LOCUS       NM_172362               8140 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens potassium voltage-gated channel subfamily H member 1
            (KCNH1), transcript variant 1, mRNA.
ACCESSION   NM_172362
VERSION     NM_172362.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8140)
  AUTHORS   Wu,R., Li,X., Meng,Z., Li,P., He,Z. and Liang,L.
  TITLE     Phenotypic and genetic analysis of children with unexplained
            neurodevelopmental delay and neurodevelopmental comorbidities in a
            Chinese cohort using trio-based whole-exome sequencing
  JOURNAL   Orphanet J Rare Dis 19 (1), 205 (2024)
   PUBMED   38764027
  REMARK    GeneRIF: Phenotypic and genetic analysis of children with
            unexplained neurodevelopmental delay and neurodevelopmental
            comorbidities in a Chinese cohort using trio-based whole-exome
            sequencing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8140)
  AUTHORS   Tian,M.Q., Li,R.K., Yang,F., Shu,X.M., Li,J., Chen,J., Peng,L.Y.,
            Yu,X.H. and Yang,C.J.
  TITLE     Phenotypic expansion of KCNH1-associated disorders to include
            isolated epilepsy and its associations with genotypes and molecular
            sub-regional locations
  JOURNAL   CNS Neurosci Ther 29 (1), 270-281 (2023)
   PUBMED   36285361
  REMARK    GeneRIF: Phenotypic expansion of KCNH1-associated disorders to
            include isolated epilepsy and its associations with genotypes and
            molecular sub-regional locations.
REFERENCE   3  (bases 1 to 8140)
  AUTHORS   Napoli,G., Panzironi,N., Traversa,A., Catalanotto,C., Pace,V.,
            Petrizzelli,F., Giovannetti,A., Lazzari,S., Cogoni,C.,
            Tartaglia,M., Carella,M., Mazza,T., Pizzuti,A., Parisi,C. and
            Caputo,V.
  TITLE     Potassium Channel KCNH1 Activating Variants Cause Altered
            Functional and Morphological Ciliogenesis
  JOURNAL   Mol Neurobiol 59 (8), 4825-4838 (2022)
   PUBMED   35639255
  REMARK    GeneRIF: Potassium Channel KCNH1 Activating Variants Cause Altered
            Functional and Morphological Ciliogenesis.
REFERENCE   4  (bases 1 to 8140)
  AUTHORS   Jones,D.K.
  TITLE     Hysteretic hERG channel gating current recorded at physiological
            temperature
  JOURNAL   Sci Rep 12 (1), 5950 (2022)
   PUBMED   35396394
  REMARK    GeneRIF: Hysteretic hERG channel gating current recorded at
            physiological temperature.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8140)
  AUTHORS   Toplak,Z., Merzel,F., Pardo,L.A., Peterlin Masic,L. and Tomasic,T.
  TITLE     Molecular Dynamics-Derived Pharmacophore Model Explaining the
            Nonselective Aspect of KV10.1 Pore Blockers
  JOURNAL   Int J Mol Sci 22 (16), 8999 (2021)
   PUBMED   34445705
  REMARK    GeneRIF: Molecular Dynamics-Derived Pharmacophore Model Explaining
            the Nonselective Aspect of KV10.1 Pore Blockers.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8140)
  AUTHORS   Schonherr,R., Lober,K. and Heinemann,S.H.
  TITLE     Inhibition of human ether a go-go potassium channels by
            Ca(2+)/calmodulin
  JOURNAL   EMBO J 19 (13), 3263-3271 (2000)
   PUBMED   10880439
REFERENCE   7  (bases 1 to 8140)
  AUTHORS   Pardo,L.A., del Camino,D., Sanchez,A., Alves,F., Bruggemann,A.,
            Beckh,S. and Stuhmer,W.
  TITLE     Oncogenic potential of EAG K(+) channels
  JOURNAL   EMBO J 18 (20), 5540-5547 (1999)
   PUBMED   10523298
REFERENCE   8  (bases 1 to 8140)
  AUTHORS   Hoshi,N., Takahashi,H., Shahidullah,M., Yokoyama,S. and
            Higashida,H.
