LOCUS       NM_002237               2189 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens potassium voltage-gated channel modifier subfamily G
            member 1 (KCNG1), mRNA.
ACCESSION   NM_002237
VERSION     NM_002237.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2189)
  AUTHORS   Kuhnisch,J., Thiering,E., Heitmuller,D., Tiesler,C.M., Grallert,H.,
            Heinrich-Weltzien,R., Hickel,R. and Heinrich,J.
  CONSRTM   GINI-10 Plus Study Group; LISA-10Plus Study Group
  TITLE     Genome-wide association study (GWAS) for molar-incisor
            hypomineralization (MIH)
  JOURNAL   Clin Oral Investig 18 (2), 677-682 (2014)
   PUBMED   23918034
REFERENCE   2  (bases 1 to 2189)
  AUTHORS   Mederos Y Schnitzler,M., Rinne,S., Skrobek,L., Renigunta,V.,
            Schlichthorl,G., Derst,C., Gudermann,T., Daut,J. and
            Preisig-Muller,R.
  TITLE     Mutation of histidine 105 in the T1 domain of the potassium channel
            Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4
  JOURNAL   J Biol Chem 284 (7), 4695-4704 (2009)
   PUBMED   19074135
REFERENCE   3  (bases 1 to 2189)
  AUTHORS   Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D.,
            Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W.
            and Wang,X.
  TITLE     International Union of Pharmacology. LIII. Nomenclature and
            molecular relationships of voltage-gated potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 473-508 (2005)
   PUBMED   16382104
  REMARK    Review article
REFERENCE   4  (bases 1 to 2189)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   5  (bases 1 to 2189)
  AUTHORS   Su,K., Kyaw,H., Fan,P., Zeng,Z., Shell,B.K., Carter,K.C. and Li,Y.
  TITLE     Isolation, characterization, and mapping of two human potassium
            channels
  JOURNAL   Biochem Biophys Res Commun 241 (3), 675-681 (1997)
   PUBMED   9434767
REFERENCE   6  (bases 1 to 2189)
  AUTHORS   Post,M.A., Kirsch,G.E. and Brown,A.M.
  TITLE     Kv2.1 and electrically silent Kv6.1 potassium channel subunits
            combine and express a novel current
  JOURNAL   FEBS Lett 399 (1-2), 177-182 (1996)
   PUBMED   8980147
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA684016.1, CN301212.1,
            BC046629.2, AF033383.1, BG029104.1 and CN480356.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002237.3.
            
            Summary: Voltage-gated potassium (Kv) channels represent the most
            complex class of voltage-gated ion channels from both functional
            and structural standpoints. Their diverse functions include
            regulating neurotransmitter release, heart rate, insulin secretion,
            neuronal excitability, epithelial electrolyte transport, smooth
            muscle contraction, and cell volume. This gene encodes a member of
            the potassium channel, voltage-gated, subfamily G. This gene is
            abundantly expressed in skeletal muscle. Multiple alternatively
            spliced transcript variants have been found in normal and cancerous
            tissues. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046629.2, SRR3476690.990094.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371571.5/ ENSP00000360626.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-515               DA684016.1         1-515
            516-811             CN301212.1         268-563
            812-1232            BC046629.2         812-1232
            1233-1540           AF033383.1         969-1276
            1541-1749           BG029104.1         441-649
            1750-2189           CN480356.1         18-457              c
FEATURES             Location/Qualifiers
     source          1..2189
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.13"
     gene            1..2189
                     /gene="KCNG1"
                     /gene_synonym="K13; KCNG; kH2; KV6.1"
                     /note="potassium voltage-gated channel modifier subfamily
                     G member 1"
                     /db_xref="GeneID:3755"
                     /db_xref="HGNC:HGNC:6248"
                     /db_xref="MIM:603788"
     exon            1..238
                     /gene="KCNG1"
                     /gene_synonym="K13; KCNG; kH2; KV6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            239..1038
                     /gene="KCNG1"
                     /gene_synonym="K13; KCNG; kH2; KV6.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1806
                     /gene="KCNG1"
                     /gene_synonym="K13; KCNG; kH2; KV6.1"
                     /note="potassium channel KH2; potassium channel Kv6.1;
