LOCUS       NM_133329               3709 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens potassium voltage-gated channel modifier subfamily G
            member 3 (KCNG3), transcript variant 1, mRNA.
ACCESSION   NM_133329
VERSION     NM_133329.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3709)
  AUTHORS   Peretti,M., Badaoui,M., Girault,A., Van Gulick,L., Mabille,M.P.,
            Tebbakha,R., Sevestre,H., Morjani,H. and Ouadid-Ahidouch,H.
  TITLE     Original association of ion transporters mediates the ECM-induced
            breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership
  JOURNAL   Sci Rep 9 (1), 1175 (2019)
   PUBMED   30718673
  REMARK    GeneRIF: Original association of ion transporters mediates the
            ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2
            partnership.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3709)
  AUTHORS   Martinez,R., Stuhmer,W., Martin,S., Schell,J., Reichmann,A.,
            Rohde,V. and Pardo,L.
  TITLE     Analysis of the expression of Kv10.1 potassium channel in patients
            with brain metastases and glioblastoma multiforme: impact on
            survival
  JOURNAL   BMC Cancer 15, 839 (2015)
   PUBMED   26530050
  REMARK    GeneRIF: the correlation between dismal prognosis and Kv10.1
            expression to patients with brain metastases or glioblastoma
            multiforme and, moreover, they strongly suggest a role of tricyclic
            antidepressants for personalized therapy of brain malignancies.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3709)
  AUTHORS   Pardo,L.A., Gomez-Varela,D., Major,F., Sansuk,K., Leurs,R.,
            Downie,B.R., Tietze,L.F. and Stuhmer,W.
  TITLE     Approaches targeting K(V)10.1 open a novel window for cancer
            diagnosis and therapy
  JOURNAL   Curr Med Chem 19 (5), 675-682 (2012)
   PUBMED   22204340
  REMARK    GeneRIF: [review] an overview of the current status of data linking
            K(V)10.1 to cancer, and techniques that could exploit K(V)10.1's
            properties for the management of cancer
            Review article
REFERENCE   4  (bases 1 to 3709)
  AUTHORS   Mederos Y Schnitzler,M., Rinne,S., Skrobek,L., Renigunta,V.,
            Schlichthorl,G., Derst,C., Gudermann,T., Daut,J. and
            Preisig-Muller,R.
  TITLE     Mutation of histidine 105 in the T1 domain of the potassium channel
            Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4
  JOURNAL   J Biol Chem 284 (7), 4695-4704 (2009)
   PUBMED   19074135
REFERENCE   5  (bases 1 to 3709)
  AUTHORS   Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D.,
            Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W.
            and Wang,X.
  TITLE     International Union of Pharmacology. LIII. Nomenclature and
            molecular relationships of voltage-gated potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 473-508 (2005)
   PUBMED   16382104
  REMARK    Review article
REFERENCE   6  (bases 1 to 3709)
  AUTHORS   Vega-Saenz de Miera,E.C.
  TITLE     Modification of Kv2.1 K+ currents by the silent Kv10 subunits
  JOURNAL   Brain Res Mol Brain Res 123 (1-2), 91-103 (2004)
   PUBMED   15046870
REFERENCE   7  (bases 1 to 3709)
  AUTHORS   Ottschytsch,N., Raes,A., Van Hoorick,D. and Snyders,D.J.
  TITLE     Obligatory heterotetramerization of three previously
            uncharacterized Kv channel alpha-subunits identified in the human
            genome
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7986-7991 (2002)
   PUBMED   12060745
  REMARK    GeneRIF: Obligatory heterotetramerization of three previously
            uncharacterized Kv channel subunits identified in human genome
            (Kv6.3)(Kv10.1) (Kv11.1)
REFERENCE   8  (bases 1 to 3709)
  AUTHORS   Sano,Y., Mochizuki,S., Miyake,A., Kitada,C., Inamura,K., Yokoi,H.,
            Nozawa,K., Matsushime,H. and Furuichi,K.
  TITLE     Molecular cloning and characterization of Kv6.3, a novel modulatory
            subunit for voltage-gated K(+) channel Kv2.1
  JOURNAL   FEBS Lett 512 (1-3), 230-234 (2002)
   PUBMED   11852086
  REMARK    GeneRIF: These results indicate that Kv6.3 is a novel member of the
            voltage-gated K(+) channel which functions as a modulatory subunit
            of the Kv2.1 channel.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF348982.1, BC071558.1 and
            AC025750.10.
            
            On Nov 23, 2018 this sequence version replaced NM_133329.5.