  TITLE     KCR1, a membrane protein that facilitates functional expression of
            non-inactivating K+ currents associates with rat EAG
            voltage-dependent K+ channels
  JOURNAL   J Biol Chem 273 (36), 23080-23085 (1998)
   PUBMED   9722534
REFERENCE   9  (bases 1 to 8140)
  AUTHORS   Occhiodoro,T., Bernheim,L., Liu,J.H., Bijlenga,P., Sinnreich,M.,
            Bader,C.R. and Fischer-Lougheed,J.
  TITLE     Cloning of a human ether-a-go-go potassium channel expressed in
            myoblasts at the onset of fusion
  JOURNAL   FEBS Lett 434 (1-2), 177-182 (1998)
   PUBMED   9738473
REFERENCE   10 (bases 1 to 8140)
  AUTHORS   Warmke,J.W. and Ganetzky,B.
  TITLE     A family of potassium channel genes related to eag in Drosophila
            and mammals
  JOURNAL   Proc Natl Acad Sci U S A 91 (8), 3438-3442 (1994)
   PUBMED   8159766
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092017.2, AJ001366.1,
            AF078742.1 and AC096636.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_172362.2.
            
            Summary: Voltage-gated potassium (Kv) channels represent the most
            complex class of voltage-gated ion channels from both functional
            and structural standpoints. Their diverse functions include
            regulating neurotransmitter release, heart rate, insulin secretion,
            neuronal excitability, epithelial electrolyte transport, smooth
            muscle contraction, and cell volume. This gene encodes a member of
            the potassium channel, voltage-gated, subfamily H. This member is a
            pore-forming (alpha) subunit of a voltage-gated non-inactivating
            delayed rectifier potassium channel. It is activated at the onset
            of myoblast differentiation. The gene is highly expressed in brain
            and in myoblasts. Overexpression of the gene may confer a growth
            advantage to cancer cells and favor tumor cell proliferation.
            Alternative splicing of this gene results in two transcript
            variants encoding distinct isoforms. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1), also known as eagB, encodes
            the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF078742.1, SRR1803612.181704.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271751.10/ ENSP00000271751.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC092017.2         77029-77061         c
            34-761              AJ001366.1         1-728
            762-3241            AF078742.1         595-3074
            3242-8139           AC096636.1         127716-132613
            8140-8140           AC096636.1         132614-132614
FEATURES             Location/Qualifiers
     source          1..8140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     gene            1..8140
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /note="potassium voltage-gated channel subfamily H member
                     1"
                     /db_xref="GeneID:3756"
                     /db_xref="HGNC:HGNC:6250"
                     /db_xref="MIM:603305"
     exon            1..282
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..3173
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ether-a-go-go, Drosophila, homolog of; ether-a-go-go
                     potassium channel 1; EAG channel 1; voltage-gated
