LOCUS       NM_002236               2292 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens potassium voltage-gated channel modifier subfamily F
            member 1 (KCNF1), mRNA.
ACCESSION   NM_002236
VERSION     NM_002236.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2292)
  AUTHORS   Chen,C.Y., Wu,P.Y., Van Scoyk,M., Simko,S.A., Chou,C.F. and
            Winn,R.A.
  TITLE     KCNF1 promotes lung cancer by modulating ITGB4 expression
  JOURNAL   Cancer Gene Ther 30 (3), 414-423 (2023)
   PUBMED   36385523
  REMARK    GeneRIF: KCNF1 promotes lung cancer by modulating ITGB4 expression.
REFERENCE   2  (bases 1 to 2292)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2292)
  AUTHORS   Gutman,G.A., Chandy,K.G., Grissmer,S., Lazdunski,M., McKinnon,D.,
            Pardo,L.A., Robertson,G.A., Rudy,B., Sanguinetti,M.C., Stuhmer,W.
            and Wang,X.
  TITLE     International Union of Pharmacology. LIII. Nomenclature and
            molecular relationships of voltage-gated potassium channels
  JOURNAL   Pharmacol Rev 57 (4), 473-508 (2005)
   PUBMED   16382104
  REMARK    Review article
REFERENCE   4  (bases 1 to 2292)
  AUTHORS   Ottschytsch,N., Raes,A., Van Hoorick,D. and Snyders,D.J.
  TITLE     Obligatory heterotetramerization of three previously
            uncharacterized Kv channel alpha-subunits identified in the human
            genome
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7986-7991 (2002)
   PUBMED   12060745
REFERENCE   5  (bases 1 to 2292)
  AUTHORS   Su,K., Kyaw,H., Fan,P., Zeng,Z., Shell,B.K., Carter,K.C. and Li,Y.
  TITLE     Isolation, characterization, and mapping of two human potassium
            channels
  JOURNAL   Biochem Biophys Res Commun 241 (3), 675-681 (1997)
   PUBMED   9434767
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC019041.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2018 this sequence version replaced NM_002236.4.
            
            Summary: Voltage-gated potassium (Kv) channels represent the most
            complex class of voltage-gated ion channels from both functional
            and structural standpoints. Their diverse functions include
            regulating neurotransmitter release, heart rate, insulin secretion,
            neuronal excitability, epithelial electrolyte transport, smooth
            muscle contraction, and cell volume. This gene encodes a member of
            the potassium channel, voltage-gated, subfamily F. This gene is
            intronless and expressed in all tissues tested, including the
            heart, skeletal muscle, brain, kidney, and pancreas. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC026110.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295082.3/ ENSP00000295082.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2292              AC019041.8         7-2298
FEATURES             Location/Qualifiers
     source          1..2292
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..2292
                     /gene="KCNF1"
                     /gene_synonym="IK8; KCNF; kH1; KV5.1"
                     /note="potassium voltage-gated channel modifier subfamily
                     F member 1"
                     /db_xref="GeneID:3754"
                     /db_xref="HGNC:HGNC:6246"
                     /db_xref="MIM:603787"
     exon            1..2292
                     /gene="KCNF1"
                     /gene_synonym="IK8; KCNF; kH1; KV5.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             494..1978
                     /gene="KCNF1"
                     /gene_synonym="IK8; KCNF; kH1; KV5.1"
                     /note="potassium channel KH1; voltage-gated potassium
                     channel subunit Kv5.1"
                     /codon_start=1
                     /product="voltage-gated potassium channel regulatory
                     subunit KCNF1"
                     /protein_id="NP_002227.2"
                     /db_xref="CCDS:CCDS1676.1"
                     /db_xref="GeneID:3754"
                     /db_xref="HGNC:HGNC:6246"