            
            Summary: Voltage-gated potassium (Kv) channels represent the most
            complex class of voltage-gated ion channels from both functional
            and structural standpoints. Their diverse functions include
            regulating neurotransmitter release, heart rate, insulin secretion,
            neuronal excitability, epithelial electrolyte transport, smooth
            muscle contraction, and cell volume. This gene encodes a member of
            the potassium channel, voltage-gated, subfamily G. This member is a
            gamma subunit functioning as a modulatory molecule. Alternative
            splicing results in two transcript variants encoding distinct
            isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), also known as Kv10.1b,
            encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071558.1, AF454548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306078.2/ ENSP00000304127.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AF348982.1         116-120
            6-243               BC071558.1         1-238
            244-244             AC025750.10        57639-57639         c
            245-2143            BC071558.1         240-2138
            2144-2144           AC025750.10        7482-7482           c
            2145-3245           BC071558.1         2140-3240
            3246-3246           AC025750.10        6380-6380           c
            3247-3709           BC071558.1         3242-3704
FEATURES             Location/Qualifiers
     source          1..3709
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21"
     gene            1..3709
                     /gene="KCNG3"
                     /gene_synonym="KV10.1; KV6.3"
                     /note="potassium voltage-gated channel modifier subfamily
                     G member 3"
                     /db_xref="GeneID:170850"
                     /db_xref="HGNC:HGNC:18306"
                     /db_xref="MIM:606767"
     exon            1..1146
                     /gene="KCNG3"
                     /gene_synonym="KV10.1; KV6.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             482..1792
                     /gene="KCNG3"
                     /gene_synonym="KV10.1; KV6.3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     voltage-gated potassium channel 6.3; potassium
                     voltage-gated channel, subfamily G, member 3;
                     voltage-gated potassium channel Kv10.1; voltage-gated
                     potassium channel subunit Kv6.4; voltage-gated potassium
                     channel subunit Kv6.3; voltage-gated potassium channel
                     subunit Kv10.1; potassium channel, voltage gated modifier
                     subfamily G, member 3; voltage-gated potassium channel
                     regulatory subunit KCNG3"
                     /codon_start=1
                     /product="voltage-gated potassium channel regulatory
                     subunit KCNG3 isoform 1"
                     /protein_id="NP_579875.1"
                     /db_xref="CCDS:CCDS1809.1"
                     /db_xref="GeneID:170850"
                     /db_xref="HGNC:HGNC:18306"
                     /db_xref="MIM:606767"
                     /translation="MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSE
                     RDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWG
                     LEGAHLEYCCQRRLDDRMSDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRT
                     FEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGR
                     EPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTG
                     ENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAM
                     AIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGV
                     CVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSRSLSTEFLN"
     exon            1147..3709
                     /gene="KCNG3"
                     /gene_synonym="KV10.1; KV6.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3687..3692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNG3"
                     /gene_synonym="KV10.1; KV6.3"
                     /note="hexamer: AATAAA"
     polyA_site      3709
                     /gene="KCNG3"
                     /gene_synonym="KV10.1; KV6.3"
                     /note="major polyA site"
ORIGIN      
        1 actttgcctc tcgcctctgg acggcggcgg ggcggccgcc ggattcgcgg ccgcagggag
       61 cgccggagac ggggagctat tccgccccgg cggctccatt cggcgcccgc agccctcagg