                     potassium channel subunit Kv10.1; potassium channel,
                     voltage gated eag related subfamily H, member 1; potassium
                     voltage-gated channel, subfamily H (eag-related), member
                     1; voltage-gated delayed rectifier potassium channel
                     KCNH1; ether-a-go-go 1"
                     /codon_start=1
                     /product="voltage-gated delayed rectifier potassium
                     channel KCNH1 isoform 1"
                     /protein_id="NP_758872.1"
                     /db_xref="CCDS:CCDS1496.1"
                     /db_xref="GeneID:3756"
                     /db_xref="HGNC:HGNC:6250"
                     /db_xref="MIM:603305"
                     /translation="MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVY
                     SNDGFCKLSGYHRAEVMQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKK
                     NRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTS
                     SRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKT
                     TWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGP
                     AGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQI
                     PPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHW
                     MACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVY
                     ISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYAN
                     TNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRAD
                     ICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSG
                     SLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLE
                     FYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRL
                     FQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPV
                     SFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKA
                     ESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSF
                     YPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFE
                     ISRPQSPESERDIFGAS"
     exon            283..406
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..513
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            514..642
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..761
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..1235
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1665
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1865
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2118
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2315
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..8140
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8120..8125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /note="hexamer: AATAAA"
     polyA_site      8140
                     /gene="KCNH1"
                     /gene_synonym="EAG; EAG1; h-eag; hEAG; hEAG1; K(V)10.1;
                     Kv10.1; TMBTS; ZLS1"
                     /note="major polyA site"
ORIGIN      
        1 gcactgcgag gcgggccgca gggagggagg cgcgaagagg gcgcgagggt agcagccaga
       61 gggagccgcc agccctgcct gcggatcccc gccgggcgca tggggcgctt cgagccggga
      121 ctgcgtgcgg gccccgaggc cagtttcctg ctgtcgtaag aagccgcgcc aggacgcccg