                     /db_xref="MIM:603787"
                     /translation="MDGSGERSLPEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQY
                     PETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKK
                     GICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGR
                     WRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCMGTIPELQVLDAEGNRVE
                     HPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLG
                     ARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVG
                     IFVFSALGYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFL
                     CGVIAIALPIHPIINNFVRYYNKQRVLETAAKHELELMELNSSSGGEGKTGGSRSDLD
                     NLPPEPAGKEAPSCSSRLKLSHSDTFIPLLTEEKHHRTRLQSCK"
     regulatory      2270..2275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="KCNF1"
                     /gene_synonym="IK8; KCNF; kH1; KV5.1"
                     /note="hexamer: AATAAA"
     polyA_site      2292
                     /gene="KCNF1"
                     /gene_synonym="IK8; KCNF; kH1; KV5.1"
                     /note="major polyA site"
ORIGIN      
        1 ctattgtgtt tagaaaaggc tcgggcaaag ccagcccaag ttcgctctct gcacacctcg
       61 agcacctcgc ggacggcgtg ggtccgccag ctccgggacc tgccgccgct gcctgcgcgc
      121 cccggggcgg aggacggtgc cagccgccca cgaggagacc ccgctcccgc aggaggccga
      181 gctgaagcgg cggagcgcgc cgccagccag ccggggtgag tgccccgggc gaggccggcg
      241 gccgccaaag cccccgcggg ctcgcccggg cgcccggatg ccagccccga gccccgccgc
      301 cgggtgcatg cctcccccgc ggcgcgcccc cgcaggctgc tgcccgctgt gaccgccctt
      361 ccccgcaggc gggcgccggc caggctctcc ccgagatcag cgcacgggtg gcacccgccg
      421 gacccccagc ggcagcggcg gcggcggctg cagggggcgc ggggcggagg ctgcgagggc
      481 gcgcgcgggg aggatggacg ggtccgggga gcgcagcctc ccggagccgg gcagccagag
      541 ctccgctgcc agcgacgaca tagagatagt cgtcaacgtg gggggcgtgc ggcaggtgct
      601 gtacggggac ctcctcagtc agtaccctga gacccggctg gcggagctca tcaactgctt
      661 ggctgggggc tacgacacca tcttctccct gtgcgacgac tacgaccccg gcaagcgcga
      721 gttctacttt gacagggacc cggacgcctt caagtgtgtc atcgaggtgt actatttcgg
      781 ggaggtccac atgaagaagg gcatctgccc catctgcttc aagaacgaga tggacttctg
      841 gaaggtggac ctcaagttcc tggacgactg ttgcaagagc cacctgagcg agaagcgcga
      901 ggagctggag gagatcgcgc gccgcgtgca gctcatcctg gacgacctgg gcgtggacgc
      961 agccgagggc cgctggcgcc gctgccagaa gtgcgtctgg aagttcctgg agaagcccga
     1021 gtcgtcgtgc ccggcgcggg tggtggccgt gctctccttc ctgctcatcc tcgtctcgtc
     1081 cgtggtcatg tgcatgggca ccatccccga gctgcaggtg ctggacgccg agggcaaccg
     1141 cgtggagcac ccgacgctgg agaacgtgga gacggcgtgc attggctggt tcaccctgga
     1201 gtacctgctg cgcctcttct cgtcacccaa caagctgcac ttcgcgctgt ccttcatgaa
     1261 cattgtggac gtgctggcca tcctcccctt ctacgtgagc ctcacgctca cgcacctggg
     1321 tgcccgcatg atggagctga ccaacgtgca gcaggccgtg caggcgctgc ggatcatgcg
     1381 catcgcgcgc atcttcaagc tggcccgcca ctcctcgggc ctgcagaccc tcacctatgc
     1441 cctcaagcgc agcttcaagg aactggggct gctgctcatg tacctggcag tgggtatctt
     1501 cgtcttctct gccctgggct acaccatgga gcagagccat ccagagaccc tgtttaagag
     1561 catcccccag tccttctggt gggccatcat caccatgacc accgtcggct acggcgacat
     1621 ctaccccaag accacgctgg gcaagctcaa cgcggccatc agcttcttgt gtggtgtcat
     1681 cgccatcgcc ctgcccatcc accccatcat caacaacttt gtcaggtact acaacaagca
     1741 gcgcgtcctg gagaccgcgg ccaagcacga gctggagctg atggaactca actccagcag
     1801 cgggggcgag ggcaagaccg ggggctcccg cagtgacctg gacaacctcc ctccagagcc
     1861 tgcggggaag gaggcgccga gctgcagcag ccggctgaag ctctcccaca gcgacacctt
     1921 catccccctc ctgaccgagg agaagcacca caggacccgg ctccagagtt gcaagtgaca
     1981 ggagggcccc tcaggcagag atggaccagg cggtggacag atgggtagat gtggcaggca
     2041 tgtcatcgac agcacagaag ggctgtcctg tgtcccccca accctcccct ggacagactc
     2101 tgaaggccct cccggcacct ctgccaaggc tgggtaagac tcctctatgt tgcctgctgt
     2161 ccaggagccc gggagggagg ggtgtgcagg agccgcaggg ccgtgtggga cgagtggagg
     2221 ccgcggcctg gctggcacga gagcccacgc ccgcttctgt atctccctca ataaagcctc
     2281 ctgctctgtg ca
//