      121 gggtcggccc cgcggcttgg gagagggcac cgcggcctcg gtgtgcgcag ccctcgggcg
      181 cgagggtcgg cggcgcggac acagccgcgt tcccagccgg tggggctcag cgctggcgcc
      241 ggcgaggact ccccggccac ccgcaggtac cgccgggcgg agggcgcgct actagcagcg
      301 ccggagatac tcgagcccag ggacccccgg gccagcggag ggcaggagcg gagccccgag
      361 ggagcgcggg ccccgacggc gcgctccccc gtcagccacg ggcaggcagg ccccgcgtgg
      421 cggcttgggg tggggggctg cagcggggcc ctcgggccga aagtcccccg ggcggccagc
      481 catgaccttc gggcgcagcg gggcggcctc ggtggtgctg aacgtgggcg gcgcccggta
      541 ttcgctgtcc cgggagctgc tgaaggactt cccgctgcgc cgcgtgagcc ggctgcacgg
      601 ctgccgctcc gagcgcgacg tgctcgaggt gtgcgacgac tacgaccgcg agcgcaacga
      661 gtacttcttc gaccggcact cggaggcctt cggcttcatc ctgctctacg tgcgcggcca
      721 cggcaagctg cgcttcgcgc cgcggatgtg cgagctctcc ttctacaacg agatgatcta
      781 ctggggcctg gagggcgcgc acctcgagta ctgctgccag cgccgcctcg acgaccgcat
      841 gtccgacacc tacaccttct actcggccga cgagccgggc gtgctgggcc gcgacgaggc
      901 gcgccccggc ggggccgagg cggctccctc caggcgctgg ctggagcgca tgcggcggac
      961 cttcgaggag cccacgtcgt cgctggccgc gcagatcctg gctagcgtgt cggtggtgtt
     1021 cgtgatcgtg tccatggtgg tgctgtgcgc cagcacgttg cccgactggc gcaacgcagc
     1081 cgccgacaac cgcagcctgg atgaccggag caggtactcc gccggccctg ggagggagcc
     1141 ctccgggata attgaagcta tctgcatagg ttggttcact gccgagtgca tcgtgaggtt
     1201 cattgtctcc aaaaacaagt gtgagtttgt caagagaccc ctgaacatca ttgatttact
     1261 ggcaatcacg ccgtattaca tctctgtgtt gatgacagtg tttacaggcg agaactctca
     1321 actccagagg gctggagtca ccttgagggt acttagaatg atgaggattt tttgggtgat
     1381 taagcttgcc cgtcacttca ttggtcttca gacactcggt ttgactctca aacgttgcta
     1441 ccgagagatg gttatgttac ttgtcttcat ttgtgttgcc atggcaatct ttagtgcact
     1501 ttctcagctt cttgaacatg ggctggacct ggaaacatcc aacaaggact ttaccagcat
     1561 tcctgctgcc tgctggtggg tgattatctc tatgactaca gttggctatg gagatatgta
     1621 tcctatcaca gtgcctggaa gaattcttgg aggagtttgt gttgtcagtg gaattgttct
     1681 attggcatta cctatcactt ttatctacca tagctttgtg cagtgttatc atgagctcaa
     1741 gtttagatct gctaggtata gtaggagcct ctccactgaa ttcctgaatt aatgcattgc
     1801 aaatcaattc ttgcatacac ttcatagaaa gactttgatg ctgcttcata tttatgtgtt
     1861 tcttgctggg tgagcactgc agtggcattg tcatcatctt ggtagggtaa aaattatcct
     1921 tcccagccga agggataaaa cagtttactt gttatggagt aaatagaatt gagactgcaa
     1981 aggaagaata atgactccta gagtaaactt taggacccgg ttttatttag acttgttttc
     2041 ccgtttcctt gaatgattac acatttttaa aaaatacatt atttgaacat tttaaaacag
     2101 aaaggtacta ttttccaaat gtttttccat cttatgaatt cagaagaagc ttggaactta
     2161 tagtgttttt tgtttgagag taacattttc atttctaaat gttttataat ttctcatatc
     2221 aatgtcagaa gtatcctgga aacatatgtc acatgcggga actgtttaac aaatacttta
     2281 aaaatttggc caaaatttaa actgtataat ggagctagat acaagcaaga atagtatttg
     2341 aaagactttt ccagcatact tctcaattct ttgctttatt tttgtgccaa ttattcacct
     2401 tatcgtgccg cttcatggaa gcttgagtat gttctccctt ttccattttg gatttatctc
     2461 tttactgtaa tgactcaaaa ggtatttaag aattgacgag agcttgtgtt gtttagcatc
     2521 ttactggata atatttgaat tcattgctgt tcctaggtga taactgtcct aatatttaga
     2581 tgtccaaaca agaatacttc caacataaaa attataatag gaataatttg agatgactca
     2641 atattacaac ctcttcttct cttaacctcc tcccccaaac actagaggtt taataagact
     2701 tatcagatga aaggatattt atatagcctt ttagtagcaa agtcatactt acgtgttgtc
     2761 actggattat cataaaaggg agaaattaaa tattactgta ctcttagttg ctgtgtagct
     2821 aagtcaattt taagccagta aaagcgatgg atacataatg atttgatctg atctttaact
     2881 attgtgaatc acagctacac caaaactctt cttgtaagaa tactgactaa tatgccatgt
     2941 taatctggct agattattag gactagataa tgtaaaagtg atgattgttt agtaactaaa
     3001 ttttagcaac agaaattaga attttgcttt ttcaaccagt taccataaag aagttagtgt
     3061 atatataaac acaaataatt agtgacagat tcataaaaaa ttgaatgttg tacacagtaa
     3121 ttttgtcaga ggtagagaag acagggattg ggaagtggtg ggtgatggag gacctggata
     3181 tatttatcaa ataaagggtt accagaagtg ttcattaaag gaattttagc catcatctag
     3241 ttcaaacctc aactattaca ggtagaaaat cagggcagga gagaatataa ttgtgaagga
     3301 gtcagggcta acacctggat ctccagaaac ctagcccagc aggttaatct tcacacatct
     3361 ctgggttctg agaaaagcct ggaaaaatca cacttctttg tcattgtcat gctgaggtaa
     3421 taatagcaaa actgttttct ttcccttaat ttcctttcct aagcttatgt aatagtttgg
     3481 ccattaaata tcttgcccta ttttccctat tactgctagt atgctacttc ttacataccc
     3541 aaaagaaatt cagttattta ttgtatattt attgtattct aatataattg aaataaatgg
     3601 catggattta ttttttctta actatttgga ttaaagcttt gtggttcatg caaacaatgt
     3661 gcagatgata gcacctccat attactaata aaaatatgat aaccatcaa
//