      181 ccggaccccg agctgctggg aggatgacca tggctggggg caggagggga ctagtggccc
      241 ctcaaaacac gtttctggag aatattgttc ggcggtccaa tgatactaat tttgtgttgg
      301 ggaatgctca gatagtggac tggcctattg tgtacagcaa tgatggattt tgcaagctgt
      361 ctggctatca cagggcagaa gtgatgcaaa aaagcagcac ctgcagtttt atgtatgggg
      421 agctgactga taaagacacg attgaaaaag tgcggcaaac atttgagaac tatgagatga
      481 attcctttga aattctgatg tacaagaaga acaggacacc tgtgtggttc tttgtgaaaa
      541 ttgctccaat tcgaaacgaa caggataaag tggttttatt tctttgcact ttcagtgaca
      601 taacagcttt caaacagcca attgaggatg attcatgtaa aggctggggg aagtttgctc
      661 ggctgacaag agcactgaca agcagcaggg gtgtcctgca gcagctggct ccaagcgtgc
      721 aaaaaggcga gaatgtccac aagcactccc gcctggcaga ggtcctacag ctgggctcag
      781 acatccttcc ccagtacaag caagaggcac caaagactcc ccctcacatc atcttacatt
      841 attgtgtttt taagaccacg tgggattgga tcatcttgat cttgaccttc tatacagcca
      901 tcttggtccc ttataatgtc tccttcaaaa ccaggcagaa taatgtggcc tggctggttg
      961 ttgatagcat cgtggatgtt atctttttgg tggacattgt gctcaatttt cataccacct
     1021 ttgttggacc agcaggggag gtgatttctg accccaaact tatccgcatg aactacctga
     1081 agacgtggtt tgtgattgac cttctgtcct gtttgccata tgatgtcatc aacgcttttg
     1141 agaacgtgga tgaggttagt gcctttatgg gtgatccagg gaagattggt tttgctgatc
     1201 agattccacc accactggag gggagagaga gtcagggcat cagcagcctg ttcagctctc
     1261 taaaagttgt ccggctgctc cgtcttgggc gagtggcccg taagctggac cactacattg
     1321 aatatggagc tgctgtgctg gtcctgctgg tgtgtgtgtt tgggctggct gcacactgga
     1381 tggcctgcat ctggtacagc attggggact atgagatctt tgacgaggac accaagacaa
     1441 tccgcaacaa cagctggctg taccaactag cgatggacat tggcacccct taccagttta
     1501 atgggtctgg ctcagggaag tgggaaggtg gtcccagcaa gaattctgtc tacatctcct
     1561 cgttgtattt cacaatgacc agcctcacca gtgtgggctt tgggaacatc gccccatcca
     1621 cagacattga gaagatcttt gcagtggcca tcatgatgat tggctcactt ctctatgcca
     1681 ccatcttcgg gaatgtgacg actattttcc aacagatgta tgccaacacc aacagatacc
     1741 atgagatgct caacagtgtt cgggacttcc tgaagctcta ccaggtgcca aaaggattga
     1801 gtgagcgagt aatggattat attgtgtcca cttggtccat gtccagaggc attgacacag
     1861 agaaggtcct gcagatctgc cccaaggaca tgagagccga catctgcgtg cacctgaacc
     1921 gcaaggtgtt caaggagcac ccggccttcc ggctggccag tgatggctgc ctccgggcac
     1981 tggccatgga gttccagacg gtgcactgtg ccccagggga cctcatctac catgcaggag
     2041 agagcgttga cagcctctgc tttgtggttt ctggctccct ggaggtgatc caagatgatg
     2101 aggtggtggc cattctagga aaaggagacg tgtttggaga tgtgttctgg aaggaagcca
     2161 cccttgccca gtcctgtgcc aatgttaggg ccttgaccta ctgtgatctg catgtgatca
     2221 agcgggatgc cctgcagaaa gtgctggaat tctacacggc cttctcccat tccttctccc
     2281 ggaacctgat tctgacgtac aacttgagga agaggattgt gttccggaag atcagcgatg
     2341 tgaaacgtga agaggaagaa cgcatgaaac gaaagaatga ggcccccctg atcttgcccc
     2401 cggaccaccc tgtccggcgc ctcttccaga gattccgaca gcagaaagag gccaggctgg
     2461 cagctgagag agggggccgg gacctggatg acctagatgt ggagaagggc aatgtcctta
     2521 cagagcatgc ctccgccaac cacagcctcg tgaaggccag cgtggtcacc gtgcgtgaga
     2581 gtcctgccac gcccgtatcc ttccaggcag cctccacctc cggggtgcca gaccacgcaa
     2641 agctacaggc gccagggtcc gagtgcctgg gccccaaggg gggcgggggc gattgtgcca
     2701 agcgcaaaag ctgggcccgc ttcaaagatg cttgcgggaa gagtgaggac tggaacaagg
     2761 tgtccaaggc tgagtcgatg gagacacttc ccgagaggac aaaagcgtca ggcgaggcca
