LOCUS       NM_172347               5503 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens potassium voltage-gated channel modifier subfamily G
            member 4 (KCNG4), mRNA.
ACCESSION   NM_172347
VERSION     NM_172347.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5503)
  AUTHORS   Lacroix,G., Bhat,S., Shafia,Z. and Blunck,R.
  TITLE     KCNG4 Genetic Variant Linked to Migraine Prevents Expression of
            KCNB1
  JOURNAL   Int J Mol Sci 25 (16), 8960 (2024)
   PUBMED   39201645
  REMARK    GeneRIF: KCNG4 Genetic Variant Linked to Migraine Prevents
            Expression of KCNB1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5503)
  AUTHORS   Lee,M.C., Nahorski,M.S., Hockley,J.R.F., Lu,V.B., Ison,G.,
            Pattison,L.A., Callejo,G., Stouffer,K., Fletcher,E., Brown,C.,
            Drissi,I., Wheeler,D., Ernfors,P., Menon,D., Reimann,F.,
            Smith,E.S.J. and Woods,C.G.
  TITLE     Human Labor Pain Is Influenced by the Voltage-Gated Potassium
            Channel KV6.4 Subunit
  JOURNAL   Cell Rep 32 (3), 107941 (2020)
   PUBMED   32697988
  REMARK    GeneRIF: Human Labor Pain Is Influenced by the Voltage-Gated
            Potassium Channel KV6.4 Subunit.
REFERENCE   3  (bases 1 to 5503)
  AUTHORS   Stas,J.I., Bocksteins,E., Labro,A.J. and Snyders,D.J.
  TITLE     Modulation of Closed-State Inactivation in Kv2.1/Kv6.4
            Heterotetramers as Mechanism for 4-AP Induced Potentiation
  JOURNAL   PLoS One 10 (10), e0141349 (2015)
   PUBMED   26505474
  REMARK    GeneRIF: KvS subunits modify the pharmacological response of Kv2
            subunits when assembled in heterotetramers and illustrate the
            potential of KvS subunits to provide unique properties to the
            heterotetramers, as is the case for 4-AP on Kv2.1/Kv6.4 channels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5503)
  AUTHORS   David,J.P., Stas,J.I., Schmitt,N. and Bocksteins,E.
  TITLE     Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and
            heterotetrameric Kv2.1/Kv6.4 channels
  JOURNAL   Sci Rep 5, 12813 (2015)
   PUBMED   26242757
  REMARK    GeneRIF: KCNE5 subunits may affect Kv2.1 homotetramers and
            Kv2.1/Kv6.4 heterotetramers in vivo, resulting in more
            tissue-specific fine-tuning mechanisms.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5503)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   6  (bases 1 to 5503)
  AUTHORS   Bocksteins,E., Labro,A.J., Mayeur,E., Bruyns,T., Timmermans,J.P.,
            Adriaensen,D. and Snyders,D.J.
  TITLE     Conserved negative charges in the N-terminal tetramerization domain
            mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels
  JOURNAL   J Biol Chem 284 (46), 31625-31634 (2009)
   PUBMED   19717558
REFERENCE   7  (bases 1 to 5503)
  AUTHORS   Mederos Y Schnitzler,M., Rinne,S., Skrobek,L., Renigunta,V.,
            Schlichthorl,G., Derst,C., Gudermann,T., Daut,J. and
            Preisig-Muller,R.
  TITLE     Mutation of histidine 105 in the T1 domain of the potassium channel
            Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4
  JOURNAL   J Biol Chem 284 (7), 4695-4704 (2009)
   PUBMED   19074135
  REMARK    GeneRIF: Mutation of histidine 105 in the T1 domain of the
            potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and
            Kv6.4.
REFERENCE   8  (bases 1 to 5503)
  AUTHORS   Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D.,
            Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W.
            and Wang,X.
