacctg cagaagcagc ccaagggcaa gcacaagctc
      961 aataaggggg tgtttgggga gaaaccaaac ttgcctgagt acaaagtagc cgccatccgg
     1021 aagtcgccct tcatcctgtt gcactgtggg gcactgagag ccacctggga tggcttcatc
     1081 ctgctcgcca cactctatgt ggctgtcact gtgccctaca gcgtgtgtgt gagcacagca
     1141 cgggagccca gtgccgcccg cggcccgccc agcgtctgtg acctggccgt ggaggtcctc
     1201 ttcatccttg acattgtgct gaatttccgt accacattcg tgtccaagtc gggccaggtg
     1261 gtgtttgccc caaagtccat ttgcctccac tacgtcacca cctggttcct gctggatgtc
     1321 atcgcagcgc tgccctttga cctgctacat gccttcaagg tcaacgtgta cttcggggcc
     1381 catctgctga agacggtgcg cctgctgcgc ctgctgcgcc tgcttccgcg gctggaccgg
     1441 tactcgcagt acagcgccgt ggtgctgaca ctgctcatgg ccgtgttcgc cctgctcgcg
     1501 cactgggtcg cctgcgtctg gttttacatt ggccagcggg agatcgagag cagcgaatcc
     1561 gagctgcctg agattggctg gctgcaggag ctggcccgcc gactggagac tccctactac
     1621 ctggtgggcc ggaggccagc tggagggaac agctccggcc agagtgacaa ctgcagcagc
     1681 agcagcgagg ccaacgggac ggggctggag ctgctgggcg gcccgtcgct gcgcagcgcc
     1741 tacatcacct ccctctactt cgcactcagc agcctcacca gcgtgggctt cggcaacgtg
     1801 tccgccaaca cggacaccga gaagatcttc tccatctgca ccatgctcat cggcgccctg
     1861 atgcacgcgg tggtgtttgg gaacgtgacg gccatcatcc agcgcatgta cgcccgccgc
     1921 tttctgtacc acagccgcac gcgcgacctg cgcgactaca tccgcatcca ccgtatcccc
     1981 aagcccctca agcagcgcat gctggagtac ttccaggcca cctgggcggt gaacaatggc
     2041 atcgacacca ccgagctgct gcagagcctc cctgacgagc tgcgcgcaga catcgccatg
     2101 cacctgcaca aggaggtcct gcagctgcca ctgtttgagg cggccagccg cggctgcctg
     2161 cgggcactgt ctctggccct gcggcccgcc ttctgcacgc cgggcgagta cctcatccac
     2221 caaggcgatg ccctgcaggc cctctacttt gtctgctctg gctccatgga ggtgctcaag
     2281 ggtggcaccg tgctcgccat cctagggaag ggcgacctga tcggctgtga gctgccccgg
     2341 cgggagcagg tggtaaaggc caatgccgac gtgaaggggc tgacgtactg cgtcctgcag
     2401 tgtctgcagc tggctggcct gcacgacagc cttgcgctgt accccgagtt tgccccgcgc
     2461 ttcagtcgtg gcctccgagg ggagctcagc tacaacctgg gtgctggggg aggctctgca
     2521 gaggtggaca ccagctccct gagcggcgac aataccctta tgtccacgct ggaggagaag
     2581 gagacagatg gggagcaggg ccccacggtc tccccagccc cagctgatga gccctccagc
     2641 cccctgctgt cccctggctg cacctcctca tcctcagctg ccaagctgct atccccacgt
     2701 cgaacagcac cccggcctcg tctaggtggc agagggaggc caggcagggc aggggctttg
     2761 aaggctgagg ctggcccctc tgctccccca cgggccctag aggggctacg gctgcccccc
     2821 atgccatgga atgtgccccc agatctgagc cccagggtag tagatggcat tgaagacggc
     2881 tgtggctcgg accagcccaa gttctctttc cgcgtgggcc agtctggccc ggaatgtagc
     2941 agcagcccct cccctggacc agagagcggc ctgctcactg ttccccatgg gcccagcgag
     3001 gcaaggaaca cagacacact ggacaagctt cggcaggcgg tgacagagct gtcagagcag
     3061 gtgctgcaga tgcgggaagg actgcagtca cttcgccagg ctgtgcagct tgtcctggcg
     3121 ccccacaggg agggtccgtg ccctcgggca tcgggagagg ggccgtgccc agccagcacc
     3181 tccgggcttc tgcagcctct gtgtgtggac actggggcat cctcctactg cctgcagccc
     3241 ccagctggct ctgtcttgag tgggacttgg ccccaccctc gtccggggcc tcctcccctc
     3301 atggcaccct ggccctgggg tcccccagcg tctcagagct ccccctggcc tcgagccaca
     3361 gctttctgga cctccacctc agactcagag ccccctgcct caggagacct ctgctctgag
     3421 cccagcaccc ctgcctcccc tcctccttct gaggaagggg ctaggactgg gcccgcagag
     3481 cctgtgagcc aggctgaggc taccagcact ggagagcccc caccagggtc agggggcctg
     3541 gccttgccct gggaccccca cagcctggag atggtgctta ttggctgcca tggctctggc
     3601 acagtccagt ggacccagga agaaggcaca ggggtctgag taccagccct agaactcagc
     3661 gttgccaggt gtgctgccat ctgctgttcg gcccaacctc agagtgaagg cagggtggca
     3721 gcctccccac ggactccatg cggcccgctg gctcagggca gggagcctgg aagcaaagga
     3781 ggacctggct cctgactctc agagaggata ggctggatcc ctggggcagg cctctcctcg
     3841 gcctgctcct ctgacctccc ggtctccctc tgcaggctgg gggcagaggc ctgaggacaa
     3901 ggaagagctt tgccatcccc tgcatgtgcc cctgcctcta cctgtcccca aatttttata
     3961 ttaaaaaaaa aaaataaaat aaactacttt ggaacctggt gctttttatt tacaaaagaa
     4021 aaa
//