     2821 cactgaagaa gacagactcg tgtgacagtg gcatcaccaa gagcgacttg cgcctggaca
     2881 acgtgggtga ggccaggagt ccccaggatc ggagtcccat cctggcagag gtcaagcatt
     2941 cgttctaccc catccctgag cagacgctgc aggccacagt cctggaggtg aggcacgagc
     3001 tgaaggagga catcaaggcc ttaaacgcca aaatgaccaa tattgagaaa cagctctctg
     3061 agatactcag gatattaact tccagaagat cctctcagtc tcctcaggag ttgtttgaaa
     3121 tatcgaggcc acagtcccca gaatcagaga gagacatttt tggagccagc tgagaggtct
     3181 atttaaaaaa aaagtcagag acagatacct ccaaccctgc cgtcaccacc acccctacca
     3241 catatgtcca catgaccaac aattttcaag taggcttttc ctaacagaaa aagtggggcc
     3301 agtggcttag acgtgctctt tctctatctg gaaaaagata tgggaagggt agcgtgcccc
     3361 taccctgcaa ggtggcagct gcatctgaac cgtctttgca caattttgga agaagggaca
     3421 tgctgtctaa agggtatttt ccttcatttt taatttttta ctaccatgat atttgtaaaa
     3481 gattaaaact accagaacag agcagcagcc atctggggac tggtgggaaa gtgccgagaa
     3541 cctctcatgt atatactatg ctgggctcct ttgccaagac cccccatgga ctgcagtggg
     3601 ccaaggactt cccggcatcc ccgtccttgt acagcccgtg tctgacgtca ccatgttttc
     3661 ctgtagttgt catttataac tagctcggga caagcagagc ttgagggaca ggagggtaga
     3721 gctcagaaac tttctgtctc atggttaagg ccagaaaagc agctgcaggt gtggtgcatg
     3781 cctcccatag acacttgaag ctgggaatcc tcaggtctcc ttccccaaag gaggtgaggc
     3841 aagggtaaga gctggagagg ggcccttaag atccaggggt tctctgcggt gcaacccata
     3901 gcctgctcct ctgggacagt tgacagggag ggctctggag tgcctggctg agcctctggc
     3961 cctgctccat gctgctggcc tcacacacag gctcccttgc ttctgttcct tcttggcctc
     4021 ttcccaagtg tccccatggc attcctcagg gtatggagca tcggcaggaa gggtcatgag
     4081 cccagagttg ctttattaac aaagcagaca cacagacaca cacaacctca gaactgtagc
     4141 aagtgctatg tttatacttt gattctcatt gggattgccc tgcagacctt tgtattttgt
     4201 tcaccgcacg gggtcattat aggcacttgg gagccatgct gggccttatt ttaaagccag
     4261 tctctctatt tcctattaaa gtcagtagga tttcaagaga aaatggaaaa agactgcagg
     4321 atcatgattg tactctcttc aggagctgga aagagaatga agcagtgagt ttccagctct
     4381 ctgtaaggtg atggagagaa gtggccttgg agctgtggct cccagtgatg gtcacagaac
     4441 tgcgtatggg ccatccaagc ccctatgcca cgatgctcgg ggacacttca ctgcctcatg
     4501 gtcacctaag tcaggttatt catgtgcttg ggcttctctc aatggcatct gagaaaggaa
     4561 aggagtgaag tctcttccag gcacagtgga gctggccggg gcatatgccc tagagagagg
     4621 tgtcaggacc ccaaatactg acacgcaagg ttagaagttc agctctgaaa agtcaacttg
     4681 gagggaatgg aattaggagt acaggtgaca gcatggactt atccagggag cttacctttg
     4741 cctgtgttag acggtgaccc cattcctggt acctctgccc taccaaagat attcagtgtt
     4801 tctgagagcc tccggtctga gactgcccac caccccaccc caccccacct ccttagtcct
     4861 gcccagtgct cacggcgagt cccagggctg ggccctcggt tgtctgtgca aggcagggct
     4921 gacctctcct ggttcgcagg gttggcacag atggccctgg gaagacaagg cctgcgagct
     4981 caagggagag tcctgctcca tgagccctaa cctcatatgt agcttctcac atcaggctta
     5041 caggggctgc ccctggcttc tccaggttgc gacataatta gatttagcct cagatggcgg
     5101 catacaagta agaggaagtc taatttccta aggccgagtc acaactatct gtgactttga
     5161 ataaagctgt gaggccttca gcctctttca cttgagaagc tgccaaccag tccttgggta
     5221 agaggccgta aaatatctgg aatcccatct gttggctgcc ccctaacatt ctagtctgcc
     5281 atttcttaaa catgctcctc aacctgcttc tgaagtttag gacccaccac ttttaaggca
     5341 gggcaggcct ctaatcaccc ccaaaaccca gcctcagaag aacctgccac tggagacact
     5401 tttttgcctc tcagctctcc agggacttga tgacaggctt cttgtctggc acccaacggt
     5461 caatgtcaag aggccctgcc atttccctcc agctctgcct gagggagacg gatgtccgtg