  TITLE     International Union of Pharmacology. LIII. Nomenclature and
            molecular relationships of voltage-gated potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 473-508 (2005)
   PUBMED   16382104
  REMARK    Review article
REFERENCE   9  (bases 1 to 5503)
  AUTHORS   Ottschytsch,N., Raes,A.L., Timmermans,J.P. and Snyders,D.J.
  TITLE     Domain analysis of Kv6.3, an electrically silent channel
  JOURNAL   J Physiol 568 (Pt 3), 737-747 (2005)
   PUBMED   16096342
  REMARK    GeneRIF: This study suggests that the silent behaviour of Kv6.3 is
            largely caused by the C-terminal part of its sixth transmembrane
            domain that causes ER retention of the subunit.
REFERENCE   10 (bases 1 to 5503)
  AUTHORS   Ottschytsch,N., Raes,A., Van Hoorick,D. and Snyders,D.J.
  TITLE     Obligatory heterotetramerization of three previously
            uncharacterized Kv channel alpha-subunits identified in the human
            genome
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7986-7991 (2002)
   PUBMED   12060745
  REMARK    GeneRIF: Obligatory heterotetramerization of three previously
            uncharacterized Kv channel subunits identified in human genome
            (Kv6.3)(Kv10.1) (Kv11.1)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009123.7.
            
            On Sep 24, 2020 this sequence version replaced NM_172347.2.
            
            Summary: Voltage-gated potassium (Kv) channels represent the most
            complex class of voltage-gated ion channels from both functional
            and structural standpoints. Their diverse functions include
            regulating neurotransmitter release, heart rate, insulin secretion,
            neuronal excitability, epithelial electrolyte transport, smooth
            muscle contraction, and cell volume. This gene encodes a member of
            the potassium channel, voltage-gated, subfamily G. This member
            functions as a modulatory subunit. The gene has strong expression
            in brain. Multiple alternatively spliced variants have been found
            in normal and cancerous tissues. [provided by RefSeq, Jul 2008].
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC109203.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308251.6/ ENSP00000312129.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               AC009123.7         99569-99911         c
            344-1139            AC009123.7         96629-97424         c
            1140-5503           AC009123.7         78556-82919         c
FEATURES             Location/Qualifiers
     source          1..5503
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.1"
     gene            1..5503
                     /gene="KCNG4"
                     /gene_synonym="KV6.3; KV6.4"
                     /note="potassium voltage-gated channel modifier subfamily
                     G member 4"
                     /db_xref="GeneID:93107"
                     /db_xref="HGNC:HGNC:19697"
                     /db_xref="MIM:607603"
     exon            1..343
                     /gene="KCNG4"
                     /gene_synonym="KV6.3; KV6.4"