                     potassium channel, voltage gated modifier subfamily G,
                     member 1; voltage-gated potassium channel subunit Kv6.1;
                     potassium voltage-gated channel, subfamily G, member 1"
                     /codon_start=1
                     /product="voltage-gated potassium channel regulatory
                     subunit KCNG1"
                     /protein_id="NP_002228.2"
                     /db_xref="CCDS:CCDS13436.1"
                     /db_xref="GeneID:3755"
                     /db_xref="HGNC:HGNC:6248"
                     /db_xref="MIM:603788"
                     /translation="MTLLPGDNSDYDYSALSCTSDASFHPAFLPQRQAIKGAFYRRAQ
                     RLRPQDEPRQGCQPEDRRRRIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDIL
                     NVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDH
                     LDGCCKRRYLQKIEEFAEMVEREEEDDALDSEGRDSEGPAEGEGRLGRCMRRLRDMVE
                     RPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGHCSQMCHNVFIVESVCV
                     GWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSY
                     LDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFA
                     PLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGIL
                     LMAFPVTSIFHTFSRSYLELKQEQERVMFRRAQFLIKTKSQLSVSQDSDILFGSASSD
                     TRDNN"
     exon            1039..2189
                     /gene="KCNG1"
                     /gene_synonym="K13; KCNG; kH2; KV6.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2168..2173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNG1"
                     /gene_synonym="K13; KCNG; kH2; KV6.1"
                     /note="hexamer: AATACA"
     polyA_site      2189
                     /gene="KCNG1"
                     /gene_synonym="K13; KCNG; kH2; KV6.1"
                     /note="major polyA site"
ORIGIN      
        1 gcactcggag cccggcgggg accgggaggc agagacgggg cggccgtggc tccgagggcg
       61 ggagctgagc cgggccccgg gaccgaagtt tggcggcggc tccgggaggc agagcgggct
      121 ccccgggcga cttccaggcc cctctcgcgt cctcgccccg gacccgtggg cagccggggg
      181 gaacggaagc cgcggccggg ccaactccga ggcggggacg ccgcgacggg aacttgaggc
      241 ccgagaggga tgtgaaggcc caaaatgacc ctcttaccgg gagacaattc tgactacgac
      301 tacagcgcgc tgagctgcac ctcggacgcc tccttccacc cggccttcct cccgcagcgc
      361 caggccatca agggcgcgtt ctaccgccgg gcgcagcggc tgcggccgca ggatgagccc
      421 cgccagggct gtcagcccga ggaccgccgc cgtcggatca tcatcaacgt aggcggcatc
      481 aagtactcgc tgccctggac cacgctggac gagttcccgc tgacgcgcct gggccagctc
      541 aaggcctgca ccaacttcga cgacatcctc aacgtgtgcg atgactacga cgtcacctgc
      601 aacgagttct tcttcgaccg caacccgggg gccttcggca ctatcctgac cttcctgcgc
      661 gcgggcaagc tgcggctgct gcgcgagatg tgcgcgctgt ccttccagga ggagctgctg
      721 tactggggca tcgcggagga ccacctggac ggctgctgca agcgccgcta cctgcagaag
      781 attgaggagt tcgcggagat ggtggagcgg gaggaagagg acgacgcgct ggacagcgag
      841 ggccgcgaca gcgagggccc ggccgagggc gagggccgcc tggggcgctg catgcggcga
      901 ctgcgcgaca tggtggagag gccgcactcg gggctgcctg gcaaggtgtt cgcctgcctg
      961 tcggtgctct tcgtgaccgt caccgccgtc aacctctccg tcagcacctt gcccagcctg
     1021 agggaggagg aggagcaggg ccactgttcc cagatgtgcc acaacgtctt catcgtggag
     1081 tcggtgtgcg tgggctggtt ctccctggag ttcctcctgc ggctcattca ggcgcccagc
     1141 aagttcgcct tcctgcggag cccgctgacg ctgatcgacc tggtggccat cctgccctac
     1201 tacatcacgc tgctggtgga cggcgccgcc gcaggccgtc gcaagcccgg cgcgggcaac
     1261 agctacctgg acaaggtggg gctggtgctg cgcgtgctgc gggcgctgcg catcctgtac
     1321 gtgatgcgcc tggcgcgcca ctccctgggg ctgcagacgc tggggctcac ggcccgccgc
     1381 tgcacccgcg agttcgggct cctgctgctc ttcctctgcg tggccatcgc cctcttcgcg
     1441 cccctgctct acgtcatcga gaacgagatg gccgacagcc ccgagttcac cagcatccct
     1501 gcctgctact ggtgggctgt catcaccatg acgacggtgg gctatggcga catggtcccc
     1561 aggagcaccc cgggccaggt agtggccctg agcagcatcc tgagcggcat cctgctcatg
     1621 gccttcccag tcacctccat cttccacacc ttctcccgct cctacctgga gctcaagcag
     1681 gagcaagaga gggtgatgtt ccggagggcg cagttcctca tcaaaaccaa gtcgcagctg
     1741 agcgtgtccc aggacagtga catcttgttc ggaagtgcct cctcggacac cagagacaat
     1801 aactgagcgc ggaggacacg cctgccctgc ctgccatctg tggcccgaag ccattgccat
     1861 ccactgcaga cgcctggaga gggacaggcc gcttccgagt gcagtcctgg cgcagcaccg
     1921 actcccacgc acccggggaa ggacaccctc actcccacac cccgggaaga acactagaac
     1981 atcagcagag gggccctgcc cctccgcctg cagccgtgaa aggaagctgg gtcatcagcc
     2041 cagccccgcc caccccagcc cctatgtgtg tttccctcaa taaggagatg ccttgttctt
     2101 ttcaccatgc aaataacatg cccagcaaaa acttgcttta tgggtctgcc tggagaaaaa
     2161 aaaaaaaaat acaaacagca gaaacagca
//