     5521 aaatttctca gacctctggg tatgaggggc aaagatggta taaggctttg aagtccagac
     5581 atgttcttgg ggggaatgta gctttaggaa tgcactcgtg aatcagcgca aactgggctc
     5641 atgactggaa gccagctcct gcggcaggaa tctgttcatc ttgggtcaca ggtgcacgtg
     5701 tgggtgcatg ggctttattc tcctgtaatc ctccctagga tttgagggat tttttgctgt
     5761 aattgttttc tttgaaaaaa cattgtgtaa atgagccaaa cctttctccc ttccttttcg
     5821 caccatgaac ttgaccgcag gctgctttgt gctgactgcc ttcccatgcc aggatgccac
     5881 tctgggttcc cgagccagga ccatgtgcct cagataccag tgacctgagc cttccagtat
     5941 aaaccattat ctggtggctg gagagagatt agggaaacaa aaagttacta ggtatgggac
     6001 agaacattta gacttcagaa aaagtatgcc aagagagaac agatttgccc aggatgtatg
     6061 tttttcctct ttgaggagtc ggggcatgat atgtggcacc attatctagt aagtgctggt
     6121 tatttgattt ctactaaatt ctttactttg aatgtcattc atattgaagc tccatttccc
     6181 agagaatatc ctgacaggct gctttgaaga gggtaggtcc tgtccctgtc acttggctgc
     6241 tggttgaacg tgctcctccc ggctgatgga ggggtgggtt taaggttaac tctaagaact
     6301 aagatggtca atgaggtggt gtttgttctt ggtggggggg cattgactcc agcaatgggc
     6361 gctgccatcc catatactta caaagggctc ctccactgga catgacaaga tagccaaagg
     6421 acggaaacag agacgaccat ttggttgaga aaccaaattg tctagtgtac aattaatgca
     6481 actcattgca ttcatgaatg caactcattg cattaatgca atgctacatt atgctaataa
     6541 ggttacaaca ttaatgctac aggatagccc aagtatttaa aaagctgagc ccatttagca
     6601 gccttccagc aaacttttgg aaatgcattt cttacttgat ttcttcttgt tatccaatcc
     6661 ctggggactg ttttacccac aacctcttcg atccagtgtg ctgctgttgg ccaaacatca
     6721 gcccctttcc tggaatcctc ctctttcaaa agtggggagg gctgggcagg ggtaaaaatg
     6781 tactatacca ccccatccca ttcagcaagc ttcctctcca aatccttaaa tggaaggtag
     6841 aagtattatg ccaactgtca agctctttgt ccaggccctt gtggggacta aatgaactct
     6901 ttaggaatac taggtatagg aagactaggt ataggaagat tctcatttcc ccttgttgca
     6961 ctgaccacta tgtctcccat gcatactctg ggaaatttta ggagccctgg tggagataca
     7021 cgttgctgat gtgcatttga ttaataggtt ttactatgtc ttgcaataaa gacgtttagc
     7081 cttaagaccc ttgaatggaa ctccagctgt gatagagctg ccaatgcccc ttcctctctc
     7141 ctcccttatc acctagtgtt gcttaaagag gaggccattg agggcacact tgatgcccca
     7201 gacagcctcc ctctgttgct aaatcattgt tattgctcta tatactgcct tctcactcgc
     7261 ttcaattaaa aattaccttc accagctcct gtgccctcca cctgggggag acttcatgat
     7321 cctctcagca ctgactgcaa acatcagaga aaaaaacatt ttctcaccaa aggtgttcat
     7381 gttgagaagt tttaatttct accccctaca gctcaaaaga atcaatgtga atttatctgc
     7441 agcttaaatt caagtgaaac ttcattctca tgcaagcata tcagacttat tctggaacct
     7501 ctagaactgg acttgaattc cctgcaggtg ccagactggt gggtgccctc cctgcctgcc
     7561 attaaacttt tcttacagcc actgtccctt tatctgtgac ttctgagtca tccgacggat
     7621 ccattagttg ttcaatgaga agttcacaga tcttgtatca ggatataaac tgatcttatg
     7681 ttgaaggatg caccctcccc taatgaatgt attctcttaa tattccgatg ctgtatttgt
     7741 gcatcagttg gagactgtcc acatccgaca tttcaccgac acctcaagga cacttctact
     7801 tatgagcagt tcatcattct ggggcttctc cttatattaa tactctttcc attgagtcct
     7861 gccaaatcct ttattgggtt ttctttttcc tttgcatctg tcactttgtc caaatgagca
     7921 tgaataaaca aaagtgtaaa tgagctgata ctatttttgt ggtcagctga ggatgctgcc
     7981 aagaacacca ctgtatatct gtggcttggg aatgttaaga ggaacgtgca ggcccttcca
     8041 ttgatgatat tcccttctca acatttttaa acaagcacaa atgatatttg taaaaaaaaa
     8101 aagttttatt tattatggta ataaactatt ttatacatga
//