                     /inference="alignment:Splign:2.1.0"
     exon            344..1139
                     /gene="KCNG4"
                     /gene_synonym="KV6.3; KV6.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..1943
                     /gene="KCNG4"
                     /gene_synonym="KV6.3; KV6.4"
                     /note="voltage-gated potassium channel Kv6.3; potassium
                     channel, voltage gated modifier subfamily G, member 4;
                     voltage-gated potassium channel subunit Kv6.4;
                     voltage-gated potassium channel subunit Kv6.3"
                     /codon_start=1
                     /product="voltage-gated potassium channel regulatory
                     subunit KCNG4"
                     /protein_id="NP_758857.1"
                     /db_xref="CCDS:CCDS10945.1"
                     /db_xref="GeneID:93107"
                     /db_xref="HGNC:HGNC:19697"
                     /db_xref="MIM:607603"
                     /translation="MPMPSRDGGLHPRHHHYGSHSPWSQLLSSPMETPSIKGLYYRRV
                     RKVGALDASPVDLKKEILINVGGRRYLLPWSTLDRFPLSRLSKLRLCRSYEEIVQLCD
                     DYDEDSQEFFFDRSPSAFGVIVSFLAAGKLVLLQEMCALSFQEELAYWGIEEAHLERC
                     CLRKLLRKLEELEELAKLHREDVLRQQRETRRPASHSSRWGLCMNRLREMVENPQSGL
                     PGKVFACLSILFVATTAVSLCVSTMPDLRAEEDQGECSRKCYYIFIVETICVAWFSLE
                     FCLRFVQAQDKCQFFQGPLNIIDILAISPYYVSLAVSEEPPEDGERPSGSSYLEKVGL
                     VLRVLRALRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFSPLVYVA
                     EKESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPA
                     TSIFHTFSHSYLELKKEQEQLQARLRHLQNTGPASECELLDPHVASEHELMNDVNDLI
                     LEGPALPIMHM"
     exon            1140..5503
                     /gene="KCNG4"
                     /gene_synonym="KV6.3; KV6.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2555..2560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNG4"
                     /gene_synonym="KV6.3; KV6.4"
                     /note="hexamer: AGTAAA"
     polyA_site      2577
                     /gene="KCNG4"
                     /gene_synonym="KV6.3; KV6.4"
     regulatory      5464..5469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNG4"
                     /gene_synonym="KV6.3; KV6.4"
                     /note="hexamer: ATTAAA"
     polyA_site      5503
                     /gene="KCNG4"
                     /gene_synonym="KV6.3; KV6.4"
                     /note="major polyA site"
ORIGIN      
        1 gacagctgcc ctggctccct cccagcaaga acccccagac cctcatctct cataaggaaa
       61 gggacttctg ggtcctttaa aaaaaaaaaa aaatcccacc tcaatccccc agggctctcc
      121 tgcagctgct ggagagagag atgcagaatg aatgaacttc tggtttctgg aggaggcacg
      181 ggaagaaaga ttggaaactg actctgctag aaactgctgt tttggggatt tttttcttcc
      241 ccttcatctc caccagaaac ctgtcccttc cctgggcacc aagagatggg ctccccttgc
      301 ctggcagaga aacagctgga aactggctcc ctgagacaag aagactggta aacccagcgc
      361 ttcctacctg gtggtcttca gcaatgccca tgccttccag agacgggggc ctgcatccca
      421 gacaccacca ctatggttcc cacagccctt ggagtcagct cctgtccagc cccatggaga
      481 cgccgtccat caagggcctt tactaccgga gggtgcggaa ggtgggtgcc ctggacgcct
      541 ccccagtgga cctgaagaag gagatcctga tcaacgtggg gggcaggagg tatctcctcc
      601 cctggagcac actggaccgg ttcccgctga gccgcctgag caaactcagg ctctgtcgga
      661 gctacgagga gatcgtgcag ctctgcgatg attacgacga ggacagccag gagttcttct
      721 tcgacaggag ccccagcgcc ttcggggtga tcgtgagctt cctggcggcc gggaagctgg
      781 tgcttctgca ggagatgtgc gcgctgtcct tccaggagga gctggcctac tggggcatcg
      841 aggaggccca cctggagagg tgctgcctgc ggaagctgct gaggaagctg gaggagctgg
      901 aggagctggc caagctgcac agggaggacg tactgaggca gcagagggag acccgccgcc
      961 ccgcctcgca ctcctcgcgc tggggcctgt gcatgaaccg gctgcgcgag atggtggaaa
     1021 acccgcagtc cgggctgccc gggaaggtct tcgcttgcct ctccatcctc ttcgtggcca
     1081 ccacagccgt cagcctgtgt gtcagcacca tgcccgacct cagggcagag gaggaccagg
     1141 gcgaatgctc tcggaagtgc tactatattt tcatcgtgga gaccatctgc gtggcctggt
     1201 tctccctgga gttctgcctg cggtttgtcc aggcccaaga caagtgtcag ttcttccagg
     1261 ggcccctgaa catcatcgac atcctggcca tctccccata ctacgtgtcg ctggcggtgt
     1321 ctgaggagcc cccggaggac ggcgagaggc cgagcgggag ctcctacctg gagaaggtgg
     1381 ggctggtcct gcgtgtgctg cgagcgctgc gcatcctcta cgtgatgcgc ctggctcgcc
     1441 actcgctggg gctgcagacg ctggggctca ccgtgcgccg ttgcacacgt gagttcggcc
     1501 tgctccttct cttcctggcc gtggccatca ccctcttctc ccctttggtc tacgtggccg
     1561 agaaggagtc cgggcgggtg ctggagttca ccagcatccc cgcctcctat tggtgggcca
     1621 tcatctccat gacaacggtg ggctacgggg acatggtgcc ccgcagtgtg ccaggccaga
     1681 tggtggccct cagcagcatc ctgagcggga tcctcatcat ggccttcccg gccacgtcta
     1741 tcttccacac cttctcccac tcctacctgg agctcaagaa ggagcaggag cagcttcagg
     1801 cccgcctccg ccacctccaa aacaccggtc cagccagtga atgtgaactc ctggaccccc
     1861 atgtggccag tgaacatgag ctcatgaacg atgtcaatga cctaatcctg gagggcccag
     1921 ccttgcctat catgcacatg taactcagca ccccccatga ctacatggta acctcaaccc
     1981 atcaccctgc ctgaaacaca ctcaagggta ccccgcatag accacctggt ggtgtttcta
     2041 gagcccaggg aagactttca aagctggagg ggcataaggc cacagaggct gtgtgtctgt
     2101 gatccttgtc cctcggggcc ccgatgtccc aggctgactg tgtccagcct gcttgccttt
     2161 tcctctctct gcccatctac tgagcatgtc caatcttgct ggagtagctc agtctccttt
     2221 cattctcttt tccttcccag cagaggcttt aacatcccag gctgggttct ggatgcccat
     2281 agaactggta accattggta tttgcatact gagcctatgt aatttcatga tttccctaag
     2341 accctccttc ctgggccatg ccaccactgg aaatcaaagg tccagtcact gcaaacccct
     2401 ctaatcagat ctccccaccc aacctttcca cgggttccag agggatcaat atgttctcct
     2461 tctgctcacc accaccagtg atatttccct aatgctgcta cctcccgcca gctctgaaca
     2521 cttgtagcta agaaggcaga atcagccttt ttgcagtaaa tctcatgttg aggctgatgc
     2581 ccccaagcct gccatccttt acctggagct caagaaggag caggcatccc caggcatgcc
     2641 tgggatctgt gacctgggac ctgggacctg ggacctgggc agaaactcca ctttccagca
     2701 cagccaggcc ctccctggcc gcctggactc ttggtgtggt gttctccagt tatccagtcc
     2761 ttagccttga cagagacaaa ctctttcagg gtccatgttg tcccttgaga ggatcgttcc
     2821 tgctgctggt tgctcccaca ctgcaggggc cttagctttt catccacagc tgagccccca
     2881 tggactcaat gtagctttgg cacagaaaca aggggaattg taggtgctgt cccttgctgg
     2941 cttcccagac tagtcatctc catgctggag gatagacatt cttagctcac atttcaatgt
     3001 attcatttct gcattcatct gtgaacagag tctgtccttt gcatccaggg gaggaggcag
     3061 atggaggtct gagtcactgg agataaacca gcatattctg agagcaggca ggaaggagca
     3121 atgacttcca agcagtgggc tcccaaaggc ctcacagaga catgggcagg gctggagagt
     3181 agaggtgtat tttaggagat gaagctgaac agctgggttg ggttgagaag gcgtgggcct
     3241 tgaatgcttt atggagggca gagtgatgtg cacaggctgt gggttaggga gatgatgagg
     3301 ctggattggg catgagaagc ccagtttggg atgaggagcc attgagccat tcaggcaaga
     3361 cagccctccc tccttcacgg gcttaatcct gcaagattct gtcaaatcct ggcttctccc
     3421 agcaggacac accttggaga catcctgatg gcacttcccc agagtggcat ggcccacata
     3481 ggagtttgct gttggctcta ggactcttga agaaagtgca caagatcaaa acaggtgaca
     3541 gtgaagtggt ttcggccctg ccaatctgat atcgtgtacg tatgagagtg gtcagcattt
     3601 taccactggt aacaagttcc ttgctgttca ttcattctgc tagttttttg cgatttcccg
     3661 ctgtgtgcca ggcatagtcc tccactgatg gcaatgccag acagcagcgt ggcagagggc
     3721 tctggcccag gaagcaccct gcaccagcac ctagcgtcca gggagccttg gcctcctggc
     3781 gagcctgcct ttccttggag tcctccaggt gtccccccaa ctatacaggc acatgtcccc
     3841 attcttttag accccaatct ttcccaagct gacatgtcac caggtgacat agtggttcag
     3901 tggccatgac acaaggaaag ccccttcacc ctataaaatc cccagcctgg atggccactc
     3961 cactccacaa agtgacaggc agattcccat aagcgttgcg tagaaattcc atgtcacagg
     4021 caccttggac agtagccata gaagtgtttc tgttccagag taacatttta tttattactt
     4081 atttatttat ttatttattg acagagtctc tctctgtccg ccaggctgga gtgcagtggc
     4141 ttgatcccag ctcactgcaa cctccgcctc ctgggttcaa gcaattctcc tgcctcagcc
     4201 tcccaaatag cggggattac aggcacccac cacctgtaat cccagctatt tggagatcaa
     4261 atgctcagct aatttgatat ttttagtaga gacaaggttt caccatgtgg acaggctggt
     4321 cttgaactcc tgatgtcagg tgatccgcct gcctcggcct cccaaagtgc tggaattaca
     4381 ggcacgagcc accgcacccg gcccagacta acattttttt tttttttttt tttgagacag
     4441 agtctccctc tgtcacccag gctggagtgc agtggctcaa tctcggctca ctgcaagctc
     4501 cgcctcccag gttcacgcca ttctcctgcc tcagcctcct gagtagctgt gactacaggt
     4561 gccaccacca cgcctggata attttttgta tttttaggag agacggggtt tcaccatgtt
     4621 agccaggatg gtctccatct cctgacctcg tgatccgccc gcctcggcct cccaaagtgc
     4681 tgggattaca ggcgtgagcc accgtgccca agcctgacta acattttaat aactacgctt
     4741 aggcaaaata gtaaaaggac aaagtctccc acttactctc tttctgggga ctgactggct
     4801 tgggcgctgg ctgaaaccca gtgtcttcac tccctgtgtg acctcgggca ggccccttcc
     4861 ccctcagtta gctgcaggca ggtgttggac tagatctgtg gttttctgac ctgggttcca
     4921 caaagcaagc tcagggactg tcctgcggat gaagaagacc agcagcaaag caggcagagc
     4981 tctgcctcct ggggcaaaac atttgcaatt aatgacactg aaaagaatgt gcaaatcccc
     5041 agtctcctct ccttcccgtc agtgtccagc ccagcccttt gaactgagtg gtaagctcat
     5101 tctggaacca gagacaaagc ctaaacagcc actggaaggt ctgggaccca catcagcccc
     5161 cacatctgcc ctgccttctc atcgaagaca tattttgtgc gcatgcctgg tgaaaacttc
     5221 ttaatgacag ctctgcccat ccctgtaact ggcttctacc caggcatatc ccttctcctc
     5281 tgcttcacct accagacctc ttcaccaaag tgtgccagca ctaaaagaaa catttaaaat
     5341 caaaattagg tgaagcacca ccaccattat gagattctat agtgtcttaa tgttcaccca
     5401 gttgagattc tctgctaaat tagacatgga aaattggaat tgattgctcg catgtggggc
     5461 ttaattaaac gctctatttt ttctccctgg taatgtccca gga
//
